Overview of T-2 Toxin Enterotoxicity: From Toxic Mechanisms and Detoxification to Future Perspectives

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(7), P. 3314 - 3324

Published: Feb. 8, 2024

Fusarium species produce a secondary metabolite known as T-2 toxin, which is the primary and most harmful toxin found in type A trichothecenes. widely food grain-based animal feed endangers health of both humans animals. exposure animals occurs primarily through administration; therefore, first organ that targets gut. In this overview, research progress, toxicity mechanism, detoxification were reviewed, future directions proposed. damages intestinal mucosa destroys structure barrier function; furthermore, disrupts microbiota, causes flora disorders, affects normal metabolic function, kills epidermal cells by inducing oxidative stress, inflammatory responses, apoptosis. The mechanism intestine stress. Currently, selenium plant extracts are mainly used to exert antioxidant effects alleviate enterotoxicity toxin. studies, use genomic techniques find upstream signaling molecules associated with enterotoxin will provide new ideas for prevention toxicity. purpose paper review progress on propose treatment

Language: Английский

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A scoping review on mycotoxin-induced neurotoxicity

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 17, 2025

Language: Английский

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Review of neurotoxicity of T-2 toxin

Mycotoxin Research, Journal Year: 2024, Volume and Issue: 40(1), P. 85 - 95

Published: Jan. 13, 2024

Language: Английский

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T-2 Toxin Nephrotoxicity: Toxic Effects, Mechanisms, Mitigations, and Future Perspectives

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

T-2 toxin is a highly toxic fungal that threatens humans and animals' health. As major detoxifying metabolic organ, the kidney also target of toxin. This article reviews nephrotoxicity research progress, covering renal structure function damage, mechanisms, detoxification methods to future directions. damages structure, causing dysfunction. The mechanism involves multiple factors including oxidative stress, endoplasmic reticulum mitophagy, inflammatory responses, apoptosis, which are intertwined interdependent. Current strategies mainly involve reducing in feedstuff using antioxidant substances, but both have limits. Future should focus on cells sensitivity toxin, exploring key molecules toxin's nephrotoxicity, injury's impact other organs, better methods. review aims guide underpin toxin-induced prevention treatment.

Language: Английский

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T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1

Chemosphere, Journal Year: 2023, Volume and Issue: 341, P. 140087 - 140087

Published: Sept. 5, 2023

Language: Английский

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Betulinic acid attenuates T-2 toxin-induced lung injury by activating Nrf2 signaling pathway and inhibiting MAPK/NF-κB signaling pathway

Toxicon, Journal Year: 2024, Volume and Issue: unknown, P. 107652 - 107652

Published: Feb. 1, 2024

Language: Английский

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The role of gut microbiota in anorexia induced by T-2 toxin

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116612 - 116612

Published: June 18, 2024

T-2 toxin is one of trichothecene mycotoxins, which can impair appetite and decrease food intake. However, the specific mechanisms for toxin-induced anorexia are not fully clarified. Multiple research results had shown that gut microbiota have a significant effect on regulation. Hence, this study purposed to explore potential interactions regulate factors in induced by toxin. The divided mice into control group (CG, 0 mg/kg BW toxin) toxin-treated (TG, 1 toxin), oral gavage 4 weeks, construct subacute poisoning mouse model. This data proved was able induce an increased contents gastrointestinal hormones (CCK, GIP, GLP-1 PYY), neurotransmitters (5-HT SP), as well pro-inflammatory cytokines (IL-1β, IL-6 TNF-α) serum mice. disturbed composition microbiota, especially, Faecalibaculum Allobaculum, positively correlated with CCK, GLP-1, 5-HT, IL-1β, TNF-α, played certain role regulating host appetite. In conclusion, changes (especially increase abundance Allobaculum) promote upregulation hormones, neurotransmitters, cytokines, may be mechanism anorexia.

Language: Английский

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Peroxiredoxin 4 Ameliorates T-2 Toxin-Induced Growth Retardation in GH3 Cells by Inhibiting Oxidative Stress and Apoptosis

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5491 - 5491

Published: Nov. 21, 2024

T-2 toxin, a highly toxic type A trichothecene, is secondary fungal metabolite produced by various Fusarium species. The consumption of food and feed contaminated with toxin major factor contributing to growth retardation, posing significant risks both human animal health. However, the specific targets mechanisms that mitigate toxin-induced retardation remain unclear. In this study, transcriptomic analysis was employed identify key differentially expressed genes associated alleviation retardation. Peroxiredoxin 4 (PRDX4), gene linked oxidative stress apoptosis, found be one most downregulated in toxin-treated GH3 cells, an vitro model experiments demonstrated significantly increased reactive oxygen species' production, cell cycle arrest while reducing activity antioxidant enzymes (superoxide dismutase glutathione peroxidase) PRDX4 expression cells. Furthermore, silencing exacerbated whereas overexpression effectively mitigated these effects. These findings highlight protective role counteracting suggesting can serve as therapeutic target for treatment

Language: Английский

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Exposome and detoxification

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 359 - 376

Published: Nov. 29, 2024

Language: Английский

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