Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1653 - 1653
Published: Aug. 22, 2023
The
liver
is
an
organ
that
particularly
exposed
to
reactive
oxygen
species
(ROS),
which
not
only
arise
during
metabolic
functions
but
also
the
biotransformation
of
xenobiotics.
disruption
redox
balance
causes
oxidative
stress,
affects
function,
modulates
inflammatory
pathways
and
contributes
disease.
Thus,
stress
implicated
in
acute
injury
pathogenesis
prevalent
infectious
or
chronic
diseases
such
as
viral
hepatitis
B
C,
alcoholic
fatty
disease,
non-alcoholic
disease
(NAFLD)
steatohepatitis
(NASH).
Moreover,
plays
a
crucial
role
progression
fibrosis,
cirrhosis
hepatocellular
carcinoma
(HCC).
Herein,
we
provide
overview
on
effects
pathophysiology
mechanisms
by
promotes
Molecular Biomedicine,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Oct. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
动物学研究,
Journal Year:
2023,
Volume and Issue:
44(1), P. 183 - 218
Published: Jan. 1, 2023
The
innate
immune
system
protects
the
host
from
external
pathogens
and
internal
damage
in
various
ways.
cGAS-STING
signaling
pathway,
comprised
of
cyclic
GMP-AMP
synthase
(cGAS),
stimulator
interferon
genes
(STING),
downstream
adaptors,
plays
an
essential
role
protective
defense
against
microbial
DNA
damaged-associated
is
responsible
for
immune-related
diseases.
After
binding
with
DNA,
cytosolic
cGAS
undergoes
conformational
change
DNA-linked
liquid-liquid
phase
separation
to
produce
2'3'-cGAMP
activation
endoplasmic
reticulum
(ER)-localized
STING.
However,
further
studies
revealed
that
predominantly
expressed
nucleus
strictly
tethered
chromatin
prevent
nuclear
functions
differently
cytosolic-localized
cGAS.
Detailed
delineation
this
including
its
structure,
signaling,
regulatory
mechanisms,
great
significance
fully
understand
diversity
will
be
benefit
treatment
inflammatory
diseases
cancer.
Here,
we
review
recent
progress
on
above-mentioned
perspectives
pathway
discuss
new
avenues
study.
Ageing Research Reviews,
Journal Year:
2023,
Volume and Issue:
91, P. 102068 - 102068
Published: Sept. 12, 2023
Alzheimer's
disease
(AD)
represents
the
most
frequent
type
of
dementia
in
elderly
people.
Two
major
forms
exist:
sporadic
-
causes
which
have
not
yet
been
fully
understood
and
familial
inherited
within
families
from
generation
to
generation,
with
a
clear
autosomal
dominant
transmission
mutations
Presenilin
1
(PSEN1),
2
(PSEN2)
or
Amyloid
Precursors
Protein
(APP)
genes.
The
main
hallmark
AD
consists
extracellular
deposits
amyloid-beta
(Aβ)
peptide
intracellular
hyperphosphorylated
form
tau
protein.
An
ever-growing
body
research
supports
viral
infectious
hypothesis
AD.
In
particular,
it
has
shown
that
several
herpes
viruses
(i.e.,
HHV-1,
HHV-2,
HHV-3
varicella
zoster
virus,
HHV-4
Epstein
Barr
HHV-5
cytomegalovirus,
HHV-6A
B,
HHV-7),
flaviviruses
Zika
Dengue
fever
Japanese
encephalitis
virus)
as
well
Human
Immunodeficiency
Virus
(HIV),
hepatitis
(HAV,
HBV,
HCV,
HDV,
HEV),
SARS-CoV2,
Ljungan
virus
(LV),
Influenza
A
Borna
could
increase
risk
Here,
we
summarized
discussed
these
results.
Based
on
findings,
significant
issues
for
future
studies
are
also
put
forward.
Micromachines,
Journal Year:
2022,
Volume and Issue:
13(3), P. 428 - 428
Published: March 10, 2022
Mortality
from
liver
disease
conditions
continues
to
be
very
high.
As
diseases
manifest
and
progress
silently,
prompt
measures
after
diagnosis
are
essential
in
the
treatment
of
these
conditions.
Microfluidic
organs-on-chip
platforms
have
significant
potential
for
study
pathophysiology
vitro.
Different
liver-on-a-chip
microphysiological
been
reported
cell-signaling
pathways
such
as
those
activating
stellate
cells
within
diseases.
Moreover,
drug
efficacy
might
evaluated
on
a
cellular
metabolic
level.
Here,
we
present
comprehensive
review
used
modelling
First,
briefly
introduce
concept
importance
organs-on-a-chip
studying
vitro,
reflecting
existing
reviews
healthy
platforms.
Second,
techniques
cell
cultures
microfluidic
devices,
including
2D,
3D,
spheroid
cells,
explained.
Next,
types
(NAFLD,
ALD,
hepatitis
infections,
injury)
on-chip
explained
further
overview
design
methods
developing
Finally,
some
challenges
solutions
them
reviewed.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3487 - 3487
Published: Feb. 9, 2023
Liver
disease
is
one
of
the
leading
public
health
problems
faced
by
healthcare
practitioners
regularly.
As
such,
there
has
been
a
search
for
an
inexpensive,
readily
available,
non-invasive
marker
to
aid
in
monitoring
and
prognosticating
hepatic
disorders.
Recently,
red
blood
cell
distribution
width
(RDW)
found
be
associated
with
various
inflammatory
conditions
implications
its
use
as
potential
assessing
progression
prognosis
multiple
conditions.
Multiple
factors
effect
production
whereby
dysfunction
any
process
can
lead
anisocytosis.
Furthermore,
chronic
state
leads
increased
oxidative
stress
produces
cytokines
causing
dysregulation
intracellular
uptake
both
iron
vitamin
B12,
which
reduction
erythropoiesis
increase
RDW.
This
literature
review
reviews
in-depth
pathophysiology
that
may
RDW
correlation
liver
diseases,
including
hepatitis
B,
C,
E,
non-alcoholic
fatty
disease,
autoimmune
hepatitis,
primary
biliary
cirrhosis,
hepatocellular
carcinoma.
In
our
review,
we
examine
prognostic
predictive
injury
disease.
Life,
Journal Year:
2024,
Volume and Issue:
14(2), P. 190 - 190
Published: Jan. 28, 2024
Human
viruses
and
from
animals
can
cause
illnesses
in
humans
after
the
consumption
of
contaminated
food
or
water.
Contamination
may
occur
during
preparation
by
infected
handlers,
production
because
unsuitably
controlled
working
conditions,
following
animal-based
foods
a
zoonotic
virus.
This
review
discussed
recent
information
available
on
general
clinical
characteristics
viruses,
viral
foodborne
outbreaks
control
strategies
to
prevent
contamination
products
Viruses
are
responsible
for
greatest
number
caused
food,
risk
assessment
experts
regard
them
as
high
safety
priority.
concern
is
well
founded,
since
significant
increase
has
occurred
over
past
20
years.
Norovirus,
hepatitis
A
E
rotavirus,
astrovirus,
adenovirus,
sapovirus
major
common
associated
with
water
illness
outbreaks.
It
also
suspected
that
many
human
including
Aichi
virus,
Nipah
tick-borne
encephalitis
H5N1
avian
influenza
coronaviruses
(SARS-CoV-1,
SARS-CoV-2
MERS-CoV)
have
potential
be
transmitted
via
products.
evident
adoption
strict
hygienic
processing
measures
farm
table
required
contaminating
our
food.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11213 - 11213
Published: Oct. 18, 2024
Liver
inflammation
is
frequently
linked
to
oxidative
stress
and
dysregulation
of
bile
acid
fatty
metabolism.
This
review
focuses
on
the
farnesoid
X
receptor
(FXR),
a
critical
regulator
homeostasis,
its
interaction
with
nuclear
factor
erythroid
2-related
2
(Nrf2),
key
modulator
cellular
defense
against
stress.
The
explores
interplay
between
FXR
Nrf2
in
liver
inflammatory
diseases,
highlighting
potential
therapeutic
effects
natural
agonists.
Specifically,
compounds
such
as
auraptene,
cafestol,
curcumin,
fargesone
A,
hesperidin,
lycopene,
oleanolic
acid,
resveratrol,
rutin,
ursolic
withaferin
A
are
reviewed
for
their
ability
modulate
both
pathways.
article
discusses
alleviate
inflammation,
stress,
damage
diseases
metabolic-associated
disease
(MAFLD),
cholestatic
injury,
viral
hepatitis.
In
addition,
we
address
molecular
mechanisms
driving
including
immune
responses,
accumulation,
while
also
summarizing
relevant
experimental
models.
emphasizes
promising
targeting
pathways
using
compounds,
paving
way
future
treatments
diseases.
Finally,
limitations
clinical
application
were
indicated,
further
research
directions
proposed.
Review
CRISPR-Cas
System:
Novel
Experimental
Therapeutic
and
Diagnostic
Approaches
for
Chronic
Liver
Diseases
Teja
Naveen
Sata
Senthil
Kumar
Venugopal
*
Faculty
of
Life
Sciences
Biotechnology,
South
Asian
University,
New
Delhi
110068,
India
Correspondence:
[email protected];
Tel.:
+91-1135656620;
Fax:
+91-1124122511
Received:
7
February
2025;
Accepted:
26
Published:
8
April
2025
Abstract:
liver
disease
(CLD),
a
significant
ailment,
contributes
to
nearly
two
million
deaths
annually.
CLD
can
be
caused
by
alcohol
consumption,
fat,
viral
infections,
genetic
disorders.
Accurate
diagnosis
application
therapeutics
are
crucial
strategies
enhancing
the
management
CLD.
The
system,
originally
prokaryotic
innate
immunity
mechanism,
has
evolved
into
current-generation
tool
therapeutic
diagnostic
applications.
cis-cleavage
feature
system
involves
crRNA-guided
specific
target
cleavage.
This
mechanism
is
utilized
development
therapeutics.
Few
systems
possess
additional
trans-cleavage,
which
non-specific
cleavage,
also
known
as
collateral
unique
exploited
generate
diagnostics.
In
hepatitis,
CRIPSR-Cas
have
been
concurrently
applied
reported
genome-targeted
detection
systems.
Research
on
alcoholic
non-alcoholic
fatty
diseases
mainly
focuses
targeting
progression
factors.
Also,
CRISPR-Cas-based
gene
editing
used
manage
hepatocellular
carcinoma,
oncogene-targeted
therapies
biomarker
Various
non-viral
delivery
proposed
developing
Despite
limited
progress,
potential
broader
in
review
describes
comprehensive
use
experimental
approaches
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Feb. 23, 2024
Animal
models
of
infectious
disease
often
serve
a
crucial
purpose
in
obtaining
licensure
therapeutics
and
medical
countermeasures,
particularly
situations
where
human
trials
are
not
feasible,
i.e.,
for
those
diseases
that
occur
infrequently
the
population.
The
common
marmoset
(
Callithrix
jacchus
),
Neotropical
new-world
(platyrrhines)
non-human
primate,
has
gained
increasing
attention
as
an
animal
model
number
given
its
small
size,
availability
evolutionary
proximity
to
humans.
This
review
aims
(i)
discuss
pros
cons
by
providing
brief
snapshot
how
marmosets
currently
utilized
biomedical
research,
(ii)
summarize
evaluate
relevant
aspects
immune
system
study
diseases,
(iii)
provide
historical
backdrop,
outlining
significance
importance
developing
reliable
test
novel
therapeutics,
(iv)
summary
which
exists,
followed
in-depth
discussion
two
studied
bacterial
(tularemia
melioidosis)
one
viral
(viral
hepatitis
C).
