Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors

Gastroenterology Review, Journal Year: 2019, Volume and Issue: 14(2), P. 89 - 103

Published: Jan. 1, 2019

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Gastroenterology Review/Przegląd Gastroenterologiczny. 2019;14(2):89-103. doi:10.5114/pg.2018.81072. APA Rawla, P., Sunkara, T., & Barsouk, (2019). Gastroenterologiczny, 14(2), 89-103. https://doi.org/10.5114/pg.2018.81072 Chicago Prashanth, Tagore Adam Barsouk. 2019. "Epidemiology factors". Gastroenterologiczny 14 (2): Harvard pp.89-103. MLA Prashanth et al. factors." vol. 14, no. 2, 2019, pp. Vancouver

Language: Английский

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Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 4, 2020

Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly glycosylated proteins called mucins plays essential roles in providing lubrication for passage food, participating cell signaling pathways and protecting host epithelium from commensal microorganisms invading pathogens, as well toxins other environmental irritants. These can be broadly classified into either secreted gel-forming mucins, those that provide structural backbone barrier, or transmembrane form glycocalyx covering underlying epithelial cells. Goblet cells dispersed among intestinal are chiefly responsible synthesis secretion within gut heavily influenced by interactions with immune system. Evidence both clinical animal studies have indicated several GI conditions, including inflammatory bowel disease (IBD), colorectal cancer, numerous enteric infections accompanied considerable changes mucin quality quantity. include, but not limited to, impaired goblet function, dysregulation altered post-translational modifications. The current review aims to highlight functional features production immunological regulation impact these key elements context barrier function defense inflammation.

Language: Английский

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Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

Cell Death and Differentiation, Journal Year: 2019, Volume and Issue: 26(11), P. 2447 - 2463

Published: March 8, 2019

Language: Английский

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TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway

Journal of Experimental & Clinical Cancer Research, Journal Year: 2016, Volume and Issue: 35(1)

Published: Sept. 19, 2016

Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate biological function clinical significance human colon cancer. We analyzed the expression of TIMP1 both public database (Oncomine TCGA) 94 cases primary cancer matched normal tissue specimens. The underlying mechanisms altered on cell tumorigenesis, proliferation, metastasis were explored vitro vivo. was overexpressed tumorous tissues lymph node specimens than tissues. aberrant significantly associated with regional (p = 0.033), distant 0.039), vascular invasion 0.024) American Joint Committee Cancer (AJCC) stage 0.026). Cox proportional hazards model showed that an independent prognostic indicator disease-free survival (HR 2.603, 95 % CI: 1.115–6.077, p 0.027) overall 2.907, 1.254–6.737, 0.013) for patients Consistent this, our findings highlight suppression decreased but increased apoptosis by inducing specific regulated FAK-PI3K/AKT MAPK pathway. might play important promoting tumorigenesis as potential

Language: Английский

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The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)

Oncology Letters, Journal Year: 2018, Volume and Issue: unknown

Published: May 9, 2018

Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and epigenetic aberrations within cells. The progression colorectal adenoma to carcinoma is caused by three major pathways: Microsatellite instability, chromosomal instability CpG island methylator phenotype. A growing body scientific evidences suggests that CRC a heterogeneous disease, characteristics tumors determine their prognostic outcome response targeted therapies. Early diagnosis effective therapies based on current knowledge molecular are essential successful treatment CRC. Therefore, present review summarized understanding CRC, discussed its implications for therapy.

Language: Английский

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Long Intergenic Noncoding RNA 00511 Acts as an Oncogene in Non–small-cell Lung Cancer by Binding to EZH2 and Suppressing p57

Molecular Therapy — Nucleic Acids, Journal Year: 2016, Volume and Issue: 5, P. e385 - e385

Published: Jan. 1, 2016

Long noncoding RNAs (lncRNAs) play crucial roles in carcinogenesis. However, the function and mechanism of lncRNAs human non-small-cell lung cancer (NSCLC) are still remaining largely unknown. intergenic RNA 00511 (LINC00511) has been found to be upregulated acts as an oncogene breast cancer, but little is known about its expression pattern, biological underlying NSCLC. Herein, we identified LINC00511 oncogenic lncRNA by driving tumorigenesis We was associated with oncogenesis, tumor size, metastasis, poor prognosis Moreover, affected cell proliferation, invasiveness, apoptosis multiple NSCLC lines. Mechanistically, bound histone methyltransferase enhancer zeste homolog 2 ((EZH2, catalytic subunit polycomb repressive complex (PRC2), a highly conserved protein that regulates gene methylating lysine 27 on H3), acted modular scaffold EZH2/PRC2 complexes, coordinated their localization, specified modification pattern target genes, including p57, consequently altered biology. Thus, mechanistically, functionally, clinically Targeting pathway may meaningful for treating patients

Language: Английский

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Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression

Biochemical and Biophysical Research Communications, Journal Year: 2016, Volume and Issue: 478(2), P. 811 - 817

Published: Aug. 6, 2016

Language: Английский

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Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer

International Journal of Clinical Oncology, Journal Year: 2021, Volume and Issue: 26(8), P. 1353 - 1419

Published: June 29, 2021

Abstract Hereditary colorectal cancer (HCRC) accounts for < 5% of all cases. Some the unique characteristics commonly encountered in HCRC cases include early age onset, synchronous/metachronous occurrence, and multiple cancers other organs. These necessitate different management approaches, including diagnosis, treatment or surveillance, from sporadic management. There are two representative HCRC, named familial adenomatous polyposis Lynch syndrome. Other than these syndromes, related disorders have also been reported. Several guidelines hereditary already published worldwide. In Japan, first guideline was prepared by Japanese Society Cancer Colon Rectum (JSCCR), 2012 revised 2016. This version immediately translated into English 2017. Since then, several new findings novel disease concepts to discovered. The currently diagnosed rate daily clinical practice is relatively low; however, this predicted increase era genomic medicine, with advancement multi-gene panel testing whole genome testing, among others. Under circumstances, JSCCR 2020 were consensus members Guideline Committee, based on a careful review evidence retrieved literature searches, considering medical health insurance system actual settings Japan. Herein, we present HCRC.

Language: Английский

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Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Jan. 21, 2020

Hypoxic tumors are refractory to DNA damage drugs. However, the underlying mechanism has yet be elucidated. We aimed identify lncRNAs that upregulated under hypoxia and their effects on colorectal cancer (CRC).CRC cells were treated with 1% O2 hypoxia. integrated these RNA-seq of 4 paired CRC tissues TCGA data get candidate lncRNAs. Multiple in vitro vivo assays used explore role LUCAT1 CRC.We identified a hypoxia-induced lncRNA facilitated growth contributed drug resistance both vivo. Mechanically, interacts polypyrimidine tract binding protein 1 (PTBP1) cells, facilitates association set related genes PTBP1, thus resulting altered alternative splicing genes. Moreover, ectopic expression PTBP1 knockdown abrogated induced by knockdown. Chemotherapeutics combined via antisense oligonucleotides (ASO) would better outcome vivo, compared group chemotherapeutic only. Notably, is tissues, adjacent normal tissues; patients higher have worse prognosis poorly responded chemotherapy clinic.Our suggested utilizes develop drugs, disrupting LUCAT1/PTBP1 axis might promising therapeutic strategy for hypoxic tumors.

Language: Английский

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α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

Nature Cancer, Journal Year: 2020, Volume and Issue: 1(3), P. 345 - 358

Published: March 20, 2020

Language: Английский

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