Sex differences in the risk profiles for anemia in people living with HIV, A cross sectional study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0319611 - e0319611

Published: March 10, 2025

Background Anemia in people living with HIV (PLWH) significantly impacts quality of life and health outcomes. This study aimed to determine sex differences factors associated anemia PLWH at Livingstone University Teaching Hospital, Zambia. Methods cross-sectional involved 631 aged 18 years or older who had been on combinational ART for least 6 months. Data was collected via standardized questionnaires medical records. defined as haemoglobin levels < 13 g/dL men 12 women, based WHO criteria. Logistic regression models assessed the factors, stratified by sex. Results Participants a median age 44 years, female preponderance 64.2%. The overall prevalence 36%, higher females (41.1%) compared males (27.2%) (p 0.001). In females, waist circumference (AOR = 0.97, 95% CI: 0.95-0.99, P 0.018), albumin 0.96, 0.92-0.99, 0.047), NNRTI regimens 2.78, 1.34-5.78, 0.006), microcytosis 3.18, 1.26-8.03, 0.014), hypertension (OR 0.34, 0.13-0.87, 0.024) were linked adjusted analysis but these associations abrogated male Conclusions We found 36% among PLWH, (41%) (27%), including severe forms anemia. Among lower circumference, levels, regimens, microcytosis, blood pressure not males. Further studies are warranted.

Language: Английский

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Diagnostic utility of haematological parameters for tuberculosis in children living with HIV (0–14 years): a retrospective cohort study

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 16, 2025

Language: Английский

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Anemia of inflammation and iron metabolism in chronic diseases

Revista Clínica Española (English Edition), Journal Year: 2024, Volume and Issue: 224(9), P. 598 - 608

Published: Sept. 3, 2024

Language: Английский

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Anemia de la inflamación y metabolismo del hierro en las enfermedades crónicas

Revista Clínica Española, Journal Year: 2024, Volume and Issue: 224(9), P. 598 - 608

Published: Sept. 3, 2024

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Prevalence and Factors Associated with Moderate-to-Severe Anaemia Among Virally Suppressed People with HIV at a Tertiary Hospital in Zambia

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Objective Anaemia is associated with an increased risk of disease progression and all-cause mortality among HIV-infected individuals, regardless the type anaemia, but magnitude greater more severe anaemia. Although anaemia PLWH has been extensively studied, focus primarily on its prevalence association in untreated or poorly controlled HIV cases. This study aimed to investigate prevalence, factors moderate-to-severe virally suppressed patients at a tertiary hospital Zambia. Methods We conducted cross-sectional ART treated for least 6 months between October 2023 February 2024 Livingstone University Teaching Hospital (LUTH). Sociodemographic, clinical, laboratory were data collected. was defined based World Health Organisation (WHO) classification, as haemoglobin concentration lower than normal i.e. <12 g/dl females <13 males. The primary outcome level below 10.9 classification. Logistic regression performed identify Results Among 823 participants viral suppression, overall 29.4% (n=242; 95% confidence interval (CI): 26.3-32.6) 14.2% (n=117, CI: 11.7-18), respectively. Females exhibited significantly higher odds compared males (adjusted ratio (AOR) 2.65; 1.21-5.81). Lower lymphocyte count (AOR 0.542; 0.33-0.90), BMI 1.06; 1.01-1.12), Microcytosis 14.35; 7.33 - 28.08) Participants non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens had likelihood those integrase strand transfer (INSTI) 5.16; 1.02-26.24). Conclusion found PLWH, suggesting beyond contribute persistence this cohort. Female gender, count, BMI, low mean corpuscular volume, NNRTI-based independently Further research warranted explain underlying mechanisms optimize clinical management improve outcomes PLWH.

Language: Английский

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Prevalence and factors associated with moderate-to-severe anaemia among virally suppressed people with HIV at a tertiary hospital in Zambia

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0303734 - e0303734

Published: Aug. 26, 2024

Objective Anaemia is associated with an increased risk of disease progression and all-cause mortality among HIV-infected individuals, regardless the type anaemia, but magnitude greater more severe forms anaemia. Although anaemia PLWH has been extensively studied, focus primarily on its prevalence association in untreated or poorly controlled HIV cases. This study aimed to investigate prevalence, factors moderate-to-severe virally suppressed patients at a tertiary hospital Zambia. Methods We conducted cross-sectional ART-treated for least 6 months Livingstone University Teaching Hospital (LUTH). Sociodemographic, clinical, laboratory were data collected. The primary outcome moderate was defined as follows; anemia haemaoglobin levels between 8.0–10.9 g/ haemoglobin less than 8.0 g/dL according WHO classification. Logistic regression performed identify Results Among 823 participants viral suppression, overall 29.4% (n = 242; 95% confidence interval (CI): 26.3–32.6) 14.2% 117, CI: 11.7–18), respectively. In adjusted logistic analysis, women had higher odds compared men (AOR 2.618, CI 1.182–5.799). Lymphocyte count 0.525, 0.31–0.90) BMI 1.0671, 1.01–1.13) also significant factors. Microcytosis 49.79, 12.95–191.49) normocytosis 4.38, 1.22–15.75) strongly macrocytosis. NNRTI treatment INSTI 5.231, 1.04–26.33). Traditional like CD4+ tuberculosis infection not significant. Conclusion found PLWH, suggesting beyond contribute persistence this cohort. Women, lower lymphocyte count, BMI, low mean corpuscular volume (microcytosis) indicative microcytic NNRTI-based ART regimens independently Further research warranted explain underlying mechanisms optimize clinical management improve outcomes PLWH.

Language: Английский

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Challenges and Recent Advances in Erythropoietin Stability.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Sept. 28, 2024

Erythropoietin (EPO) is a pivotal hormone that regulates red blood cell production, predominantly synthesized by the kidneys and also produced liver. Since introduction of recombinant human EPO (rh-EPO) in 1989 through DNA technology, therapeutic landscape for anemia has been improved. rh-EPO's market expansion substantial, with its application extending across various conditions such as chronic kidney disease, cancer-related anemia, other disorders. Despite success, significant concerns remain regarding stability EPO, which critical preserving biological activity ensuring efficacy under diverse environmental conditions. Instability issues, including degradation loss activity, challenge both drug development treatment outcomes. Factors contributing to instability include temperature fluctuations, light exposure, interactions substances. To overcome these challenges, pharmaceutical research focused on developing innovative strategies stabilizing agents, advanced formulation techniques, optimized storage This review article explores multifaceted aspects stability, examining impact clinical development. It provides comprehensive current stabilization strategies, use excipients, lyophilization, novel delivery systems.

Language: Английский

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Importance of trace elements in the immunometabolic health of people living with HIV/AIDS: a literature review

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)

Published: Dec. 21, 2024

Language: Английский

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