Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 403 - 403

Published: March 13, 2025

Background: Carotenoids are bioactive tetraterpenoid C40 pigments that actively synthesized by plants, bacteria, and fungi. Compounds such as α-carotene, β-carotene, lycopene, lutein, astaxanthin, β-cryptoxanthin, fucoxanthin, zeaxanthin have attracted increasing attention for their antiaging properties. They exhibit antioxidant, neuroprotective, anti-inflammatory properties, contributing to the prevention treatment of age-related diseases. Objectives: The aim this study was comprehensively analyze pharmacological potential biological mechanisms carotenoids associated with disorders evaluate application in nutraceuticals, pharmaceuticals, cosmeceuticals. Methods: A systematic review studies published over past two decades conducted using databases PubMed, Scopus, Web Science. selection criteria included clinical, silico, vivo, vitro investigating therapeutic effects carotenoids. Results: demonstrate a variety health benefits, including macular degeneration, cancer, cognitive decline, metabolic disorders, skin aging. Their role nutraceuticals is well supported ability modulate oxidative stress inflammatory pathways. In show promising results formulations targeting neurodegenerative diseases disorders. cosmeceuticals, they improve protecting it against UV radiation damage. However, bioavailability, optimal dosages, toxicity, interactions other compounds remain critical factors maximize efficacy still require careful evaluation scientists. Conclusions: interventions applications fields. Further research needed optimize formulas, confirm long-term safety effectiveness, especially aging population.

Language: Английский

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Importance of Antioxidant Supplementation during In Vitro Maturation of Mammalian Oocytes

Veterinary Sciences, Journal Year: 2022, Volume and Issue: 9(8), P. 439 - 439

Published: Aug. 18, 2022

The in vitro embryo production (IVEP) technique is widely used the field of reproductive biology. In maturation (IVM) first and most critical step IVEP, during which, oocyte matured an artificial medium under strict laboratory conditions. Despite all progress quality oocytes remains inferior to that those vivo. accumulation substantial amounts reactive oxygen species (ROS) within IVM has been regarded as one main factors altering quality. One promising approaches overcome ROS supplementation with antioxidants. this article, we discuss recent advancements depicting adverse effects on mammalian oocytes. We also potential use antioxidants their effect both rate.

Language: Английский

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Ferulic Acid Enhances Oocyte Maturation and the Subsequent Development of Bovine Oocytes

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14804 - 14804

Published: Sept. 30, 2023

Improving the quality of oocytes matured in vitro is integral to enhancing efficacy embryo production. Oxidative stress one primary causes decline vitro. In this study, ferulic acid (FA), a natural antioxidant found plant cell walls, was investigated evaluate its impact on bovine oocyte maturation and subsequent embryonic development. Bovine cumulus–oocyte complexes (COCs) were treated with different concentrations FA (0, 2.5, 5, 10, 20 μM) during (IVM). Compared control group, supplementation 5 μM significantly enhanced rates expansion cumulus cells area, as well cleavage blastocyst formation after fertilization (IVF) somatic nuclear transfer (SCNT). Furthermore, observed effectively decrease levels ROS improve their mitochondrial function. Our experiments demonstrate that can maintain antioxidants (GSH, SOD, CAT) oocytes, thereby alleviating oxidative induced by H2O2. RT-qPCR results revealed that, treatment, relative mRNA expression genes related (GDF-9 BMP-15), (HAS2, PTX3, CX37, CX43), pluripotency (OCT4, SOX2, CDX2) increased. conclusion, these findings IVM enhance developmental potential embryos.

Language: Английский

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Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

Sci, Journal Year: 2024, Volume and Issue: 6(2), P. 36 - 36

Published: June 13, 2024

Aging is a complex biological and physiological change that leads to loss of function in all living organisms. Although the mechanism behind aging process still largely unknown, scientific studies have shown oxidative stress age-related low autophagy, which are associated with various chronic diseases such as cancer, diabetes, cardiovascular diseases, neurodegenerative promote aging. Interestingly, many medicinal plants their biologically active compounds ability extend lifespan they can inhibit autophagy. This review evaluates provides up-to-date information on anti-aging potential bioactive edible plants. In this study, seventeen (17) from effects were reviewed. vivo vitro showed these exhibit via mechanisms activation increases antioxidant enzymes, reductions reactive oxygen species, inhibition inflammatory markers, downregulation senescence genes. study suggests containing may health lifespan. However, exact mechanisms, effective doses, clinical trials, genotoxic agents should be further investigated.

Language: Английский

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Ceria Nanoparticles Improve the Quality of Aging Oocytes in Mice by Enhancing ROS Scavenging Ability

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: 8(2), P. 992 - 1001

Published: Jan. 21, 2025

If fertilization does not occur in a timely manner after ovulation, then that can lead to aging and decline relation oocyte quality, which have detrimental effects on subsequent embryo development offspring. Reactive oxygen species (ROS) induced oxidative stress is the main factor deterioration of aging. Herein, ceria nanoparticles (NPs) been developed as ROS scavengers improve quality oocytes. We found NPs could effectively inhibit senescence-induced morphological changes lower accumulation In addition, reduced abnormal spindle distribution improved mitochondrial function. Ceria also oocytes by increasing scavenging capacity rather than inhibiting generation capacity. Furthermore, increased rate blastocyst formation conclude enhance potential reducing level stress.

Language: Английский

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Tauroursodeoxycholic Acid Enhances the Quality of Postovulatory Aged Oocytes by Alleviating Oxidative Stress, Apoptosis, and Endoplasmic Reticulum Stress in Pigs

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(3), P. 265 - 265

Published: March 12, 2025

One of the major factors causing reduced developmental capacity aged porcine oocytes is induction oxidative stress during oocyte aging. Tauroursodeoxycholic acid (TUDCA) supports cellular function by acting as an antioxidant and free radical scavenger. The aim this study to evaluate whether exogenous supplementation TUDCA in vitro maturation system can ameliorate compromised quality mitigating production. We found that was able effectively maintain normal morphology, cortical granule distribution, spindle structure postovulatory Additionally, blastocyst rate total cell number blastocysts were significantly increased treated with TUDCA. Importantly, ROS levels, expression levels GSH SOD1 genes, improved mitochondrial membrane potential ratio. Further demonstrated alleviated apoptosis oocytes, confirmed decreased Caspase 3 ratio BAX BCL2. Interestingly, could alleviate phenomenon endoplasmic reticulum triggered aging process. Taking these findings together, our demonstrates beneficially affects suppressing stress, apoptosis, stress.

Language: Английский

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Ameliorative Effect of Lycopene on Follicular Reserve Depletion, Oxidative Damage, Apoptosis Rate, and Hormonal Profile during Repeated Superovulations in Mice

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(9), P. 414 - 414

Published: Sept. 6, 2024

Superovulation is a crucial step in assisted reproductive technology that involves the administration of gonadotrophins. Repeated superovulations result severe ovarian damage. The present study investigated effect vivo lycopene on damage induced by four successive cycles superovulation. Superovulated mice were simultaneously administered intraperitoneally with saline (R4) or 5 mg/kg (R4-Lyc). evaluated parameters count different types follicles, expression antioxidant- and apoptosis-related genes, serum concentrations estradiol, progesterone, inhibin-B. Increased numbers healthy follicles decreased atretic observed R4-Lyc group compared to those R4 group. Moreover, significantly higher mRNA levels

Language: Английский

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Lycopene Improves Maturation Rate and Antioxidant Status of in vitro Matured Mouse Oocytes

International Journal of Veterinary Science, Journal Year: 2022, Volume and Issue: 2, 2023, P. 248 - 254

Published: Jan. 1, 2022

The present study aimed to investigate the effect of lycopene supplementation in vitro maturation (IVM) medium mouse oocytes on their rate and oxidative biomarkers levels. Lycopene concentrations 50, 100, 200, 400nM were tested. effects under heat stress conditions also explored. Cumulus-oocyte complexes (COCs) collected from ovaries super-ovulated mice via puncturing technique incubated IVM for 17h. To simulate stress, COCs an containing 100µM hydrogen peroxide (H2O2) with or without lycopene. Additionally, mimic matured at 40℃ Among four tested concentrations, 200nM achieved highest improvement oocyte maturation. H2O2, malondialdehyde (MDA), total antioxidant capacity (TAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) altered by treatment: H2O2 MDA significantly decreased, meanwhile TAC, GSH, CAT SOD increased. rates revealed a significant decline following exposure stresses. Interestingly, rescued stressed thermally challenged as they appeared comparable those control oocytes. Taken together, our data report beneficial suggest candidate factor improving quality mammalian embryos.

Language: Английский

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The Effect of Different Levels of Lycopene in Egg Yolk Citrate Extenders on Post-Thawed Semen Qualities of Belgian Blue Crossbreed Bull

Advances in Animal and Veterinary Sciences, Journal Year: 2023, Volume and Issue: 11(6)

Published: Jan. 1, 2023

As many as seven 500-kg-Belgian-Blue-Crossbreed-bulls aged four years old were kept in a mooring cage and served with forage concentrate (CP 16%) at 10% 3% to the body weight, respectively.There also added some egg yolk citrate diluent of 2.9% (v/v), Sodium dihydrate buffer, 100 mL distilled water, an mixture proportion 20% 8% (v/v) glycerol (Merck, Germany), penicillin (1,000 IU/mL), streptomycin mg/mL).Sperm was diluted 50 million/mL treated lycopene extract levels 0% (control), 1%, 2%, 3%, 4% diluent, equilibrated temperature 5°C for 4 hours, packed 0.25 ml straw, refrozen into liquid nitrogen vapor about 5 cm above surface 10 minutes.Freezing run by immersing 24 hours before post-thawing examination.Results showed that spermatozoa supplemented (P3) had better quality than found other treatments, namely motility freezing (70.86%) post thawing (53.00%); viability (76.00%) (60.14%); plasma membrane integrity (71.29%) (59.86%); lowest abnormality level post-thawing, (17.29%) (24.14%), respectively.

Language: Английский

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