Chemosphere, Journal Year: 2024, Volume and Issue: 366, P. 143487 - 143487
Published: Oct. 1, 2024
Language: Английский
Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(4), P. 1285 - 1305
Published: Feb. 20, 2024
The discovery of naturally occurring organohalogen compounds has increased astronomically in the 55 years since they were first discovered─from fewer than 50 1968 to a combined 7,958 described examples three comprehensive reviews. present survey, which covers period 2021–2023, brings number known natural organohalogens approximately 8,400. organization is according species origin, and coverage includes marine terrestrial plants, fungi, bacteria, sponges, corals, cyanobacteria, tunicates, other organisms.
Language: Английский
Citations
28
Horticulturae, Journal Year: 2022, Volume and Issue: 8(1), P. 58 - 58
Published: Jan. 8, 2022
Cyanobacteria, also called blue-green algae, are a group of prokaryotic microorganisms largely distributed in both terrestrial and aquatic environments. They produce wide range bioactive compounds that mostly used cosmetics, animal feed human food, nutraceutical pharmaceutical industries, the production biofuels. Nowadays, research concerning use cyanobacteria agriculture has pointed out their potential as biofertilizers source compounds, such phycobiliproteins, for plant pathogen control inducers systemic resistance. The alternative products place synthetic ones disease is encouraged by European Directive 2009/128/EC. present up-to-date review gives an overall view recent results on bioprotective effect against fungal oomycete phytopathogens biostimulant properties. We highlight need considering several factors proper sustainable management agricultural crops, ranging from mechanisms which reduce diseases modulate resistance to enhancement growth.
Language: Английский
Citations
43
Toxins, Journal Year: 2023, Volume and Issue: 15(3), P. 233 - 233
Published: March 21, 2023
Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, terrestrial ecosystems. The health significance these metabolites, which include genotoxic- neurotoxic agents, is confirmed by continued associations between the occurrence animal human acute toxic events and, long term, cyanobacteria neurodegenerative diseases. Major mechanisms related to neurotoxicity compounds (1) blocking key proteins channels; (2) inhibition essential enzymes mammalian cells such as protein phosphatases phosphoprotein well new molecular targets toll-like receptors 4 8. One widely discussed implicated includes misincorporation cyanobacterial non-proteogenic amino acids. Recent research provides evidence that non-proteinogenic acid BMAA produced have multiple effects on translation process bypasses proof-reading ability aminoacyl-tRNA-synthetase. Aberrant generated non-canonical may be factor neuronal death neurodegeneration. We hypothesize production acids more general mechanism, leading mistranslation, affecting homeostasis, targeting mitochondria eukaryotic cells. It can evolutionarily ancient initially developed control phytoplankton communities during algal blooms. Outcompeting gut symbiotic microorganisms lead dysbiosis, increased permeability, shift blood-brain-barrier functionality, eventually, mitochondrial dysfunction high-energy demanding neurons. A better understanding interaction metabolism nervous system will crucial target or prevent
Language: Английский
Citations
23
Toxins, Journal Year: 2024, Volume and Issue: 16(1), P. 42 - 42
Published: Jan. 12, 2024
Cetaceans are well-regarded as sentinels for toxin exposure. Emerging studies suggest that cetaceans can also develop neuropathological changes associated with neurodegenerative disease. The occurrence of neuropathology makes an ideal species examining the impact marine toxins on brain across lifespan. Here, we describe TAR DNA-binding protein 43 (TDP-43) proteinopathy and Alzheimer's disease (AD) in a beached harbor porpoise (
Language: Английский
Citations
9
Allergologie select, Journal Year: 2024, Volume and Issue: 8(01), P. 90 - 198
Published: Jan. 1, 2024
None.
Citations
7
Reviews in Aquaculture, Journal Year: 2024, Volume and Issue: 16(3), P. 1186 - 1211
Published: Jan. 14, 2024
Abstract The increasing global population has led to rising demand for food, particularly protein. As an excellent source of protein, fish play a crucial role in meeting this demand, making aquaculture highly impactful industry. Floating cages have been developed as method management and production achieve high productivity volume. However, these intensive farming practices can contribute eutrophication, leading changes primary producers promoting the excessive proliferation cyanobacteria. Cyanobacteria blooms pose significant consequences aquatic ecosystems, including potential risks exposed harmful cyanobacterial metabolites. Cyanobacterial metabolites encompass various chemical classes, such terpenoids, carotenoids, alkaloids, cyanopeptides, amino acids, organophosphates, macrolides, lipopolysaccharides. Some compounds' toxicity impact on farms still need be better understood. Cyanotoxins off‐flavour compounds water quality health hazards humans throughout food chain. Therefore, cyanobacteria economic, environmental, public implications. This review examines concerns associated with natural products farming, off‐flavours, known cyanotoxins, other potentially toxic compounds, while exploring their socioeconomic environmental risks.
Language: Английский
Citations
6
Pneumologie, Journal Year: 2024, Volume and Issue: 78(10), P. 693 - 784
Published: Feb. 9, 2024
This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case indoor exposure - Update 2023", presented July 2023 by German Society Hygiene, Environmental Medicine and Preventive (Gesellschaft für Umweltmedizin und Präventivmedizin, GHUP), collaboration with Austrian scientific medical societies, experts. Indoor growth a potential health risk, even if quantitative and/or causal relationship between occurrence individual species problems has yet to be established. There no evidence for moisture/mould damage human diseases, mainly because ubiquitous presence fungi hitherto inadequate diagnostic methods. Sufficient association following effects been established for: allergic respiratory rhinitis, rhino-conjunctivitis, bronchopulmonary aspergillosis (ABPA), other mycosis (ABPM), aspergilloma, Aspergillus bronchitis, asthma (manifestation, progression, exacerbation), bronchitis (acute, chronic), community-acquired pneumonia, hypersensitivity pneumonitis (HP; extrinsic alveolitis (EEA)), invasive Aspergillosis, mycoses, organic dust toxic syndrome (ODTS) [workplace exposure], promotion infections, pulmonary (subacute, rhinosinusitis chronically invasive, or granulomatous, allergic). In this context sensitizing moulds obviously low compared environmental allergens. Recent studies show comparatively sensitization prevalence 3-22,5 % general population across Europe. Limited suspected exist respect atopic eczema (atopic dermatitis, neurodermatitis; manifestation), chronic obstructive disease (COPD), mood disorders, mucous membrane irritation (MMI), odor effects, sarcoidosis. (iv) Inadequate insufficient acute idiopathic hemorrhage infants, airborne transmitted mycotoxicosis, arthritis, autoimmune cancer, fatigue (CFS), endocrinopathies, gastrointestinal multiple chemical sensitivity (MCS), sclerosis, neuropsychological neurotoxic renal reproductive rheumatism, sick building (SBS), sudden infant death syndrome, teratogenicity, thyroid urticaria.The risk infection posed regularly occurring indoors healthy persons; most are group 1 few 2 (
Language: Английский
Citations
6
Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 462, P. 123077 - 123077
Published: June 2, 2024
Language: Английский
Citations
5
Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Aug. 23, 2024
Metropolitan Mexico City (MMC) children and young adults exhibit overlapping Alzheimer Parkinsons’ diseases (AD, PD) TAR DNA-binding protein 43 pathology with magnetic ultrafine particulate matter (UFPM) industrial nanoparticles (NPs). We studied magnetophoresis, electron microscopy energy-dispersive X-ray spectrometry in 203 brain samples from 14 children, 27 adults, ALS cases/controls. Saturation isothermal remanent magnetization (SIRM), capturing magnetically unstable FeNPs ̴ 20nm, was higher caudate, thalamus, hippocampus, putamen, motor regions subcortical vs. cortical SIRM MMC ≤ 40y. Motion behavior associated exposures 25–100 mT exhibited IRM saturated curves at 50–300 to change NPs position and/or orientation situ . Targeted profiles moving under AC/AD fields could distinguish controls. Motor neuron accumulation potentially interferes action potentials, ion channels, nuclear pores enhances the membrane insertion process when coated lipopolysaccharides. TEM EDX showed 7–20 nm NP Fe, Ti, Co, Ni, V, Hg, W, Al, Zn, Ag, Si, S, Br, Ce, La, Pr abnormal neural vascular organelles. Brain of particles start childhood cytotoxic, hyperthermia, free radical formation, motion 30–50 μT (DC fields) are critical given ubiquitous electric induce damage. Magnetic UFPM/NPs a fatal cargo children’s brains, preventable AD, PD, FTLD, environmental threat. Billions people risk. clearly poisoning ourselves.
Language: Английский
Citations
5
Ecology and Society, Journal Year: 2023, Volume and Issue: 28(1)
Published: Jan. 1, 2023
Lake Victoria, bordered by Kenya, Tanzania, and Uganda, provides one of the largest freshwater fisheries in world supports millions small-scale fishing communities. Historical environmental change, including population growth, nutrient loading, introduced invasive species, rising temperatures, has resulted eutrophication persistent cyanobacterial harmful algae blooms (cyanoHABs) over recent decades, particularly shallower gulfs, bays, inlets. CyanoHABs impact food web dynamics compromise water security for nearshore fisher populations. In this study, we examine social-ecological on health these eutrophic regions, Winam Gulf Victoria. persist months produce microcystins hepatotoxins at levels unsafe human health. We assessed potential risk contribution microcystin exposure through fish consumption, addition to source, conducted 400 household surveys. Average concentrations exceeded World Health Organization (WHO) guideline drinking consistently during long dry season, cell counts surpassed WHO standards recreational 84% samples. Hazard quotients consumed young children were 5 10 times higher than permissible levels. addition, fishers chronicled profound ecosystem changes with direct livelihood, fisheries, quality 77.4% reporting a decline profit or catch, 83.1% adverse impacts cyanoHABs lake, 98.2% indicators declining lake overall. Through application lens public model, identified spheres influence that modify how experience HABs related stressors risks provide starting point which identify sustainable strategies improve livelihood
Language: Английский
Citations
12