Recent progress of nanomedicine in managing dry eye disease

Advances in Ophthalmology Practice and Research, Journal Year: 2024, Volume and Issue: 4(1), P. 23 - 31

Published: Jan. 29, 2024

Dry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5 % to 50 %, impacting substantial proportion individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for diseases, it suffers drawbacks such as low bioavailability, rapid metabolism, and frequent requirements. Fortunately, advancements nanomedicine offer effective solutions address aforementioned issues provide assistance treatment DED. considered multifactorial surface tear film, which integrity film function structure plays crucial role maintaining homeostasis surface. conventional involves utilization artificial products, cyclosporin, corticosteroids, mucin secretagogues, nonsteroidal anti-inflammatory drugs. Furthermore, presently field study, numerous clinical trials underway various nanotherapeutics including nanoemulsions, nanosuspensions, liposomes, micelles. Notably, some these innovative nanoformulations have already received FDA approval novel remedies DED, advancement poised enhanced prospects solve shortcomings existing treatments partially. This article provides an overview latest treatment, while expected witness remarkable breakthrough shortly development nanomedicine, bringing promising patients suffering conditions.

Language: Английский

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Overview of Dry Eye Disease for Primary Care Physicians

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 460 - 460

Published: March 6, 2025

Dry eye disease (DED), also known as keratoconjunctivitis sicca, is a multifactorial ocular characterized by tear film insufficiency due to diverse etiologies including aging, incomplete and infrequent blinking, hormonal changes, medications, systemic diseases. Classified into aqueous-deficient dry (ADDE), evaporative (EDE), mixed subtypes, DED presents with symptoms such irritation, stinging, redness, foreign body sensation, sensitivity light, blurred or fluctuating vision. While rare, severe cases may lead vision loss. With its rising global prevalence across age groups, poses significant public health challenge. Primary care physicians (PCPs), often the first point of contact for patients, require timely screening management strategies. This review explores epidemiology, pathophysiology, clinical manifestations, diagnosis, DED, emphasizing practical approaches PCPs. narrative was conducted searching MEDLINE, PubMed, Google Scholar databases relevant articles. Diagnostic approaches, detailed history taking, patient-reported questionnaires, differential assessments are discussed alongside strategies, symptomatic ophthalmic treatment, risk factor mitigation (e.g., reduced digital device screen time), prevention, nutrition. By providing synopsis early that PCPs encounter, managing in primary setting, guidelines on when refer specialty care, this comprehensive aims equip knowledge improve optimize patient outcomes.

Language: Английский

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Optimizing Diagnosis and Management of Dry Eye Disease: A Practical Framework for Hong Kong

Ophthalmology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Dry eye disease (DED) poses a significant and escalating public health challenge. Effective diagnosis is crucial for optimal management. However, current practices are complicated time-consuming. This paper proposes revised framework diagnosing treating in Hong Kong, explicitly tailored to the local healthcare context incorporating insights from global consensus guidelines. The emphasizes streamlined assessment strategy prioritizes direct symptom-based questioning alongside objective tests. It also includes simplified corneal staining grading scheme reduce complexity, considering limited consultation time available Kong. Furthermore, clearly outlines appropriate treatment options based on disease's severity etiological cause(s) focuses need long-term management through follow-up or referrals. By addressing multifaceted nature of DED constraints, this seeks enhance patient outcomes timely accurate DED.

Language: Английский

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Areas for improvement in the current care and treatment of dry eye disease

Expert Review of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

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Formulation and evaluation of the effects of ophthalmic nanoemulsion of Nigella sativa seed extract on atropine-induced dry eye in mice

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100541 - 100541

Published: Feb. 27, 2024

Nigella sativa L. seed from the Ranunculaceae family, whose many therapeutic effects have been stated in recent research, is one of herbs with known anti-inflammatory effects. may on dry eye, a disease that manifests symptoms redness, burning, foreign body sensation, and sensitivity to light. To evaluate extract nanoemulsion atropine-induced eye mice. The hydro-alcoholic was prepared using maceration method (10% w/w). Subsequently, by Tween 20 80 surfactants different ratios, desired achieved. DLS, Zeta potential, TEM, FT-IR tests were used determine size morphology nanoparticles. A total number 36 adult male mice this study divided equally into six groups, each receiving compound according protocol three groups drops daily. Tear production evaluated Schirmer's test reported as ratio first-day tear days 1, 7, 14. According investigations DLS method, Nanoparticles' 10.4 nm. TEM image revealed nanoparticle emulsion has spherical shape an approximate 10 results -37.6 mv, which sufficient quality. final composition chosen 5% extract, 75% water, 20% surfactant 1:4. indicated highest dose (1%) resulted most significant amount production, compared lower doses (0.5% 0.1%) control group. This showed potentially positive effect eyes. Thus, employment should be considered treatment eye.

Language: Английский

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Therapeutic Targets in the Management of Dry Eye Disease Associated with Sjögren’s Syndrome: An Updated Review of Current Insights and Future Perspectives

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1777 - 1777

Published: March 20, 2024

Dry eye disease (DED) is a continuing medical challenge, further worsened in the autoimmune inflammatory hyperactivation milieu of Sjögren's syndrome (SS) due to disturbances innate and adaptive immunity with malfunctioning neuro-endocrine control. However, pathogenetic mechanisms SS DED are not fully established. This review summarized available evidence, from systematic reviews, meta-analyses, randomized clinical trials, for efficacy safety ocular therapeutics management DED. Relevant studies were obtained major databases using appropriate keywords. The largely empirical symptomatic, supportive, restorative treatments have significant limitations as they do alter local systemic progression. Topical therapies expanded include biologics, surgical approaches, scleral lens fitting, lid margin disease, treatments, nutritional support, transplantation stem cells. They curative, cannot permanently restore surface's homeostasis. These approaches efficacious short term most studies, more variability outcome measures among long term. offers an interdisciplinary perspective that enriches our understanding updated addresses current knowledge gaps identifies promising areas future research overcome this challenge.

Language: Английский

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Quintessence of currently approved and upcoming treatments for dry eye disease

Graefe s Archive for Clinical and Experimental Ophthalmology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Language: Английский

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Effects of Topical 0.05% Cyclosporine A on Dry Eye Symptoms and Parameters Following Small Incision Lenticule Extraction

Journal of Refractive Surgery, Journal Year: 2024, Volume and Issue: 40(4)

Published: April 1, 2024

Purpose: To evaluate the effects of topical 0.05% cyclosporine A on Ocular Surface Disease Index (OSDI) score and ocular surface parameters after small incision lenticule extraction (SMILE) for myopia. Methods: In this study, 151 patients who underwent SMILE were randomized into control group (71 eyes) (80 eyes). Both groups received standard treatment during 1 month SMILE. Over next 3 months, The continued therapy (0.3% sodium hyaluronate) additional A. OSDI total subscale scores, non-invasive tear break-up time (NIBUT), lipid layer thickness (LLT), meniscus height (TMH) assessed preoperatively postoperatively. Results: Compared to baseline, scores significantly increased in both ( P < .001). exhibited lower administering versus = .026). At follow-up, NIBUT, LLT, TMH values decreased compared baseline .05). higher group, returning preoperative 2 months. Overall, NIBUT follow-up not different between two groups; however, LLT .001 .041, respectively) by repeated measures analysis variance. Conclusions: Topical was effective relieving subjective dry eye symptoms maintaining stability early postoperative period [ J Refract Surg . 2024;40(4):e229–e238.]

Language: Английский

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Low friction hydrogel with diclofenac eluting ability for dry eye therapeutic contact lenses

Methods, Journal Year: 2024, Volume and Issue: 234, P. 67 - 84

Published: Nov. 29, 2024

When placed in the eye, contact lenses (CLs) disturb tear fluid and affect natural tribological behaviour of eye. The disruption mechanics between ocular tissues can increase frictional shear stress dryness, causing discomfort. Ultimately, continuous CLs wear trigger inflammation which is particularly critical for people suffering from dry In this work, a double strategy was followed to obtain therapeutic daily disposable eye: hydroxyethyl methacrylate (HEMA) based hydrogel coated with two polysaccharides, chitosan (CHI) hyaluronic acid (HA) posteriorly loaded an anti-inflammatory drug (diclofenac, DCF). Material sterilisation carried out by high hydrostatic pressure (HHP) combined moderate temperature. friction coefficient (μ) determined presence different biomolecules (cholesterol, lysozyme albumin) using nanotribometer. Drug release experiments were performed static hydrodynamic conditions. material extensively characterised, regarding surface morphology/topography, optical properties, water content swelling behaviour, wettability, ionic oxygen permeability mechanical properties. It found that coating did not impair physico-chemical properties relevant material's application CLs. Besides, it also ensured sustained DCF 24 h tests conditions simulate those increasing significantly amount released. reduced friction, improving lubrication ability hydrogel, presented antibacterial against S. aureus, P. aeruginosa B. Cereus. samples reveal any signs cytotoxicity or potential eye irritation. Overall, may be useful produce able alleviate symptoms discomfort wearers.

Language: Английский

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Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review

Bioengineering, Journal Year: 2023, Volume and Issue: 11(1), P. 39 - 39

Published: Dec. 29, 2023

Dry eye disease (DED) is an emerging health issue affecting millions of individuals annually. Ocular surface disorders, such as DED, are characterized by inflammation triggered various factors. This condition can lead to tear deficiencies, resulting in the desiccation ocular surface, corneal ulceration/perforation, increased susceptibility infections, and a higher risk severe visual impairment blindness. Currently, clinical management DED primarily relies on supportive palliative measures, including frequent lifelong use different lubricating agents. While some advancements like punctal plugs, non-steroidal anti-inflammatory drugs, salivary gland autografts have been attempted, they shown limited effectiveness. Recently, there promising developments treatment biomaterials nano-systems, hydrogels, contact lenses for drug delivery, cell-based therapies, biological approaches, tissue-based regenerative therapy. article specifically explores strategies reported so far treating DED. The aim discuss their potential long-term cures while also considering factors that limit feasibility These offer hope more effective sustainable options future.

Language: Английский

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