Unveiling the Global Surge of Mpox (Monkeypox): A comprehensive review of current evidence

The Microbe, Journal Year: 2024, Volume and Issue: 4, P. 100141 - 100141

Published: Aug. 17, 2024

Monkeypox, now named mpox, has emerged as a significant public threat, evidenced by the 2022 outbreak affecting over seventy countries globally. This infectious disease presents debilitating symptoms, including painful skin rashes, mucosal lesions, enlarged lymph nodes, and fever. The situation intensifies with concerns about novel transmission route, specifically through sexual contact, evolution of more transmissible strains. Complicating matters further is documented spillback mpox from humans to animals, raising potential for new animal reservoirs. study utilized systematic approach gather, analyse, interpret data regarding global outbreaks, phylogenomics, human APOBEC3 enzyme activity, antiviral resistance issues, application One Health intervention. Emphasizing covers various aspects, zoonotic origins, pathogenesis, changing epidemiological landscapes, phylogenomic diversity, clade dynamics. review underscores crucial role collaboration in understanding combatting making it valuable resource shaping effective prevention control measures on scale.

Language: Английский

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Global prevalence and correlates of mpox vaccine acceptance and uptake: a systematic review and meta-analysis

Communications Medicine, Journal Year: 2024, Volume and Issue: 4(1)

Published: July 8, 2024

Vaccination has been recommended as one of the most potent ways controlling mpox (formerly, monkeypox) outbreak, particularly among high-risk groups. Here, we evaluated prevalence vaccine acceptance and uptake globally.

Language: Английский

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Previous Vaccination History and Psychological Factors as Significant Predictors of Willingness to Receive Mpox Vaccination and a Favorable Attitude towards Compulsory Vaccination

Vaccines, Journal Year: 2023, Volume and Issue: 11(5), P. 897 - 897

Published: April 25, 2023

During the ongoing multi-country monkeypox (Mpox) outbreak, healthcare workers (HCWs) have represented a key group in mitigating disease spread. The current study aimed to evaluate attitude of nurses and physicians Jordan towards Mpox vaccination, as well their compulsory vaccination against coronavirus 2019 (COVID-19), influenza, Mpox. An online survey was distributed January 2023 based on previously validated 5C scale for psychological determinants vaccination. Previous behavior assessed by inquiring about history getting primary booster COVID-19 influenza vaccine uptake during COVID-19, any uptake. sample consisted 495 respondents: (

Language: Английский

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The Global Monkeypox (Mpox) Outbreak: A Comprehensive Review

Vaccines, Journal Year: 2023, Volume and Issue: 11(6), P. 1093 - 1093

Published: June 12, 2023

Monkeypox (Mpox) is a contagious illness that caused by the monkeypox virus, which part of same family viruses as variola, vaccinia, and cowpox. It was first detected in Democratic Republic Congo 1970 has since sporadic cases outbreaks few countries West Central Africa. In July 2022, World Health Organization (WHO) declared public-health emergency international concern due to unprecedented global spread disease. Despite breakthroughs medical treatments, vaccines, diagnostics, diseases like still cause death suffering around world have heavy economic impact. The 85,189 reported Mpox 29 January 2023 raised alarm bells. Vaccines for vaccinia virus can protect against monkeypox, but these immunizations were stopped after smallpox eradicated. There are, however, treatments available once taken hold. During 2022 outbreak, most occurred among men who had sex with men, there range 7–10 days between exposure onset symptoms. Three vaccines are currently used virus. Two initially developed smallpox, third specifically designed biological-terrorism protection. vaccine an attenuated, nonreplicating also be immunocompromised individuals, marketed under different names regions. second vaccine, ACAM2000, recombinant second-generation smallpox. recommended use preventing infection not individuals certain health conditions or during pregnancy. LC16m8, licensed attenuated lack B5R envelope-protein gene reduce neurotoxicity. generates neutralizing antibodies multiple poxviruses broad T-cell responses. immune response takes 14 dose two 4 weeks ACAM2000 maximal immunity development. efficacy current outbreak uncertain. Adverse events been reported, next generation safer specific needed. Although some experts claim developing large spectrum specificity advantageous, epitope-focused immunogens often more effective enhancing neutralization.

Language: Английский

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Perception of and Vaccine Readiness towards Mpox among Men Who Have Sex with Men Living with HIV in China: A Cross-Sectional Study

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 528 - 528

Published: Feb. 23, 2023

Men who have sex with men (MSM) living HIV make up the majority of cases in current Mpox outbreak. We aimed to investigate perception and vaccine readiness towards among MSM China.This cross-sectional online study was conducted from 10 August 9 September 2022. Participants responded survey questions about their socio-demographic information, status, sexual behaviors, knowledge Mpox, attitudes vaccines.A total 577 participated study. A 37.6% expressed concerns epidemic China, 56.8% were willing get vaccine. had > four partners previous three months (aOR = 1.9 95% CI: 1.2-2.8 Ref: 0), close contact individuals a day (3.1, 1.5-6.5 0-3), worried China (1.6, 1.1-2.3 No), believed that vaccines are safe (6.6, 2.7-16.4 No or not sure) effective (1.9, 1.1-3.3 No) for people more likely be high school education below (0.5, 0.3-0.9 Postgraduate diploma), sometimes 0.3-0.8 Often), seldom, never Often) followed news unwilling vaccine.The ongoing pandemic has attracted widespread China. Having contacts, worrying epidemic, believing vaccine's safety efficacy predictors willingness Efforts should made raise awareness potential risk this at-risk population. Public health strategies fully address vaccination willingness.

Language: Английский

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Current knowledge of human Mpox viral infection among healthcare workers in Cameroon calls for capacity-strengthening for pandemic preparedness

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 12, 2024

Introduction An increased incidence of human Monkeypox (Mpox) cases was recently observed worldwide, including in Cameroon. To ensure efficient preparedness and interventions the health system, we sought to assess knowledge Mpox's transmission, prevention, response among healthcare workers (HCWs) Methods A cross-sectional online survey conducted HCWs Cameroon using 21-item questions adapted from United States Centers for Disease Control Prevention (US-CDC) standard questionnaire on Mpox. The overall Mpox assessed by cumulative score categorized as excellent (≥80%, 17/21) or good (≥70%, ≥15/21) knowledge. regression analysis used identify predictors Results enrolled 377 participants, but only responses 342 participants were analyzed. Overall, 50.6% female 59.6% aged 30 years younger. majority medical doctors (50.3%); most worked central-level hospitals (25.1%) had 1–5 experience (70.7%). total up 92.7% aware Mpox, with social media (58.7%) radio/television (49.2%) main sources. mean 14.0 ± 3.0 (4 20), 12.9% having (≥80%) 42.1% Younger age (26–30 old) associated knowledge, while workplace type (aOR [95% CI]: 4.01 [1.43–11.24]). Knowledge treatment/management generally poor across different professional categories. Conclusion is substandard professionals. Thus, optimal immediate similar emerging pathogens, capacity-strengthening programs should be organized encouraging scientific literature organizational websites.

Language: Английский

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Assessment of Monkeypox (MPOX) Knowledge and Vaccination Intention among Health and Life Sciences Students in Algeria: A Cross-Sectional Study

Infectious Disease Reports, Journal Year: 2024, Volume and Issue: 16(2), P. 170 - 180

Published: Feb. 22, 2024

Monkeypox (MPOX) is a viral zoonotic disease affecting endemically the Central and Western regions of Africa. The ongoing outbreak in non-endemic countries has made this global concern. While no cases have been reported Algeria, it important to raise awareness about prepare for potential outbreak, especially light neighboring Middle East North African (MENA) countries. This study aimed evaluate knowledge attitude Algerian Health Life Sciences students toward MPOX its vaccine through an anonymous online survey. A total 196 participated study. Students medicine (64.3%), females (85.7%), those under 20 years age (55.1%) were most represented. results revealed low level represented by score only 42.8% correct answers with multiple gaps epidemiology, etiology, clinical manifestations MPOX. veterinary sciences showed highest levels (OR: 6.71; CI95%: 1.23–36.77), while aged between 30 old 0.11; 0.02–0.79) vaccinated against seasonal flu 0.42; 0.21–0.85) associated knowledge. Regarding vaccination, found moderate acceptance (48.5%) among surveyed Natural having high conspiracy belief (VCBS) showing lowest acceptance. These findings highlight need educational programs intensified public campaigns improve emphasize importance vaccination preventing outbreaks overcoming reluctance.

Language: Английский

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A hybrid forecasting technique for infection and death from the mpox virus

Digital Health, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 1, 2023

The rising of new cases and death counts from the mpox virus (MPV) is alarming. In order to mitigate impact MPV it essential have information virus's future position using more precise time series stochastic models. this present study, a hybrid forecasting system has been developed for infection world daily cumulative confirmed series.

Language: Английский

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Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark

Vaccines, Journal Year: 2023, Volume and Issue: 11(7), P. 1167 - 1167

Published: June 27, 2023

(1) Background: Here, we investigate the incidence of mpox and factors associated with vaccine uptake in mainly well-treated men who have sex are living HIV (MSMWH). (2) Methods: This study included 727 MSMWH from Copenhagen co-morbidity infection (COCOMO) 1 May to 31 October 2022. Mpox vaccination status were obtained Danish Microbiology Database The Vaccination Register. willingness was assessed through an online survey. (3) Results: At a median follow-up 180 days, 13 (1.8%) participants had laboratory-confirmed infections. Furthermore, 238 (32.7%) received vaccine. A sexually transmitted disease (STD) preceding two years higher risk (hazard ratio 7.1; 95% confidence interval (CI) [1.9-26.9]) odds (adjusted 3.1; CI [2.2-4.6]). 401 (55.2%) responded 228 (57.0%) reported very high willingness. self-perceived uptake. (4) Conclusions: low. prior STD both vaccination. Despite high-risk sexual behavior willingness, sizable fraction not been vaccinated.

Language: Английский

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Global knowledge and attitudes towards mpox (monkeypox) among healthcare workers: a systematic review and meta-analysis

International Health, Journal Year: 2023, Volume and Issue: 16(5), P. 487 - 498

Published: Oct. 20, 2023

Abstract Background The recent increase in human mpox (monkeypox) cases emphasizes the importance of early detection, prompt response and preventive management to control spread disease. Healthcare workers (HCWs) play a crucial role this process. This study aimed determine global knowledge attitudes towards among HCWs. Methods searched multiple databases, including Google Scholar, Scopus, PubMed/MEDLINE, Science Direct, Web Science, Embase, Springer ProQuest, locate various publications. search was limited English-language articles published between May 2022 (when incidence reported) August 2023. Joanna Briggs Institute (JBI) quality checklist utilized evaluate included studies. Data were obtained using Microsoft Excel spreadsheet subsequently scrutinized through STATA software, version 14. heterogeneity studies assessed inverse variance Cochran Q statistics based on I2 test statistics. Dersimonian Liard random effects models used where existed. Subgroup analysis univariate multivariable metaregression techniques examine causes heterogeneity. Results A total 22 studies, for (27 731 HCWs) 6 (14 388 HCWs), meta-analysis. pooled estimates good positive HCWs 26.0% (95% confidence interval [CI] 17.8 34.2) 34.6% CI 19.0 50.2), respectively. Moreover, 34.8% 24.1 45.6) with <5 y work experience 41.6% 33.1 50) individuals possessing >5 professional background. Conclusions Good is at low level. It suggested that training sessions should be tailored younger less healthcare experience. Additionally, it essential identify strategies how improve better practice about disease worldwide.

Language: Английский

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