Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 5, 2023

The gut microbiota is a rich and dynamic ecosystem that actively interacts with the human body, playing significant role in state of health disease host. Diet, exercise, mental health, other factors have exhibited ability to influence bacterial composition, leading changes can prevent improve, or favor worsen, both intestinal extra-intestinal conditions. Altered microbial states, ‘dysbiosis’, associated conditions diseases are often characterized by shifts abundance diversity, including an impaired Firmicutes Bacteroidetes ratio. By understanding effect lifestyle on microbiota, personalized advice be generated suit each individual profile foster adoption ameliorate dysbiosis. delivery effective reliable advice, however, depends not only available research current topic, but also methods used assess individuals discover associations, which introduce bias at multiple stages. aim this review summarize how variability defined what choices shown association composition. Furthermore, popular investigate outlined, focus possible caused lack use standardized methods. Finally, overview based testing presented, underlining its power limitations.

Language: Английский

---

Unraveling the Impact of Gut and Oral Microbiome on Gut Health in Inflammatory Bowel Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3377 - 3377

Published: July 29, 2023

Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic inflammation of the gastrointestinal tract (GIT). IBD mainly includes two distinct diseases, namely Crohn's and ulcerative colitis. To date, precise etiology these conditions not fully elucidated. Recent research has shed light on significant role oral gut microbiome in development progression its collective influence health. This review aims to investigate connection between context IBD, exploring intricate interplay microbial communities their impact overall advances have revealed compelling link microbiome, highlighting pivotal maintaining The cavity GIT are interconnected ecosystems that harbor implicated pathogenesis several ways. Reduction diversity abundance beneficial bacterial species with colonization opportunistic pathogens can induce inflammation. Some arise from origin, especially patients diseases such as periodontitis. It essential discern mechanisms transmission, health potential dysbiosis development. By elucidating this relationship, we enhance our understanding identify therapeutic avenues for managing disease. Furthermore, innovative strategies modulating promote prevent occurrence progression.

Language: Английский

---

Positive effects of physical activity in autism spectrum disorder: how influences behavior, metabolic disorder and gut microbiota

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 10, 2023

Autism spectrum disorder is a neurodevelopmental characterized by social interactions and communication skills impairments that include intellectual disabilities, delays self-injurious behaviors; often are present systemic comorbidities such as gastrointestinal disorders, obesity cardiovascular disease. Moreover, in recent years has emerged link between alterations the intestinal microbiota neurobehavioral symptoms children with autism disorder. Recently, physical activity exercise interventions known to be beneficial for improving interaction composition of microbiota. In our review we intend highlight how different types sports can help improve behaviors also show positive effects on gut composition.

Language: Английский

---

Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1708 - 1708

Published: March 3, 2025

Background/Objectives: Physical exercise can have significant consequences for the gastrointestinal tract, which is why there been studies into its influence on treatment of conditions such as colorectal cancer, inflammatory bowel diseases (IBD), and irritable syndrome (IBS), being that epidemiological evidence has a protective effect against colon cancer. This review aims to demonstrate mechanisms action physical in well benefits associated with digestive system, addition gathering training recommendations treating different diseases. Results: modulates motility, permeability, immune responses, microbiota composition, both beneficial adverse effects depending intensity duration. Regular moderate improved quality life IBD IBS, reduced cancer risk, potential symptom relief constipation. However, high-intensity may exacerbate gastroesophageal reflux symptoms increase risk bleeding. While aerobic extensively studied, resistance health remain underexplored. Conclusions: New methodologies techniques, molecular biology study gastric receptors, led advances understanding changes exercise. These cover intensities are investigated experimental models clinical studies.

Language: Английский

---

ECCO Topical Review: Roadmap to Optimal Peri-Operative Care in IBD

Journal of Crohn s and Colitis, Journal Year: 2022, Volume and Issue: 17(2), P. 153 - 169

Published: Sept. 2, 2022

Abstract Background and aims Despite the advances in medical therapies, a significant proportion of patients with inflammatory bowel diseases [IBD] require surgical intervention. This Topical Review to offer expert consensus practice recommendations for peri-operative care optimize outcomes IBD who undergo surgery. Methods A multidisciplinary panel healthcare providers systematically reviewed aspects relevant IBD. Consensus statements were developed using Delphi methodology. Results total 20 current positions following systematic review literature covering use medication period, nutritional assessment intervention, physical psychological rehabilitation prehabilitation, immediate postoperative care. Conclusion Peri-operative planning optimization patient are imperative ensure favourable reduced morbidity. provides applicable period undergoing

Language: Английский

---

Cross talk between the gut microbiome and host immune response in ulcerative colitis: nonpharmacological strategies to improve homeostasis

AJP Gastrointestinal and Liver Physiology, Journal Year: 2022, Volume and Issue: 323(6), P. G554 - G561

Published: Oct. 25, 2022

Ulcerative colitis (UC) is a chronic disease that characterized by diffuse inflammation of the colonic and rectal mucosa. The burden UC rising globally with significant disparities in levels trends different countries. pathogenesis involves presence pathogenic factors including genetic, environmental, autoimmune, immune-mediated components. Evidence suggests disturbed interactions between host immune system gut microbiome contribute to origin development UC. Current medications for include antibiotics, corticosteroids, biological drugs, which can have deleterious off-target effects on microbiome, contributing increased susceptibility severe infections immunosuppression. Alternative, nonpharmacological, behavioral interventions been proposed as safe effective treatments alleviate UC, while also holding potential improve overall life quality. This mini-review will discuss case In addition, we suggest nonpharmacological strategies aimed at restoring proper microbial-immune relationship.

Language: Английский

---

Fatigue, Physical Activity, and Quality of Life in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 49 - 58

Published: Jan. 1, 2024

Purpose: The benefits of physical activity (PA) are widely recognized, but the intensity PA in inflammatory bowel disease (IBD) patients with varying levels remains controversial. We aimed to investigate relationship between levels, fatigue, and other health-related quality life (QoL) Chinese IBD patients. Patients Methods: study is a cross-sectional investigation conducted at comprehensive diagnosis treatment facility East China, spanning from August 2022 February 2023. A total 245 participants were initially enrolled, after excluding individuals incomplete data about crucial exposure outcome variables, final sample size amounted 237. Participants provided questionnaire encompassing sociodemographic factors, clinical information, International Physical Activity Questionnaire (IPAQ), Multidimensional Fatigue Inventory (MFI-20), Inflammatory Bowel Disease (IBDQ). Correlation analysis was employed assess variables. Results: majority (144) exhibited low PA. Furthermore, 40.5% all reported experiencing fatigue. Individuals had an average MIF-20 score 62.9± 16.0. showed that significantly negatively associated fatigue (r = − 0.224, p < 0.001). Additionally, also correlated anxiety 0.150, 0.05) depression 0.242, On hand, positively 0.171, 0.01). our indicated sleep disorders both 0.349, 0.01) 0.354, Conclusion: low, there high prevalence among IBD. strong negative correlation positive life. Keywords: activity, disease,

Language: Английский

---

Nutrition interventions and clinical outcomes of pregnant women with gestational diabetes mellitus: More than meets the eye

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(1), P. 126 - 128

Published: Jan. 12, 2024

In the retrospective study by Luo et al regarding clinical outcomes in gestational diabetes mellitus (GDM), results are statistically significant favour of benefits individualized nutrition interventions enumerated therein. The has provided important evidence to improve maternal and child health Asian population. methods, however, appear have considerable limi-tations, wherein time point diagnosis GDM, severity selection bias, compliance therapy, covariates, observable microvascular abnormalities confounding effect added insulin not been considered. We suggestions external validity study, including use Equator Network reporting guidelines inclusion overweight obese patients future studies.

Language: Английский

---

The Paraguayan gut microbiome contains high abundance of the phylum Actinobacteriota and reveals the influence of health and lifestyle factors

Gut Microbes Reports, Journal Year: 2024, Volume and Issue: 1(1), P. 1 - 16

Published: May 2, 2024

Most gut microbiome studies are focused on populations from developed nations. However, this overlooks the role played by host genetics, lifestyle, and diet, highlighting need to evaluate under-represented populations. Thus, we performed first study a Paraguayan cohort via 16S rRNA sequencing PICRUSt2 analysis. We evaluated fecal samples 60 participants Asunción, while considering categories such as body-mass-index (BMI), sex, age, clinical history. Firmicutes (76.0 ± 11.6%), Actinobacteriota (10.4 7.9%) Bacteroidota (9.4 11.4%) were most abundant phyla. Similarly, genera Blautia (14.1 7.5%), Faecalibacterium (8.07 6.8%), Bacteroides (6.7 6.8%). Likewise, microbial pathways predicted be involved with sugar metabolism fermentation. Interestingly, some significantly impacted composition function, BMI (Moryella, Bifidobacterium), sex (Faecalibacterium), others. Additionally, dysbiotic indices differed values previously reported homeostatic. These observations highlight for further studies, species genetics. work expands knowledge of Collective South, contrasts found herein reinforce research human traditionally understudied.

Language: Английский

---

Diagnosis and Medical Treatment of Acute and Chronic Idiopathic Pouchitis in Inflammatory Bowel Disease

Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 979 - 979

Published: June 13, 2024

Despite the decreased rates in inflammatory bowel disease (IBD) colectomies due to high advances therapeutic options, a significant number of patients still require proctocolectomy with ileal pouch-anal anastomosis (IPPA) for ulcerative colitis (UC). Pouchitis is most common complication these patients, where up 60% develop one episode pouchitis first two years after UC surgery IPAA severe negative impact on their quality life. Acute cases usually respond well antibiotics, but 15% will refractory that requires initiation advanced immunosuppressive therapies. For chronic idiopathic pouchitis, current recommendations suggest using same options as IBD terms biologics and small molecules. However, available data are limited regarding effectiveness different or molecules management this condition, all evidences arise from case series studies. Vedolizumab only biologic agent has received approval treatment adult moderately severely active pouchitis. fact rapidly evolving development novel molecules, presence represents an exclusion criterion trials. Recommendations approach conditions range low very certainty evidence, resulting randomized controlled trials The review focuses

Language: Английский

---