Recent Progress on Techniques in the Detection of Aflatoxin B1 in Edible Oil: A Mini Review DOI Creative Commons
Shipeng Yin, Liqiong Niu,

Yuanfa Liu

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6141 - 6141

Published: Sept. 20, 2022

Contamination of agricultural products and foods by aflatoxin B1 (AFB1) is becoming a serious global problem, the presence AFB1 in edible oil frequent has become inevitable, especially underdeveloped countries regions. As results from possible degradation aflatoxins interaction resulting toxic compound with food components, it could cause chronic disease or severe cancers, increasing morbidity mortality. Therefore, rapid reliable detection methods are essential for checking occurrence foodstuffs to ensure safety. Recently, new biosensor technologies have research hotspot due their characteristics speed accuracy. This review describes various such as chromatographic spectroscopic techniques, ELISA biosensing along advantages weaknesses, control provides insight into future work. Although compared other technologies, technology involves cross integration multiple spectral nano materials, great potential, some challenges regarding stability, cost, etc., need further studies.

Language: Английский

Effective Physical Methods for Aflatoxin B1 Removal in Food: A Comprehensive Review DOI

Qingwei Cai,

Lixiang Zhu,

Peng Chen

et al.

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111215 - 111215

Published: Feb. 1, 2025

Language: Английский

Citations

1
Diosmetin alleviates AFB1-induced endoplasmic reticulum stress, autophagy, and apoptosis via PI3K/AKT pathway in mice DOI Creative Commons
Zhenlin Li, Mengjie Liu, Jie Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117997 - 117997

Published: March 1, 2025

Aflatoxin B1 (AFB1), a prevalent agricultural mycotoxin, represents serious health hazard to humans and animals owing its toxic effects. Diosmetin (DIOS), naturally occurring flavonoid, has demonstrated potential hepatoprotective properties. This research seeks investigate the mechanisms by which DIOS mitigates AFB1-induced hepatotoxicity in mice. The mice were divided into four groups: control (CON), AFB1, DIOS+AFB1, DIOS. Over 28 - day period, all groups administered their respective treatments via oral gavage. CON group was given an equivalent volume of PBS, AFB1 received (0.4 mg/kg/day), DIOS+AFB1 treated with (20 mg/kg/day) combination alone. Then various experiments used evaluate hepatotoxic effects Our findings initially that induced liver injury, oxidative stress, endoplasmic reticulum (ER) apoptosis autophagy. treatment notably ameliorated damage lowering LDH MDA levels, increasing total antioxidant capacity enhancing GSH-Px, SOD CAT activities. Additionally, dampened secretion inflammatory cytokines IL-1β TNF-α, blocked NF-κB pathway. Moreover, administration lessened ER stress-mediated inhibiting mRNA protein expressions GRP78, p-PERK, p-elF2α, ATF6 ATF4, while concurrently upregulating Bcl-2 expression reducing Bax Cleaved Caspase-3 expressions. Furthermore, also found suppress levels LC3B, Beclin-1, ATG5, p62, promote AKT phosphorylation. Overall, effectively mitigated inflammation, autophagy inhibition pathway stimulation PI3K/AKT results imply may be viable therapeutic approach for prevention caused exposure.

Language: Английский

Citations

1
Aflatoxins in Feed: Types, Metabolism, Health Consequences in Swine and Mitigation Strategies DOI Creative Commons
Roua Gabriela Popescu,

Andreea Luminița Rădulescu,

Sergiu Emil Georgescu

et al.

Toxins, Journal Year: 2022, Volume and Issue: 14(12), P. 853 - 853

Published: Dec. 3, 2022

Feeding farm animals with aflatoxin-contaminated feed can cause various severe toxic effects, leading to increased susceptibility infectious diseases and mortality, weight loss, poor performance reduced reproductive capability. Following ingestion of contaminated foodstuffs, aflatoxins are metabolized biotransformed differently in animals. Swine metabolism is not effective detoxifying excreting aflatoxins, meaning the risk aflatoxicosis increased. Thus, it great importance elucidate all metabolic pathways associated this mycotoxin. The damage induced by AFB1 cells tissues consists inhibition cell proliferation, carcinogenicity, immunosuppression, mutagenicity, oxidative stress, lipid peroxidation DNA damage, pathological lesions liver, spleen, lymph node, kidney, uterus, heart, lungs swine. At present, a challenging task serious concern completely remove their metabolites from feedstuff; thus, aim study was literature review on deleterious effects swine metabolism, as well alternatives that contribute detoxification or amelioration aflatoxin-induced animal feed.

Language: Английский

Citations

37
Analytical approach to assess anti-nutritional factors of grains and oilseeds: A comprehensive review DOI Creative Commons

Pushpanjali Purohit,

H. S. Rawat,

N. C. Verma

et al.

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 14, P. 100877 - 100877

Published: Nov. 21, 2023

This review aims to explore the various antinutritional factors found in grains and oilseeds, their sources, different methods employed mitigate effects. Both traditional innovative processing techniques have been utilized reduce antinutrients. Traditional such as dehulling, soaking, boiling, pressure cooking, sprouting, fermentation proven effective reducing specific antinutrients like α-galactosides, phytic acid, enzyme inhibitors, lathyrogens, lectins, saponins, tannins. However, optimization of these is necessary maximize effectiveness minimize antinutrient content. The also provides an overview analytical used quantify oilseeds. These encompass classical gravimetric titrimetric analysis, potentiometric titrations, chromatographic electrophoretic separation techniques, well spectroscopic methods, fluorescence, biosensors. A systematic chronological approaches detection systems presented. Furthermore, identifies research gaps highlights potential areas for future exploration field By addressing gaps, we can further enhance our understanding develop more strategies antinutrients, thus promoting utilization oilseeds optimal health benefits.

Language: Английский

Citations

22
SERS and MRS signals engineered dual-mode aptasensor for simultaneous distinguishment of aflatoxin subtypes DOI
Honghui Cao, Dan Liang,

Kaizhen Tang

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 462, P. 132810 - 132810

Published: Oct. 20, 2023

Language: Английский

Citations

21
Occurrence of Mycotoxins in Dried Fruits Worldwide, with a Focus on Aflatoxins and Ochratoxin A: A Review DOI Creative Commons
Miguel Ángel González‐Curbelo, Bülent Kabak

Toxins, Journal Year: 2023, Volume and Issue: 15(9), P. 576 - 576

Published: Sept. 18, 2023

Dried fruits are popular and nutritious snacks consumed worldwide due to their long shelf life concentrated nutrient content. However, can be contaminated with various toxigenic fungal species during different stages, including cultivation, harvesting, processing, drying, storage. Consequently, these products may contain high levels of mycotoxins. This risk is particularly pronounced in developed countries the impact climate change. Several factors contribute mycotoxin production, type fruit, geographical location, conditions, harvest treatments, storage management practices. The main mycotoxins dried aflatoxins (AFs) ochratoxin A (OTA), which induce human health problems economic losses. Mycotoxin contamination vary significantly depending on geographic origin (vine fruits, figs, dates, apricots, prunes, mulberries). aim this review was fill knowledge gap by consolidating data from regions understand global picture identify higher risks. By research origins stages supply chain, intends shed light potential events pre-harvest, storage, trading, while also highlighting effects conditions change contamination.

Language: Английский

Citations

19
HacA, a key transcription factor for the unfolded protein response, is required for fungal development, aflatoxin biosynthesis and pathogenicity of Aspergillus flavus DOI
Min Yu, Xiaoling Zhou, Dongyue Chen

et al.

International Journal of Food Microbiology, Journal Year: 2024, Volume and Issue: 417, P. 110693 - 110693

Published: April 5, 2024

Language: Английский

Citations

6
Baicalin protects against hepatocyte injury caused by aflatoxin B1 via the TP53-related ferroptosis Pathway DOI Creative Commons

H. Zhang,

Jian-Zhu Luo,

Chenlu Lan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116661 - 116661

Published: July 1, 2024

Baicalin has antioxidative, antiviral, and anti-inflammatory properties. However, its ability to alleviate oxidative stress (OS) DNA damage in liver cells exposed aflatoxin B1 (AFB1), a highly hepatotoxic compound, remains uncertain. In this study, the protective effects of baicalin on AFB1-induced hepatocyte injury mechanisms underlying those were investigated. Stable cell lines expressing CYP3A4 established using lentiviral vectors assess levels by conducting assays determine content reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD). Additionally, was evaluated 8-hydroxy-2-deoxyguanosine (8-OHdG) comet assays. Transcriptome sequencing, molecular docking, vitro experiments conducted injury. vivo, rat model induced AFB1 used evaluate baicalin. vitro, significantly attenuated caused due OS, as determined decrease ROS, MDA, SOD levels. also considerably decreased hepatocytes. This effect found be closely associated with TP53-mediated ferroptosis pathway. To elaborate, physically interacts P53, leading suppression expression GPX4 SLC7A11, which turn inhibits ferroptosis. vivo findings showed that AFB1-treated tissues, γ-H2AX an increase SLC7A11 Overexpression TP53 weakened can OS via theoretical foundation for use protecting from toxic AFB1.

Language: Английский

Citations

6
Biocontrol of Pathogen Microorganisms in Ripened Foods of Animal Origin DOI Creative Commons
Josué Delgado, Micaela Álvarez, Eva Cebrián

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1578 - 1578

Published: June 14, 2023

Ripened foods of animal origin comprise meat products and dairy products, being transformed by the wild microbiota which populates raw materials, generating highly appreciated over world. Together with this beneficial microbiota, both pathogenic toxigenic microorganisms such as

Language: Английский

Citations

16
Alternaria mycotoxins in food and feed: Occurrence, biosynthesis, toxicity, analytical methods, control and detoxification strategies DOI

Adhishree Nagda,

Mukesh Meena

Food Control, Journal Year: 2023, Volume and Issue: 158, P. 110211 - 110211

Published: Nov. 29, 2023

Language: Английский

Citations

14