Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(11)
Published: Nov. 1, 2023
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Language: Английский
Viruses, Journal Year: 2024, Volume and Issue: 16(1), P. 112 - 112
Published: Jan. 12, 2024
This study investigates the intricate interplay between Metabolic-associated Fatty Liver Disease (MAFLD) and COVID-19, exploring impact of MAFLD on disease severity, outcomes, efficacy antiviral agent Paxlovid (nirmatrelvir/ritonavir). MAFLD, affecting a quarter global population, emerges as potential risk factor for severe yet underlying pathophysiological mechanisms remain elusive. focuses clinical significance Paxlovid, first orally bioavailable granted Emergency Use Authorization in United States. Notably, outcomes from phase II/III trials exhibit an 88% relative reduction COVID-19-associated hospitalization or mortality among high-risk patients. Despite conflicting data association COVID-19 this research strives to bridge gap by evaluating effectiveness patients with addressing scarcity relevant studies.
Language: Английский
Citations
6
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 4, 2024
This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry (ACE2 rs2074192) on COVID-19 severity their association nonalcoholic fatty liver disease (MAFLD). We did not observe a significant between SNPs severity. While IFNAR2 rs2236757 A allele was correlated higher creatinine levels upon admission G lower band neutrophils discharge, these findings require further investigation. The distribution OAS gene (rs10774671 rs10735079) differ MAFLD patients non-MAFLD patients. Our population's ACE2 rs2074192 genotypes alleles differed from that European reference population. Overall, our suggest specific may be major contributors to patient population, highlighting potential role other genetic factors environmental influences.
Language: Английский
Citations
6
Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 985 - 985
Published: June 19, 2024
Metabolic-associated fatty liver disease (MAFLD) is a risk factor for severe COVID-19. This study explores the potential influence of gut hormone receptor and immune response gene expression on COVID-19 outcomes in MAFLD patients.
Language: Английский
Citations
5
Infection, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract Purpose Steatotic liver diseases (SLD) have become more prevalent over the last decade and are associated not only with cardiometabolic but also psychological symptoms (depression, fatigue). These common in post-COVID syndrome (PCS). Therefore, aim of study was to analyze burden SLD PCS patients. Methods We systematically screened all patients from our outpatient clinic using transient elastography, structured questionnaires for neurocognitive evaluation blood sample analysis. Controls without known were recruited assessed same approach. Results 560 103 healthy controls included. The overall prevalence high both cohorts (57 vs. 53%). frequently male (41 24%), older (52 44 years) had (87.0 46.4%). Cognitive impairment related than no-SLD group (OR: 1.68, CI: 1.14–2.46, p = 0.008). presence severe COVID-19 hospitalization 2.91, 1.85–4.56, < 0.001). Within 1 year follow-up, 152 289 described a resolution irrespective or absence (log-rank 0.96). Conclusions is cognitive dysfunction PCS. Longitudinal studies needed assess role hepatic steatosis, development post-acute infection regulation (e.g., SARS-CoV-2) differentiate between SLD-associated
Language: Английский
Citations
0
Viruses, Journal Year: 2023, Volume and Issue: 15(10), P. 2093 - 2093
Published: Oct. 14, 2023
Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic, but can result a fatal outcome; therefore, predictions severity are important. The goal was to investigate human genetic factors that associated with children. Single-nucleotide polymorphisms following genes were studied: ACE2 (rs2074192), IFNAR2 (rs2236757), TYK2 (rs2304256), OAS1 (rs10774671), OAS3 (rs10735079), CD40 (rs4813003), FCGR2A (rs1801274) CASP3 (rs113420705). In case-control study 30 mild or moderate course disease; severe symptoms multisystem inflammatory syndrome (MIS-C) 15 who healthy, did not have SARS-CoV-2 (PCR negative, Ig G negative). revealed rs2074192 (allele T), rs2236757 A), rs10774671 rs4813003 C), rs113420705 C) male sex contribute MIS-C 85.6% cases. World Health Organization reported new variants may cause previously unseen Although has limitations due cohort size, findings help provide better understanding infection proactive pediatric patient management.
Language: Английский
Citations
10
Published: May 13, 2024
Metabolic-associated fatty liver disease (MAFLD) is a risk factor for severe COVID-19. This study explores the potential influence of gut hormone receptor and immune response gene expression on COVID-19 outcomes in MAFLD patients. Methods: We investigated levels AHR, FFAR2, FXR, TGR5 patients with compared to controls. examined associations between clinical outcomes. Results: displayed altered AHR expression, potentially impacting recovery. Downregulated correlated increased coagulation parameters. Elevated FFAR2 linked specific cell populations hospital stay duration. Significantly lower FXR was observed both Conclusion: Our findings suggest modulatory roles MAFLD.
Language: Английский
Citations
3
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: April 25, 2025
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex metabolic disorder characterized by hepatic lipid accumulation and subsequent inflammation. This condition closely linked to syndrome obesity, with its prevalence rising due sedentary lifestyles high-calorie diets. The pathogenesis of MAFLD involves multiple factors, including insulin resistance, lipotoxicity, oxidative stress, inflammatory responses. gut microbiota plays crucial role in development, dysbiosis contributing inflammation through various mechanisms, such as enhanced intestinal permeability the translocation bacterial products like lipopolysaccharide (LPS). Microbial metabolites, short-chain acids (SCFAs) bile acids, influence function immune responses, potential implications for progression. Specific microbiome signatures have been identified patients, offering diagnostic therapeutic targets. Moreover, gut-derived toxins, endotoxins, lipopolysaccharides, trimethylamine-N-oxide significantly damage inflammation, highlighting interplay between health. review comprehensively examines MAFLD, focusing on underlying pathogenic biomarkers, emerging microbiome-targeted strategies management.
Language: Английский
Citations
0
Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1938 - 1938
Published: Dec. 18, 2024
Metformin, a widely used antidiabetic medication, has emerged as promising broad-spectrum antiviral agent due to its ability modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes energy reserves that viruses rely on, effectively limiting the replication of pathogens such influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting mTOR pathway, crucial protein synthesis reactivation, is particularly significant managing infections caused by CMV, EBV. Furthermore, reduces oxidative stress reactive oxygen species (ROS), which are critical replicating arboviruses Zika dengue. The drug also regulates immune responses, differentiation, inflammation, disrupting life cycle HPV potentially other viruses. These diverse mechanisms suppress replication, enhance system functionality, contribute better clinical outcomes. This multifaceted approach highlights metformin’s potential an adjunctive therapy treating wide range infections.
Language: Английский
Citations
2
Published: March 27, 2024
This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes asso-ciated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry (ACE2 rs2074192) on COVID-19 severity their association non-alcoholic fatty liver disease (MAFLD). We did not observe a significant between SNPs severity. While IFNAR2 rs2236757 A allele correlated higher creatinine levels upon admission G lower band neu-trophils discharge, these findings require further investigation. The distribution OAS gene (rs10774671, rs10735079 differ MAFLD non-MAFLD patients. Our population's ACE2 rs2074192 genotypes alleles differed from European reference population. Overall, our suggest that specific may be major contributors to patient population, highlighting potential role other genetic factors environmental influences.
Language: Английский
Citations
1
CHILD`S HEALTH, Journal Year: 2024, Volume and Issue: 19(3), P. 162 - 174
Published: May 26, 2024
The literature review highlights the issue of genetic risk factors associated with development metabolic dysfunction-associated fatty liver disease. Human examinations revealed 132 genes among which 32 loci are strongly pathogenesis It has been found that developing disease is carried by single-nucleotide variants various whose products involved in lipid and carbohydrate metabolism, maintenance redox state, inflammation fibrosis tissue, components reactome. authors presented a detailed list singling out those influence directly steatohepatitis fibrosis. Also, they emphasized it protein 3 containing patatin-like phospholipase domain, transmembrane 6 superfamily member 2, 17b-hydroxysteroid dehydrogenase type 13 characterized highest degree association (odds ratio > 1.6) compared to other identified gene studies. combination several polymorphisms increases severity additive steatogenic effect domain 2 probably due an increased expression de novo lipogenesis. emphasize need for assessment disease, should include molecular testing at early stage examination.
Language: Английский
Citations
1