Causes of digestive symptoms in patients with COVID-19 DOI Open Access
A. S. Nikitina, O. V. Zamahina

Scientific Bulletin of the Omsk State Medical University, Journal Year: 2023, Volume and Issue: 3(4), P. 14 - 25

Published: Dec. 15, 2023

This literature review discusses the problem of causes digestive symptoms in COVID-19 patients, examining papers which SARS-CoV-2 gastrointestinal infection was underlying cause and occurrence such associated with exacerbation pre-existing, including previously undiagnosed GI diseases. Objective: to identify most likely patients. Materials Methods. We searched 59 sources from eLibrary, PubMed, Scopus, Google scholar databases. All were published last 4 years. Results. The resulting coronavirus lesions are caused by direct disruption intestinal barrier; also, these may be a manifestation or debut chronic diseases on background COVID-19, exacerbate course infection; result therapy. A differential diagnosis inflammatory bowel diseases, liver acute biliary pancreatitis is required patients diarrhea, abdominal pain, elevated blood pancreatic enzymes. correlation gastroenterological lesion can established comparing clinical picture detection RNA virus stool, histologic specimens, but sometimes there no unambiguous answer. Specific changes computed tomography angiography cavity organs (peri-intestinal fatty tissue strands against wall thickening) described only initial stage at later stages nonspecific. Data endoscopic studies limited single cases case series describing nonspecific findings suggesting that directly damages mucosal surfaces. calls into question results have been conducted, retrospective did not evaluate baseline presence prior COVID-19. Due peculiarities interaction body cells diversity manifestations disease, combined approach necessary.

Language: Английский

Gut Microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients DOI Creative Commons
Paula Luciana Scalzo, Austin Marshall, Sirena Soriano

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 14, 2025

Abstract Background Infection with SARS-CoV-2, the virus responsible for COVID-19, can lead to a range of physical symptoms and mental health challenges, including stress, anxiety, depression. These effects are particularly pronounced in hospitalized patients, likely due virus’s direct indirect impact on nervous system. Gut dysbiosis, an imbalance gut microbiome, has been implicated immune dysfunction chronic inflammation COVID-19 patients. However, interactions between microbiome composition remain incompletely understood. Methods We investigated association symptoms, cytokine profiles, microbiota 124 collected data demographics, severity, indicators (stress, depression). profiling was performed using full-length 16 S rRNA gene sequencing evaluate microbial diversity composition. Results severity categorized as low (27.4%), moderate (29.8%), or critical (42.8%). Common included fever (66.1%) cough (55.6%), while somatic (27.3%), anxiety depressive (39%), stress (80.5%) were frequently self-reported. Elevated interleukin-6 levels severe cases highlighted systemic inflammation, reduced bacterial diversity, among women obese correlated higher disease severity. Notably, genus Mitsuokella associated increased distress, Granulicatella linked illness. Conclusions Our findings reveal significant associations status, dysbiosis results indicate potential microbiome-targeted therapies mitigate psychological complications improve recovery outcomes this population.

Language: Английский

Citations

1
Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon by Activating the BDNF-TrkB-PLC/IP3 Pathway to Reconstruct the Intestinal Nerve and Barrier DOI
Shengnan Zhu,

Qiangqing Yu,

Yifan Xue

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cathartic colon (CC) is a type of slow-transit constipation caused by patient's long-term use irritating laxatives. Probiotics play crucial role in managing constipation.

Language: Английский

Citations

0
Comparable gut mucosal breakdown and microbial translocation in severe COVID-19 with and without HIV infection DOI
Sabrina Marozin, Valeria Bono,

Martina Mazzoccoli

et al.

AIDS, Journal Year: 2025, Volume and Issue: 39(7), P. 921 - 923

Published: May 8, 2025

In this study, we explored the link between gut impairment and severe COVID-19 in people with HIV (PWH). We compared PWH to HIV-uninfected individuals hospitalized for same condition. Despite more clinical symptoms PWH, did not observe significant differences barrier dysfunction markers two groups. Our findings suggest a SARS-CoV-2 pneumonia damage, independent of status, warranting further investigation into its role severity.

Language: Английский

Citations

0
Gastrointestinal Barrier Disruption in Post‐COVID Syndrome Fatigue Patients DOI Creative Commons
Johanna Rohrhofer,

Viktoria Wolflehner,

Johannes Schweighardt

et al.

Allergy, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

ABSTRACT Background Post‐COVID Syndrome (PCS) is the term for a condition with persistent symptoms in proportion of COVID‐19 patients after asymptomatic, mild, or severe disease courses. Numbers vary, but current estimate that approximately 10% develop PCS. The aim our study was to evaluate impact SARS‐CoV‐2 infection on gastrointestinal (GI) tract and associations development PCS fatigue, post‐exertional malaise (PEM), orthostatic dysregulation, autonomous and/or neurocognitive dysregulation. Methods By combining medical record data from prospective observational symptom analysis before, during, infection, we aimed identify potential risk factors predictive markers Additionally, analyzed blood, saliva, stool samples this well‐characterized patient cohort biologically validate findings. Results We identified significant between pre‐existing GI complaints Fatigue. showed higher LBP/sCD14 ratios, lower IL‐33 levels, IL‐6 levels compared control groups. Our results highlight critical role post‐viral Conclusion propose viral disrupts pathways related innate immune response barrier function, evidenced by intestinal low‐grade inflammation leakage. Monitoring crucial identifying clinical phenotypes Understanding interaction infections, responses, gut integrity could lead more effective diagnostic treatment strategies, ultimately reducing burden patients.

Language: Английский

Citations

0
Repurposing TAK875 as a novel STAT3 inhibitor for treating inflammatory bowel disease DOI

Xinlian He,

Xupeng Gou,

Dongmei Fan

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 219, P. 115957 - 115957

Published: Dec. 2, 2023

Language: Английский

Citations

4
Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis DOI Creative Commons
Peng Ge, Yalan Luo, Jie Liu

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(12)

Published: Dec. 1, 2023

Abstract The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development pancreatitis is a subject ongoing debate within academic discourse. Establishing causal link between COVID‐19 and may not be fully supported by relying only retrospective studies or case reports. This study examined relationship phenotypes Mendelian randomization (MR) method. identification instrumental variables (single nucleotide polymorphisms) that exhibit robust association with was accomplished through meticulous process rigorous screening procedures. We included chronic (CP) as outcomes in MR analysis, even though no definitive exist CP. A direct genetically predicted risk cannot established. There an over designation cause pancreatitis.

Language: Английский

Citations

4
Editor-in-Chief articles of choice and comments at the year-end of 2023 DOI Creative Commons
Andrzej S. Tarnawski

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(1), P. 1 - 8

Published: Jan. 6, 2024

As the Editor-in-Chief of

Language: Английский

Citations

0
Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality—A systematic review and meta-analysis DOI Creative Commons
Kazuki Santa,

Raita Tamaki,

Kenji Watanabe

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 7, 2024

Background As the novel coronavirus disease 2019 (COVID-19) pandemic subsides, clinical sequelae are becoming more problematic. Interestingly, statistical data indicate that Africa has experienced lowest number of cases and deaths, with an unexpected phenomenon where deaths from COVID-19 not increased significantly. Several studies have investigated relationship between diet coronavirus. However, no systematic review/meta-analysis conclusively linked (phytochemicals vitamin D) gut microbiota in context COVID-19. Methods This study examined responses to Japan Africa, formulating following hypotheses: (1) a healthy is effective against COVID-19, (2) blood D levels associated mortality, (3) microbiota. To investigate these hypotheses, keyword search meta-analysis were conducted using PubMed, each hypothesis was tested. Results found diet, particularly rich phytochemicals such as polyphenols flavonoids, An association detected mortality. The its amelioration. These findings may significant implications for only understanding but also future prevention pneumonia.

Language: Английский

Citations

0
Gut microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients DOI Creative Commons
Paula Luciana Scalzo, Austin Marshall, Sirena Soriano

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

COVID-19 patients often exhibit altered immune responses and neuropsychiatric symptoms during hospitalization. However, the potential interactions with gut microbiome profiles have not been fully characterized. Here, disease severity was classified as low (27.4%), moderate (29.8%), critical (42.8%). Fever (66.1%) cough (55.6%) were common symptoms. Additionally, 27.3% reported somatic symptoms, experienced anxiety, 39% had depressive 80.5% stress. Gut profiling performed using full-length 16S rRNA gene sequencing. Elevated interleukin-6 levels observed in most severe cases, indicating systemic inflammation. Reduced bacterial diversity more pronounced women obese correlated higher severity. The presence of genus

Language: Английский

Citations

0
GASTROINTESTINAL SYMPTOMS ARE ASSOCIATED WITH SEVERITY OF CORONAVIRUS DISEASE 2019: A SYSTEMATIC REVIEW DOI Creative Commons

Lie Milka Ardena Lianto

Journal of Advance Research in Medical & Health Science (ISSN 2208-2425), Journal Year: 2023, Volume and Issue: 9(6), P. 49 - 53

Published: June 22, 2023

Background: Aim: This study aims to summarize and evaluate the association between GI symptoms in COVID-19 disease severity. Methods: A systematic search strategy was conducted across several electronic reference databases (PubMed, Cochrane Library, Google Scholar) included articles published 2019–2023. Duplicate publications, review articles, incomplete were excluded. Results: Database searches identified a total of 17632 articles. Of these, 100 passed screening process, resulting 15 for full-text assessment. Among them, 6 did not outcome interest. Hence, we found 9 appropriate studies included. Conclusion: Current findings are insufficient establish severity patients.

Language: Английский

Citations

0