Faculty Reviews,
Journal Year:
2021,
Volume and Issue:
10
Published: Nov. 10, 2021
Osteoarthritis
(OA)
is
a
chronic
musculoskeletal
disease
with
polygenic
and
heterogeneous
nature.
In
addition,
when
clinical
manifestations
appear,
the
evolution
of
usually
already
irreversible.
Therefore,
efforts
on
OA
research
are
focused
mainly
discovery
therapeutic
targets
reliable
biomarkers
that
permit
early
identification
different
OA-related
parameters
such
as
diagnosis,
prognosis,
or
phenotype
identification.
To
date,
potential
candidate
protein
have
been
associated
aspects
disease;
however,
there
currently
no
gold
standard.
this
sense,
genomic
data
could
act
complementary
diagnosis
prognosis
even
help
to
identify
disease.
review,
we
will
describe
most
recent
advances
in
genetic
over
past
three
years.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(14), P. 4886 - 4886
Published: July 10, 2020
Osteoporosis
is
a
major
concern
worldwide
and
can
be
attributed
to
an
imbalance
between
osteoblastic
bone
formation
osteoclastic
resorption
due
the
natural
aging
process.
Heritable
factors
account
for
60-80%
of
optimal
mineralization;
however,
finer
details
pathogenesis
remain
elucidated.
Micro
RNA
(miRNA)
long-non-coding
(lncRNA)
are
two
targets
that
have
recently
come
into
spotlight
their
ability
control
gene
expression
at
post-transcriptional
level
provide
epigenetic
modification.
miRNAs
class
non-coding
RNAs
approximately
18-25
nucleotides
long.
It
thought
up
60%
human
protein-coding
genes
may
regulated
by
miRNAs.
They
been
found
regulate
controls
osteoblast-dependent
osteoclast-related
remodeling.
lncRNAs
highly
structured
transcripts
longer
than
200
do
not
translate
proteins.
very
complex
secondary
tertiary
structures
same
degradation
processes
as
messenger
RNAs.
The
fact
they
rapid
turnover
sponge
function
in
binding
lead
lncRNA
itself.
act
signaling,
decoy,
framework
molecules,
or
primers.
Current
evidence
suggests
chromatin
transcriptional
well
regulators.
With
regards
osteoporosis,
involved
proliferation,
apoptosis,
inflammatory
response
bone.
This
review,
which
based
on
systematic
appraisal
current
literature,
provides
molecular
genetic
opinions
roles
osteoporosis.
Further
research
modification
regulatory
these
molecules
will
bring
us
closer
potential
disease-modifying
treatment
However,
more
issues
regarding
detailed
actions
osteoporosis
unknown
controversial
warrant
future
investigation.
Stem Cell Research & Therapy,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Jan. 21, 2021
Abstract
Osteogenic
differentiation
and
bone
regeneration
are
complex
processes
involving
multiple
genes
steps.
In
this
review,
we
summarize
the
effects
of
long
noncoding
RNA
(lncRNA)
H19
on
osteogenic
differentiation.
includes
matrix
secretion
calcium
mineralization
as
hallmarks
osteoblast
absorption
phosphorus
osteoclast
Mesenchymal
stem
cells
(MSCs)
form
osteoprogenitor
cells,
pre-osteoblasts,
mature
osteoblasts,
osteocytes
through
induction
lncRNAs
regulate
expression
coding
play
essential
roles
in
regeneration.
The
lncRNA
is
known
to
have
vital
induction.
This
review
highlights
role
a
novel
target
for
promotion
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: March 12, 2021
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
of
unknown
etiology,
mainly
manifested
by
persistent
abnormal
proliferation
fibroblast-like
synoviocytes
(FLSs),
inflammation,
synovial
hyperplasia
and
cartilage
erosion,
accompanied
joint
swelling
destruction.
Abnormal
expression
or
function
long
noncoding
RNAs
(lncRNAs)
are
closely
related
to
human
diseases,
including
cancers,
mental
diseases
others.
The
sequence
spatial
structure
lncRNAs,
the
disorder
interaction
with
binding
protein
will
lead
change
gene
in
way
epigenetic
modification.
Increasing
evidence
demonstrated
that
lncRNAs
were
involved
activation
FLSs,
which
played
key
role
pathogenesis
RA.
In
this
review,
research
progress
RA
was
systematically
summarized,
diagnosis
RA,
regulatory
mechanism
intervention
treatment
Furthermore,
activated
signal
pathways,
DNA
methylation
other
have
also
been
overview
review.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 6, 2025
Injuries
associated
with
contemporary
life,
such
as
automobile
crashes
and
sports
injuries,
can
lead
to
large
numbers
of
traumatic
neuromuscular
injuries
that
are
intimately
bone
fractures.
Regulatory
non-coding
RNAs
play
essential
roles
in
multiple
cellular
processes,
including
osteogenic
differentiation
healing.
In
this
review,
we
discuss
the
most
recent
advances
our
understanding
regulatory
RNA
biology
stem,
stromal
progenitor
cells.
We
focused
on
circular
RNAs,
small
nucleolar
PIWI-interacting
comprehensively
summarized
their
biological
functions
well
discussed
significance
for
healing
tissue
regeneration.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 2, 2025
Maternally
expressed
gene
3
(MEG3),
a
long
non-coding
RNA,
plays
pivotal
role
in
various
biological
processes,
including
tumorigenesis.
Aberrant
expression
of
MEG3
has
been
implicated
several
cancers,
genitourinary
malignancies.
This
comprehensive
review
explores
the
multifaceted
functions
context
cancers
through
unravelling
molecular
mechanisms
underlying
influence
on
cellular
proliferation,
apoptosis,
invasion,
and
metastasis.
Additionally,
we
discuss
potential
clinical
implications
as
biomarker
therapeutic
target
cancers.
By
unraveling
intricate
these
this
aims
to
contribute
development
novel
strategies
for
diagnosis
treatment
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: May 16, 2022
The
circadian
clock
refers
to
the
intrinsic
biological
rhythms
of
physiological
functions
and
behaviours.
It
synergises
with
solar
cycle
has
profound
effects
on
normal
metabolism
organismal
fitness.
Recent
studies
have
suggested
that
exerts
great
influence
differentiation
stem
cells.
Here,
we
focus
close
relationship
between
mesenchymal
cell
fate
decisions
in
skeletal
system.
underlying
mechanisms
include
hormone
signals
activation
repression
different
transcription
factors
under
regulation.
Additionally,
interacts
epigenetic
modifiers
non-coding
RNAs
is
even
involved
chromatin
remodelling.
Although
specificity
safety
therapy
need
be
further
studied,
regulation
cells
can
regarded
as
a
promising
candidate
for
health
improvement
disease
prevention.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(23), P. 6102 - 6102
Published: Dec. 3, 2021
Recent
advances
in
molecular
biology
have
discovered
the
mysterious
role
of
long
non-coding
RNAs
(lncRNAs)
as
potential
biomarkers
for
cancer
diagnosis
and
targets
advanced
therapy.
Studies
shown
that
lncRNAs
take
part
incidence
development
cancers
humans.
However,
previously
they
were
considered
mere
RNA
noise
or
transcription
byproducts
lacking
any
biological
function.
In
this
article,
we
present
a
summary
progress
on
ascertaining
functions
five
(HOTAIR,
NEAT1,
H19,
MALAT1,
MEG3)
female-oriented
cancers,
including
breast
gynecological
with
perspective
carcinogenesis,
proliferation,
metastasis.
We
provide
current
state
knowledge
from
past
years
literature
to
discuss
clinical
importance
such
therapeutic
early
diagnostic
biomarkers.
reviewed
consequences,
either
oncogenic
tumor-suppressing
features,
their
aberrant
expression
cancers.
tried
explain
established
mechanism
by
which
regulate
proliferation
metastasis
competing
miRNAs
other
mechanisms
involved
via
regulating
genes
signaling
pathways.
addition,
revealed
association
between
stated
chemo-resistance
radio-resistance
applications
future
perspectives.
