Published: March 1, 2025
Language: Английский
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)
Published: March 23, 2024
Photothermal agents (PTAs) with desirable near-infrared (NIR) absorption and excellent photothermal conversion efficiency (PCE) are ideal candidates for cancer treatment. However, numerous PTAs still require high-intensity long-duration laser irradiation to completely ablate the tumor during therapy (PTT) process, resulting in light damage healthy skin tissue as well limiting their biomedical applications. Integrating intense NIR high PCE into a single small-molecule PTA is an important prerequisite realizing efficient PTT, but serious challenge. Herein, series of donor-acceptor type (CC1 NC4) designed through molecular engineering strategy. Theoretical calculations experimental results show that effect from CC1 NC4 significantly enhanced expected. Notably, nanoparticles exhibit absorption, superhigh up 88.9% photoacoustic imaging imaging, effective reactive oxygen species generation photodynamic (PDT). The superior PTT/PDT synergistic phototherapeutic efficacy demonstrated by complete elimination vivo upon one-time, low-intensity, short-duration (808 nm, 330 mW cm
Language: Английский
Citations
7
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Endowing cyanine dyes with hydrophilicity, long blood circulation, tumor targeting, and robust therapeutic efficacy in the second near-infrared (NIR-II) window is challenging for cancer treatment. Herein, we develop cell membrane-coated albumin-NIR-II dye assemblies, denoted as LZ-1105@HAm, to optimize photophysical properties of aqueous solution NIR-II fluorescence (FL)/photoacoustic (PA)/photothermal (PT) multimodality imaging-guided homologous targeting photothermal therapy. LZ-1105@HAm exhibits good extends half-life circulation from 0.634 ± 0.058 1.919 0.107 h, enhances FL/PA/PT imaging capabilities vitro vivo, improves conversion efficiency 34.6% 45.4%. Additionally, membrane coating confers assemblies tumor-specific capability, increasing accumulation enabling efficient ablation. Upon 1064 nm laser irradiation, demonstrates significantly improved efficacy. This research provides a strategy constructing dye-based nanotheranostics potential clinical application prospects.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Cell membrane coating has emerged as a promising strategy for the surface modification of biomaterials with biological membranes, serving cloak that can carry more functions. The cloaked inherit diverse intrinsic biofunctions derived from different cell sources, including enhanced biocompatibility, immunity evasion, specific targeting capacity, and immune regulation regenerative microenvironment. characteristics biomimicry biointerfacing have demonstrated versatility technology on variety biomaterials, thus, furthering research into wide range biomedical applications clinical translation. Here, preparation coatings is emphasized, sizes coated nanoscale to macroscale well engineering strategies introduce additional are summarized. Subsequently, utilization biomimetic membrane-cloaked in discussed, drug delivery, imaging phototherapy, cancer immunotherapy, anti-infection detoxification, implant modification. In conclusion, latest advancements preclinical studies, along multiple benefits membrane-coated nanoparticles (NPs) systems, elucidated.
Language: Английский
Citations
1
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Photothermal therapy (PTT) is a promising minimally invasive treatment that converts light energy into localized heat for tumor ablation. Indocyanine green (ICG), the only clinically approved photothermal agent (PTA), suffers from rapid photobleaching and poor retention, underscoring urgent need next-generation PTAs with improved properties. In this study, we report AzuGlu-BODIPY, novel azulene-containing BODIPY-based PTA incorporating 1,2,3,4-tetrahydroquinoline glucose, designed to overcome these limitations. AzuGlu-BODIPY demonstrates high conversion efficiency (PCE) of 51%, effective near-infrared (NIR) absorption, thermal stability in both dimethyl sulfoxide (DMSO) aqueous solutions. vitro studies revealed potent efficacy against cancer cell lines, IC50 values 3.1–4.6 μM under 808 nm laser irradiation, while vivo experiments showed complete regression 4T1 tumor-bearing mice following administration treatment. These results suggest as provide versatile platform advancing azulene-based enhanced functionality PTT.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 10, 2024
Photothermal immunotherapy is regarded as the ideal cancer therapeutic modality to against malignant solid tumors; however, its benefits are often modest and require improvement. In this study, a thermoresponsive nanoparticle (BTN@LND) composed of photothermal agent (PTA) pyroptosis inducer (lonidamine) were developed enhance applications. Specifically, our "two-step" donor engineering strategy produced strong NIR-II-absorbing organic small-molecule PTA (BTN) that exhibited high NIR-II performance (ε
Language: Английский
Citations
5
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134746 - 134746
Published: Aug. 13, 2024
Language: Английский
Citations
4
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(10), P. 4765 - 4773
Published: Sept. 20, 2024
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Despite being a groundbreaking approach to treating colorectal cancer (CRC), the efficacy of immunotherapy is significantly compromised by immunosuppressive tumor microenvironment and dysbiotic intestinal microbiota. Here, leveraging superior carrying capacity innate immunity-stimulating property living bacteria, nanomedicine-engineered bacterium, LR-S-CD/CpG@LNP, with optical responsiveness, immune-stimulating activity, ability regulate microbiota metabolome developed. Immunoadjuvant (CpG) carbon dot (CD) co-loaded plant lipid nanoparticles (CD/CpG@LNPs) are constructed conjugated surface Limosilactobacillus reuteri (LR) via reactive oxygen species (ROS)-responsive linkers. The inherent photothermal photodynamic properties oral CD/CpG@LNPs induce in situ cytotoxic ROS generation immunogenic cell death cells. generated neoantigens released CpG function as potent vaccine that stimulates maturation immature dendritic mature cells metabolites secreted LR subsequently facilitated infiltration T lymphocytes eradicate tumors. further vivo results demonstrate photo-immunotherapy microbial metabolite regulation LR-S-CD/CpG@LNPs collectively suppressed growth orthotopic tumors their liver metastases, presenting promising avenue for synergistic treatment CRC route.
Language: Английский
Citations
4
Rare Metals, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Language: Английский
Citations
3
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 671, P. 125221 - 125221
Published: Jan. 19, 2025
Language: Английский
Citations
0