SARS-CoV-2 Secondary Spillover: From Doubt to Evidence DOI Creative Commons
AbdulRahman A. Saied, Faten F. Mohammed, Asmaa A. Metwally

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 19, 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the culprit behind disease 2019 (COVID-19) and it believed that bats may have been source. SARS-CoV-2 can naturally infect humans various animal species, including pets, farm animals, zoo wild animals might serve as potential reservoirs for viral transmission to humans. Most infected with are associated exposure humans; therefore, characterized by zoonosis reverse zoonosis. It critical quickly detect classify variants of concern in both domestic animals. In addition, it’s possible novel emerging due mutation, making infection incidental hosts worrying. Here, we discuss most recent information on spreading among humans, importance genomic research, active surveillance these help us understand spread viruses emergence variants.

Language: Английский

Application of Next-Generation Sequencing (NGS) Techniques for Selected Companion Animals DOI Creative Commons
Kinga Domrazek, P. Jurka

Animals, Journal Year: 2024, Volume and Issue: 14(11), P. 1578 - 1578

Published: May 27, 2024

Next-Generation Sequencing (NGS) techniques have revolutionized veterinary medicine for cats and dogs, offering insights across various domains. In parasitology, NGS enables comprehensive profiling of parasite populations, aiding in understanding transmission dynamics drug resistance mechanisms. infectious diseases, facilitates rapid pathogen identification, characterization virulence factors, tracking outbreaks. Moreover, sheds light on metabolic processes by elucidating gene expression patterns pathways, essential diagnosing disorders designing tailored treatments. autoimmune helps identify genetic predispositions molecular mechanisms underlying immune dysregulation. Veterinary oncology benefits from through personalized tumor profiling, mutation analysis, identification therapeutic targets, fostering precision approaches. Additionally, plays a pivotal role genetics, unraveling the basis inherited diseases facilitating breeding programs healthier animals. Physiological investigations leverage to explore complex biological systems, gene–environment interactions pathways governing health disease. Application treatment planning enhances efficacy enabling strategies individual animals their ultimately advancing care companion

Language: Английский

Citations

5
Detection of SARS-CoV-2 RNA in a Zoo-Kept Red Fox (Vulpes vulpes) DOI Creative Commons
Tatjana Chan, Julia Ginders, Evelyn Kuhlmeier

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 521 - 521

Published: March 28, 2024

Many different animal species are susceptible to SARS-CoV-2, including a few Canidae (domestic dog and raccoon dog). So far, only experimental evidence is available concerning SARS-CoV-2 infections in red foxes (

Language: Английский

Citations

4
Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs? DOI Creative Commons
Leira Fernández‐Bastit, Júlia Vergara‐Alert, Joaquím Segalés

et al.

Current Opinion in Virology, Journal Year: 2023, Volume and Issue: 63, P. 101365 - 101365

Published: Oct. 2, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic virus able to infect humans and multiple nonhuman animal species. Most natural infections in companion, captive zoo, livestock, wildlife species have been related reverse transmission, raising concern about potential generation of reservoirs due human–animal interactions. To date, American mink white-tailed deer are the only that led extensive intraspecies transmission SARS-CoV-2 after zoonosis, leading an efficient spread subsequent animal-to-human transmission. Viral host adaptations increase probability new variants' emergence could cause major global health impact. Therefore, applying One Health approach crucial prevent overcome future threats for human, animal, environmental fields.

Language: Английский

Citations

9
Assessing the Potential Role of Cats (Felis catus) as Generators of Relevant SARS-CoV-2 Lineages during the Pandemic DOI Creative Commons
Ninnet Gómez‐Romero, Francisco Javier Basurto-Alcántara, Lauro Velazquez‐Salinas

et al.

Pathogens, Journal Year: 2023, Volume and Issue: 12(11), P. 1361 - 1361

Published: Nov. 16, 2023

Several questions regarding the evolution of SARS-CoV-2 remain poorly elucidated. One these is possible evolutionary impact after infection in domestic animals. In this study, we aimed to evaluate potential role cats as generators relevant lineages during pandemic. A total 105 full-length genome viral sequences obtained from naturally infected pandemic were evaluated by distinct algorithms. Analyses enhanced, including a set highly related recovered human populations. Our results showed apparent high susceptibility compared with other animal species. Evolutionary analyses indicated that phylogenomic characteristics displayed cat populations influenced dominance specific genetic groups affecting However, disparate dN/dS rates at some genes between and humans suggested two species may suggest different constraint for SARS-CoV-2. Interestingly, branch selection analysis evidence natural emergence five Although apparently irrelevant public health pandemic, our additional studies are needed understand

Language: Английский

Citations

7
Investigations on the Potential Role of Free-Ranging Wildlife as a Reservoir of SARS-CoV-2 in Switzerland DOI Creative Commons

Juliette Kuhn,

Iris Marti,

Marie-Pierre Ryser-Degiorgis

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1407 - 1407

Published: Sept. 3, 2024

Amid the SARS-CoV-2 pandemic, concerns surfaced regarding spread of virus to wildlife. Switzerland lacked data concerning exposure free-ranging animals during this period. This study aimed investigate potential Swiss wildlife SARS-CoV-2. From 2020 2023, opportunistically collected samples from 712 shot or found dead wild mustelids (64 European stone and pine martens, 13 badgers, 10 polecats), canids (449 red foxes, 41 gray wolves, one golden jackal) felids (56 Eurasian lynx, 18 wildcats), as well 45 captured (39 6 wildcats) were tested. A multi-step serological approach detecting antibodies spike protein receptor binding domain (RBD) N-terminal S1 subunit followed by surrogate neutralization (sVNT) pseudotype-based assays against different variants was performed. Additionally, viral RNA loads quantified in lung tissues oronasal, oropharyngeal, rectal swabs reverse transcription polymerase chain reactions (RT-qPCRs). Serologically, confirmed 14 foxes (prevalence 3.1%, 95% CI: 1.9-5.2%), two lynx (2.2%, 0.6-7.7%), wildcat (4.2%, 0.2-20.2%). Two positive exhibited activity BA.2 BA.1 Omicron variants. No active infection (viral RNA) detected any animal is first report wildcats worldwide. It confirms but does not provide evidence reservoir formation. Our results underscore susceptibility populations importance understanding diseases a One Health Concept.

Language: Английский

Citations

2
A Risk Factor Analysis of SARS-CoV-2 Infection in Animals in COVID-19-Affected Households DOI Creative Commons
Evelyn Kuhlmeier, Tatjana Chan, Marina L. Meli

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 731 - 731

Published: March 11, 2023

A higher prevalence of SARS-CoV-2 infections in animals that have close contact with SARS-CoV-2-positive humans (“COVID-19 households”) has been demonstrated several countries. This prospective study aimed to determine the from Swiss COVID-19 households and assess potential risk factors for infection. The included 226 companion (172 cats, 76.1%; 49 dogs, 21.7%; 5 other animals, 2.2%) 122 336 human household members (including 230 people). were tested viral RNA using an RT-qPCR and/or serologically antibodies neutralizing activity. Additionally, surface samples animal fur beds underwent RT-qPCR. questionnaire about hygiene, intensity was completed by members. total (21.7%) 31 (25.4%) positive/questionably positive SARS-CoV-2, including 37 172 cats (21.5%) 12 dogs (24.5%). significantly more often than SARS-CoV-2-negative (p = 0.011). Significantly multivariable analysis minors. For a shorter length outdoor access frequency removing droppings litterboxes associated infection rates. emphasizes behavior owners living conditions can influence likelihood animals. Therefore, it is crucial monitor transmission dynamics as well identify possible infected households.

Language: Английский

Citations

5
SARS-CoV-2 Research in Dogs (Canis lupus familiaris) and Felines (Felis silvestris catus) Domiciled in an International Border Region (Paraguay and Brazil) DOI
Laísa Marina Rosa Rey, Robson Michael Delai, Aline Cristiane Cechinel Assing Batista

et al.

Vector-Borne and Zoonotic Diseases, Journal Year: 2024, Volume and Issue: 24(9), P. 625 - 631

Published: June 3, 2024

COVID-19 is an infectious disease caused by SARS-CoV-2 that has become a serious threat to public health owing its rapid spread from aerosols infected people. Despite being considered strictly human disease, there are reports in the literature about animals with confirmed presence of virus.

Language: Английский

Citations

1
SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports DOI Open Access
Sarah Jones, Grace Tyson, Richard Orton

et al.

Published: Aug. 4, 2023

Although domestic cats are susceptible to infection with SARS-CoV-2, the role of virus in causing feline disease is less well defined. We conducted a large-scale study identify SARS-CoV-2 infections UK pet cats, using active and passive surveillance. Remnant respiratory swab samples, submitted for other pathogen testing between May 2021 February 2023, were screened RT-qPCR. In addition, we appealed veterinarians samples from suspected having clinical infections. Bespoke neutralising antibodies was also performed, on request, cases. One RT-qPCR-positive cat identified surveillance (1/549, 0.18 %), during Delta wave (1/175, 0.57 %). Passive detected one infected Alpha variant, two ten tested wave. No after emergence Omicron BA.1 its descendants although 374 by eleven describe four cases RT-qPCR and/or serology, that presented range signs, as their genome sequences. Our results demonstrate that, uncommon, can do occur.

Language: Английский

Citations

3
A comprehensive dataset of animal-associated sarbecoviruses DOI Creative Commons
Bo Liu, Peng Zhao, Panpan Xu

et al.

Scientific Data, Journal Year: 2023, Volume and Issue: 10(1)

Published: Oct. 7, 2023

Language: Английский

Citations

3
COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019−April 2023 DOI Creative Commons
Tommy Dickey,

Heather Junqueira

Journal of Osteopathic Medicine, Journal Year: 2023, Volume and Issue: 123(11), P. 509 - 521

Published: July 15, 2023

This review was undertaken to provide information concerning the advancement of research in area COVID-19 screening and testing during worldwide pandemic from December 2019 through April 2023. In this review, we have examined safety, effectiveness, practicality utilizing trained scent dogs clinical public situations for screening. Specifically, results 29 dog peer-reviewed studies were compared with real-time reverse-transcription polymerase chain reaction (RT-PCR) rapid antigen (RAG) methods.The aims systematically evaluate strengths weaknesses screening.At time submission our earlier paper August 2021, found only four papers: three one preprint perspective paper. March 2023, first author conducted new literature searches MEDLINE/PubMed, Google Scholar, Cochrane Library websites. Again, keyword phrases utilized included "COVID detection dogs," sniffer dogs." The Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA) 2020 Checklist followed ensure that adhered evidence-based guidelines reporting. Utilizing reviewed papers, compiled statistics intercompare summarize basic their training, populations study participants, types sampling methods, comparative tests utilized, effectiveness screening.A total 8,043 references identified search. After removal duplicates, there 7,843 screened. Of these, 100 considered full-text eligibility, 43 qualitative synthesis, quantitative analysis. most relevant categorized. all provided 92.3 % reached sensitivities exceeding 80 32.0 specificities 97 %. However, 84.0 reported above 90 Highlights demonstrating include: (1) samples breath, saliva, trachea-bronchial secretions urine as well face masks articles clothing can be utilized; (2) detect presymptomatic asymptomatic patients; (3) SARS-CoV-2 variants Long COVID-19; (4) differentiate infections other novel respiratory viruses.The method is comparable or some cases superior RT-PCR test RAG test. Trained effectively quick (seconds minutes), nonintrusive, accurate settings thus reduce spread virus viruses. Finally, described serve increase medical community's public's knowledge acceptance major contributors global efforts fight diseases.

Language: Английский

Citations

2