Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135156 - 135156
Published: July 11, 2024
Language: Английский
EBioMedicine, Journal Year: 2024, Volume and Issue: 103, P. 105118 - 105118
Published: April 13, 2024
BackgroundMicroplastic (MP) pollution has emerged as a significant environmental concern worldwide. While extensive research focused on their presence in marine organisms and ecosystems, potential impact human health, particularly the circulatory system, remains understudied. This project aimed to identify quantify mass concentrations, polymer types, physical properties of MPs thrombi surgically retrieved from both arterial venous systems at three anatomically distinct sites, namely, cerebral arteries brain, coronary heart, deep veins lower extremities. Furthermore, this study investigate association between levels disease severity.MethodsThrombus samples were collected 30 patients who underwent thrombectomy procedures due ischaemic stroke (IS), myocardial infarction (MI), or vein thrombosis (DVT). Pyrolysis–gas chromatography spectrometry (Py-GC/MS) was employed concentrations MPs. Laser direct infrared (LDIR) spectroscopy scanning electron microscopy (SEM) used analyse Demographic clinical information also examined. A rigorous quality control system eliminate contamination.FindingsMPs detected by Py-GC/MS 80% (24/30) obtained with IS, MI, DVT, median 61.75 μg/g, 141.80 69.62 respectively. Among 10 target types MP polymers, polyamide 66 (PA66), polyvinyl chloride (PVC), polyethylene (PE) identified. Further analyses suggested that higher may be associated greater severity (adjusted β = 7.72, 95% CI: 2.01–13.43, p < 0.05). The level D-dimer MP-detected group significantly than MP-undetected (8.3 ± 1.5 μg/L vs 6.6 0.5 μg/L, 0.001). Additionally, LDIR analysis showed PE dominant among 15 identified MPs, accounting for 53.6% all mean diameter 35.6 μm. shapes polymers using SEM found heterogeneous.InterpretationThis presents qualitative quantitative evidence thrombotic diseases through use multimodal detection methods. Higher increased severity. Future larger sample size is urgently needed sources exposure validate observed trends study.FundingThis funded SUMC Scientific Research Initiation Grant (SRIG, No. 009-510858038), Postdoctoral (No. 202205230031-3), 2020 Li Ka Shing Foundation Cross-Disciplinary 2020LKSFG02C).
Language: Английский
Citations
32
European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(172), P. 230226 - 230226
Published: April 30, 2024
Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals particles known as micro- nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected different locations of human body, including our lungs. This is likely a consequence MNP exposure through air we breathe. Yet, still lack comprehensive understanding impact may on respiratory disease health. In this review, collated current body evidence implications inhalation lung health vitro , vivo occupational studies. We focused interactions between pollution specific lung-resident cells diseases. conclude it evident possess capacity affect tissue remains unclear which extent occurs ambient levels MNPs, emphasising need for more evaluation environmental everyday life.
Language: Английский
Citations
27
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170664 - 170664
Published: Feb. 2, 2024
Language: Английский
Citations
19
Microplastics and Nanoplastics, Journal Year: 2024, Volume and Issue: 4(1)
Published: June 24, 2024
Abstract The limited available data on human internal exposure poses a significant challenge in assessing the risks associated with micro and nanoplastics (MNPs) to health. A contributing factor this is scarcity of sensitive analytical methods quantify mass concentration plastic polymers blood. In study we present an improved validated method for quantitatively analysing polyethylene (PE), terephthalate (PET), poly(vinyl chloride) (PVC), poly(methyl methacrylate) (PMMA), polypropylene, polystyrene whole blood samples. We introduce apply stringent quality assurance control procedures, including validation using samples continuous monitoring batch analyses ensure reliability. Expanding upon prior pioneering work by Leslie et al. (2022), optimised pyrolysis-gas chromatography–mass spectrometry (Py-GC-MS) conditions enhance sensitivity selectivity. Recovery experiments demonstrated high level accuracy precision, values ranging from 68 109% Applying ( n = 68), identified 64 samples, PE as predominant polymer, followed PVC, PET, PMMA. 17 polymer concentrations were found exceed limit quantitation, mean 1070 ng/mL summed concentrations, between 170 2490 ng/mL. sum across all 68) was 268 These findings underscore pressing need further research aimed at comprehensive MNP quantification matrices, considering potential health implications.
Language: Английский
Citations
19
International Journal of Impotence Research, Journal Year: 2024, Volume and Issue: unknown
Published: June 19, 2024
Language: Английский
Citations
15
Kidney International, Journal Year: 2024, Volume and Issue: 106(3), P. 400 - 407
Published: June 18, 2024
Language: Английский
Citations
12
Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 358 - 358
Published: May 11, 2024
Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat human health. Inhalation toxicological studies crucial for assessing the effects MPs and exposure-reduction measures. This communication paper addresses important health concerns related MPs, taking into consideration three levels complexity, i.e., themselves, additives present plastics, exogenous substances adsorbed onto them. approach aims obtain comprehensive profile deposited lungs, encompassing local systemic effects. The physicochemical characteristics may play pivotal role toxicity. Although evidence suggests toxic animal cell models, no established causal link with pulmonary or diseases humans has established. transfer associated chemicals from lungs bloodstream and/or circulation remains be confirmed humans. Understanding toxicity requires multidisciplinary investigation using One Health approach.
Language: Английский
Citations
11
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 173, P. 117618 - 117618
Published: March 6, 2024
Language: Английский
Citations
9
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)
Published: Jan. 14, 2025
Microplastic pollution contributes to the rise of antibiotic-resistance. Everyday items like food containers, water bottles, clothing, and cosmetics can increase people's resistance antibiotics. Microplastics in environment serve as a suitable substrate for production "antibiotic-resistant genes" (ARGs). These genes are protected by bacterial chromosomes, phages, plasmids, which biological vectors capable spreading transferring antibiotic-resistance humans, thereby reducing their ability fight infections. In this study, we reviewed several articles that evaluated abundance ARGs changes expression different environments. were observed upon exposure antibiotics such tetracycline, sulfamethoxazole, macrolides, others, well microplastics, nanoplastics, or combination both. To assess impact these stressors on ARG abundance, compiled data from various studies using heatmaps tables abundances tissues By synthesizing information, aimed identify upregulated downregulated response each stressor. Our findings provide insights into potential risks posed environmental pollutants underscore importance understanding dynamics stressors.
Language: Английский
Citations
1
Environmental Geochemistry and Health, Journal Year: 2025, Volume and Issue: 47(4)
Published: Feb. 27, 2025
Language: Английский
Citations
1