Challenges, progress and promises of metabolite annotation for LC–MS-based metabolomics

Current Opinion in Biotechnology, Journal Year: 2018, Volume and Issue: 55, P. 44 - 50

Published: Aug. 20, 2018

Language: Английский

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Meat: The balance between nutrition and health. A review

Meat Science, Journal Year: 2016, Volume and Issue: 120, P. 145 - 156

Published: April 13, 2016

Language: Английский

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Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

Oncotarget, Journal Year: 2015, Volume and Issue: 6(16), P. 13858 - 13898

Published: May 27, 2015

// Didier Rémond 1, 2 , Danit R. Shahar 3 Doreen Gille 4 Paula Pinto 5, 6 Josefa Kachal 7 Marie-Agnès Peyron Claudia Nunes Dos Santos 6, 8 Barbara Walther Alessandra Bordoni 9 Dupont 10 Lidia Tomás-Cobos 11 Guy Vergères 1 UMR 1019, UNH, CRNH Auvergne, INRA, 63000 Clermont-Ferrand, France Clermont Université, Université d’Auvergne, Unité de Nutrition Humaine, BP 10448, Department of Public Health, The S. Daniel Abraham International Center for Health and Nutrition, Ben-Gurion University the Negev, 84105 Beer-Sheva, Israel Institute Food Sciences IFS, Agroscope, Federal Economic Affairs, Education Research EAER, 3003 Berne, Switzerland 5 Escola Superior Agrária, Insituto Politécnico Santarém, 2001-904 Santarem, Portugal Instituto Tecnologia Química e Biológica, Universidade Nova Lisboa, 2780-157 Oeiras, Israeli Ministry 93591 Jerusalem, Biologia Experimental Tecnológica, Agri-Food Technologies, Bologna, 47521 Cesena, Italy 1253, Science et Technologie du Lait & l’Œuf, 35000 Rennes, ainia Centro Tecnológico, E46980 Paterna (Valencia), Spain Correspondence to: Vergères, e-mail: [email protected] Keywords: malnutrition, gastrointestinal tract, aging, dietary solutions, gerotarget Received: May 06, 2015      Accepted: 13, Published: 27, 2015 ABSTRACT Although prevalence malnutrition in old age is increasing worldwide a synthetic understanding impact aging on intake, digestion, absorption nutrients still lacking. This review article aims at filling gap knowledge between functional decline tract (GIT) consequences health status elderly. Changes GIT include mechanical disintegration food, motor function, food transit, chemical functionality intestinal wall. These alterations progressively decrease ability to provide organism with adequate levels nutrients, what contributes development malnutrition. Malnutrition, turn, increases risks range pathologies associated most organ systems, particular nervous-, muscoskeletal-, cardiovascular-, immune-, skin systems. In addition psychological, economics, societal factors, solutions preventing should thus propose guidelines products that integrate nutritional Achieving this goal will request identification, validation, correlative analysis biomarkers nutrient bioavailability,

Language: Английский

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Use of Metabolomics in Improving Assessment of Dietary Intake

Clinical Chemistry, Journal Year: 2017, Volume and Issue: 64(1), P. 82 - 98

Published: Oct. 17, 2017

Abstract BACKGROUND Nutritional metabolomics is rapidly evolving to integrate nutrition with complex data discover new biomarkers of nutritional exposure and status. CONTENT The purpose this review provide a broad overview the measurement techniques, study designs, statistical approaches used in metabolomics, as well describe current knowledge from epidemiologic studies identifying metabolite profiles associated intake individual nutrients, foods, dietary patterns. SUMMARY A wide range technologies, databases, computational tools are available phenotypic information. Biomarkers identified use high-throughput techniques include amino acids, acylcarnitines, carbohydrates, bile purine pyrimidine metabolites, lipid classes. most extensively studied food groups fruits, vegetables, meat, fish, bread, whole grain cereals, nuts, wine, coffee, tea, cocoa, chocolate. We 16 that evaluated signatures Dietary patterns examined included vegetarian lactovegetarian diets, omnivorous diet, Western patterns, prudent Nordic Mediterranean diet. Although many foods have been identified, those may not be sensitive or specific intakes. Some represent short-term intakes rather than long-term habits. Nonetheless, holds promise for development robust unbiased strategy measuring Still, technology intended complementary, replacement, traditional well-validated assessment methods such frequency questionnaires can measure usual relevant studies.

Language: Английский

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Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

Metabolites, Journal Year: 2020, Volume and Issue: 10(1), P. 37 - 37

Published: Jan. 15, 2020

Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed hundreds to thousands metabolites, whereby the bioactivity can be represented by synergism between several metabolites. However, isolating every single compound from extract is not always possible due complex chemistry and presence most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool analysis crude extracts, leading paradigm shift research. Analytical methods such mass spectrometry (MS) nuclear magnetic resonance (NMR) used comprehensively annotate constituents plant screening, discovery well quality control purposes those required phytomedicine. In this review, current advancements sample preparation, measurements, data presented alongside few case studies successful applications these processes product discovery.

Language: Английский

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Diet, nutrition, and cancer: past, present and future

Nature Reviews Clinical Oncology, Journal Year: 2016, Volume and Issue: 13(8), P. 504 - 515

Published: March 8, 2016

Language: Английский

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Computational Metabolomics: A Framework for the Million Metabolome

Chemical Research in Toxicology, Journal Year: 2016, Volume and Issue: 29(12), P. 1956 - 1975

Published: Sept. 15, 2016

"Sola dosis facit venenum." These words of Paracelsus, "the dose makes the poison", can lead to a cavalier attitude concerning potential toxicities vast array low abundance environmental chemicals which humans are exposed. Exposome research teaches that 80–85% human disease is linked exposures. The exposome estimated include >400,000 chemicals, most uncharacterized with regard health. In fact, mass spectrometry measures >200,000 m/z features (ions) in microliter volumes derived from samples; unidentified. This crystallizes grand challenge for chemical toxicology: develop reliable and affordable analytical methods understand health impacts extensive experience. To this end, there appears be no choice but abandon limitations measuring one at time. present review looks progress computational metabolomics provide probability-based annotation linking ions known serve as foundation unambiguous designation unidentified toxicologic study. We characterize terms accurate m/z, chromatographic retention time, correlation adduct, isotopic fragment forms, association metabolic pathways measurement collision-induced dissociation products, collision cross section, chirality. Such information support largely system documenting surveillance biomonitoring. Assembly data would resource risks low-abundance

Language: Английский

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Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial

The Lancet Diabetes & Endocrinology, Journal Year: 2017, Volume and Issue: 5(3), P. 184 - 195

Published: Jan. 13, 2017

BackgroundAccurate monitoring of changes in dietary patterns response to food policy implementation is challenging. Metabolic profiling allows simultaneous measurement hundreds metabolites urine, the concentrations which can be affected by intake. We hypothesised that metabolic profiles urine samples developed under controlled feeding conditions reflect intake and used model classify free-living populations.MethodsIn this randomised, controlled, crossover trial, we recruited healthy volunteers (aged 21–65 years, BMI 20–35 kg/m2) from a database clinical research unit UK. four interventions with stepwise variance concordance WHO eating guidelines aim prevent non-communicable diseases (increase fruits, vegetables, whole grains, fibre; decrease fats, sugars, salt). Participants attended inpatient stays (72 h each, separated at least 5 days), during they were given one intervention. The order diets was randomly assigned across study visits. Randomisation done an independent investigator, use opaque, sealed, sequentially numbered envelopes each contained random order. investigators not masked intervention, but analysing data randomisation During period, collected daily over three timed periods: morning (0900–1300 h), afternoon (1300–1800 evening overnight (1800–0900 h); 24 obtained pooling these samples. Urine assessed proton nuclear magnetic resonance (1H-NMR) spectroscopy, diet-discriminatory identified. urinary metabolite models for diet identified associated profiles, then validated using INTERMAP UK cohort (n=225) healthy-eating Danish (n=66). This registered ISRCTN, number ISRCTN43087333.FindingsBetween Aug 13, 2013, May 18, 2014, contacted 300 people letter invitation. 78 responded, whom 26 eligible invited attend health screening. Of 20 participants who 19 completed all 72 between Oct 2, July 29, consumed provided. Analysis 1H-NMR spectroscopy indicated distinct. Significant differences seen lowest highest risks. Application derived validation datasets confirmed association (p<0·0001) (p<0·0001).InterpretationUrinary highly environment groups into consumers lower or higher disease risk on basis multivariate patterns. approach enables objective population settings enhances validity reporting.FundingUK National Institute Health Research Medical Council.

Language: Английский

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Biomarkers of Nutrition and Health: New Tools for New Approaches

Nutrients, Journal Year: 2019, Volume and Issue: 11(5), P. 1092 - 1092

Published: May 16, 2019

A main challenge in nutritional studies is the valid and reliable assessment of food intake, as well its effects on body. Generally, intake measurement based self-reported dietary questionnaires, which have inherent limitations. They can be overcome by use biomarkers, capable objectively assessing consumption without bias assessment. Another major goal to determine biological foods their impact health. Systems analysis dynamic responses may help identify biomarkers indicative body at same time, possibly relation individuals’ health/disease states. Such could used quantify validate analyse physiological or pathological certain components diets, persons with specific deficiency, provide information inter-individual variations formulate personalized recommendations achieve optimal health for particular phenotypes, currently referred “precision nutrition.” In this regard, holistic approaches using global methods (omics approaches), gathering high amounts data, appear very useful new enhance our understanding role disease.

Language: Английский

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High-Definition Medicine

Cell, Journal Year: 2017, Volume and Issue: 170(5), P. 828 - 843

Published: Aug. 1, 2017

Language: Английский

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