Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity

Molecules, Journal Year: 2021, Volume and Issue: 26(19), P. 6076 - 6076

Published: Oct. 8, 2021

Probiotics are beneficial active microorganisms that colonize the human intestines and change composition of flora in particular parts host. Recently, use probiotics to regulate intestinal improve host immunity has received widespread attention. Recent evidence shown play significant roles gut microbiota composition, which can inhibit colonization pathogenic bacteria intestine, help build a healthy mucosa protective layer, enhance immune system. Based on close relationship between immunity, it become an extremely effective way by regulating microbiome with probiotics. In this review, we discussed influence probiotics, microbiota, life quality. We further emphasized regulation microflora through thereby enhancing improving people’s lives.

Language: Английский

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Mechanisms of Oxidative Stress in Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7898 - 7898

Published: April 26, 2023

Metabolic syndrome is a cluster of conditions associated with the risk diabetes mellitus type 2 and cardiovascular diseases (CVDs). closely related to obesity. Increased adiposity promotes inflammation oxidative stress, which are precursors various complications involving metabolic components, namely insulin resistance, hypertension, hyperlipidemia. An increasing number studies confirm importance stress chronic in etiology syndrome. However, few have reviewed mechanisms underlying role contributing In this review, we highlight by reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, impair antioxidant function Biomarkers can be used disease diagnosis evaluation severity.

Language: Английский

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Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: March 26, 2021

Colorectal cancer (CRC) is one of the most common cancers worldwide. As with other cancers, CRC a multifactorial disease due to combined effect genetic and environmental factors. Most cases are sporadic, but small proportion hereditary, estimated at around 5-10%. In both, tumor interacts heterogeneous cell populations, such as endothelial, stromal, immune cells, secreting different signals (cytokines, chemokines or growth factors) generate favorable microenvironment for invasion metastasis. There ample evidence that inflammatory processes have role in carcinogenesis progression CCR. Different profiles activation can promote pro anti-tumor pathways; hence they studied key target control progression. Additionally, intestinal mucosa close contact microorganism community, including bacteria, bacteriophages, viruses, archaea, fungi composing gut microbiota. Aberrant composition this microbiota, together alteration diet‐derived microbial metabolites content (such butyrate polyamines) compounds has been related CRC. Some pks+ Escherichia coli Fusobacterium nucleatum , involved colorectal through pathomechanisms induction mutations epithelial cells modulation microenvironment. Epithelial from Pattern-recognition receptors G-protein coupled (receptor butyrate), suggesting their be regulated by microbiota metabolites. review, we discuss how dynamics metabolites, interplays sporadic hereditary CRC, modulating

Language: Английский

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Obesity and gut–microbiota–brain axis: A narrative review

Journal of Clinical Laboratory Analysis, Journal Year: 2022, Volume and Issue: 36(5)

Published: April 14, 2022

Abstract Introduction Obesity is a major health problem that associated with many physiological and mental disorders, such as diabetes, stroke, depression. Gut microbiota has been affirmed to interact various organs, including the brain. Intestinal their metabolites might target brain directly via vagal stimulation or indirectly through immune‐neuroendocrine mechanisms, they can regulate metabolism, adiposity, homoeostasis energy balance, central appetite food reward signaling, which together have crucial roles in obesity. Studies support concept of bidirectional signaling within gut–brain axis (GBA) pathophysiology obesity, mediated by metabolic, endocrine, neural, immune system mechanisms. Materials methods Scopus, PubMed, Google Scholar, Web Science databases were searched find relevant studies. Results The (GBA), connection between gut brain, influences function behavior three different pathways. Neural pathway mainly consists enteric nervous (ENS) vagus nerve. Endocrine pathway, however, affects neuroendocrine particularly hypothalamus–pituitary–adrenal (HPA) immunological pathway. Several alterations microbiome lead modulating metabolic pathways eating behaviors host GBA. Therefore, novel therapies targeting microbiome, i.e., fecal transplantation supplementation probiotics prebiotics, be potential treatment for Conclusion This study corroborates effect on body weight. results show becoming new antiobesity therapies.

Language: Английский

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Exploring the Links between Obesity and Psoriasis: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7499 - 7499

Published: July 6, 2022

Obesity is a major public health issue worldwide since it associated with the development of chronic comorbidities such as type 2 diabetes, dyslipidemias, atherosclerosis, some cancer forms and skin diseases, including psoriasis. Scientific evidence has indicated that possible link between obesity psoriasis may be multifactorial, highlighting dietary habits, lifestyle, certain genetic factors microbiome leading in progress both pathologies because they are pro-inflammatory state. Thus, inflammation management plausible target for psoriasis, not only sick adipose tissue secretome profile but also due to relationship rest immune derangements initiation maintenance. Hence, this review will provide general molecular overview present recent therapeutic advances treating problem.

Language: Английский

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Mediterranean Diet on Sleep: A Health Alliance

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2998 - 2998

Published: July 21, 2022

The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so it considered one the healthiest patterns. Clinical trials mechanistic studies have demonstrated its peculiar foods nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, tumorigenesis, thus preventing age-associated chronic improving wellbeing health. Nocturnal sleep an essential physiological function, whose alteration health outcomes diseases. Scientific evidence suggests are related in bidirectional relationship, understanding this association important given their role disease prevention. In review, we surveyed literature concerning current state from epidemiological on impact nighttime quantity quality. available indicate greater adherence to adequate duration several indicators better Potential mechanisms mediating effect described, gap-in-knowledge new research agenda corroborate findings discussed.

Language: Английский

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The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115276 - 115276

Published: Aug. 4, 2023

Short-chain fatty acids (SCFAs) derived from the fermentation of carbohydrates by gut microbiota play a crucial role in regulating host physiology. Among them, acetate, propionate, and butyrate are key players various biological processes. Recent research has revealed their significant functions immune inflammatory responses. For instance, reduces development interferon-gamma (IFN-γ) generating cells while promoting regulatory T (Treg) cells. Propionate inhibits initiation Th2 response dendritic (DCs). Notably, SCFAs have an inhibitory impact on polarization M2 macrophages, emphasizing immunomodulatory properties potential for therapeutics. In animal models asthma, both propionate suppress pathway, thus reducing allergic airway inflammation. Moreover, dysbiosis leading to altered SCFA production been implicated prostate cancer progression. trigger autophagy promote accelerating tumor advancement. Manipulating microbiota- producing holds promise treatment. Additionally, enhance expression hypoxia-inducible factor 1 (HIF-1) blocking histone deacetylase, resulting increased antibacterial effectors improved macrophage-mediated elimination microorganisms. This highlights antimicrobial defense mechanisms. comprehensive review provides in-depth analysis latest functional aspects underlying mechanisms relation macrophage activities wide range diseases, including infectious diseases cancers. By elucidating intricate interplay between functions, this aims contribute understanding therapeutic pave way future interventions targeting disease management.

Language: Английский

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A Review of the Relationship between Gut Microbiome and Obesity

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(1), P. 610 - 610

Published: Jan. 2, 2023

Obesity is a rapidly growing problem of public health on worldwide scale, responsible for more than 60% deaths associated with high body mass index. Recent studies underpinned the augmenting importance gut microbiota in obesity. Gut alterations affect energy balance host organism; namely, as factor affecting production from diet and genes regulating expenditure storage. composition characterised by constant variability, affected several dietary factors, suggesting probability that manipulation may promote leaning or prevent Our narrative review summarizes results recent years stress effect development It investigates factors (diet, components, lifestyle, environment) might composition. Possible strategies prevention and/or treatment obesity include restoring modifying consuming prebiotics probiotics, fermented foods, fruits, vegetables, avoiding foods animal origin saturated fat sugar.

Language: Английский

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Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106337 - 106337

Published: July 6, 2024

Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.

Language: Английский

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Probiotics and gut microbiome − Prospects and challenges in remediating heavy metal toxicity

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 420, P. 126676 - 126676

Published: July 17, 2021

Language: Английский

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