Neuroimmunological Effect of Vitamin D on Neuropsychiatric Long COVID Syndrome: A Review DOI Open Access
Ting‐Bin Chen, Ching‐Mao Chang, Cheng‐Chia Yang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3802 - 3802

Published: Aug. 30, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of disease 2019 (COVID-19). COVID-19 now recognized as a multiorgan with broad spectrum manifestations. A substantial proportion individuals who have recovered from are experiencing persistent, prolonged, and often incapacitating sequelae, collectively referred to long COVID. To date, definitive diagnostic criteria for COVID diagnosis remain elusive. An emerging public health threat neuropsychiatric COVID, encompassing range manifestations, such sleep disturbance, anxiety, depression, brain fog, fatigue. Although precise mechanisms underlying complications presently not fully elucidated, neural cytolytic effects, neuroinflammation, cerebral microvascular compromise, breakdown blood–brain barrier (BBB), thrombosis, hypoxia, neurotransmitter dysregulation, provoked neurodegeneration pathophysiologically linked long-term consequences, in addition systemic hyperinflammation maladaptation renin–angiotensin–aldosterone system. Vitamin D, fat-soluble secosteroid, potent immunomodulatory hormone potential beneficial effects on anti-inflammatory responses, neuroprotection, monoamine neurotransmission, BBB integrity, vasculometabolic functions, gut microbiota, telomere stability different phases SARS-CoV-2 infection, acting through both genomic nongenomic pathways. Here, we provide an up-to-date review pathophysiology plausible neurological contributions vitamin D mitigating

Language: Английский

Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination DOI Open Access
Alaa Elmazny, Rehab Magdy, Mona Hussein

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 273(6), P. 1349 - 1358

Published: Jan. 27, 2023

Language: Английский

Citations

15
A mid‑pandemic night's dream: Melatonin, from harbinger of anti‑inflammation to mitochondrial savior in acute and long COVID‑19 (Review) DOI Creative Commons
Ioannis Lempesis, Vasiliki Georgakopoulou, Russel J. Reıter

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(3)

Published: Jan. 26, 2024

Coronavirus disease 2019 (COVID‑19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS‑CoV‑2), has triggered worldwide pandemic with symptoms ranging from asymptomatic to chronic, affecting practically every organ. Melatonin, an ancient antioxidant found in all living organisms, been suggested as safe and effective therapeutic option for the treatment of SARS‑CoV‑2 infection due its good safety characteristics broad‑spectrum antiviral medication properties. Melatonin is essential various metabolic pathways governs physiological processes, such sleep‑wake cycle circadian rhythms. It exhibits oncostatic, anti‑inflammatory, anti‑aging properties, exhibiting promise use numerous disorders, including COVID‑19. The preventive effects melatonin have widely explored number conditions well‑established experimental ischemia/reperfusion investigations, particularly coronary heart stroke. Clinical research evaluating COVID‑19 shown improved outcomes, reduced hospitalization durations; however, trials are small. can alleviate mitochondrial dysfunction COVID‑19, improve immune cell function provide However, potential remains underexplored funding limitations thus further investigations required.

Language: Английский

Citations

5
Neurological Complications of COVID-19: A Review of the Literature DOI Open Access

Lucy Dale

Cureus, Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 3, 2022

Coronavirus disease 2019 (COVID-19) has caused the most unprecedented health crisis since 1918 H1N1 pandemic. Whilst COVID-19 is traditionally considered to be a respiratory disease, it important understand that this virus potential disseminate throughout body causing multi-organ failure. Both peripheral and central neurological systems have been shown greatly affected. This review aims look at available literature published on summarize main complications seen so far.

Language: Английский

Citations

20
Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19 DOI Open Access
Marina Khodanovich, Daria Kamaeva, Anna Naumova

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11291 - 11291

Published: Sept. 25, 2022

Long-term neurological and mental complications of COVID-19, the so-called post-COVID syndrome or long COVID, affect quality life. The most persistent manifestations COVID include fatigue, anosmia/hyposmia, insomnia, depression/anxiety, memory/attention deficits. physiological basis psychiatric disorders is still poorly understood. This review summarizes current knowledge sequelae in patients discusses brain demyelination as a possible mechanism these with focus on neuroimaging findings. Numerous reviews, experimental theoretical studies consider one mechanisms central neural system impairment. Several factors might cause demyelination, such inflammation, direct effect virus oligodendrocytes, cerebrovascular disorders, inducing myelin damage. There contradiction between solid fundamental underlying injuries relatively little published clinical evidence related to COVID-19 patients. reason for this probably lies fact that used conventional MRI techniques, which can detect only large, clearly visible demyelinating lesions. A very limited number use specific methods quantification detected changes white matter tracts 3 10 months after acute phase COVID-19. Future research applying quantitative assessment combination psychological will help understanding associated demyelination.

Language: Английский

Citations

20
Inflammatory and mental health sequelae of COVID-19 DOI Creative Commons
Jennifer M. Loftis, Evan J. Firsick, Kate Shirley

et al.

Comprehensive Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 15, P. 100186 - 100186

Published: May 18, 2023

The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment ("brain fog"), depression, anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]. present study sought examine the role predictors symptom severity in context COVID-19. Adults (n = 52) who tested or positive for were asked complete self-report questionnaires provide blood samples multiplex immunoassays. Participants assessed at baseline a follow-up visit (∼4 weeks later). Individuals without reported significantly lower PHQ-4 scores visit, compared (p 0.03; 95% CI-1.67 −0.084). experienced neuro-PASC had moderate range. majority people experiencing brain fog (70% vs. 30%). Those more severe higher scores, those mild disease 0.008; CI 1.32 7.97). Changes accompanied by alterations immune factors, particularly monokine induced gamma interferon (IFN-γ) (MIG, a. k.a. CXCL9). These findings add growing evidence supporting usefulness circulating MIG levels biomarker reflecting IFN-γ production, which is important because individuals have elevated responses internal proteins.

Language: Английский

Citations

12
The determinants of COVID-induced brain dysfunctions after SARS-CoV-2 infection in hospitalized patients DOI Creative Commons

Shahwar Yasir,

Yu Jin, Fuleah A. Razzaq

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 8, 2024

The severity of the pandemic and its consequences on health social care systems were quite diverse devastating. COVID-19 was associated with an increased risk neurological neuropsychiatric disorders after SARS-CoV-2 infection. We did a cross-sectional study 3 months post-COVID 178 Cuban subjects. Our has unique CUBAN cohort hospitalized patients healthy constructed latent variable for pre-health conditions (PHC) through Item Response Theory (IRT) symptoms (Post-COVID-NPS) Factor Analysis (FA). There seems to be potential causal relationship between determinants CIBD post-COVID-NPS in patients. relationships accessed by Structural Equation Modeling (SEM) revealed that PHC (

Language: Английский

Citations

4
Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models DOI Open Access

Hong‐Yi Zheng,

Tian‐Zhang Song,

Yong‐Tang Zheng

et al.

动物学研究, Journal Year: 2024, Volume and Issue: 45(4), P. 747 - 766

Published: Jan. 1, 2024

The distribution of the immune system throughout body complicates

Language: Английский

Citations

4
Prevalence and Factors Associated with Common Mental Disorders and Posttraumatic Stress Disorder Among Healthcare Workers in a Reference Center for Infectious Diseases During the COVID-19 Pandemic: A Survey-Based Cross-Sectional Study DOI Open Access
Patrícia Guimarães, Raquel de Vasconcellos Carvalhães de Oliveira,

Rocicley Amud

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(2), P. 271 - 271

Published: Feb. 13, 2025

A cross-sectional survey conducted between July and September 2020 August 2021 estimated the prevalence predictors of common mental disorders (CMDs) post-traumatic stress disorder (PTSD) among healthcare workers (HCWs) at an infectious disease referral center during COVID-19 pandemic. CMDs were assessed using General Health Questionnaire (GHQ-12), PTSD Impact Event Scale-Revised (IES-R). Multivariate logistic regressions identified CMD PTSD. The study included 371 HCWs in 167 2021. was 34.3% (95% confidence interval (CI): 29.5-39.4) 30.5% CI: 23.7-38.1) 25.4% 21.0-30.2) 32.7% 25.6-40.5) Factors increasing odds lower education (adjusted ratio (AOR) = 3.71, 95% 1.60-8.61), lack physical activity (AOR 2.23, 1.33-3.73), experiencing symptoms 1.64, 1.02-2.64) 2020; chronic diseases 3.14, 1.34-7.35) SARS-CoV-2 testing 3.39, 1.13-10.17) raised Frontline had 0.60, 0.36-1.00) 0.33, 0.14-0.75). associated with having 2.06, 1.23-3.45), living high-risk individuals 1.75, 1.03-2.95), losing loved ones 1.86, 1.09-3.17) 2020. Chronic increased 2.20, 1.25-3.86) 2.30, 1.03-5.13), while age decreased them 0.95, 0.93-0.98) 0.91-0.99). Younger conditions particularly affected. These findings highlight urgent need for targeted emotional support management programs HCWs.

Language: Английский

Citations

0
Does Having COVID-19 Infection History Lead to a Different Clinical Presentation and Treatment Response in Patients with Major Depression? DOI
Zeynel Kılıç, Mustafa Uğurlu, Esra Kabadayı Şahin

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 224 - 231

Published: March 4, 2025

Language: Английский

Citations

0
The Neurobiology of Comorbidities DOI
Mojtaba Oraki Kohshour,

Alba Navarro-Flores,

Monika Budde

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0