Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers DOI Open Access
Igor A. Butovich, Amber Wilkerson, Seher Yüksel

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13512 - 13512

Published: Aug. 31, 2023

The main function of exocrine Meibomian glands (MGs) is to produce a lipid-rich secretion called meibum which plays critical role in maintaining the ocular surface homeostasis humans and most mammals. chemical composition meibum, its quantity produced by MGs, largely determine whether it can fulfill successfully. Aging was frequently associated with onset various MG-related pathologies. goal this study how aging affects mice, identify possible molecular markers aging. Unbiased, untargeted targeted lipidomic evaluation mouse MG lipids conducted using liquid chromatography-high-resolution mass spectrometry, results were analyzed Principal Component, Orthogonal Projections Latent Structures Discriminant, Partial Least Square Discriminant Analyses. We found that leads dysregulation lipid metabolism changing ratios major classes (such as wax esters, triacylglycerols, phospholipids) progressive manner. Several species belong these groups are proposed clear model.

Language: Английский

Is Thermal Pulsation Therapy Effective for Dry Eyes Before and After Cataract Surgery? A Systematic Review and Meta-Analysis DOI Creative Commons
Kuo-Su Chen,

Hoi-Chun Chan,

Chi‐Ming Chan

et al.

Clinical ophthalmology, Journal Year: 2025, Volume and Issue: Volume 19, P. 19 - 33

Published: Jan. 1, 2025

Meibomian gland dysfunction (MGD) is a primary cause of evaporative dry eye disease (DED), which often exacerbated by cataract surgery due to surgical trauma and inflammation. Thermal pulsation therapy (TPT) aims enhance meibomian function relieve symptoms. We conducted systematic review meta-analysis evaluate the effectiveness TPT in managing symptoms associated with surgery. A search was performed December 2024 across PubMed, ScienceDirect, CINAHL, Cochrane Central Register Controlled Trials identify original research on efficacy addressing surgery-related The quality included studies evaluated using Risk Bias Non-Randomized Studies Interventions tool, results visualized through Robvis 2.0 tool developed Collaboration. yielded 365 records, seven met inclusion criteria for this meta-analysis. Key outcomes analyzed yielding liquid secretion (MGYLS) score, tear break-up time (TBUT), ocular surface index (OSDI) lipid layer thickness (LLT). revealed moderate effect TPT, small but clinically significant improvement observed MGYLS scores (Cohen's d = 0.29, p 0.033) TBUT 0.15, 0.029). However, effects OSDI LLT were not statistically significant. Study heterogeneity varied, some exhibiting considerable variability. provides meaningful improvements patients experiencing after surgery, although did achieve statistical significance. variability study highlights need well-designed, high-quality confirm these findings durability TPT's therapeutic both before

Language: Английский

Citations

5
Exploring the effect of chlorogenic acid on oxidative stress and autophagy in dry eye mice via the AMPK/ULK1 pathway DOI Creative Commons
Huimei Chen, Jian Shi,

Yu Tang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177311 - 177311

Published: Jan. 1, 2025

Language: Английский

Citations

1
Efficacy of Eyelid Warming Devices as first-step treatment in Meibomian Gland Dysfunction: A systematic review with meta-analysis. DOI Creative Commons
Antonio Ballesteros‐Sánchez, Carlos Rocha‐de‐Lossada, José‐María Sánchez‐González

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Meibomian gland dysfunction DOI Creative Commons

Murugesan Vanathi

Indian Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: 73(2), P. 155 - 156

Published: Jan. 24, 2025

Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease[1] with reported rates ranging between 21 and 29.5% in Africans Caucasians, 71.0% Arabs, 67.5% Hispanics[2] 55% Indians.[3,4] The two vicious circles MGD disease (DED) are intricately interlinked meibomian blockage, dropout, inflammation playing a significant role affecting tear film integrity.[5] circle self-stimulated by microbiological changes, which result increased melting temperature meibum subsequent reinforcing MGD. MGD-associated instability provides an entry point into DED leads to hyperosmolarity inflammation, both consequences DED. clinical types range from isolated can be either asymptomatic or symptomatic (as non-cicatricial cicatricial conjunctivitis, occurring concurrence ocular surface diseases (such as Steven Johnson syndrome, graft versus host disease, etc.), evaporative associated other blepharo-conjunctivitis blepharokeratoconjunctivitis. Ocular index score, breakup time estimation, staining scores, osmolarity evaluation help estimating damage staging [Table 1] being elaborated severity altered expressibility quality secretions glands defining influencing extent damage.[6]Table 1: stagingDescriptive detailing expressed based on count number affected that visualized secretion, evaluated using finger evaluator. Five each nasal, central, temporal regions need assessed examine secretion (grade 3 – clear liquid, grade 2 milky 1 thick (toothpaste/ inspissated), 0 no secretion), providing score 0–45 (maximum 45 across 15 glands). Slit lamp biomicroscopic examination evaluate lid margin orifices helps all unaffected fluid mild digital pressure, partial obstruction 1–2 three more partially obstructed opaque one/two several frothy discharge, 4 than blocked remaining blocked). Demodex infestation now envisaged one major causes blockage inflammation.[7] Management strategies for defined stages lifestyle modifications, eyelid hygiene, warming massage, oral tetracycline derivatives therapy, topical azithromycin, lubricants anti-inflammatory treatment, anti-demodex treatments. Pulsed therapy low-potency steroids also advocated severe plus stages. Therapy electrical heating devices raise about 40°C bring liquefaction obstructive glandular such Lipiflow MiBO Thermoflow commercial devices, enhance treatment efficacy cases.[8] Intense pulse light has been implicated effect cases In conclusion, observed commonly type multifactorial resulting primary hyperkeratinization gland, abnormal corneal damage, DED.[9] Its chronicity have deleterious effects patient's life needs particular attention eyes considered cataract, glaucoma, refractive, keratoplasty surgeries. It imperative identify manage main pathogenic mechanisms involved customize accordance individual patient.

Language: Английский

Citations

0
Overview of Dry Eye Disease for Primary Care Physicians DOI Creative Commons
J.S. Kwon,

Amirhossein Moghtader,

Christie Kang

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 460 - 460

Published: March 6, 2025

Dry eye disease (DED), also known as keratoconjunctivitis sicca, is a multifactorial ocular characterized by tear film insufficiency due to diverse etiologies including aging, incomplete and infrequent blinking, hormonal changes, medications, systemic diseases. Classified into aqueous-deficient dry (ADDE), evaporative (EDE), mixed subtypes, DED presents with symptoms such irritation, stinging, redness, foreign body sensation, sensitivity light, blurred or fluctuating vision. While rare, severe cases may lead vision loss. With its rising global prevalence across age groups, poses significant public health challenge. Primary care physicians (PCPs), often the first point of contact for patients, require timely screening management strategies. This review explores epidemiology, pathophysiology, clinical manifestations, diagnosis, DED, emphasizing practical approaches PCPs. narrative was conducted searching MEDLINE, PubMed, Google Scholar databases relevant articles. Diagnostic approaches, detailed history taking, patient-reported questionnaires, differential assessments are discussed alongside strategies, symptomatic ophthalmic treatment, risk factor mitigation (e.g., reduced digital device screen time), prevention, nutrition. By providing synopsis early that PCPs encounter, managing in primary setting, guidelines on when refer specialty care, this comprehensive aims equip knowledge improve optimize patient outcomes.

Language: Английский

Citations

0
Is Botulinum toxin A effective in treating dry eye disease? A systematic review and meta-analysis DOI
Kuo-Su Chen,

Hoi-Chun Chan,

Chi-Ming Chan

et al.

Eye, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Novel treatments for dry eye syndrome DOI

Esther Roucaute,

Marcela Huertas-Bello, Alfonso L. Sabater

et al.

Current Opinion in Pharmacology, Journal Year: 2024, Volume and Issue: 75, P. 102431 - 102431

Published: Jan. 25, 2024

Language: Английский

Citations

3
Understanding Ocular Graft-Versus-Host Disease to Facilitate an Integrated Multidisciplinary Approach DOI Creative Commons
Pier Luigi Surico, Zhonghui Luo

Transplantation and Cellular Therapy, Journal Year: 2024, Volume and Issue: 30(9), P. S570 - S584

Published: July 8, 2024

Ocular Graft-versus-Host Disease (oGVHD) remains a challenging and potentially devastating complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). It significantly impacts the quality of life affected survivors, however, is often underrecognized particularly during early stages. Targeting all providers in HSCT community who see patients regularly frequently for their post-allo-HSCT care, this review opinion piece introduces basic concepts ocular surface pathophysiology, dissects different stages clinical presentation oGVHD, explains why current diagnostic criteria tend to capture late disease stages, highlights warning signs development, hope facilitate prompt referral oGVHD suspects specialist care. In addition introducing comprehensive list treatment options, emphasizes therapeutic strategy options that are safe effective be initiated by any care provider. We believe empowering as well beyond disciplinary boundaries, order provide most cohesive integrated our multidisciplinary approach.

Language: Английский

Citations

3
Tolerability of Current Treatments for Dry Eye Disease: A Review of Approved and Investigational Therapies DOI Creative Commons
Preeya K. Gupta, Rolando Toyos, John D. Sheppard

et al.

Clinical ophthalmology, Journal Year: 2024, Volume and Issue: Volume 18, P. 2283 - 2302

Published: Aug. 1, 2024

Dry eye disease (DED) is a common, multifactorial ocular impacting 5% to 20% of people in Western countries and 45% 70% Asian countries. Despite the prevalence DED number treatment approaches available, signs symptoms continue limit quality life for many patients. Standard over-the-counter behavior/environmental modifications may help some cases but more persistent forms often require pharmacological interventions. Approved investigational pharmaceutical attempt treat different ways tend have varying tolerability among While several are standard severe disease, mechanical options provide alternate modalities that balance efficacy comfort. Newer target causes DED, utilizing novel delivery methods minimize irritation adverse events. Here, we review approved treating compare patient tolerability.

Language: Английский

Citations

3
Recommendations for nutritional supplements for dry eye disease: current advances DOI Creative Commons

Ying Cong,

Yibing Zhang,

Yutong Han

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact oral supplements, varying composition dosage, on symptoms DED. main components these supplements include fish oils (Omega-3 acids), vitamins, trace elements, phytochemical extracts. Beyond well-known nutrients, it necessary explore whether novel nutrients might contribute more management. This review provides comprehensive update therapeutic potential presents new perspectives combination treatment.

Language: Английский

Citations

2