Formulation, characterization, and in vitro antifungal efficacy of luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against a panel of resistant fungal strains DOI Creative Commons

Mohsen Nosratabadi,

Robab Ebrahimi Barogh,

Seyyed Mobin Rahimnia

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 10, 2024

Abstract Luliconazole (LCZ) is a topical imidazole antifungal agent with broad-spectrum activity. However, LCZ faces challenges like low aqueous solubility, skin retention, and penetration, limiting its dermal bioavailability effectiveness in drug delivery. This study aims to formulate, characterize, assess the vitro efficacy of luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against resistant fungal strains. The LCZ-NLCs were synthesized using modified emulsification-solvent evaporation method. Characterization included poly-dispersity index (PDI), zeta potential, entrapment efficiency (EE %), Field Emission Scanning Electron Microscopy (FESEM), Differential Calorimetry (DSC) analysis, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) study. Additionally, in vitro release experiments, kinetic analysis data, cytotoxicity assays, susceptibility tests conducted. results revealed that exhibited nanoscale dimensions, uniform dispersion, favorable potential. The encapsulation NLCs was around 90%. FESEM showed spherical nanoparticles consistent shape. ATR-FTIR indicated no chemical interaction between excipients. In experiments suggested significantly improved drug's dissolution rate. Stability testing also colloidal nanometer ranges samples. Also, toxicity within tested concentration. Furthermore, demonstrated potent activity both isolates. findings suggest formulation developed this research could be promising treatment for superficial infections, especially cases infections.

Language: Английский

Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells DOI
Seyyed Mobin Rahimnia, Majid Saeedi, Jafar Âkbari

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(6)

Published: June 19, 2024

Language: Английский

Citations

4
Potential of the Nano-Encapsulation of Antioxidant Molecules in Wound Healing Applications: An Innovative Strategy to Enhance the Bio-Profile DOI Creative Commons
Supandeep Singh Hallan, Francesca Ferrara, Rita Cortesi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 641 - 641

Published: Jan. 31, 2025

Naturally available antioxidants offer remarkable medicinal applications in wound healing. However, the encapsulation of these phytoactive moieties into suitable nano-scale drug delivery systems has always been challenging due to their inherent characteristics, such as low molecular weight, poor aqueous solubility, and inadequate skin permeability. Here, we provide a systematic review focusing on major obstacles hindering development various lipid polymer-based transporters carry cargos targeted site. Additionally, this covers possibility combining effects polymer within one system, which could increase permeability threshold. Moreover, lack physical characterization techniques challenges associated with scaling up progression nano-carriers limit utility biomedical applications. In context, consistent progressive approaches for addressing shortcomings are introduced, prospects discussed detail.

Language: Английский

Citations

0
Liposomes and niosomes approaches for wound healing DOI
Sandra Aparecida de Assis,

Sara Lima Alves

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 161 - 185

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Novel Niosomal Gel for Topical Delivery of Miltefosine Against Trichophyton indotineae Dermatophytosis in Animal Model DOI
Iman Haghani, Fatemeh Ebrahimi, Mahdi Abastabar

et al.

Mycoses, Journal Year: 2025, Volume and Issue: 68(3)

Published: March 1, 2025

ABSTRACT Introduction Dermatophytosis, a cutaneous fungal infection worldwide, is generally localised to the skin's superficial layers and keratinised structures. Although most agents are susceptible current antifungal drugs available in clinical settings, frequent relapses failures, especially cases due Trichophyton indotineae , have been frequently reported. Therefore, alternative targets therapeutic approaches highly required. In present study, we compared efficacies of terbinafine with conventional niosomal forms miltefosine (MFS) against dermatophytosis guinea pig model. Material Methods Initially, 30 pigs were divided into five groups (e.g., untreated control, treated by MFS gel 1%, 1% niosome) infected terbinafine‐resistant subsequently scored both clinically mycologically until day 35 inoculation. was encapsulated niosomes, elastic vesicles made non‐ionic surfactants that enhance drug delivery through skin. Results showed significantly reduced lesion scores, mycological evidence inflammation control terbinafine‐treated ( p < 0.05). Moreover, score did not differ from > Histopathological analysis confirmed epidermal thickening burden models 1%. Conclusion The findings highlighted as potentially effective, targeted therapy for drug‐resistant T. offering safer more effective topical oral treatments. However, further studies warranted continue correlating these outcomes.

Language: Английский

Citations

0
Luliconazole-loaded nanostructured lipid carrier: formulation, characterization, and in vitro antifungal evaluation against a panel of resistant fungal strains DOI Creative Commons

Mohsen Poursadeqiyan,

Seyyed Mobin Rahimnia,

Robab Ebrahimi Barogh

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Luliconazole (LCZ) is a topical imidazole antifungal agent with broad-spectrum activity. However, LCZ encounters challenges such as low aqueous solubility, skin retention, and penetration, which reduce its dermal bioavailability hinder efficacy in drug delivery. The aim of the present study was to formulate, characterize, evaluate vitro luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against panel resistant fungal strains. LCZ-NLCs were synthesized using modified emulsification-solvent evaporation technique. Characterization involved assessing parameters poly-dispersity index (PDI), zeta potential, encapsulation efficiency (EE %), Field Emission Scanning Electron Microscopy (FESEM), Differential Calorimetry (DSC) analysis, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR). Furthermore, release experiments, analysis kinetics, cytotoxicity assessments, susceptibility tests performed part study. findings indicated that displayed nanoscale dimensions, uniform dispersion, favorable potential. NLCs approximately 90%. FESEM revealed spherical nanoparticles consistent shape. ATR-FTIR no chemical interaction between excipients. In experiments demonstrated notably improved drug's dissolution rate. stability testing confirmed colloidal nanometer ranges samples. Additionally, toxicity within tested concentration. Moreover, potent activity isolates. suggest formulation developed this research could be promising treatment for superficial infections, especially cases infections. needs further ex vivo ensure safety efficacy.

Language: Английский

Citations

1
Formulation, characterization, and in vitro antifungal efficacy of luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against a panel of resistant fungal strains DOI Creative Commons

Mohsen Nosratabadi,

Robab Ebrahimi Barogh,

Seyyed Mobin Rahimnia

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 10, 2024

Abstract Luliconazole (LCZ) is a topical imidazole antifungal agent with broad-spectrum activity. However, LCZ faces challenges like low aqueous solubility, skin retention, and penetration, limiting its dermal bioavailability effectiveness in drug delivery. This study aims to formulate, characterize, assess the vitro efficacy of luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against resistant fungal strains. The LCZ-NLCs were synthesized using modified emulsification-solvent evaporation method. Characterization included poly-dispersity index (PDI), zeta potential, entrapment efficiency (EE %), Field Emission Scanning Electron Microscopy (FESEM), Differential Calorimetry (DSC) analysis, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) study. Additionally, in vitro release experiments, kinetic analysis data, cytotoxicity assays, susceptibility tests conducted. results revealed that exhibited nanoscale dimensions, uniform dispersion, favorable potential. The encapsulation NLCs was around 90%. FESEM showed spherical nanoparticles consistent shape. ATR-FTIR indicated no chemical interaction between excipients. In experiments suggested significantly improved drug's dissolution rate. Stability testing also colloidal nanometer ranges samples. Also, toxicity within tested concentration. Furthermore, demonstrated potent activity both isolates. findings suggest formulation developed this research could be promising treatment for superficial infections, especially cases infections.

Language: Английский

Citations

0