Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine

Nanotheranostics, Journal Year: 2023, Volume and Issue: 7(4), P. 424 - 449

Published: Jan. 1, 2023

Medical imaging is an important factor for diagnosis.It can be used to diagnose patients, differentiate disease stages, and monitor treatment regimens.Although different technologies are available, MRI sensitive over other modalities as it capable of deep tissue penetration allowing image the anatomical, structural, molecular level diseased organs.Thus, screening tool staging.One components contrast agents which increase sensitivity technology.While types iron-oxide based nanoparticles (IONPS) widely these easy formulate, functionalize, biocompatible cost effective.In addition its use agents, have been drug carriers diseases ranging from cancer, cardiovascular diseases, neurological disorders, autoimmune infectious diseases.For last two decades, there has advancement in nanotheranostics, where IONPs formulated carry one system so that image-guided therapy real-life response tissue.This technology stratify patients into responders non-responders reduce adverse toxicity lead a tailored treatment.However, success nanotheranostics depends on several factor, including identification associated biomarkers targeted during formulation.While many challenges exist clinical translation still potential implemented personalized strategy.In this review article, we discussed relation their application diagnosis medicine.

Language: Английский

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The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116894 - 116894

Published: Aug. 14, 2023

Language: Английский

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Recent advances in magnetic nanoparticles: Key applications, environmental insights, and future strategies

Sustainable materials and technologies, Journal Year: 2024, Volume and Issue: 40, P. e00985 - e00985

Published: May 20, 2024

Language: Английский

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Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Oct. 31, 2023

Abstract Nanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, complexion. The can be further sealed using suitable lipids polymers to avoid leakage drugs at non‐target site, protect therapeutics from biological conditions, control release for prolonged period. Recently, have grasped attention researchers in area cancer by overcoming drawbacks associated delivery immunotherapeutic, targeted therapeutic, chemotherapeutic agents. Interestingly, several reports also witnessed potential theranostics. Owing this supremacy, could an apt platform therapy diagnosis. current review discusses general aspects, types, preparation methods In addition, ambit treating different is meticulously discussed, along detailed descriptions corresponding patents. Furthermore, role phototherapy theranostics selectively canvassed.

Language: Английский

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Interventional nanotheranostics in hepatocellular carcinoma

Nanotheranostics, Journal Year: 2023, Volume and Issue: 7(2), P. 128 - 141

Published: Jan. 1, 2023

Interventional nanotheranostics is a system of drug delivery that does dual function; along with the therapeutic action, it also have diagnostic features. This method helps in early detection, targeted delivery, and least chances damage to surrounding tissue. It ensures highest efficiency for management disease. Imaging near future quickest most accurate detection After combing both effective measures, meticulous system. Nanoparticles such as Gold NPs, Carbon Silicon NPS, etc. The article emphasizes on effect this treatment Hepatocellular Carcinoma. one widely spreading diseases theranostics trying make scenario better. review suggests pitfall current how can help. describes mechanism used generate its believes interventional do rainbow color. hindrance flourishing miraculous technology.

Language: Английский

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Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 27, 2023

Abstract Hepatocellular carcinoma (HCC) has the sixth-highest new incidence and fourth-highest mortality worldwide. Transarterial chemoembolization (TACE) is one of primary treatment strategies for unresectable HCC. However, therapeutic effect still unsatisfactory due to insufficient distribution antineoplastic drugs in tumor tissues worsened post-embolization microenvironment (TME, e.g., hypoxia reduced pH). Recently, using nanomaterials as a drug delivery platform TACE therapy HCC been research hotspot. With development nanotechnology, multifunctional nanoplatforms have developed embolize vasculature, creating conditions improving bioavailability tissues. Currently, researchers are focusing on functionalizing achieve high loading efficacy, thorough vascular embolization, targeting, controlled sustained release drugs, real-time imaging process facilitate precise embolization enable procedures follow-up lesions. Herein, we summarized recent advances applications functionalized based against HCC, believing that developing these may be promising approach

Language: Английский

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Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(12), P. 6010 - 6034

Published: Nov. 6, 2023

Nanotheranostics is a rapidly developing field that integrates nanotechnology, diagnostics, and therapy to provide novel methods for imaging treating wide categories of diseases. Targeted nanotheranostics offers platform the precise delivery theranostic agents, their therapeutic outcomes are monitored in real-time. Presently, vivo magnetic resonance imaging, fluorescence ultrasound photoacoustic (PAI), etc. noninvasive techniques preclinically available tracking small animals. Additionally, preclinical essential drug development, phenotyping, understanding disease stage progression its associated mechanisms. Small animal technique theranostics applications due merits being nonionizing, real-time, portable, able penetrate deep tissues. Recently, different types contrast agents have been explored, such as microbubbles, echogenic exosomes, gas-vesicles, nanoparticles-based agents. Moreover, an optical image obtained through creates ultrasonic waves when pulsed laser light used expose object picture tissue's distribution energy absorption on object. Contrast may be endogenous (hemoglobin, melanin, DNA/RNA) or exogenous (dyes nanomaterials-based agents). The integration with allows simultaneous treatment diseases animals, which provides information about response progression. In this review, we covered various imaging. discussed systems integrated application. Further, briefly current challenges

Language: Английский

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Transferrin-Modified Triptolide Liposome Targeting Enhances Anti-Hepatocellular Carcinoma Effects

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2869 - 2869

Published: Oct. 23, 2023

Triptolide (TP) is an epoxy diterpene lactone compound isolated and purified from the traditional Chinese medicinal plant Tripterygium wilfordii Hook. f., which has been shown to inhibit proliferation of hepatocellular carcinoma. However, due problems with solubility, bioavailability, adverse effects, use effectiveness drug are limited. In this study, a transferrin-modified TP liposome (TF-TP@LIP) was constructed for delivery TP. The thin-film hydration method used prepare TF-TP@LIP. physicochemical properties, loading, particle size, polydispersity coefficient, zeta potential liposomes were examined. inhibitory effects TF-TP@LIP on tumor cells in vitro assessed using HepG2 cell line. biodistribution its anti-tumor investigated tumor-bearing nude mice. results showed that spherical, had size 130.33 ± 1.89 nm −23.20 0.90 mV, electronegative. Encapsulation loading 85.33 0.41% 9.96 0.21%, respectively. preparation stable serum over 24 h biocompatibility slow release drug. Flow cytometry fluorescence microscopy uptake significantly higher than TP@LIP (p < 0.05), while MTT assays indicated mean median inhibition concentrations (IC50) TP, TP@LIP, TF-TP@ 90.6 nM, 56.1 42.3 respectively, treated 48 h. Real-time imaging significant accumulation DiR-labeled TF-TP@LIPs at sites mice, contrast DiR-only or DiR-labeled, indicating modification transferrin enhanced targeting tissues. Compared groups, group effect growth. H&E staining inhibited growth did not induce any pathological changes heart, liver, spleen, kidneys all liver kidney indices within normal range, no differences compared control group, safety preparation. findings by tumor-targeting ability improved their vivo. Reducing distribution tissues decreasing toxic suggest warrants further investigation clinical application.

Language: Английский

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Upgraded theragnostic strategies of multivariate nano gold in the management of hepatocellular carcinoma

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101342 - 101342

Published: Sept. 24, 2024

Language: Английский

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Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 955 - 955

Published: April 28, 2022

The greatest challenge associated with topical drug delivery for the treatment of diseases affecting posterior segment eye is to overcome poor bioavailability carried molecules. Nanomedicine offers possibility obstacles related physiological mechanisms and ocular barriers by exploiting different routes. Functionalization nanosystems fluorescent probes could be a useful strategy understand pathway taken nanocarriers into globe improve desired targeting accuracy. application fluorescence decorate nanocarrier surfaces or encapsulation fluorophore molecules makes light probe in landscape diagnostics theranostics. In this review, state art on routes administration reported, focus pathways undertaken after application. Numerous studies are reported first section, confirming that use within nanoparticles already spread tracking biodistribution studies. section presents used nanosystems’ cellular internalization permeation tissues; discussions classification according their nature (lipid-based, polymer-based, metallic-based protein-based) follows. following sections dedicated diagnostic theranostic uses, respectively, which represent an innovation field obtained combining dual goals single system. For its great potential, would experience development near future. Finally, brief overview markers clinical trials market field.

Language: Английский

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