Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1916 - 1916

Published: July 10, 2023

Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Remarkable advancements in AI technology machine learning present transformative opportunity the drug discovery, formulation, testing of pharmaceutical dosage forms. By utilizing algorithms analyze extensive biological data, including genomics proteomics, researchers can identify disease-associated targets predict their interactions with potential candidates. This enables more efficient targeted approach thereby increasing likelihood successful approvals. Furthermore, contribute reducing development costs by optimizing research processes. Machine assist experimental design pharmacokinetics toxicity capability prioritization optimization lead compounds, need for costly animal testing. Personalized medicine approaches be facilitated through real-world patient leading effective treatment outcomes improved adherence. comprehensive review explores wide-ranging applications delivery form designs, process optimization, testing, pharmacokinetics/pharmacodynamics (PK/PD) studies. an overview various AI-based utilized technology, highlighting benefits drawbacks. Nevertheless, continued investment exploration industry offer exciting prospects enhancing processes care.

Language: Английский

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Exosome nanovesicles: A potential carrier for therapeutic delivery

Nano Today, Journal Year: 2023, Volume and Issue: 49, P. 101771 - 101771

Published: Feb. 7, 2023

Exosomes are small nanosized biovesicles that form when multivesicular bodies and the plasma membrane fuse released into surrounding body fluids. They best known for their multifunction in mediating intercellular communication by transferring various biomolecules, including DNA, RNAs, proteins, lipids, a short- long-distance manner have been identified as health disease messengers. Importantly, exosomes necessary physiological processes disease. The generation of depends on status disease, which usually exhibits opposite roles inducing enhanced cellular stress damage. Recently, exosome-based nanotechnologies provided unprecedented opportunities to boost developments exosome-related biology, chemistry, pathology, therapeutics different diseases based unique structural/compositional/morphological characteristics next-generation nanomedicines. Herein, we provide comprehensive overview recent advances exosome nanotechnology research, classification, isolation preparation, constitution, biological function, nanobiomedical applications treatment diagnosis. Furthermore, future prospects were also concluded. This review will more inspiration promoting development advanced theranostic nanoplatforms nanotechnology.

Language: Английский

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

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mRNA-Based Vaccine for COVID-19: They Are New but Not Unknown!

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 507 - 507

Published: Feb. 22, 2023

mRNA vaccines take advantage of the mechanism that our cells use to produce proteins. Our proteins based on knowledge contained in DNA; each gene encodes a unique protein. The genetic information is essential, but cannot it until molecules convert into instructions for producing specific vaccinations provide ready-to-use constructing BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) both are newly approved mRNA-based COVID-19 have shown excellent protection efficacy. In total, there five more vaccine candidates under different phases clinical development. This review specifically focused covering its development, mechanism, aspects.

Language: Английский

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Management of patients with multiple myeloma and COVID-19 in the post pandemic era: a consensus paper from the European Myeloma Network (EMN)

Leukemia, Journal Year: 2023, Volume and Issue: 37(6), P. 1175 - 1185

Published: May 4, 2023

Language: Английский

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Molnupiravir: A Versatile Prodrug against SARS-CoV-2 Variants

Metabolites, Journal Year: 2023, Volume and Issue: 13(2), P. 309 - 309

Published: Feb. 20, 2023

The nucleoside analog β-D-N4-hydroxycytidine is the active metabolite of prodrug molnupiravir and accepted as an efficient drug against COVID-19. Molnupiravir targets RNA-dependent RNA polymerase (RdRp) enzyme, which responsible for replicating viral genome during replication process certain types viruses. It works by disrupting normal function RdRp causing it to make mistakes genome. These can prevent from being transcribed, converted into a complementary DNA template, translated, or functional protein. By these crucial steps in process, effectively inhibit virus reduce its ability cause disease. This review article sheds light on impact SARS-CoV-2 variants concern, such delta, omicron, hybrid/recombinant variants. detailed mechanism molecular interactions using docking dynamics have also been covered. safety tolerability patients with comorbidities emphasized.

Language: Английский

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An Overview of the Use of Nanoparticles in Vaccine Development

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(12), P. 1828 - 1828

Published: June 9, 2023

Vaccines represent one of the most significant advancements in public health since they prevented morbidity and mortality millions people every year. Conventionally, vaccine technology focused on either live attenuated or inactivated vaccines. However, application nanotechnology to development revolutionized field. Nanoparticles emerged both academia pharmaceutical industry as promising vectors develop future Regardless striking nanoparticles vaccines research variety conceptually structurally different formulations proposed, only a few them advanced clinical investigation usage clinic so far. This review covered some important developments applied technologies last years, focusing successful race for preparation lipid employed anti-SARS-CoV-2

Language: Английский

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Engineered exosomes for cancer theranostics: Next-generation tumor targeting

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 85, P. 104579 - 104579

Published: May 18, 2023

Exosomes are multivesicular bodies of which the plasma membrane fuse to release caring moiety into surrounding body fluids. They best known for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell another. These "naturally equipped" nanovesicles could be therapeutically targeted or engineered drug delivery systems. The use exosomes cancer detection prognosis has attracted a great deal interest academics. In addition chemical, biological, genetic engineering approaches, other current exosomal alteration methodologies hold promise advancement therapeutic medicines cancer. this review, we highlight theranostic potential cancers.

Language: Английский

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Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Language: Английский

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mRNA Technology in Modern Medicine: Review and Future Prospects

Deleted Journal, Journal Year: 2025, Volume and Issue: 2, P. 1 - 1

Published: Jan. 17, 2025

Messenger RNA (mRNA) technology has revolutionized modern medicine, particularly in developing vaccines and gene therapies. While its prominence soared during the COVID-19 pandemic, foundation was built on decades of meticulous research. This review explores historical evolution mRNA technology, stabilization delivery breakthroughs, applications combating infectious diseases, cancer, genetic disorders. The study utilized a systematic search peer-reviewed articles from leading databases such as PubMed Scopus, focusing advancements clinical applications. Future potential treating chronic enhancing immunotherapy, addressing public health emergencies is also discussed, emphasizing need for sustained research innovation to harness transformative capabilities fully.

Language: Английский

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