MONITORING THE FOLLOW-UP OF AUTOIMMUNE CHRONIC ATROPHIC GASTRITIS USING PARIETAL CELL ANTIBODIES AND MARKERS OF GASTRIC FUNCTION

Journal of Translational Autoimmunity, Journal Year: 2025, Volume and Issue: 10, P. 100273 - 100273

Published: Jan. 22, 2025

Increased interest in the pathogenesis and evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to search for serological markers that can be used detect changes gastric mucosa at an early stage monitor course disease. Parietal cell autoantibodies have been proposed as suitable immunological damage, they detected serum when symptoms are not yet present. However, utility measuring only level parietal follow-up A-CAG does appear suffice. Recent evidence suggested that, monitoring A-CAG, antibodies should associated with evaluation function through biochemical hormonal tests, such pepsinogens gastrin 17. This integrated approach will allow more effective real-time state mucosa. As is a progressive disorder increased risk cancer neuroendocrine tumors, precise patients atrophy needs better defined. Further longitudinal studies large cohorts must performed long-term follow-up.

Language: Английский

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Prevalence and evolution of newly diagnosed autoimmune gastritis in a large Spanish retrospective cohort.

Revista Española de Enfermedades Digestivas, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

There is a growing interest in autoimmune gastritis (AIG), particularly regarding its prevalence and natural history. Retrospective observational study including all patients with positive parietal cell antibodies performance of gastroscopy between 2013 2023. The first subsequent was defined as follow-up endoscopy considered for histological comparison. Categorization stages made into stage 0 (potential), I (non-atrophic gastritis), II (atrophic gastritis) III (dysplasia, neuroendocrine tumor or adenocarcinoma). total 426 were included, 316 females median 54.4 years (IQR 45.3-63.2). During this period, 26798 underwent at least one upper endoscopy, so the AIG 1.6% (95% CI 1.4-1.7%). Histologically, 105 classified potential (24.7%), 99 (23,2%), 215 (50.5%) 7 (1.6%). 15364 presented follow endoscopy. A significant increase advanced observed (difference 18.72.1% 95% 7.61.4%-292.6%; p=0.0013) decrease GAI -20.214% 11.8-5.5% -28.722.5%; p<0.001). At baseline 39 exhibited hyperplastic polyps (9.2%), 8 fundic gland (1.9%), 3 adenomas low-grade dysplasia (0.7%) G1 tumours (0.7%). Only patient (0.2%) diagnosed signet-ring gastric carcinoma. low among undergoing gastroscopy. Biopsies revealed that around half population atrophy notable progressive disease.

Language: Английский

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Parietal Cell Antibody Levels Among Chronic Gastritis Patients in a Country With Low Helicobacter pylori Infection: Epidemiology, Histopathological Features, and H. pylori Infection

Helicobacter, Journal Year: 2025, Volume and Issue: 30(2)

Published: March 1, 2025

ABSTRACT Background Despite the low prevalence of Helicobacter pylori in Indonesia, high incidence gastritis, predominantly atrophic suggests that factors such as autoimmune gastritis (AIG) contribute to this unusual pattern. This study aims investigate epidemiology AIG, histopathology, and its association with H. status Indonesia. Methods A cross‐sectional was conducted various regions Indonesia between 2014 2017; 380 eligible sera gastric biopsies were available when conducted. As many 138 samples included based on initial examination by updated Sydney system. The diagnosis AIG confirmed serologic testing for parietal‐cell antibodies (PCA) detailed histopathological assessment sparing antrum features. Results Among study, 78.99% (109/138) PCA positive (≥ 10 RU/mL) 0.72% (1/138) considered be diagnosed (spared from features). majority cases (61/109; 55.96%) a significant correlation ( p < 0.05, R = 0.31). Additionally, found infection level features 0.05). Conclusion demonstrates without is not attributable only single AIG‐positive case found. These findings underscore important role pathogenic factor chronic highlight mechanisms triggering immune responses driving disease progression changes.

Language: Английский

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Current research status and hotspots of precancerous lesions of gastric cancer: a bibliometric analysis

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 29, 2025

Background Gastric cancer is the fifth most common worldwide, and its lack of specific symptoms presents a significant challenge for early diagnosis. Therefore, identification detection precancerous lesions gastric (PLGC) are essential prevention. We performed comprehensive bibliometric analysis to explore research trends emerging topics in this field, aiming deepen our understanding PLGC. Objective This study utilizes approach with network progress PLGC research. The findings aim provide foundation guidance further in-depth investigations into Methods used VOSviewer CiteSpace software collect relevant literature on from Web Science Core Collection, covering period 2005 2024. Data visualization was number publications, countries, institutions, journals, authors, keywords, citation counts these articles. Results A total 1,141 articles were included analysis. results showed year-on-year increase publications country, institution, author, journal highest publication output field China, Peking University, Wei-Cheng You, World Journal Gastroenterology , respectively. frequently occurring keywords “Helicobacter pylori,” “intestinal metaplasia,” “risk,” “infection,” “atrophic gastritis.” Additionally, “chronic atrophic gastritis” “inflammation” have emerged as hot future Conclusion highlights research, valuable studies. Our indicate that mechanistic studies clinical diagnosis will be key areas focus upcoming

Language: Английский

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Autoimmune gastritis studies and gastric cancer: True renaissance or bibliometric illusion

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(32), P. 3783 - 3790

Published: Aug. 26, 2024

A bibliometric analysis of studies dedicated to autoimmune gastritis (AIG) recently published demonstrated a noteworthy surge in publications over the last three years. This can be explained by numerous from different regions world reporting results several that stimulated reassessment our view AIG as precancerous condition. Follow-up and retrospective analyses showed risk gastric cancer (GC) patients is much lower than expected if ever being infected with

Language: Английский

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Improving the Diagnosis of Autoimmune Gastritis: From Parietal Cell Antibodies to H+/K+ ATPase Antibodies

Diagnostics, Journal Year: 2024, Volume and Issue: 14(16), P. 1721 - 1721

Published: Aug. 8, 2024

Parietal cell autoantibodies (PCAs), which recognize the enzyme H+/K+-ATPase as a target, are considered to be diagnostic marker of autoimmune gastritis and pernicious anemia; these conditions characterized by presence corpus atrophic gastritis. Circulating PCAs can detected using several analytical methods that commonly available in clinical laboratory. Traditionally, indirect immunofluorescence (IIF) on rodent or primate stomach tissue is used screening test for detection PCAs. However, IIF suffers from high inter-observer variability lacks standardization. In addition, like immunoblotting, results expressed only qualitative semi-quantitative manner. Based few studies reviewed herein, quantitative enzyme-linked immunosorbent assays (ELISAs) fluorescence immunoassays (FEIAs) purified perform better than PCAs, displaying higher sensitivity utility monitoring disease. light their accuracy, solid-phase should preferred The use detect antibodies versus specific subunit (α β) currently confined world research. Further investigation required define detection.

Language: Английский

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Mapping the evolution of liver aging research: A bibliometric analysis

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(41), P. 4461 - 4480

Published: Oct. 23, 2024

BACKGROUND With the increasing of global aging population, healthy and prevention age-related diseases have become increasingly important. The liver, a vital organ involved in metabolism, detoxification, digestion, immunity, holds pivotal role process organisms. Although extensive research on liver has been carried out, no bibliometric analysis conducted to evaluate scientific progress this area. AIM To analyze basic knowledge, development trends, current frontiers field via methods. METHODS We analyses range analytical tools including Python, bibliometrix package R, CiteSpace, VOSviewer. retrieved publication data from Web Science Core Collection Database. A knowledge map was constructed display contributions different authors, journals, countries, institutions, as well patterns co-occurrence keywords co-cited references. Additionally, gene regulation pathways associated with were analyzed STRING database. RESULTS identified 4288 articles aging, authored by 24034 contributors 4092 institutions across 85 countries. Notably, years 1991 2020 presented significant bursts output. United States led terms publications (n = 1008, 25.1%), citations 55205), international collaborations (multiple country 214). Keywords such “lipid metabolism”, “fatty disease”, “inflammation”, “liver fibrosis” “target” prominent, highlighting hotspots. top 64 genes, each which appeared at least 8 articles, essential for cell survival phosphatidylinositol 3-kinase/protein kinase B, Forkhead box O p53 signaling pathways. CONCLUSION This study highlights key areas offers comprehensive overview insights into potential value collaborative pursuits clinical implementations.

Language: Английский

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A bibliometric analysis of interstitial cells of Cajal research

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 20, 2024

The significance of interstitial cells Cajal (ICC) in the gastrointestinal tract has garnered increasing attention. In recent years, approximately 80 articles on ICC have been published annually various journals. However, no bibliometric study specifically focused literature related to ICC. Therefore, we conducted a comprehensive analysis reveal dynamic scientific developments, assisting researchers exploring hotspots and emerging trends while gaining global perspective. We search Web Science Core Collection (WoSCC) from January 1, 2013, December 31, 2023, identify relevant employed software, namely VOSviewer CiteSpace, analyze aspects including annual publication output, collaborations, research hotspots, current status, development this domain. A total 891 English papers were 359 journals by 928 institutions 57 countries/regions. According keyword literature, mainly "c-Kit," "expression," "smooth muscle," "nitric oxide" over past 11 years. with "SIP syncytium," "ANO1," "enteric neurons," "gastrointestinal stromal tumors (GIST)," "functional dyspepsia (FD)," there growing interest relationship between ANO1, SIP syncytium, ICC, as well role treatment GIST FD. Bibliometric revealed status research. association enteric neurons versus FD become focus further collaboration scale are still needed. Our is particularly valuable gastroenterology, oncology, cell biology, providing insights that can guide future directions.

Language: Английский

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Unveiling early stage autoimmune gastritis: novel endoscopic insights from two case reports

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 17, 2024

The predominant characteristic of autoimmune gastritis (AIG) is corpus-dominant advanced atrophy, which mostly observed in the middle to late stages. More reports are needed on endoscopic features early stage. In this report, we present two cases early-stage AIG examinations showed no atrophy gastric mucosa but displayed a transition collecting venules from regular an irregular arrangement. addition, yellowish-white cobblestone-like elevations were fundic gland region. Histologically, manifestations included pseudohypertrophy and protrusion parietal cells into lumen, possibly along with hyperplasia G cells, lymphocytic infiltration potentially pseudopyloric metaplasia. Serologically, anti-parietal cell antibody returned positive results, whereas anti-intrinsic factor yielded negative results. study, summarized some patients, aiming provide clues for endoscopists detect AIG.

Language: Английский

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Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Guillain-Barré syndrome (GBS) and autoimmune gastritis (AIG) are both diseases (ADs) that have a low prevalence in China. Both conditions involve the immune system mistakenly attacking body's own tissues. GBS primarily affects peripheral nervous system, leading to muscle weakness paralysis, while AIG targets stomach lining, causing inflammation reduced absorption of vital nutrients. Subacute combined degeneration (SCD) spinal cord is most common neurological manifestation vitamin B12 deficiency. As yet, there been no reported cases patients with complications including SCD. We report case 54-year-old male patient who had experiencing progressive numbness his extremities, burning tingling sensations, cotton-stepping sensation, difficulty walking for three weeks. He was admitted hospital underwent an extensive medical workup. Magnetic resonance imaging (MRI) cervical spine showed abnormal signal intensity consistent typical manifestations Gastric endoscopy revealed local atrophy gastric corpus, tissue biopsy indicated atrophic intestinal metaplasia, diagnosis AIG. Lumbar puncture cerebrospinal fluid (CSF) results albumincytological dissociation, further confirming GBS. treated intravenous immunoglobulin methylcobalamin therapy these significant clinical improvement upon discharge.

Language: Английский

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