Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Aug. 2, 2024
Alzheimer's disease (AD) is a common neurodegenerative disease, which can lead to cognitive impairment and dementia. Since AD tightly associated with aging cellular senescence, objective of this study was investigate the association between senescence-related genes proteins (SRGs SRPs) development AD.
Language: Английский
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: Jan. 8, 2024
Purpose To investigate the role of senescence-related cytokines (SRCs) in pathophysiology age-related macular degeneration (AMD). Design The whole study is based on single-cell and bulk tissue transcriptomic analysis human neuroretinas with or without AMD. data was obtained from Gene-Expression Omnibus (GEO) database. Methods For analysis, gene expression matrix goes through quality control (QC) filtering, being normalized, scaled integrated for downstream analysis. further analyses were performed using Seurat R package CellChat package. After cell type annotation, phenotype functional markers microglia investigated cell-cell communication performed. GSE29801 dataset contains neuroretina ( n = 118) group AMD patients. SPP1 subtypes compared by Student’s t -test. In addition, classified into SPP1-low SPP1-high groups according to level SPP1. differentially expressed genes between these two subsequently identified pathway enrichment conducted. Results Secreted phosphoprotein 1, as an SRC, revealed be highly SPP1-receptor signaling activated neuroretina. associated pro-inflammatory phagocytic state microglia. elevated late dry wet inflammatory pathways found Conclusion Our findings indicated that microglial activation might play important Therefore, serve a potential therapeutic target More vitro vivo studies are required confirm results effect SPP1-targeting strategy.
Language: Английский
Citations
6
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Feb. 1, 2024
Since age-related macular degeneration (AMD) is tightly associated with aging and cellular senescence, objective of this study was to investigate the association between plasma levels senescence-related proteins (SRPs) risk AMD.
Language: Английский
Citations
5
Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Purpose of review As the prevalence diabetes mellitus (DM) increases due to urbanization, aging populations, and lifestyle changes, it is crucial understand mechanisms, diagnosis, treatment diabetes-related bone disorders. This highlights recent advancements in field explores their implications for clinical practice research. Recent findings studies have elucidated complex interplay between health, emphasizing roles advanced glycation end-products (AGEs), inflammation, oxidative stress, senescence, molecular signaling pathways such as Wnt, mammalian target rapamycin (mTOR), exosome-mediated mechanisms. Key highlight significance marrow adipose tissue (BMAT) metabolism impact sarcopenia on fracture risk. Novel diagnostic tools, including miRNA biomarkers emerging therapeutic strategies like exosome-based therapies glycogen synthase kinase 3 beta (GSK3β) inhibitors, offer promising opportunities improving health diabetic patients. Summary The underscore need integrated managing complications. Clinicians should prioritize early screening, interventions, personalized pharmacological treatments mitigate risk improve Future research focus optimizing tools developing targeted address unique challenges disorders related diabetes.
Language: Английский
Citations
0
Bone, Journal Year: 2024, Volume and Issue: unknown, P. 117301 - 117301
Published: Oct. 1, 2024
Language: Английский
Citations
3
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 24, 2024
Background The increasing incidence of diabetes mellitus (DM) and osteoporosis have different effects on prognosis. two often co-occur, so we aimed to investigate whether DM an effect all-cause death a synergistic effect. Methods This study analyzed 18,658 subjects from five cycles the National Health Nutrition Examination Survey (NHANES). primary endpoint was death. were divided into four groups based presence or absence osteoporosis. Survival curves Cox regression analysis NHANES recommended weights used assess risk between diseased non-diseased calculate additive interactions there Results group with had lowest survival rate. After full adjustment for confounders, patients alone 30% higher compared those without (HR: 1.30, 95%CI: 1.09-1.55). Patients 67% 1.67, 95%CI:1.16-2.43) combined 127% (HR:2.27, 1.57-3.27). There interaction [RERI (95%CI): 1.03(0.55-1.50)] excess mortality 38% [AP (95% CI) 0.38(0.30-0.46)]. Conclusions might be mortality, both conditions
Language: Английский
Citations
2
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Aug. 2, 2024
Alzheimer's disease (AD) is a common neurodegenerative disease, which can lead to cognitive impairment and dementia. Since AD tightly associated with aging cellular senescence, objective of this study was investigate the association between senescence-related genes proteins (SRGs SRPs) development AD.
Language: Английский
Citations
0