Can physical exercise help people with irritable bowel syndrome? How substantial is the evidence? DOI Creative Commons
Mousa Numan Ahmad,

Obadah Mansour Thnaibat

Health sport rehabilitation, Journal Year: 2023, Volume and Issue: 9(4), P. 94 - 110

Published: Dec. 30, 2023

Purpose: Irritable bowel syndrome is one of the most common gastrointestinal disorders worldwide that negatively affect health and quality life imposes high costs. Increasing attention being paid to non-pharmacological therapies, like physical exercise, manage alleviate irritable symptoms, but underlying mechanism unclear, evidence inconclusive. This article aims provide an overview analysis recent links exercise with symptoms. Material methods. For last five years research (2018-2023), we searched several international scientific databases, including Web Science, Scopus, Science Direct, ADI, Cochrane Central Register Controlled Trials, PubMed, Medline, Clinical trials.gov, Google Scholar, WHO database. Results. Generally, exerts variable effects on gut physiology, integrity, health. Much recommended adopting regular light-to-moderate aerobic relaxation anaerobic enhance patient’s psychological well-being global symptoms. These types are purported improve function, motility, tone, habits, immunity, microbial diversity, due a decrease in stress, depression, anxiety index, symptom severity score, intestinal hypersensitivity, permeability. In contrast, more studies reported disruptive vigorous integrity physiology can compromise symptoms by inducing splanchnic hypoperfusion, epithelial wall damage, malabsorption, dysbiosis, bacterial translocation, thus calling into question positive outcomes exercise. Conclusions. There overwhelming recommending exercises for patients IBS. However, this seems low-quality, making it challenging confirm actual impacts exercise. Ethnicity, study design, type intensity methodological issues among reasons put forward account low-quality evidence. Thus, well-designed plausible studies, particularly randomized controlled trials individualized intervention settings consider frequency, intensity, time, type, volume, progression, highly demanded enable drawing specific recommendations without adverse effects.

Language: Английский

Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review DOI Creative Commons
Noemi Salmeri, Emanuele Sinagra, Carolina Dolci

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 2089 - 2089

Published: Aug. 15, 2023

Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems patient quality life. Interestingly, around 20% endometriosis patients also present with symptoms indicative IBS. The pathogenesis both these multifactorial remains be fully elucidated, but connections gut microbiota becoming more apparent. Emerging research underscores differences in composition between healthy individuals those suffering from either or Intestinal dysbiosis appears pivotal conditions, exerting an influence via similar mechanisms. It impacts intestinal permeability, triggers inflammatory reactions, initiates immune responses. Furthermore, it is entwined a bidirectional relationship brain, as part gut–brain axis, whereby influences influenced by mental health pain perception. Recent years have witnessed development microbiota-focused therapies, such low FODMAP diets, prebiotics, probiotics, antibiotics, fecal transplantation, designed tackle relieve symptoms. While promising, treatments inconsistent data, highlighting need for further research. This review explores evidence IBS endometriosis, underscoring role conditions. A deeper understanding this common mechanism may enable enhanced diagnostics therapeutic advancements.

Language: Английский

Citations

25
The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story DOI Creative Commons

Maria Skoufou,

Christina Tsigalou, Stergios Vradelis

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 194 - 194

Published: Jan. 18, 2024

Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically patients suffering from certain ailments. Although this knowledge was empirical past tomes, modern science has already verified it and expanded new limits. These microorganisms can be found nature various foods such as dairy products supplements formulated for clinical preventive use. The current review examines the different mechanisms of action probiotic strains how they interact with organism host. Emphasis is put on therapeutic use these beneficial conditions gastrointestinal tract. Diseases tract particularly any malfunction inflammation intestines seriously compromise whole organism. interaction between host’s microbiota alleviate signs symptoms while some cases, due course, intervene underlying pathology. Various safety issues probiotics also discussed.

Language: Английский

Citations

15
How gut microbiota may impact ocular surface homeostasis and related disorders DOI Creative Commons
Marc Labétoulle, Christophe Baudouin,

José Manuel Benítez del Castillo

et al.

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 100, P. 101250 - 101250

Published: March 8, 2024

Changes in the bacterial flora gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those an inflammatory, neuronal, psychological or hormonal factor involved pathogenesis and/or perception of disease. Maintaining ocular surface homeostasis is based on all these four factors, and there accumulating evidence literature relationship between microbiota diseases. The mechanisms mostly interconnected due interaction central peripheral neuronal networks, inflammatory effectors system. A better understanding influence maintenance homeostasis, onset persistence disorders could bring new insights help elucidate epidemiology pathology dynamics health Revealing exact nature associations paramount importance for developing a holistic approach using highly promising therapeutic strategies targeting

Language: Английский

Citations

12
Immune Cells, Gut Microbiota, and Vaccines: A Gender Perspective DOI Creative Commons
Pierluigi Rio, Mario Caldarelli,

Monica Chiantore

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 526 - 526

Published: March 17, 2024

The development of preventive and therapeutic vaccines has played a crucial role in preventing infections treating chronic non-communicable diseases, respectively. For long time, the influence sex differences on modifying health disease not been addressed clinical preclinical studies. interaction genetic, epigenetic, hormonal factors plays sex-related epidemiology manifestations, response to treatment. Moreover, is one leading influencing gut microbiota composition, which could further explain different predisposition diseases men women. In same way, between sexes occur also immune vaccines. This narrative review aims highlight these differences, focusing Comparative data about responses, vaccine effectiveness, side effects are reviewed. Hence, intricate interplay sex, immunity, will be discussed for its potential vaccination. Embracing sex-oriented perspective research may improve efficacy allow design tailored schedules.

Language: Английский

Citations

11
Leaky Gut Syndrome: An Interplay Between Nutrients and Dysbiosis DOI

Ana Beatriz Marcari,

Aline Dias Paiva,

Claudio Roberto Simon

et al.

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 31, 2025

Language: Английский

Citations

1
Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis DOI Creative Commons

Menghe Liu,

Ru Peng,

Chunfang Tian

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: June 13, 2024

In recent years, a growing body of research has confirmed that the gut microbiota plays major role in maintenance human health and disease. A imbalance can lead to development many diseases, such as pregnancy complications, adverse outcomes, polycystic ovary syndrome, endometriosis, cancer. Short-chain fatty acids are metabolites specific intestinal bacteria crucial for maintaining homeostasis regulating metabolism immunity. Endometriosis is result cell proliferation, escape from immune surveillance, invasive metastasis. There strong correlation between anti-proliferative anti-inflammatory effects short-chain produced by microbes endometriosis. Given mechanism action endometriosis remain unclear, this paper aims provide comprehensive review complex interactions flora, addition, we explored potential microbial-based treatment strategies providing new insights into future diagnostic tests prevention methods

Language: Английский

Citations

8
Unveiling the gut-eye axis: how microbial metabolites influence ocular health and disease DOI Creative Commons
Yvonne Nguyen,

Josephine Rudd Zhong Manis,

Nicole M. Ronczkowski

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 10, 2024

The intricate interplay between the gut microbiota and ocular health has surpassed conventional medical beliefs, fundamentally reshaping our understanding of organ interconnectivity. This review investigates into relationship microbiota-derived metabolites their consequential impact on disease pathogenesis. By examining role specific metabolites, such as short-chain fatty acids (SCFAs) like butyrate bile (BAs), herein we elucidate significant contributions to pathologies, thought-provoking traditional belief sterility, particularly in field ophthalmology. Highlighting dynamic nature its profound influence health, this underlines necessity comprehending complex workings gut-eye axis, an emerging science ready for further exploration scrutiny. While acknowledging therapeutic promise manipulating microbiome available literature advocates a targeted, precise approach. Instead broad interventions, it emphasizes potential exploiting microbiome-related focused strategy. targeted approach compared precision tool rather than broad-spectrum solution, aims explore applications context various retinal diseases. proposing nuanced strategy at microbial suggests that addressing deficiencies or imbalances through might yield expedited pronounced outcomes systemic extending eye. holds bypassing irregularity associated with microbes themselves, paving more efficient pathway toward desired optimizing implications

Language: Английский

Citations

6
Perspectives on the involvement of the gut microbiota in salt-sensitive hypertension DOI

Ya-Fan Mu,

Zhong‐Xiuzi Gao,

Zi‐Hui Mao

et al.

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(9), P. 2351 - 2362

Published: June 14, 2024

Language: Английский

Citations

6
Prebiotics Progress Shifts in the Intestinal Microbiome That Benefits Patients with Type 2 Diabetes Mellitus DOI Creative Commons
Luis Vitetta, Nick N. Gorgani,

Gemma Vitetta

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(9), P. 1307 - 1307

Published: Aug. 25, 2023

Hypoglycemic medications that could be co-administered with prebiotics and functional foods can potentially reduce the burden of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). The efficacy drugs metformin sulfonylureas enhanced by activity intestinal microbiome elaborated metabolites. Functional (e.g., oligofructose) dietary fibers treat a dysbiotic gut enhancing diversity microbial niches in gut. These beneficial shifts profiles include an increased abundance bacteria Faecalibacterium prauznitzii, Akkermancia muciniphila, Roseburia species, Bifidobacterium species. An important net effect is increase levels luminal SCFAs butyrate) provide energy carbon sources for cross-feeding activities, concomitant improvement dysbiosis attenuation inflammatory sequalae improved barrier integrity, which alleviates morbidity T2DM. Oligosaccharides administered adjunctively pharmacotherapy to ameliorate T2DM represent current plausible treatment modalities.

Language: Английский

Citations

15
Rhythmic Bacteria as Biomarkers for Circadian-Related Diseases DOI Creative Commons

Pamela Karina Ubilla,

Evandro Ferrada, Pablo A. Marquet

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Recent studies suggest that the human circadian clock influences periodic changes in composition of gut microbiota, which is essential for maintaining host health. This connection has led researchers to hypothesize disruption may impact health via microbiota. Here, we rhythmic bacteria—those whose abundance fluctuates a pattern—are key drivers differences microbiota between healthy individuals and those with circadian-related diseases. Even absence causal relation, identifying bacteria associated diseases can reveal disease biomarkers as well intervention strategies. To test this, first conducted systematic review identify reported literature. Then, mapped these onto reference dataset nearly 4,800 from previously curated metagenomic database. We use this data assess prevalence bacteria. examine significant samples diseases, including type 2 diabetes, hypertension, atherosclerotic cardiovascular disease, colorectal cancer, metabolic syndrome, inflammatory bowel compared datasets several previous their respective controls. Of eight identified studies, seven were among top 100 most prevalent abundant species gut. found bacterium Roseburia faecis be strongly exclusively suggesting its biomarker possibly coadjuvant treatment Clinical trial number: not applicable.

Language: Английский

Citations

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