Foods,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1853 - 1853
Published: June 13, 2024
Bioactive
peptides
derived
from
both
exogenous
and
endogenous
origins
have
been
studied
extensively
to
use
their
beneficial
effects
in
humans
animals.
exhibit
bodily
functions
contribute
a
healthy
gastrointestinal
system
by
influencing
barrier
functions,
immune
responses,
gut
microbiota.
Gut
microbiota
is
diverse
microbial
community
that
significantly
influences
the
overall
well-being
homeostasis
of
body.
Factors
such
as
diet,
age,
lifestyle,
medication,
environmental
circumstances
can
affect
composition
diversity
The
disturbances
or
imbalances
associated
with
various
health
problems.
interplays
between
bioactive
are
not
fully
understood,
but
hold
promise
modulators
promote
health.
Almost
all
research
on
human
health,
including
development
therapeutics
nutritional
interventions,
uses
cell
culture,
even
though
direct
biofunctional
activities
only
occur
when
absorbed
intestine
into
blood
system.
This
review
focuses
current
understanding
impact
mechanisms
novelty
this
lies
its
comprehensive
analysis
multifaceted
interactions
microbiota,
integrating
knowledge
disciplines
microbiology
nutrition.
By
elucidating
underlying
identifying
gaps,
offers
an
outlook
potential
promoting
shaping
future
therapeutic
interventions.
Annals of Microbiology,
Journal Year:
2024,
Volume and Issue:
74(1)
Published: Jan. 3, 2024
Abstract
Background
The
gut
microbiota
plays
a
crucial
role
in
regulating
the
host’s
immune
responses
during
aging,
which
was
characterized
by
different
abundance
of
bacteria
several
age
groups.
Main
body
Gut
dysbiosis
is
associated
with
antibiotic
exposure,
underlying
diseases,
infections,
hormonal
variations,
circadian
rhythm,
and
malnutrition,
either
singularly
or
combination.
appropriate
use
prebiotics
probiotics
may
be
able
to
prevent
reduce
this
disruption.
Conclusion
current
review
focuses
on
composition
across
life
cycle,
factors
affecting
changes
interventions
modulate
microbiota.
Diseases,
Journal Year:
2025,
Volume and Issue:
13(2), P. 55 - 55
Published: Feb. 13, 2025
Obesity
has
emerged
as
a
global
epidemic,
creating
an
increased
burden
of
weight-related
diseases
and
straining
healthcare
systems
worldwide.
While
the
fundamental
principle
energy
balance-caloric
intake
versus
expenditure-remains
central
to
weight
regulation,
real-world
outcomes
often
deviate
from
simplistic
predictions
due
multitude
physiological
environmental
factors.
Genetic
predispositions,
variations
in
basal
metabolic
rates,
adaptive
thermogenesis,
physical
activity,
nutrient
losses
via
fecal
urinary
excretion
contribute
interindividual
differences
homeostasis.
Additionally,
factors
such
meal
timing,
macronutrient
composition,
gut
microbiota
dynamics,
diet-induced
thermogenesis
(DIT)
further
modulate
utilization
efficiency.
This
Perspective
explores
key
determinants
balance,
while
also
highlighting
clinical
significance
thrifty
spendthrifty
phenotypes.
Key
strategies
for
individualized
management
include
precision
calorimetry,
circadian-aligned
use
protein-
whole
food
diets
enhance
DIT,
increases
non-exercise
well
mild
cold
exposure
thermogenic
agents
(e.g.,
capsaicin-like
compounds)
stimulate
brown
adipose
tissue
activity.
A
comprehensive,
personalized
approach
obesity
that
moves
beyond
restrictive
caloric
models
is
essential
achieving
sustainable
control
improving
long-term
health.
Integrating
these
multifactorial
insights
into
practice
will
treatment
strategies,
fostering
more
effective
enduring
interventions.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(3), P. 662 - 662
Published: March 6, 2023
Chlamydia
trachomatis
and
human
papillomavirus
(HPV)
are
the
most
common
pathogens
found
in
sexually
transmitted
infections
(STIs),
both
known
to
increase
risk
of
cervical
cancer
(CC)
infertility.
HPV
is
extremely
worldwide,
scientists
use
it
distinguish
between
low-risk
high-risk
genotypes.
In
addition,
transmission
can
occur
via
simple
contact
genital
area.
From
50
80%
active
individuals
become
infected
with
C.
viruses
during
their
lifetime,
up
50%
an
oncogenic
genotype.
The
natural
history
this
coinfection
strongly
conditioned
by
balance
host
microbiome
immune
condition
infecting
agent.
Though
infection
often
regresses,
tends
persist
throughout
adult
life
asymptomatically
silently.
partnership
basically
due
similarities:
routes,
reciprocal
advantages,
same
factors.
a
Gram-negative
bacteria,
similar
HPV,
intracellular
bacterium,
which
shows
unique
biphasic
development
that
helps
latter
continue
its
steady
progression
into
entire
life.
Indeed,
depending
on
individual’s
condition,
migrate
toward
upper
tract
spread
uterus,
fallopian
tubes
open
pathway
invasion.
related
female
facilitated
decay
first
line
defense
vaginal
environment,
constituted
healthy
characterized
net
equilibrium
all
components.
Thus,
aim
paper
was
highlight
complexity
fragility
microenvironment
accentuate
fundamental
role
elements
systems
involved,
including
Lactobacillus
strains
(Lactobacillus
gasseri,
jensenii,
crispatus)
immune–endocrine
system,
preserving
from
mutation.
Therefore,
age,
diet,
genetic
predisposition
together
unspecific,
persistent
low-grade
inflammatory
state
were
be
implicated
high
frequency
severity
grade
disease,
potentially
resulting
pre-cancerous
cancerous
lesions.
Foods,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1345 - 1345
Published: April 26, 2024
It
is
now
widely
recognized
that
gut
microbiota
plays
a
critical
role
not
only
in
the
development
and
progression
of
diseases,
but
also
its
susceptibility
to
dietary
patterns,
food
composition,
nutritional
intake.
In
this
comprehensive
review,
we
have
compiled
latest
findings
on
effects
nutrients
bioactive
compounds
microbiota.
The
research
indicates
certain
components,
such
as
unsaturated
fatty
acids,
fiber,
protein
significant
impact
composition
bile
salts
short-chain
acids
through
catabolic
processes,
thereby
influencing
Additionally,
these
an
effect
ratio
Firmicutes
Bacteroides,
well
abundance
specific
species
like
Akkermansia
muciniphila.
has
been
found
play
altering
absorption
metabolism
nutrients,
compounds,
drugs,
adding
another
layer
complexity
interaction
between
microbiota,
which
often
requires
long-term
adaptation
yield
substantial
outcomes.
conclusion,
understanding
relationship
can
offer
valuable
insights
into
potential
therapeutic
applications
interventions
various
diseases
health
conditions.
FEBS Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
Obesity
is
a
major
health
challenge
due
to
its
high
prevalence
and
associated
comorbidities.
The
excessive
intake
of
diet
rich
in
fat
sugars
leads
persistent
imbalance
between
energy
expenditure,
which
increases
adiposity.
Here,
we
provide
an
update
on
relevant
diet-microbe-host
interactions
contributing
or
protecting
from
obesity.
In
particular,
focus
how
unhealthy
diets
shape
the
gut
microbiota
thus
impact
crucial
intestinal
neuroendocrine
immune
system
functions.
We
describe
these
promote
dysfunction
gut-to-brain
pathways
involved
food
control
postprandial
metabolism
elevate
proinflammatory
tone,
promoting
obesity
metabolic
complications.
addition,
examples
this
knowledge
may
inspire
microbiome-based
interventions,
such
as
fecal
transplants,
probiotics,
biotherapeutics,
effectively
combat
obesity-related
disorders.
also
discuss
current
limitations
gaps
research
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(16), P. 8200 - 8216
Published: Jan. 1, 2024
Interactions
of
polyphenols
and
polysaccharides
regulate
glycolipid
metabolism
through
the
gut
microbiota,
which
is
achieved
regulation
metabolites,
intestinal
barrier
function,
signaling
pathways.
JAMA Network Open,
Journal Year:
2024,
Volume and Issue:
7(10), P. e2441970 - e2441970
Published: Oct. 28, 2024
Importance
Obesity
is
associated
with
increased
severity
of
COVID-19.
Whether
obesity
an
risk
post-acute
sequelae
SARS-CoV-2
infection
(PASC)
among
pediatric
populations,
independent
its
association
acute
severity,
unclear.
Objective
To
quantify
the
body
mass
index
(BMI)
status
before
PASC
risk,
controlling
for
severity.
Design,
Setting,
and
Participants
This
retrospective
cohort
study
occurred
at
26
US
children’s
hospitals
from
March
2020
to
May
2023
a
minimum
follow-up
179
days.
Eligible
participants
included
children
young
adults
aged
5
20
years
infection.
Data
analysis
was
conducted
October
January
2024.
Exposures
BMI
assessed
within
18
months
infection;
measure
closest
date
selected.
The
categories
healthy
weight
(≥5th
<85th
percentile
those
5-19
or
≥18.5
<25
>19
years),
overweight
(≥85th
<95th
≥25
<30
(≥95th
<120%
95th
≥30
<40
severe
(≥120%
≥40
years).
Main
Outcomes
And
Measures
identify
PASC,
diagnostic
code
specific
post–COVID-19
conditions
used
second
approach
clusters
symptoms
that
constitute
phenotype.
Relative
(RR)
quantified
by
Poisson
regression
models,
adjusting
sociodemographic,
COVID
other
clinical
factors.
Results
A
total
172
136
(mean
[SD]
age
assessment
12.6
[4.4]
years;
mean
entry,
13.1
90
187
female
[52.4%])
were
included.
Compared
weight,
had
25.4%
(RR,
1.25;
95%
CI,
1.06-1.48)
42.1%
1.42;
1.25-1.61)
when
identified
using
code.
there
any
occurrences
1.11;
1.06-1.15)
1.17;
1.14-1.21),
held
assessing
incident
1.05;
1.00-1.11),
1.13;
1.09-1.19),
1.18;
1.14-1.22).
Conclusions
Relevance
In
this
study,
elevated
significantly
in
dose-dependent
manner,
highlighting
need
targeted
care
prevent
chronic
at-risk
adults.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: June 2, 2023
Intestinal
microorganisms
play
a
crucial
role
in
shaping
the
host
immunity
and
maintaining
homeostasis.
Nevertheless,
alterations
gut
bacterial
composition
may
occur
these
have
been
linked
with
pathogenesis
of
several
diseases.
In
surgical
practice,
studies
revealed
that
microbiome
patients
undergoing
surgery
changes
post-operative
complications
seem
to
be
associated
microbiota
composition.
this
review,
we
aim
provide
an
overview
(GM)
disease.
We
refer
which
describe
GM
different
types
surgery,
focus
on
impacts
peri-operative
interventions
development
complications,
such
as
anastomotic
leak.
The
review
aims
enhance
comprehension
regarding
correlation
between
procedures
based
current
knowledge.
However,
preoperative
postoperative
synthesis
needs
further
examined
future
studies,
so
GM-targeted
measures
could
assessed
reduced.
