Change in the Clinical Picture of Hospitalized Patients with COVID-19 between the Early and Late Period of Dominance of the Omicron SARS-CoV-2 Variant

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(17), P. 5572 - 5572

Published: Aug. 26, 2023

This study aimed to compare the clinical picture of COVID-19 in initial and later period Omicron dominance identify populations still at risk. A retrospective comparison data 965 patients hospitalized during early Omicron's (EO, January-June 2022) with 897 from a (LO, July 2022-April 2023) SARSTer database was performed. Patients LO, compared EO, were older, had better condition on admission, lower need for oxygen mechanical ventilation, less frequent lung involvement imaging, showed much faster improvement. Moreover, overall mortality EO 14%, higher than that LO-9%. Despite milder course disease, exceeding 15% similar both groups among involvement. The accumulation risk factors such as an age 60+, comorbidities, involvement, saturation <90% resulted constant 98% patients, 8% 30% rate LO period. Multiple logistic regression revealed odds death phase. infections caused by currently dominant subvariants, prophylaxis is necessary people over 60 years age, especially those case pneumonia respiratory failure.

Language: Английский

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Changing epidemiology of COVID-19: potential future impact on vaccines and vaccination strategies

Expert Review of Vaccines, Journal Year: 2024, Volume and Issue: 23(1), P. 510 - 522

Published: April 24, 2024

COVID-19 was an unprecedented challenge worldwide; however, disease epidemiology has evolved, and no longer constitutes a public health emergency of international concern. Nonetheless, remains global threat uncertainties remain, including definition the end pandemic transition to endemicity, understanding true rates SARS-CoV-2 infection/transmission.

Language: Английский

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The Course of COVID-19 and Long COVID: Identifying Risk Factors among Patients Suffering from the Disease before and during the Omicron-Dominant Period

Pathogens, Journal Year: 2024, Volume and Issue: 13(3), P. 267 - 267

Published: March 20, 2024

SARS-CoV-2 has acquired many mutations that influence the severity of COVID-19's course or risk developing long COVID. In 2022, dominant variant was Omicron. This study aimed to compare COVID-19 in periods before and during dominance Omicron variant. Risk factors for COVID were also assessed. based on stationary visits patients after follow-up assessments 3 months. Clinical symptoms, comorbidities, vaccination status evaluated 1967 patients. Of analyzed group, 1308 (66.5%) affected by period dominance. The prevalence significantly lower among group (47.7% vs. 66.9%,

Language: Английский

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Respiratory syncytial virus immunoprophylaxis: Novel opportunities and a call for equity

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(2)

Published: Feb. 1, 2024

Abstract With the approval of first vaccines against respiratory syncytial virus (RSV) and a novel RSV‐neutralizing antibody, 2023 has been perceived as game‐changing year in preventing severe outcomes RSV infections infants elderly. However, costs these pharmaceuticals are high, while disproportionately impacts populations low‐to‐middle‐income regions, which may continue to suffer from lack pharmaceutical measures for prevention under health socioeconomic disparities. This paper presents an overview characteristics, clinical results, status various anti‐RSV antibodies. It posits that wealthy nations cannot monopolize immunoprophylaxis should work jointly make it available lower‐income countries. An approach toward equity based on five points is offered: (1) integration antibodies into existing global humanitarian distribution systems, (2) using affordable vaccine pricing models, (3) enforcing part national public strategy, (4) implementing equitable allocation frameworks immunoprophylaxis, (5) promoting local manufacturing. Such plan needs be put action soon possible avoid delays serving with highest related burden.

Language: Английский

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Trends of Hepatitis A Virus Infection in Poland: Assessing the Potential Impact of the COVID-19 Pandemic and War in Ukraine

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 469 - 469

Published: March 20, 2024

Hepatitis A virus (HAV) is the most common cause of acute viral hepatitis, which preventable by vaccination. This study analyzed trends HAV infections in Poland according to socio-demographic features years 2009–2022 and assessed potential impact COVID-19 pandemic (2020–2023) migration war refugees from Ukraine (since February 2022). In 2009–2022, 7115 new cases infection were diagnosed Poland, especially among men (66.4%) urban areas (77.4%). Infections at age 25–34 (median rate 0.43 per 105) women aged 15–24 0.39 105). Analysis 14-year frequency exhibited three trends, regardless gender, age, residence. The revealed a downward trend 2009–2014, increased significantly 2014–2018, decreased again after 2018. particularly rapid increase occurred between March 2017 2018 0.79 high level persisted until beginning pandemic, point it dropped but did not reach recorded before 2017. During Omicron SARS-CoV-2 dominance period, median was 0.053 105, with four-fold being observed 2022 (when began) August 2022. presented results can serve as reference for further observations Central Europe. epidemiological situation unlikely escalate requires monitoring.

Language: Английский

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The burden of infectious diseases throughout and after the COVID‐19 pandemic (2020–2023) and Russo‐Ukrainian war migration

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(5)

Published: May 1, 2024

Understanding how the infectious disease burden was affected throughout COVID-19 pandemic is pivotal to identifying potential hot spots and guiding future mitigation measures. Therefore, our study aimed analyze changes in rate of new cases Poland's most frequent diseases during entire after influx war refugees from Ukraine. We performed a registry-based population-wide Poland 24 2020 2023 compared them prepandemic period (2016-2019). Data were collected publicly archived datasets Epimeld database published by national epidemiological authority institutions. The studied (66.6%) revealed significantly negative correlations with SARS-CoV-2 infections. For majority diseases, it substantially decreased (in case 83%) 2021 (63%), following which mostly rebounded levels and, some cases, exceeded when exceptionally high annual rates scarlet fever, Streptococcus pneumoniae infections, HIV syphilis, gonococcal tick-borne encephalitis noted. Clostridioides difficile enterocolitis two-fold higher than before onward. Legionnaires' also threshold, although this due local outbreak unrelated lifted restrictions or migration refugees. migrants Ukraine could impact epidemiology sexually transmitted diseases. present analysis indicates that continued efforts are needed prevent overwhelming healthcare systems again decreasing control over other It identifies tipping points require additional measures, discussed paper, avoid escalation future.

Language: Английский

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Assessment of clinical characteristics and mortality in patients hospitalized with SARS-CoV-2 from January 2022 to November 2022, when Omicron variants were predominant in the United States

Current Medical Research and Opinion, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 15, 2025

Objective To describe the demographic/clinical characteristics, treatment patterns, and mortality among patients hospitalized with COVID-19 during Omicron predominance by immunocompromised high-risk status.

Language: Английский

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Cardiac symptoms in patients 3–6 months after contracting COVID-19– data from the polish STOP-COVID registry

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Abstract Background Common complaints of long COVID patients are cardiac symptoms such as fatigue, weakness, and a feeling palpitations. The study aimed to investigate the clinical features with persistent cardiological occurring within 3 6 months after COVID-19. Differences in ambulatory blood pressure monitoring (ABPM), Holter ECG (electrocardiogram) Echocardiography between people without were evaluated. We also assessed whether anxiety depression may be implicated outcomes. Materials methods This was retrospective affiliated STOP-COVID registry who attended follow-up visit 3–6 undergoing present performed tests: ABPM, Echocardiography. 504 additionally had GAD-2 (Generalized Anxiety Disorder 2-item) PHQ-2 (Patient Health Questionnaire-2) tests performed. Results analysis included 1080 patients. At least 1 analyzed 586 (54.3%). most common symptom fatigue (38.9%). Comparing or palpitations showed that mean value ventricular extrasystole higher former group ( p = 0.011). symptoms, there differences values 0.022) < 0.001) scales, well percentage responses related risk depression. Conclusion Cardiological among health issues must face contracting People more excessive extrasystoles than these symptoms. Trial registration Our based on medical data COVID-19 treated out-patient basis Polish Long-Covid Cardiovascular (PoLoCOV-CVD) (ClinicalTrials.gov identifier– NCT05018052, date 29.05.2020). Consent conduct obtained from Bioethics Committee District Medical Chamber Lodz (no. KB-0115/2021).

Language: Английский

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Gene-Editing and RNA Interference in Treating Hepatitis B: A Review

Viruses, Journal Year: 2023, Volume and Issue: 15(12), P. 2395 - 2395

Published: Dec. 8, 2023

The hepatitis B virus (HBV) continues to cause substantial health and economic burdens, its target of elimination may not be reached in 2030 without further efforts diagnostics, non-pharmaceutical prevention measures, vaccination, treatment. Current therapeutic options chronic HBV, based on interferons and/or nucleos(t)ide analogs, suppress the replication but do eliminate pathogen suffer from several constraints. This paper reviews progress biotechnological approaches functional definitive HBV treatments, including gene-editing tools, i.e., zinc-finger proteins, transcription activator-like effector nucleases, CRISPR/Cas9, as well therapeutics RNA interference. advantages challenges these are also discussed. Although safety efficacy tools therapies yet demonstrated, they show promise for revitalization a much-needed advance field offer viral eradication. Particular hopes related CRISPR/Cas9; however, employing this system enter clinical testing phases. In contrast, number candidates interference, intending confer cure, have already been introduced human studies. However, larger longer trials required assess their safety. Considering that is always superior treatment, it essential pursue global vaccination.

Language: Английский

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New insights into the pathogenesis of SARS-CoV-2 during and after the COVID-19 pandemic

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the distress condition known as COVID-19. This disease broadly affects several physiological systems, including gastrointestinal, renal, and central nervous (CNS) significantly influencing patient’s overall quality of life. Additionally, numerous risk factors have been suggested, gender, body weight, age, metabolic status, renal health, preexisting cardiomyopathies, inflammatory conditions. Despite advances in understanding genome pathophysiological ramifications COVID-19, its precise origins remain elusive. SARS-CoV-2 interacts with a receptor-binding domain within angiotensin-converting enzyme (ACE2). receptor expressed various organs different species, humans, abundance. Although COVID-19 has multiorgan manifestations, main pathologies occur lung, pulmonary fibrosis, failure, embolism, secondary bacterial pneumonia. In post-COVID-19 period, sequelae may occur, which causes, direct action virus, alteration immune response, alterations during infection, among others. Recognizing serious adverse health effects associated it becomes imperative to comprehensively elucidate discuss existing evidence surrounding this viral those related subsequent consequences. review aims contribute comprehensive impact long-term on human health.

Language: Английский

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