A point prevalence survey of antimicrobial use in two hospitals in Western Kenya DOI Creative Commons
Emmah Nyaboke, Joseph Ogola, Mitchel Okumu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Background Information from point prevalence surveys can guide antimicrobial stewardship programs (ASPs). The aim of the present study was to document use agents at two hospitals in Western Kenya, namely Bungoma County Referral Hospital (BCRH) and Webuye (WCH). Methods World Health Organization (WHO) Global Point Prevalence Survey (G-PPS) tool used collect sociodemographic information participants, type used, indications for use, diagnostic tests conducted on participants. Files were selected over 24 hours, data abstracted between July October 2022, analysis carried out SPSS version 26. Results Among 361 patients, 223 (61.8%) antibiotics. most common antibiotics ceftriaxone (123/237; 34.5%), metronidazole (89/237; 24.9%), flucloxacillin (36/237; 10.1%). Most (60/237; 25.4%) WCH prescribed empirically, while (46/237; 19.5%) BCRH prophylaxis. Pneumonia leading indication antibiotic prescriptions (18/169, 9.5%), clinical sepsis (17/169;9.9%) WCH. 16/237 (6.8%) patients who had an subjected culture sensitivity testing, but only 9/16 (81.8%) received results susceptibility within period. Conclusions Penicillins Cephalosporins widely prescribing/clinical practices vary one hospital another, microbiological underutilized area. There is a need enhanced

Language: Английский

Antimicrobial Resistance Patterns and Risk Factors Associated with ESBL-Producing and MDR Escherichia coli in Hospital and Environmental Settings in Lusaka, Zambia: Implications for One Health, Antimicrobial Stewardship and Surveillance Systems DOI Creative Commons
Maisa Kasanga, Geoffrey Kwenda, Jian Wu

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 1951 - 1951

Published: July 31, 2023

Antimicrobial resistance (AMR) is a public health problem threatening human, animal, and environmental safety. This study assessed the AMR profiles risk factors associated with Escherichia coli in hospital settings Lusaka, Zambia. cross-sectional was conducted from April 2022 to August using 980 samples collected clinical settings. susceptibility testing BD PhoenixTM 100. The data were analysed SPSS version 26.0. Of samples, 51% sources. Overall, 64.5% of tested positive for E. coli, which 52.5% Additionally, 31.8% ESBL, 70.1% isolates. 632 isolates, 48.3% MDR. Most isolates resistant ampicillin (83.4%), sulfamethoxazole/trimethoprim (73.8%), ciprofloxacin (65.7%) while all (100%) some levofloxacin (30.6%). drivers MDR included pus (AOR = 4.6, CI: 1.9-11.3), male sex 2.1, 1.2-3.9), water 2.6, 1.2-5.8). found that common antibiotics used humans. presence concern calls vigorous infection prevention measures surveillance reduce its burdens.

Language: Английский

Citations

15
The genetic relationship between human and pet isolates: a core genome multilocus sequence analysis of multidrug-resistant bacteria DOI Creative Commons

Antonia Genath,

Carolin Hackmann, Luisa A. Denkel

et al.

Antimicrobial Resistance and Infection Control, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 20, 2024

Language: Английский

Citations

5
Antimicrobial Use and Resistance in Animals from a One Health Perspective DOI Creative Commons
Mohamed Rhouma, Marie Archambault, Patrick Butaye

et al.

Veterinary Sciences, Journal Year: 2023, Volume and Issue: 10(5), P. 319 - 319

Published: April 28, 2023

Among the many global health issues, antimicrobial resistance (AMR) is one that exemplifies One Health approach, defined as a joint effort in which multiple disciplines collaborate to provide solutions for human, animal, and environmental [...].

Language: Английский

Citations

12
Prevalence and characterization of antimicrobial-resistant Escherichia coli in chicken meat from wet markets in Hong Kong DOI Creative Commons
F. M. Yasir Hasib, Ioannis Magouras, Sophie St‐Hilaire

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 15, 2024

Given the close contact between animals, animal products, and consumers in wet markets, fresh meat products are considered a potential source disseminator of antimicrobial-resistant (AMR) bacteria near end food chain. This cross-sectional study was conducted to estimate prevalence select AMR- E. coli chicken collected from markets Hong Kong determine target genes associated with observed resistance phenotypes. Following stratified random sampling design, 180 half-chickens were purchased 29 across 2022 immediately processed. After incubation, selective isolation performed for extended-spectrum β-lactamase producing (ESBL), carbapenem-resistant (CRE), colistin-resistant (CSR) . The bacterial isolates identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Disc Diffusion used susceptibility ESBL- CRE- isolates. broth microdilution method minimum inhibitory concentration CSR- Targeted then detected by PCR. estimated at 88.8% (95% CI: 83.4–93.1%) 6.7% 3.5–11.4%), respectively. No isolate detected. bla CTX-M-1 gene most common group isolated (80%), followed TEM (63.7%); no SHV Forty-five percent had simultaneously. mcr-1 all 12 CSR Of samples, 59 Mainland China, 121 locally sourced. There statistically significant difference two sources. Our findings can be inform safety risk assessments set stage adopting targeted control mitigation measures tailored local markets.

Language: Английский

Citations

4
Drivers of the emergence and dissemination of high-risk resistance genes in cattle farm DOI

Yanxiang Jiao,

Xingxing Zhang,

Feifan Yang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137415 - 137415

Published: Jan. 29, 2025

Language: Английский

Citations

0
Current prevalence and therapeutic strategies for porcine Streptococcus suis in China DOI Creative Commons
Ruoyi Lv, Wenjing Zhang,

Zhigang Sun

et al.

Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT Porcine Streptococcus suis is a zoonotic bacterial pathogen that poses serious threats to both human and animal health. S. ubiquitously transmitted from the swine industry environments communities. However, ambiguous epidemiological patterns escalating risk of antimicrobial resistance render infections considerable challenge. Here, we review current prevalence infection worldwide, including identified strains, routes infection, transformation genes. This comprehensive overview prevalent in offers detailed insights into therapeutic approaches for porcine alternative strategies address emerging resistant highlighting potential multitarget prevention treatment options combat infection.

Language: Английский

Citations

0
Questionnaire-Based Survey Regarding the Rational Usage of Antimicrobial Agents in Food-Producing Animals in Romania DOI Creative Commons

Ionela Popa,

Kálmán Imre, Adriana Morar

et al.

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(5), P. 408 - 408

Published: April 26, 2025

The annual rise in antimicrobial resistance (AMR) is a major public health concern. This Romanian questionnaire-based survey aimed to evaluate the appropriateness of routine use by veterinary practitioners food-producing animals and gauge their concerns about AMR. To gather data, an online questionnaire with 28 questions was developed distributed nationwide veterinarians via Google Drive network Forms. Despite this increased awareness, deviations administration persist, often due insufficient knowledge AMR mechanisms action. study underscores urgent need for prudent livestock production Romania.

Language: Английский

Citations

0
Antimicrobial Resistance in Diverse Ecological Niches—One Health Perspective and Food Safety DOI Creative Commons
Nedjeljko Karabasil, Milica Mirković, Ivan Vičić

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 443 - 443

Published: April 28, 2025

Antimicrobial resistance (AMR) is a multi-sectoral, systemic, and global issue worldwide. use (AMU) key factor in the selection of resistant bacteria within different ecological niches, from agriculture to food-producing animals humans. There question regarding extent which antibiotics livestock production primary food sector influences transmission and/or genes throughout chain thus contributes complexity development AMR Although trends prevalence foodborne pathogens have changed over time, burden niches with genes, primarily commensal microorganisms, concern. The implementation harmonized surveillance AMU would provide comprehensive insights into actual status further interventions leading its reduction. Tracking by applying advanced genome-based techniques developing shared data repositories strengthen One Health concept.

Language: Английский

Citations

0
Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Food-Producing Animals in Tamaulipas, Mexico DOI Creative Commons

Antonio Mandujano,

Diana V. Cortés-Espinosa, José Vázquez

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(6), P. 1010 - 1010

Published: June 5, 2023

Extended-spectrum β-lactamase (ESBL)-producing E. coli has become an important global problem for the public health sector. This study aims to investigate antimicrobial resistance profile among living food-producing animals in Tamaulipas, Mexico. A total of 200 fecal samples were collected from bovines, pigs, chickens and sheep. 5.0% strains phenotypically confirmed as ESBL producers. high percentage phenotypic was observed against gentamicin (93.3%), tetracycline (86.6%) streptomycin (83.3%). The gentamicin-resistant showed MDR, distributed 27 patterns different antimicrobials. gene tet(A) detected 73.3% isolates, aadA1 60.0% sul2 43.3% strains. blaCTX-M found 23.3% virulence hlyA isolates; stx1 stx2 not any strain. phylotyping indicated that isolates belonged groups (33.3%), B1 (16.6%), B2 (40.0%) D (10.0%). These results show might be a reservoir ESBL-producing bacteria may play role their spread.

Language: Английский

Citations

10
Enterobacteria in anaerobic digestion of dairy cattle wastewater: Assessing virulence and resistance for one health security DOI

Kássia Vidal Menezes,

Carlos Eduardo de Souza Duarte,

Myleny Goularte Moreira

et al.

Water Research, Journal Year: 2024, Volume and Issue: 252, P. 121192 - 121192

Published: Jan. 24, 2024

Language: Английский

Citations

3