Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis DOI Creative Commons
Marco Serafin,

Martina Vaninetti,

Ismahan Mohamed

et al.

Sleep And Breathing, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 9, 2024

The aim of the present systematic review was to corroborate existing evidence on how serum25(OH)D levels affect obstructive sleep apnea syndrome (OSAS) severity in absence comorbidities. From inception May 2024, PubMed, Scopus, and Embase electronic databases were systematically screened identify randomized controlled trials (RCTs), quasi-RCTs, prospective, retrospective studies. A strict search protocol applied following application PROSPERO, under registration number CRD42023468744. formulated question based PICO process was: "how do OSAS or result enhanced function?". Collected results finally reviewed for meta-analysis quality assessment according ROBINS-I tool. Data from 24 studies pooled divided into 15 case-control 9 cross-sectional All involved a total 2640 subjects 933 healthy subjects. underwent qualitative analysis whereas only 20 collected meta-analysis. Mild showed 25(OH)D non-statistically significant (P = 0.12) than patients moderate 0.004) severe < 0.001) differed significantly control groups. Meta-regression suggested that correlated inversely deficiency serum levels. Qualitative Egger's test revealed an elevated risk bias but low presence publication bias, respectively. Serum observed be proportional without coexisting morbidities. mild not different non-OSAS patients, suggesting vitamin supplementation improve potential disorders.

Language: Английский

Zinc, Magnesium and Vitamin K Supplementation in Vitamin D Deficiency: Pathophysiological Background and Implications for Clinical Practice DOI Open Access
Andrius Bleizgys

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 834 - 834

Published: March 14, 2024

Zinc, magnesium, and vitamin K are important nutrients for humans. There various factors that contribute to the development of their deficiency, which might result in or exacerbate diseases. These can also interact with D metabolism activity. This review discusses main aspects zinc, magnesium action body, clinical significance, “crosstalk” D, as well providing general suggestions practice when supplementation these be useful, addition supplementation.

Language: Английский

Citations

8
Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies DOI Open Access
Marius Emil Rusu, Galya Bigman, Alice S. Ryan

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2356 - 2356

Published: July 20, 2024

Aging is a complex process and significant risk factor for chronic diseases. Menopause, component of aging in women, associated with several important cardiometabolic conditions including metabolic syndrome, osteoporosis, cardiovascular Menopausal women could benefit from preventative strategies that may decrease morbidity mortality improve their quality life. Vitamins D K are essential nutrients required bone health, immune function, reducing risks, yet synergistic effect less understood women. This the first comprehensive review to summarize evidence found randomized clinical trials beneficial effects vitamin co-treatment postmenopausal In our literature search across key electronic databases such as Cochrane, PubMed, Ovid, we identified 31 pertinent studies. Overall, findings indicate combined intake vitamins positively affect health emphasizing importance maintaining healthy diet rich vegetables fermented dairy products. Given challenges obtaining all necessary solely through diet, supplements recommended promote well-being.

Language: Английский

Citations

5
Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review DOI Creative Commons
Natália M. de Oliveira, Jorge Machado,

Maria Helena Chéu

et al.

Applied Biosciences, Journal Year: 2024, Volume and Issue: 3(3), P. 392 - 425

Published: Sept. 22, 2024

The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate highly favorable to the synthesis of phenolic compounds, stored leaves; their consumption has been linked a lower cancer and cardiovascular disorders for which research interest upon this feature increased last decade. This study aimed (i) review evidence about importance leaf extract (OLE) on human health physiological effect its major compounds; (ii) update state art studies conducted technological usage extract; (iii) report potential uses OLE pharmaceuticals, food production, cosmetics; (iv) prospect future clinical applications from diverse cultivars, especially metabolic inflammatory conditions such as polycystic ovary syndrome (PCOS). Overall, cultivars richer TPC, including TFC, αT, omega-3 omega-9, present main target supplementation alone or conjunction vitaminic due nutraceutical value disorders, chronic diseases, anti-aging treatments, whereas less water content might be useful substrates preservation. With regard prospects, it would great clarify specific mechanisms underlying beneficial effects neuro-immune design safer healthier nature-based medicine wide array costly prevalent metabolic-related syndromes, namely, PCOS.

Language: Английский

Citations

5
The potential link between the development of Alzheimer’s disease and osteoporosis DOI Creative Commons

Fariha Nasme,

Jyotirmaya Behera,

Prisha Tyagi

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Vitamin D Receptor and CYP450 Enzyme Dysregulation May Mediate Oral Cancer Responsiveness DOI Open Access

Dustin Hunsaker,

Jason H. Moore, Katherine M. Howard

et al.

Targets, Journal Year: 2025, Volume and Issue: 3(1), P. 6 - 6

Published: Feb. 8, 2025

Many health benefits are associated with Vitamin D (VitD), although deficiency is poor outcomes and the increased risk of cancer development. For example, many tissue-specific enzymes involved in VitD metabolism, mutations or deletions within receptor (VDR) genes known to increase by altering their functions bioavailability, less about these phenomena oral cancers. Using well-characterized, commercially available cell lines (OKF4, HGF-1, SCC4, SCC9, SCC15, SCC25, CAL27), mRNA expression P450 cytochrome metabolic qPCR revealed differential results. One line (SCC15) did not express either FOK1 polymorphism was also least affected VitD3 administration growth assays. In contrast, most cancers were missing one more hydrolase (CYP2R1 CYP24A1) hydrolate (CYP27A1 CYP27B1) enzymes. SCC25 both inhibited assays, while SCC4 hydroxylase VitD2. These associations between (or lack thereof) VitD2 responsiveness can be used identify molecular targets, which may lead effective screening tools for VitD-related, complementary alternative therapies.

Language: Английский

Citations

0
Skeletal health DOI
Jennifer Travers,

Celina Bazaar

Nursing Made Incredibly Easy!, Journal Year: 2025, Volume and Issue: 23(2), P. 14 - 20

Published: Feb. 5, 2025

The skeletal system is constantly changing. Comprised of bones, cartilage, and other connective tissues, it provides structural support stores vital minerals for the body. Nurses play an important role in educating patients about importance nutrition exercise bone health.

Language: Английский

Citations

0
Diagnostic Approach to Abnormal Alkaline Phosphatase Value DOI

Salvatore Minisola,

Cristiana Cipriani, Luciano Colangelo

et al.

Mayo Clinic Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Insights into the role of histone lysine demethylases in bone homeostasis and skeletal diseases: A review DOI
Ruiming Wen, Ruiqi Huang, Ke Xu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141807 - 141807

Published: March 5, 2025

Language: Английский

Citations

0
Influence of the Anti-Osteoporosis Effect of Fish Collagen Supplement in Mice DOI

Wanli Chu,

Li-Chan Yang, Wen‐Chuan Lin

et al.

Universal library of medical and health sciences., Journal Year: 2025, Volume and Issue: 03(02), P. 24 - 30

Published: April 4, 2025

Background: Osteoporosis (OA) is the second most serious epidemic worldwide in chronic progressive disease. Complex fish collagen powder contains astaxanthin extract, vitamin C, K1, D3, E, A, and whole milk to protect bone health. This novel combination for improving loss has not yet been studied or discussed. Objective: trial investigated whether complex (FC) containing had an improved effect on osteoporosis. Methods: The experiment forty male Sprague-Dawley (SD) rats ages five weeks. mice were divided into groups (control, LCa+H2O, doses 0.5-flod, 1-flod, 2-flod) twelve uses blood serum biochemical value, tissue, biomechanics analyzed. Results: Twelve weeks of low calcium feeding resulted a significant reduction N-terminal telopeptides type I collagen, N-telopeptide (NTX) concentration, osteocalcin (OCN) concentration compared LCa+H2O group, LCa+FC-L, LCa+FC-M, LCa+FC-H group. According micro-computed tomography analysis, comparison femoral mineral density, trabecular area percentage, thickness increased significantly, separation decreased significantly. Conclusion: By translating experimental data daily supplement adults, it recommended that intake FC can help remodeling strength, prevention osteoporosis

Language: Английский

Citations

0
Vitamin K2 deficiency associated with short stature in children: a cross-sectional study DOI Creative Commons
Yanjie Shen,

G SHI,

Si Wen

et al.

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Short stature in children is a common concern that can result from various underlying conditions. While factors such as growth hormone deficiency and nutritional deficiencies are well-known contributors, the role of vitamin K2 (VK2) development short remains underexplored. This study aimed to investigate association between VK2 status children. A total 730 aged 3-16 years were enrolled divided into three groups: group (n = 191), near-short 357), normal 182). Clinical characteristics growth-related indicators including serum levels, bone mineral density (BMD), insulin-like factor 1 (IGF-1), 25-hydroxyvitamin D (25-(OH)D) collected. was analyzed both categorical variable (VK2 vs. status) continuous variable, logistic regression models applied assess using approaches. Correlations other also examined. The prevalence higher with (80.6%) (64.7%) compared those (32.4%) (P < 0.05). Multiple showed levels significantly associated decreased risk (aOR 0.005, 95% CI: 0.001-0.036) 0.023, 0.006-0.085); increased 5.934, 3.372-10.443) 3.233, 2.095-4.989) after adjusting for covariates. Additionally, positively correlated IGF-1-SDS 25(OH)D an Further longitudinal studies warranted elucidate causal relationship disorders pediatric populations.

Language: Английский

Citations

0