International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138195 - 138195
Published: Dec. 5, 2024
Language: Английский
Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100040 - 100040
Published: June 27, 2024
Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.
Language: Английский
Citations
20
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 30, 2024
Language: Английский
Citations
12
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144
Published: Jan. 21, 2025
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135893 - 135893
Published: Sept. 1, 2024
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047
Published: Nov. 1, 2024
Language: Английский
Citations
5
Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 227 - 227
Published: March 22, 2025
In this project, a new class of temperature- and pH-sensitive hydrogel consisting N-isopropyl acrylamide (NIPAM), hydroxyethyl methacrylate (HEMA), (AAm) was prepared via controlled route through the reversible addition–fragmentation chain-transfer (RAFT) polymerization process. Poly(ethyleneglycol) dimethacrylate (PEG-DMA) used as long-chain hydrophilic biocompatible crosslinking agent. The structure confirmed by different characteristic techniques such 1H NMR, FT-IR, SEC, morphology particle diameters were checked scanning electron microscopy (SEM) dynamic light scattering (DLS) methods. Afterward, as-prepared hydrogel, poly(NIPAM-co-HEMA-co-AAm), loaded with doxorubicin (DOX) to be pH-triggered delivery carrier. system released DOX slowly at 37 °C neutral pH, but increased release significantly 42 acidic pH. anti-cancer efficiencies free DOX, DOX–hydrogel conjugate tested in vitro using human colorectal adenocarcinoma HT-29 cell lines. Cytotoxicity evaluation compared revealed that more cancer cells killed increasing concentration. Moreover, DOX-mediated apoptosis ROS levels showed beneficial effects poly(NIPAM-co-HEMA-co-AAm) for drug delivery. Generally, results suggest can potential candidate designing systems.
Language: Английский
Citations
0
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 479 - 479
Published: July 19, 2024
Breast cancer is the most common malignancy among women and second leading cause of cancer-related death for women. Depending on tumor grade stage, breast primarily treated with surgery antineoplastic therapy. Direct or indirect side effects, emotional trauma, unpredictable outcomes accompany these traditional therapies, calling therapies that could improve overall treatment recovery experiences patients. Hydrogels, biomimetic materials 3D network structures, have shown great promise augmenting Hydrogel implants can be made adipogenic angiogenic properties tissue integration. organoids malignant tumors grown in hydrogels retain physical genetic characteristics native tumors, allowing post-surgery recapitulation diseased tissues precision medicine assessment responsiveness patient-specific cancers to treatment. Hydrogels also used as carrier matrices delivering chemotherapeutics immunotherapeutics prosthetic scaffolds. The hydrogel delivery systems achieve localized controlled medication release targeting site, enhancing efficacy minimizing adverse effects therapeutic agents delivered by procedures. This review aims summarize recent advancements utilization reconstruction, modeling, therapy discuss their limitations clinical translation.
Language: Английский
Citations
3
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
The convergence of nanotechnology and cancer therapeutics has opened new frontiers in the development advanced drug delivery systems. Among various nanocarriers, nanobubbles offer significant potential due to their unique properties, such as high payload capacity, responsiveness external stimuli like ultrasound, enhanced permeability retention (EPR) effects. Functionalizing these with chitosan, a naturally derived biopolymer known for its biocompatibility, biodegradability, ability enhance cellular uptake, further improves therapeutic efficacy. This review provides comprehensive analysis synthesis, functionalization, application chitosan-functionalized therapy. We discuss mechanism action, including targeted delivery, ultrasound-mediated release, immune modulation, alongside recent advancements challenges clinical translation. also explores future directions this rapidly evolving field, aiming insights into next-generation therapeutics.
Language: Английский
Citations
3
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 27, 2024
Gastrointestinal tumors are the main causes of death among patients. These mainly diagnosed in advanced stages and their response to therapy is unfavorable. In spite development conventional therapeutics including surgery, chemotherapy, radiotherapy immunotherapy, treatment these still challenging. As a result, new based on (nano)biotechnology have been introduced. Hydrogels polymeric 3D networks capable absorbing water swell with favorable biocompatibility. application hydrogels different human diseases, wide cancer has improved because potential drug gene delivery, boosting chemotherapy immunotherapy as well vaccines. The current review focuses role gastrointestinal tumors. provide delivery drugs (both natural or synthetic compounds co-delivery) along delivery. Along stimulate phototherapy (photothermal photodynamic therapy) suppression Besides, ability for induction immune-related cells such dendritic can boost immunotherapy. For more specific therapy, stimuli-responsive types thermo- pH-sensitive self-healing site Moreover, promising diagnosis, circulating tumor cell isolation detection biomarkers tumors, highlighting importance clinic. Hence, diagnostic therapeutic tools gastrointestimal
Language: Английский
Citations
3
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 202, P. 114422 - 114422
Published: July 20, 2024
Language: Английский
Citations
1