Epigenomes,
Journal Year:
2022,
Volume and Issue:
6(3), P. 27 - 27
Published: Aug. 26, 2022
Cannabis
is
one
of
the
most
commonly
used
and
abused
illicit
drugs
in
world
today.
The
United
States
(US)
currently
has
highest
annual
prevalence
rate
cannabis
consumption
world,
17.9%
individuals
aged
12
or
older,
it
on
rise.
With
increasing
use
comes
potential
for
an
increase
abuse,
according
to
Substance
Abuse
Mental
Health
Services
Administration
(SAMHSA),
approximately
5.1%
Americans
had
Use
Disorder
(CUD)
2020.
Research
shown
that
genetics
epigenetics
play
a
significant
role
CUD.
In
fact,
50–70%
liability
CUD
40–48%
initiation
have
been
found
be
result
genetic
factors.
usage
also
linked
increased
risk
psychiatric
disorders
Reward
Deficiency
Syndrome
(RDS)
subsets
like
schizophrenia,
depression,
anxiety,
substance
disorder.
Comprehension
epigenetic
aspects
cannabinoids
necessary
future
research,
treatment
plans,
production
pure
cannabinoid
compounds,
which
will
essential
FDA
approval.
conclusion,
having
better
understanding
underpinnings
use,
CUD,
endocannabinoid
system
as
whole
aid
development
effective
FDA-approved
therapies
advancement
personalized
medicine.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11258 - 11258
Published: Oct. 19, 2024
This
review
provides
an
overview
of
cannabis-based
phytocannabinoids,
focusing
on
their
mechanisms
action,
therapeutic
applications,
and
production
processes,
along
with
the
environmental
factors
that
affect
quality
efficacy.
Phytocannabinoids
such
as
THC
(∆9-tetrahydrocannabinol),
CBD
(cannabidiol),
CBG
(cannabigerol),
CBN
(cannabinol),
CBC
(cannabichromene)
exhibit
significant
potential
in
treating
various
physical
mental
health
conditions,
including
chronic
pain,
epilepsy,
neurodegenerative
diseases,
skin
disorders,
anxiety.
The
cultivation
cannabis
plays
a
crucial
role
determining
cannabinoid
profiles,
indoor
offering
more
control
consistency
than
outdoor
methods.
Environmental
light,
water,
temperature,
humidity,
nutrient
management,
CO2,
drying
method
used
are
key
to
optimizing
content
inflorescences.
outlines
need
for
broader
data
transfer
between
industry
technological
production,
especially
terms
what
concentration
ratios
effective
treatment.
Such
would
provide
cultivators
information
parameters
should
be
manipulated
obtain
required
final
product.
Saudi Journal of Biological Sciences,
Journal Year:
2021,
Volume and Issue:
28(12), P. 7290 - 7313
Published: Aug. 19, 2021
Cannabis
sativa,
widely
known
as
'Marijuana'
poses
a
dilemma
for
being
blend
of
both
good
and
bad
medicinal
effects.
The
historical
use
recreational
purposes
suggests
it
to
be
friendly
plant.
However,
whether
the
misuse
cannabinoids
derived
from
can
hamper
normal
body
physiology
is
focus
ongoing
research.
On
one
hand,
there
enough
evidence
suggest
that
marijuana
cause
deleterious
effects
on
various
organs
like
lungs,
immune
system,
cardiovascular
etc.
also
influence
fertility
teratogenic
other
has
been
found
offer
magical
cure
anorexia,
chronic
pain,
muscle
spasticity,
nausea,
disturbed
sleep.
Indeed,
most
recently,
United
Nations
given
its
verdict
in
favour
declaring
non-dangerous
narcotic.
This
review
provides
insights
into
health
specialized
metabolites
indicates
how
wise
steps
taken
promote
prevent
this
Molecules,
Journal Year:
2023,
Volume and Issue:
28(23), P. 7686 - 7686
Published: Nov. 21, 2023
Cannabis
plants
have
been
used
in
medicine
since
ancient
times.
They
are
well
known
for
their
anti-diabetic,
anti-inflammatory,
neuroprotective,
anti-cancer,
anti-oxidative,
anti-microbial,
anti-viral,
and
anti-fungal
activities.
A
growing
body
of
evidence
indicates
that
targeting
the
endocannabinoid
system
various
other
receptors
with
cannabinoid
compounds
holds
great
promise
addressing
multiple
medical
conditions.
There
two
distinct
avenues
development
cannabinoid-based
drugs.
The
first
involves
creating
treatments
directly
based
on
components
cannabis
plant.
second
a
singular
molecule
strategy,
which
specific
phytocannabinoids
or
newly
discovered
cannabinoids
therapeutic
pinpointed
synthesized
future
pharmaceutical
validation.
Although
potential
is
enormous,
few
cannabis-related
approved
drugs
exist,
this
avenue
warrants
further
investigation.
With
mind,
we
review
here
medicinal
properties
cannabis,
its
phytochemicals,
natural
synthetic
origin,
pitfalls
way
to
widespread
clinical
use
additional
applications
products.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(12), P. 5657 - 5699
Published: Oct. 12, 2023
Abstract
Leading
neurodegenerative
diseases
Alzheimer's
disease
(AD)
and
Parkinson's
(PD)
are
characterized
by
the
impairment
of
memory
motor
functions,
respectively.
Despite
several
breakthroughs,
there
exists
a
lack
disease‐modifying
treatment
strategies
for
these
diseases,
as
available
drugs
provide
symptomatic
relief
bring
along
side
effects.
Bioactive
compounds
reported
to
bear
neuroprotective
properties
with
minimal
toxicity,
however,
detailed
elucidation
their
modes
neuroprotection
is
lacking.
The
review
elucidates
mechanism(s)
some
major
phyto‐compounds
in
pre‐clinical
clinical
studies
AD
PD
understand
potential
combating
diseases.
Curcumin,
eugenol,
resveratrol,
baicalein,
sesamol
so
on
have
proved
efficient
countering
pathological
hallmarks
PD.
caffeine
reached
phases
while
aromadendrin,
delphinidin,
cyanidin
xanthohumol
yet
be
extensively
explored
phases.
highlights
need
extensive
investigation
stages
utilize
abilities
real
field
treatment.
Moreover,
poor
pharmacokinetic
natural
constraints
therapeutic
yields
this
suggests
plausible
contribution
nanotechnology
overcoming
limitations.
Case Studies in Chemical and Environmental Engineering,
Journal Year:
2023,
Volume and Issue:
9, P. 100550 - 100550
Published: Nov. 22, 2023
As
a
versatile
and
multipurpose
plant,
hemp
(Cannabis
sativa
L.)
possesses
immense
potential
for
its
application
in
nutraceuticals,
food
nutrition,
fibre,
construction
material.
However,
broader
industrial
potentials
are
hindered
by
the
lack
of
sufficient
knowledge
on
varietal
differences,
phytochemical
properties,
fibre
processing
techniques,
bioenergy
valorisation
whole
clinical
evidence,
standardised
quality
control
mechanisms.
In
this
context,
we
systematically
reviewed
101
reviews
655
research
papers
to
map
what
already
know
still
need
about
hemp,
across
supply
chain;
from
cultivar
selection
through
production
end
use.
We
literature
based
major
themes
sub-themes.
Existing
spanned
33
sub-themes
which
can
be
classified
under
five
broad
themes:
production,
material,
health,
futures,
education.
The
'material'
theme
(42%)
was
most
researched,
followed
'production'
(27%)
'health'
(19%).
At
sub-theme
level,
one-fifth
articles
covered
composite
material
(n
=
139),
analysis
potency
testing
45),
hempcrete
applications
43),
germination
plantation
techniques
41).
More
than
half
selected
were
published
last
three
years
(2020–2022),
concentrated
mainly
North
America,
Europe,
China.
Cannabidiol,
seed
oil
considered
as
quick
wins
industry
(hemp
champions).
Based
our
review,
have
discussed
various
gaps
priorities
chain,
beginning
early
detection
breed
hurd
residue
address
opportunities
challenges
development
products.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(10), P. e31345 - e31345
Published: May 1, 2024
In
veterinary
medicine,
Cannabis
has
been
used
to
treat
pain
conditions,
inflammation,
and
seizures.
However,
little
is
known
about
its
effect
on
dogs'
behavior.
This
preliminary
research
aims
address
this
knowledge
gap
by
evaluating
the
effectiveness
of
cannabidiol
(CBD)
oil
in
canine
behavioral
therapy.
Twenty
dogs,
diagnosed
with
disorders
housed
a
municipal
shelter,
participated
double-blind
trial.
Ten
dogs
received
CBD
treatment,
while
other
ten
control
without
CBD.
Before
(T0)
after
(T1)
all
underwent
temperament
test
assess
their
behavior
presence
four
different
stimuli:
human
stranger,
novel
object,
child-like
doll,
conspecific
(another
dog).
Each
stimulus
was
presented
individually,
behaviors
were
recorded
video
analyzed.
Additionally,
hair
samples
collected
using
shave-reshave
technique
for
cortisol
determination
through
Radio-Immuno-Assay.
No
differences
found
between
two
groups
at
both
T0
T1.
There
no
significant
responses
either
group
when
comparing
individual
treatment
appeared
vary
among
subjects.
A
increase
levels
(p-value
<0.05)
observed
treated
[T0
=
1.60
(1.44-1.93)
pg/mg,
T1
4.81(2.57-6.01)
pg/mg].
These
findings
highlight
importance
individualized
encourage
further
use
animal
medicine.
BMC Pulmonary Medicine,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 29, 2025
Cannabis
is
the
third
most
widely
used
psychoactive
substance
globally,
and
its
consumption
has
been
increasing,
particularly
with
growing
trend
of
legalization
for
medicinal
recreational
use.
Recent
studies
have
raised
concerns
about
potential
impact
cannabis
on
respiratory
health,
specifically
risk
asthma,
a
significant
public
health
concern.
This
systematic
review
aimed
to
consolidate
research
association
between
use
asthma.
A
comprehensive
search
was
conducted
across
PubMed,
Embase,
Web
Science,
covering
published
up
September
30,
2024.
We
included
peer-reviewed
observational
evaluating
link
asthma
diagnosis.
Data
synthesis
employed
random-effects
meta-analysis
account
heterogeneity.
R
statistical
software
(version
4.4)
analyses.
The
yielded
8
relevant
after
screening
1,887
records.
pooled
odds
ratio
(OR)
diagnosis
1.31,
95%
confidence
interval
(CI):
1.19-1.44,
indicating
greater
having
compared
non-users.
Moderate
heterogeneity
observed
(I²
=
46%),
sensitivity
analysis
confirmed
robustness
findings.
identifies
These
findings
emphasize
importance
raising
awareness
risks
associated
Future
should
prioritize
identifying
moderating
factors,
such
as
frequency
mode
consumption,
enhance
understanding
this
provide
stronger
evidence
base
interventions.
Not
applicable.
Medical Cannabis and Cannabinoids,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Our
objective
was
to
provide
an
overview
of
the
currently
available
scientific
and
clinical
data
supporting
use
Cannabis
Cannabis-derived
products
for
treatment
chronic
pain
disorders.
We
also
information
researchers,
clinicians,
patients
be
better
informed
understand
approach
behind
recommendation
as
a
potential
adjuvant
in
treatment/control
pain.
its
bioactive
compounds
have
sparked
interest
field
spite
controversial
history
status
controlled
substance
many
countries.
With
increase
pain,
physicians
started
look
at
alternative
ways
treat
aside
from
traditional
treatments.
One
is
cannabis
reduce/treat
disorders
based
on
anecdotal
accounts
function
phytocannabinoids.
The
two
main
cannabinoids
cannabis,
tetrahydrocannabinol
(THC)
cannabidiol,
act
CB1
CB2
receptors
(in
addition
several
additional
receptors).
It
through
these
pleiotropic
receptor
interactions
that
elicit
their
biological
including
reduction
In
this
narrative
review,
we
included
most
recent
evidence
neuropathic
cancer-induced
musculoskeletal
headaches
migraines.
Evidence
suggests
analgesic
effect
arises
combination
various
systems.
These
effects
may
maximized
with
cannabinoids.
At
same
time,
helps
minimize
undesirable
side
some
such
psychoactivity
THC.
findings,
further
research
necessary
assess
properties
other
like
cannabichromene
cannabigerol
contributions
show
