The Journal of Immunology,
Journal Year:
2021,
Volume and Issue:
207(7), P. 1725 - 1733
Published: Sept. 20, 2021
Abstract
The
trillions
of
bacteria
that
constitutively
colonize
the
human
gut
collectively
generate
thousands
unique
small
molecules.
These
microbial
metabolites
can
accumulate
both
locally
and
systemically
potentially
influence
nearly
all
aspects
mammalian
biology,
including
immunity,
metabolism,
even
mood
behavior.
In
this
review,
we
briefly
summarize
recent
work
identifying
bioactive
microbiota
metabolites,
means
through
which
they
are
synthesized,
their
effects
on
host
physiology.
Rather
than
offering
an
exhaustive
list
known
molecules,
select
a
few
examples
from
each
key
class
to
illustrate
diverse
impacts
microbiota-derived
compounds
host.
addition,
attempt
address
logic
behind
specific
biotransformations.
Finally,
outline
current
emerging
strategies
for
previously
undiscovered
may
shape
health
disease.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 8003 - 8049
Published: Jan. 1, 2021
Technological
developments
enable
the
discovery
of
novel
enzymes,
advancement
enzyme
cascade
designs
and
pathway
engineering,
moving
biocatalysis
into
an
era
technology
integration,
intelligent
manufacturing
enzymatic
total
synthesis.
Natural Product Reports,
Journal Year:
2020,
Volume and Issue:
38(5), P. 905 - 980
Published: Nov. 10, 2020
We
highlight
the
current
state
of
bacterial
terpenome,
emphasizing
discoveries,
structures,
biosynthetic
pathways,
and
biological
activities
these
terpenoid
natural
products.
Natural Product Reports,
Journal Year:
2021,
Volume and Issue:
39(2), P. 249 - 272
Published: Oct. 9, 2021
Terpenoids
have
diverse
bioecological
roles
in
all
kingdoms
of
life.
Here
we
discuss
the
evolution
and
ecological
functions
microbial
terpenoids
their
possible
applications.
Fungal
pathogens,
among
other
stressors,
negatively
impact
the
productivity
and
population
size
of
honey
bees,
one
our
most
important
pollinators
(1,
2),
in
particular
their
brood
(larvae
pupae)
(3,
4).
Understanding
factors
that
influence
disease
incidence
prevalence
may
help
us
improve
colony
health
productivity.
Here,
we
examined
capacity
a
bee-associated
bacterium,
Bombella
apis,
to
suppress
growth
fungal
pathogens
ultimately
protect
bee
from
infection.
Our
results
showed
strains
B.
apis
inhibit
two
insect
Beauveria
bassiana
Aspergillus
flavus,
vitro.
This
phenotype
was
recapitulated
vivo;
broods
supplemented
with
were
significantly
less
likely
be
infected
by
A.
flavus.
Additionally,
presence
reduced
sporulation
flavus
few
bees
infected.
Analyses
biosynthetic
gene
clusters
across
suggest
antifungal
candidates,
including
type
1
polyketide,
terpene,
aryl
polyene.
Secreted
metabolites
alone
sufficient
growth,
supporting
hypothesis
inhibition
is
mediated
an
metabolite.
Together,
these
data
can
infections
via
secretion
IMPORTANCE
Fungi
play
critical
roles
host
microbiomes
(5-7),
yet
bacterial-fungal
interactions
are
understudied.
For
insects,
fungi
leading
cause
(5,
8).
In
particular,
populations
European
(Apis
mellifera),
agriculturally
economically
species,
have
declined
part
due
pathogens.
The
far-reaching
consequences,
endangering
species
threatening
food
security
2,
9).
research
highlights
how
bacterial
symbiont
protects
Further
mechanistic
work
could
lead
development
new
treatments.
Natural Product Reports,
Journal Year:
2021,
Volume and Issue:
39(1), P. 90 - 118
Published: July 7, 2021
Covering:
up
to
2021Terpenoids
are
a
diverse
group
of
chemicals
used
in
wide
range
industries.
Microbial
terpenoid
production
has
the
potential
displace
traditional
manufacturing
these
compounds
with
renewable
processes,
but
further
titre
improvements
needed
reach
cost
competitiveness.
This
review
discusses
strategies
increase
titres
Environmental Microbiome,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Aug. 3, 2023
Plants
rely
on
their
root
microbiome
as
the
first
line
of
defense
against
soil-borne
fungal
pathogens.
The
abundance
and
activities
beneficial
microbial
taxa
at
time
prior
to
during
infection
are
key
protective
success.
If
how
invading
pathogens
can
disrupt
assembly
gene
expression
is
still
largely
unknown.
Here,
we
investigated
impact
pathogen
Fusarium
oxysporum
(fox)
rhizosphere
endosphere
microbiomes
a
fox-susceptible
fox-resistant
common
bean
cultivar.Integration
16S-amplicon,
shotgun
metagenome
well
metatranscriptome
sequencing
with
community
ecology
analysis
showed
that
fox
infections
significantly
changed
composition
in
cultivar-dependent
manner.
More
specifically,
led
increased
diversity,
network
complexity,
higher
proportion
genera
Flavobacterium,
Bacillus,
Dyadobacter
cultivar
compared
cultivar.
In
endosphere,
also
changes
assembly,
Sinorhizobium
Ensifer
Metagenome
analyses
further
revealed
enrichment
terpene
biosynthesis
genes
potential
role
suppression
upon
invasion.Collectively,
these
results
specific
bacterial
activation
putative
disease-suppressive
functions
under
siege.
Chemical Papers,
Journal Year:
2024,
Volume and Issue:
78(5), P. 2783 - 2810
Published: Feb. 19, 2024
Abstract
Due
to
their
various
applications,
terpenes
and
terpenoids
are
secondary
metabolites
of
industrial
interest.
These
compounds
can
be
found
in
a
wide
variety
organisms
from
virtually
all
biological
kingdoms.
However,
it
has
been
identified
that
factors
the
production
process,
such
as
place
time
harvest,
pretreatments,
extraction,
purification,
generate
differences
profile
obtained
organisms.
The
first
factor
influences
extraction
is
drying
since
an
inappropriate
choice
method
lead
loss
interest
or
appearance
others
arise
due
decomposition
original
molecules.
Similarly,
Soxhlet
most
used
recovery
its
high
efficiency.
unconventional
methods
have
proven
effective
alternatives
for
terpenoid
recovery,
particularly
use
microwave
high-pressure
well
solvents,
achieving
efficiencies
equal
greater
than
shorter
times.
This
review
will
address
observed
main
cause
them,
comparison
advantages
disadvantages
methodologies
drying,
separation
these
compounds.
