Improving Biosensors by the Use of Different Nanomaterials: Case Study with Microcystins as Target Analytes DOI Creative Commons

Hanbin Park,

Gahyeon Kim,

Yoseph Seo

et al.

Biosensors, Journal Year: 2021, Volume and Issue: 11(12), P. 525 - 525

Published: Dec. 20, 2021

The eutrophication of lakes and rivers without adequate rainfall leads to excessive growth cyanobacterial harmful algal blooms (CyanoHABs) that produce toxicants, green tides, unpleasant odors. rapid CyanoHABs owing global warming, climate change, the development rainforests dams considering environmental concern towards is a serious issue. Humans livestock consuming toxicant-contaminated water originated from suffer severe health problems. Among various toxicants produced by CyanoHABs, microcystins (MCs) are most harmful. Excess accumulation MC within living organisms can result in liver failure hepatocirrhosis, eventually leading death. Therefore, it essential precisely detect MCs samples. To date, liquid chromatography-mass spectrometry (LC-MS) enzyme-linked immunosorbent assay (ELISA) have been standard methods for detection provide precise results with high reliability. However, these require heavy instruments complicated operation steps could hamper portability field-readiness system. order this goal be achieved, biosensor has attracted powerful alternative detection. Thus far, several types proposed freshwater sample. introduction material useful option improve performance construct new biosensors. Introducing nanomaterials interface provides phenomena or enhances sensitivity. In recent times, different nanomaterials, such as metallic, carbon-based, transition metal dichalcogenide-based developed used fabricate biosensors This study reviews advancements nanomaterial-based

Language: Английский

Foodborne pathogens in the plastisphere: Can microplastics in the food chain threaten microbial food safety? DOI Creative Commons
Raffaella Tavelli, Martijn Callens, Charlotte Grootaert

et al.

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 129, P. 1 - 10

Published: Sept. 6, 2022

Microplastics (MPs) contaminate the global marine and terrestrial ecosystems. This environmental contamination can enter food chain, with MPs found in drinking water, fishery products other categories. Consequently, ingestion is considered main route of human exposure to MPs. Concerns exist on potential act as vectors for pathogenic bacteria, possibly threatening microbial safety. Starting from current evidence foodborne pathogens associated MPs, we review state knowledge putative role enhancing harmful bacterial traits transporting them humans. Finally, focus simultaneous uptake gut. Overall, identify major gaps, both mechanisms possible health outcomes. The scarce inconclusive results regarding effect virulence evolution, together insufficient about attachment toxins highlight need further studies. We conclude that biofilm-coated foodstuffs may pose several risks safety, but research will be essential determine extent their health.

Language: Английский

Citations

55
Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases DOI Creative Commons
Galina Nugumanova, Eugene D. Ponomarev, Sholpan Askarova

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(3), P. 233 - 233

Published: March 21, 2023

Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, terrestrial ecosystems. The health significance these metabolites, which include genotoxic- neurotoxic agents, is confirmed by continued associations between the occurrence animal human acute toxic events and, long term, cyanobacteria neurodegenerative diseases. Major mechanisms related to neurotoxicity compounds (1) blocking key proteins channels; (2) inhibition essential enzymes mammalian cells such as protein phosphatases phosphoprotein well new molecular targets toll-like receptors 4 8. One widely discussed implicated includes misincorporation cyanobacterial non-proteogenic amino acids. Recent research provides evidence that non-proteinogenic acid BMAA produced have multiple effects on translation process bypasses proof-reading ability aminoacyl-tRNA-synthetase. Aberrant generated non-canonical may be factor neuronal death neurodegeneration. We hypothesize production acids more general mechanism, leading mistranslation, affecting homeostasis, targeting mitochondria eukaryotic cells. It can evolutionarily ancient initially developed control phytoplankton communities during algal blooms. Outcompeting gut symbiotic microorganisms lead dysbiosis, increased permeability, shift blood-brain-barrier functionality, eventually, mitochondrial dysfunction high-energy demanding neurons. A better understanding interaction metabolism nervous system will crucial target or prevent

Language: Английский

Citations

23
Microbial protein sources: A comprehensive review on the potential usage of fungi and cyanobacteria in sustainable food systems DOI
Nagarjuna Prakash Dalbanjan,

Manjunath P. Eelager,

Shivayogi S. Narasagoudr

et al.

Food and Humanity, Journal Year: 2024, Volume and Issue: 3, P. 100366 - 100366

Published: July 27, 2024

Language: Английский

Citations

15
Cyanotoxin-encoding genes as powerful predictors of cyanotoxin production during harmful cyanobacterial blooms in an inland freshwater lake: Evaluating a novel early-warning system DOI
Xiaodi Duan, Chiqian Zhang,

Ian Struewing

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 830, P. 154568 - 154568

Published: March 14, 2022

Language: Английский

Citations

30
A dual-mode optical sensor for sensitive detection of saxitoxin in shellfish based on three-in-one functional nanozymes DOI
Long Wu, Yueqing Li, Yu Han

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 130, P. 106190 - 106190

Published: March 21, 2024

Language: Английский

Citations

7
A review of microcystin and nodularin toxins derived from freshwater cyanobacterial harmful algal blooms and their impact on human health DOI Creative Commons
Rajesh Melaram, Amanda Rose Newton,

A. C. Lee

et al.

Toxicology and Environmental Health Sciences, Journal Year: 2024, Volume and Issue: 16(3), P. 233 - 241

Published: June 21, 2024

Abstract The impacts of climate change on cyanobacterial harmful algal blooms (cHABs) are paramount, promoting the widespread distribution, intensity, and toxicity these phenomena in major freshwater bodies across globe. Microcystins (MCs) nodularins (NODs) monocyclic peptides that produce hepatotoxic effects living organisms. Despite efforts understanding their molecular toxicological mechanisms, we do not fully have a grasp human health associated with toxins derived from cHABs. We seek to provide current update epidemiology MCs NODs, integrating key evidence vitro, vivo, epidemiological studies. primary objective this work is understand MC NOD-producing

Language: Английский

Citations

6
Nanozyme and bifunctional nanobody-based colorimetric-SERS dual-mode Immunosensor for microcystin-LR detection DOI
Long Wu,

Luyao Jiao,

Danni Xue

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141574 - 141574

Published: Oct. 9, 2024

Language: Английский

Citations

6
Cyanotoxins in food: Exposure assessment and health impact DOI
Damjana Drobac, Nada Tokodi

Food Research International, Journal Year: 2024, Volume and Issue: 184, P. 114271 - 114271

Published: March 30, 2024

Language: Английский

Citations

5
Nodding syndrome: A role for environmental biotoxins that dysregulate MECP2 expression? DOI Creative Commons
Peter S. Spencer, Raquel Valdes Angues,

Valerie S. Palmer

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 462, P. 123077 - 123077

Published: June 2, 2024

Language: Английский

Citations

5
Harmful and beneficial properties of cyanotoxins: Two sides of the same coin DOI Creative Commons
Annarita Ricciardelli, Antonino Pollio, Maria Costantini

et al.

Biotechnology Advances, Journal Year: 2023, Volume and Issue: 68, P. 108235 - 108235

Published: Aug. 10, 2023

Cyanotoxins are by definition "harmful agents" produced cyanobacteria. Their toxicity has been extensively studied and reviewed over the years. have commonly classified, based on their poisonous effects mammals, into three main classes, neurotoxins, hepatotoxins dermatotoxins, and, considering chemical features, mainly identified as peptides, alkaloids lipopolysaccharides. Here we propose a broader subdivision of cyanotoxins eight distinct taking account molecular structures, biosynthesis modes action: alkaloids, non-ribosomal polyketides, non-protein amino acids, indole organophosphates, lipopeptides lipoglycans. For each class, structures primary mechanisms representative reported. Despite powerful biological activities, only recently scientists considered biotechnological potential cyanotoxins, applications both in medical industrial settings, even if few these reached biotech market. In this perspective, discuss uses anticancer, antimicrobial, biocidal agents, common for cytotoxic compounds. Furthermore, action, describe peculiar bioactivities several cyanotoxin such local anaesthetics, antithrombotics, neuroplasticity promoters, immunomodulating antifouling agents. review, aim to stimulate research beneficial roles which require interdisciplinary cooperation facilitate discovery innovative biotechnologies.

Language: Английский

Citations

13