Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Luteolin is widely distributed phytochemical, a flavonoid, in kingdom plantae. with potential antioxidant activity prevent ROS‐induced damages and reduce oxidative stress which mainly responsible pathogenesis of many diseases. Several chemo preventive activities therapeutic benefits are associated luteolin. prevents cancer via modulation numerous pathways, that is, by inactivating proteins; such as procaspase‐9, CDC2 cyclin B or upregulation caspase‐9 caspase‐3, cytochrome C, A, CDK2, APAF‐1, turn inducing cell cycle arrest well apoptosis. It also enhances phosphorylation p53 expression level p53‐targeted downstream gene. By Increasing BAX protein expression; decreasing VEGF Bcl‐2 it can initiate stimulate mitochondrial‐modulated functions to cause cellular death. levels p‐Akt, p‐EGFR, p‐Erk1/2, p‐STAT3. plays positive role against cardiovascular disorders improving cardiac function, the release inflammatory cytokines enzymes, prevention fibrosis hypertrophy; CTGF, TGFβ1, ANP, Nox2, Nox4 gene expressions. Meanwhile suppresses TGFβ1 JNK. helps fight diabetes inhibition alpha‐glucosidase ChE activity. catalase, superoxide dismutase, GS4. improve blood glucose, insulin, HOMA‐IR, HbA1c levels. This review an attempt elaborate molecular targets luteolin its modulating irregularities pathways overcome severe outcomes during diseases including cancer, disorders, diabetes, obesity, inflammation, Alzheimer's disease, Parkinson's hepatic renal brain injury, asthma. As has enormous benefits, could be candidate future drug development strategies.

Language: Английский

---

Design, synthesis and therapeutic exploration of nano-curcumin targeting the synergistic interactions with p53 and PARP-1 proteins in preventing food-additive induced genotoxicity and diabetic complications

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136230 - 136230

Published: Jan. 1, 2025

Language: Английский

---

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 5, 2025

Osteoarthritis (OA) is considered an advancing chronic degenerative joint disease, leading to severe physical functional impairment of patients. Its development closely related increased inflammation and oxidative stress within the joint. Ginkgetin (GK), a natural non-toxic chemical, has proven anti-inflammatory, antioxidant, anti-tumor, neuroprotective effects. First, this study utilizes network pharmacology explore intrinsic connection between GK OA. In vitro, SW1353 human cartilage cells were stimulated with Tert-butyl hydrogen peroxide (TBHP), different concentrations pre-treated evaluate its protective GK's anti-inflammatory antioxidative effects comprehensively assessed via MTT assay, western blot, cell immunofluorescence, ELISA, transcriptome sequencing. Potential underlying mechanisms also explored. vivo, OA was induced in rats anterior cruciate ligament transection (ACLT), impact on protection further histological analysis blot. Network revealed that regulates several key pathways, especially NF-κB, HIF-1, PI3K-AKT, substances like reactive oxygen species. vitro experiments showed effectively reverses damage from TBHP, inhibits inflammatory factor release, protects Extracellular matrix (ECM) degradation. These functions may be achieved NF-κB MAPK signaling pathways. vivo significantly reduced proteoglycan loss ACLT inhibited metalloproteinase 13 (MMP13) ADAMTS5 (A disintegrin thrombospondin motifs 5) production, preventing degeneration rats. findings suggest potential as therapeutic agent for OA, offering new strategies directions treatment.

Language: Английский

---

Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 126 - 126

Published: Feb. 14, 2025

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that may progress to colorectal cancer (CRC), presenting significant challenges global health. With shifts in lifestyle, the incidence of both conditions continues rise, underscoring urgent need for effective treatments. While traditional therapies can be effective, their high recurrence rates and associated adverse reactions limit broader application. Luteolin, flavonoid derived from natural plants, has emerged as promising focus IBD CRC research due its multi-target therapeutic potential. This article reviews molecular mechanisms signaling pathways through which luteolin regulates immune cell differentiation, mitigates inflammation oxidative stress, modulates gut microbiota, restores mucosal barrier function IBD. In context CRC, demonstrates anti-tumor effects by inhibiting proliferation, inducing apoptosis, suppressing migration invasion. Notably, demonstrated improvements symptoms influencing differentiation T subsets, decreasing expression mediators, activating antioxidant pathways, enhancing structure microbiota. Furthermore, advancements formulation technology, such use polymer micelles responsive nanoparticles, have greatly improved bioavailability efficacy luteolin. However, further investigation needed address potential toxicity luteolin, particularly critical transition CRC. emphasizes treatment anticipates prospects future clinical applications agent.

Language: Английский

---

Hydrothermal Synthesis of Multifunctional Polyvinyl Alcohol-based Nanocomposites Reinforced with Biosynthesized Silver Nanoparticles: Enhanced Thermal, Dielectric, and Biological Performance

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

---

Poly(Lactide) Nonwoven Fabric with Iron Coating and Its Biological Properties

Coatings, Journal Year: 2024, Volume and Issue: 14(8), P. 1050 - 1050

Published: Aug. 16, 2024

The study investigated the biological properties of a composite material composed poly(lactide) (PLA) and iron (Fe) produced by sputtering onto melt-blown nonwoven fabrics. research aimed to thoroughly understand structure these materials their potential applications in biomedicine. We conducted comprehensive chemical structural analyses using techniques such as microscopic analysis, flame atomic absorption spectrometry (FAAS), Brunauer–Emmett–Teller (BET) surface area analysis precisely determine PLA-Fe materials. Additionally, we evaluated impact on blood coagulation processes measuring activated partial thromboplastin time (aPTT) prothrombin (PT). also performed human peripheral mononuclear cells (PBM cells) including cell viability DNA damage. Our results clearly demonstrate that do not significantly influence mechanisms, they only slightly prolong aPTT have no effect PT. This suggests biomedical applications. indicate absence cyto- genotoxic against normal cells. In conclusion, findings suggest novel iron-sputtered fabrics are promising tools field biomedicine, offering potentially innovative therapeutic solutions for treatment wounds injuries.

Language: Английский

---

Preparation and Biochemical Activity of Copper-Coated Cellulose Nonwoven Fabric via Magnetron Sputtering and Alginate-Calcium Ion Complexation

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 436 - 436

Published: Sept. 26, 2024

Alginate-based materials have gained significant recognition in the medical industry due to their favorable biochemical properties. As a continuation of our previous studies, we introduced new composite consisting cellulose nonwoven fabric charged with metallic copper core (CNW-Cu0) covered calcium alginate (ALG−Ca2+) layer. The preparation process for these involved three main steps: coating via magnetron sputtering (CNW → CNW-Cu0), subsequent deposition sodium (CNW-Cu0 CNW-Cu0/ALG−Na+), followed by cross-linking chains ions (CNW-Cu0/ALG−Na+ CNW-Cu0/ALG−Ca2+). primary objective work was supply composites such biological attributes as antibacterial and hemostatic activity. Namely, equipping (copper action on representative Gram-positive Gram-negative bacteria fungal strains) induction blood plasma clotting processes (activated partial thromboplastin time (aPTT) prothrombin (PT)). We determined effect CNW-Cu0/ALG−Ca2+ viability Peripheral mononuclear (PBM) cells. Moreover, studied interactions DNA using relaxation plasmid assay. However, results showed CNW-Cu0/ALG−Ca2+’s cytotoxic properties against PBM cells time-dependent manner. Furthermore, exhibited potential interact directly DNA. demonstrated that synthesized show promising wound dressing applications.

Language: Английский

---

Characterization of the Composition of Bioactive Fractions from Dendrobium officinale Flowers That Protect against H2O2-Induced Oxidative Damage through the PI3K/AKT/Nrf2 Pathway

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3116 - 3116

Published: Sept. 29, 2024

Dendrobium officinale flowers (DOF) have previously been established as a promising source of natural antioxidants, and it is ideally suited for processing to prepare functional foods food additives. The precise extraction processes employed, however, can alter the composition antioxidant properties resultant products, characteristic compounds associated with active fractions prepared from DOF or their mechanisms action yet be reported. To clarify molecular through which these function first time, chromatography was used separate extracts, yielding five (Fr. (a—e)). Analyses activity different revealed that Fr. (d) presented most robust bioactivity. Levels total flavonoids were then measured, revealing levels positively correlated flavonoid content. found contain 20 in HPLC-Triple-TOF-MS/MS analyses. At cellular level, induce increases protective factors (SOD GSH-Px) while reducing reactive oxygen species (ROS), damage-associated (MDA, NO, TNF-α, IL-1β, IL-6), inducible nitric oxide synthase (iNOS) expression C2C12 cells had stimulated H2O2. These data thus provided support prevention oxidative stress inflammation. Network pharmacology analyses further suggested help protect against its effects on PI3K/Akt-related signaling activity. subsequently upregulate PI3K/Akt pathway-related proteins, nuclear transcription factor 2 (Nrf2), heme oxygenase 1 (HO-1) addition suppressing Kelch-like epoxide-related protein (Keap1) expression. In summary, suppress PI3K/Akt/Nrf2 pathway activation, ultimately alleviating inflammation predicted network approach. Future studies aimed at clarifying mechanistic will likely establish capable promoting health longevity.

Language: Английский

---

Luteolin, chemical feature and potential use for oral disease

Current Oral Health Reports, Journal Year: 2024, Volume and Issue: 11(4), P. 290 - 296

Published: Aug. 27, 2024

Language: Английский

---

Phytochemicals in Cancer Chemoprevention: Preclinical and Clinical Studies

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

Phytochemicals, chemicals from plants, have garnered huge attention for their potential ability to prevent cancer. In vivo and preclinical models show that they do so often by affecting the hallmarks of Phytochemicals affect key pathways involved in survival, genome maintenance, proliferation, senescence, transendothelial migration cancer cells. Some phytochemicals, namely antioxidants, can scavenge quench reactive oxygen species (ROS) lipid peroxidation DNA damage. They also trigger apoptosis stopping cell cycle at checkpoints initiate damage response. Numerous vitro studies suggest phytochemicals hinder onset progression modifying major signaling such as JAK/STAT, PI3K/Akt, Wnt, NF-kB, TGF-β, MAPK. It is a well-known fact occurrence itself very intricate process involving multiple mechanisms concurrently. Cancer prevention using an equally complex requires investigation understanding myriad processes going on cells tissues. While many established may be chemopreventive agents cancer, role clinical randomized control trials needs established. This paper aims shed light dynamics chemoprevention phytochemicals.

Language: Английский

---