TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Aspects of Molecular Medicine, Journal Year: 2023, Volume and Issue: 1, P. 100006 - 100006

Published: Jan. 1, 2023

The broad family of viruses known as anelloviruses (AV) infects both humans and numerous animal species. They have a tiny, covalently closed single-stranded DNA genome the astonishing capacity to infect very high percentage healthy ill people with chronic infections that could last lifetime. AV, particularly prototype Torquetenovirus, established successful interaction host's immune system rate at which they replicate is gauge measure overall function, even though many aspects their life cycle pathogenesis are still poorly understood.

Language: Английский

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The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses

Viruses, Journal Year: 2024, Volume and Issue: 16(1), P. 99 - 99

Published: Jan. 9, 2024

Members of the

Language: Английский

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Investigation of Oral Shedding of Torquetenovirus (TTV) in Moderate-to-Severe COVID-19 Hospitalised Patients

Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 831 - 831

Published: May 24, 2024

Background. Torquetenovirus (TTV) is a small DNA virus constituting the human virome. High levels of TTV-DNA have been shown to be associated with immunosuppression and inflammatory chronic disorders. Aim. To assess possible association between salivary viral load in patients hospitalised due COVID-19 disease severity. Methods. Saliva samples collected from 176 infected SARS-CoV-2 were used investigate presence by use real-time RT-PCR. Results. The majority male severe COVID-19. Presence was observed saliva 64.77% patients, showing 55.68% them. Patients impaired clinical conditions (p < 0.001), which evolved death = 0.003), showed higher prevalence TTV-DNA. median condition 4.99 log10 copies/mL, those who discharged evolving had values 3.96 copies/mL 6.27 respectively. A statistically significant found distribution severity 0.004) outcomes 0.001). Conclusions. These results indicate that could useful biomarker prognosis.

Language: Английский

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Dental complications as a potential indicator of Redondovirus infection: a cross-sectional study

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 5, 2024

Redondoviridae is a newly discovered virus family linked to oral and respiratory conditions in people, while there still debate about whether it also coinfected with other viruses. This study aimed determine the frequency of Redondovirus (ReDoV) nasopharyngeal samples investigate any possible links SARS-CoV-2 infections.

Language: Английский

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The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1759 - 1759

Published: Nov. 11, 2024

Saliva has emerged as a promising diagnostic fluid for viral infections, enabling the direct analysis of genetic material and detection infection markers such proteins, metabolites, microRNAs, immunoglobulins. This comprehensive review aimed to explore use saliva tool emphasizing its advantages limitations. stands out due simplicity safety in collection, along with convenience self-collection without need healthcare supervision, while potentially being comparable urine blood terms effectiveness. Herein, we highlighted significant potential assessing loads diagnosing herpesviruses, HPV, PyV, TTV, SARS-CoV-2, MPXV. The shedding underscores utility early diagnosis, monitoring progression, evaluating treatment responses. non-invasive nature collection makes it an appealing alternative more invasive methods, promoting better patient compliance facilitating large-scale screening surveillance. As such, further highlight current evidence on prognostic tool. Although amount data is already available, investigations are warranted comprehensively assess added benefit from utilization salivary biomarkers clinics. Salivary show great promise prevention complications, improving disease management control at population level. Integrating these tools into routine clinical practice could enhance personalized strategies outcomes. Future studies should focus establishing standardization protocols, validating accuracy diagnostics, expanding research capabilities biomarkers.

Language: Английский

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Maternal plasma and salivary anelloviruses in pregnancy and preterm birth

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 15, 2023

Human anelloviruses, including torque teno virus (TTV) and mini (TTMV), are ubiquitous in the general population have no known pathogenicity. We investigated prevalence viral load of TTV TTMV plasma saliva over pregnancy, assessed their association with spontaneous or medically indicated preterm birth.This is a secondary analysis Measurement Maternal Stress (MOMS) study, which recruited 744 individuals singleton pregnancies from 4 US sites (Chicago, Pittsburgh, San Antonio, rural Pennsylvania). Baseline outpatient visits took place second trimester (between 12'0 20'6/7 weeks' gestation), follow-up third 32'0 35'6/7 gestation). In case-control study design, participants who delivered (<37 weeks) resulting labor and/or premature rupture membranes ("sPTB") were compared experiencing birth ("iPTB"), delivery at term ("controls"). Plasma samples obtained during trimesters tested for presence quantity using real-time PCR. Demographic data via self-report, clinical medical record review by trained research personnel.TTV was detected 81% (second trimester) 77% (third participants, 64 60%. Corresponding detection rates 59 41% plasma, 35 24% saliva. concentrations similar between matched samples. not significantly different groups (sPTB, iPTB, controls). However, associated sPTB earlier gestational age delivery. The iPTB group either control group. saliva, among three groups. Both more prevalent increasing parity common Black Hispanic to non-Hispanic White participants.Anellovirus (specifically, TTMV) may be birth. Whether this causative remains determined.

Language: Английский

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Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(8), P. e0291027 - e0291027

Published: Aug. 31, 2023

Redondovirus (ReDoV) is a DNA virus present in the respiratory tract of many healthy individuals. Since SARS-CoV-2, responsible for COVID-19, also primarily infects same site, we evaluated whether ReDoV was at increased frequency patients with COVID-19 and influenced infection parameters.Saliva samples were collected weekly from 59 individuals 132 controls. detected by polymerase chain reaction genotypes identified metagenomics. Torque Teno Virus (TTV) these previously reported.ReDoV saliva more frequently (72.9%) than controls (50.0%) (p = 0.0015). There no associations between detection either continuous or intermittent SARS-CoV-2 shedding, duration saliva, patients' sex if B1 Gamma strain. The two strains, Brisavirus Vientovirus, equivalent frequencies ReDoV-positive Phylogenetic analysis suggested that strains Brazil similar to on other continents.ReDoV expression males females mild but its presence does not appear influence properties infection.

Language: Английский

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Detection and Genomic Characterization of Torque Teno Virus in Pneumoconiosis Patients in China

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1059 - 1059

Published: June 30, 2024

Pneumoconiosis is a common occupational disease that can worsen with accompanying infection. Torque teno virus (TTV) prevalent human multiple genotypes chronically and persistently infect individuals. However, the prevalence of TTV in pneumoconiosis patients still unclear. This research aims to detect presence alveolar lavage fluid Hunan Province China using PCR. As result, 65.5% positive rate (19 out 29) was detected. The detection varies among different stages silicosis patient ages. Nine novel genomes ranging size from 3719 3908 nt, named HNPP1, HNPP2, HNPP3, HNPP4, HNPP5, HNPP6-1, HNPP6-2, HNPP7-1 HNPP7-2, were identified. A genomic comparison phylogenetic analysis indicated these nine TTVs represent five species high genetic diversity which belong genus

Language: Английский

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Redondovirius-associated Periodontitis in People with Poor Oral Hygiene

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Objectives This study aimed to investigate the prevalence of recently emerged members Redondoviridae family (ReDoVs) in individuals with periodontitis and their association underlying diseases. Materials Methods case-control involved 230 participants, 115 chronic healthy controls from October 2023 May 2024. Demographic, health-related, behavioral data were collected. Gingival samples analyzed for ReDoVs using polymerase chain reaction (PCR), followed by sequencing phylogenetic analysis. Results detected 51.30% case group 21.74% control (p < 0.0001). ReDoV presence was associated older age, lack teeth brushing habits, smoking history 0.05). Also, a higher occurrence diseases observed among participants (24.35%) compared (4.35%). An between diabetes (OR = 9.18, 95% CI: 1.48 56.98, p 0.02). Conclusions adults poor dental hygiene those diabetes. supports possible multifactorial complex interaction ReDoVs, periodontitis, We further update message our previous highlighting that oral increases risk presence. Clinical Relevance: significantly strong correlation especially diabetic patients. could lead improved periodontal treatments focusing on bacterial factors addressing viral contributions, potentially reducing burden disease its complications.

Language: Английский

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Excreção oral de TorqueTeno vírus (TTV) em pacientes internados por complicações da COVID-19

Published: April 20, 2023

complicações da COVID-19, todos diagnosticados por RT-PCR em amostras de swab nasofaríngeo (88 casos graves e 88 moderados), nas quais investigou-se a presença SARS-CoV-2 TTV meio qPCR.

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