Biosurface and Biotribology,
Journal Year:
2015,
Volume and Issue:
1(3), P. 161 - 176
Published: Aug. 29, 2015
Multiple
biological,
synthetic
and
hybrid
polymers
are
used
for
multiple
medical
applications.
A
wide
range
of
different
is
available,
they
have
further
the
advantage
to
be
tunable
in
physical,
chemical
biological
properties
a
match
requirements
specific
This
review
gives
brief
overview
about
introduction
developments
medicine
general,
addressing
first
stable
polymers,
then
with
degradability
as
function,
followed
by
various
other
functional
responsive
polymers.
It
shown
up
that
biomedical
comprise
not
only
bulk
materials,
but
also
coatings
pharmaceutical
nano-carriers
drugs.
There
subsequently
an
most
frequently
polymer
classes.
The
main
body
structured
according
applications,
where
key
applications
currently
solutions
indicated.
Scientia Pharmaceutica,
Journal Year:
2019,
Volume and Issue:
87(3), P. 20 - 20
Published: Aug. 9, 2019
Microparticles,
microspheres,
and
microcapsules
are
widely
used
constituents
of
multiparticulate
drug
delivery
systems,
offering
both
therapeutic
technological
advantages.
Microparticles
generally
in
the
1–1000
µm
size
range,
serve
as
multiunit
systems
with
well-defined
physiological
pharmacokinetic
benefits
order
to
improve
effectiveness,
tolerability,
patient
compliance.
This
paper
reviews
their
evolution,
significance,
formulation
factors
(excipients
procedures),
well
most
important
practical
applications
(inhaled
insulin,
liposomal
preparations).
The
article
presents
structures
microparticles
(microspheres,
microcapsules,
coated
pellets,
etc.),
interpreted
microscopic
images
too.
significant
production
processes
(spray
drying,
extrusion,
coacervation,
freeze-drying,
microfluidics),
release
mechanisms,
commonly
excipients,
characterization,
novel
(microbubbles,
microsponges),
preparations
therapy
discussed
detail.
Frontiers in Pharmacology,
Journal Year:
2016,
Volume and Issue:
7
Published: June 28, 2016
Poly(lactic-co-glycolic
acid)
(PLGA)
is
the
most
widely
used
biomaterial
for
microencapsulation
and
prolonged
delivery
of
therapeutic
drugs,
proteins
antigens.
PLGA
has
excellent
biodegradability
biocompatibility
generally
recognized
as
safe
by
international
regulatory
agencies
including
United
States
Food
Drug
Administration
European
Medicines
Agency.
The
physicochemical
properties
may
be
varied
systematically
changing
ratio
lactic
acid
to
glycolic
acid.
This
in
turn
alters
release
rate
microencapsulated
molecules
from
microparticle
formulations.
obstacles
hindering
more
widespread
use
producing
sustained-release
formulations
clinical
include
low
drug
loading,
particularly
hydrophilic
small
molecules,
high
initial
burst
and/or
poor
formulation
stability.
In
this
review,
we
address
strategies
aimed
at
overcoming
these
challenges.
These
low-temperature
double-emulsion
methods
increase
drug-loading
particles
with
a
volume
inner
water
phase
suitable
pH
external
phase.
Newer
loading
desired
profiles
fabrication
multi-layered
microparticles,
nanoparticles-in-microparticles,
hydrogel
templates,
well
coaxial
electrospray,
microfluidics
supercritical
carbon
dioxide
methods.
Another
recent
strategy
promise
well-controlled
reproducible
involves
complexation
additives
such
polyethylene
glycol,
poly(ortho
esters),
chitosan,
alginate,
caffeic
acid,
hyaluronic
silicon
dioxide.
Advanced Healthcare Materials,
Journal Year:
2017,
Volume and Issue:
7(1)
Published: Nov. 24, 2017
Abstract
Poly(lactic‐
co
‐glycolic)
acid
(PLGA)
is
one
of
the
most
versatile
biomedical
polymers,
already
approved
by
regulatory
authorities
to
be
used
in
human
research
and
clinics.
Due
its
valuable
characteristics,
PLGA
can
tailored
acquire
desirable
features
for
control
bioactive
payload
or
scaffold
matrix.
Moreover,
chemical
modification
with
other
polymers
bioconjugation
molecules
may
render
functional
properties
that
make
it
Holy
Grail
among
synthetic
applied
field.
In
this
review,
physical–chemical
PLGA,
synthesis,
degradation,
conjugation
are
revised
detail,
as
well
applications
drug
delivery
regeneration
fields.
A
particular
focus
given
successful
examples
products
on
market
at
late
stages
trials,
reinforcing
potential
polymer
Progress in Biomaterials,
Journal Year:
2020,
Volume and Issue:
9(4), P. 153 - 174
Published: Oct. 15, 2020
Abstract
Polymeric
microparticles
(MPs)
are
recognized
as
very
popular
carriers
to
increase
the
bioavailability
and
bio-distribution
of
both
lipophilic
hydrophilic
drugs.
Among
different
kinds
polymers,
poly-(lactic-
co
-glycolic
acid)
(PLGA)
is
one
most
accepted
materials
for
this
purpose,
because
its
biodegradability
(due
presence
ester
linkages
that
degraded
by
hydrolysis
in
aqueous
environments)
safety
(PLGA
a
Food
Drug
Administration
(FDA)-approved
compound).
Moreover,
depends
on
number
glycolide
units
present
structure,
indeed,
lower
glycol
content
results
an
increased
degradation
time
conversely
higher
monomer
unit
decreased
time.
Due
feature,
it
possible
design
fabricate
MPs
with
programmable
time-controlled
drug
release.
Many
approaches
procedures
can
be
used
prepare
MPs.
The
chosen
fabrication
methodology
influences
size,
stability,
entrapment
efficiency,
release
kinetics.
For
example,
drugs
chemotherapeutic
agents
(doxorubicin),
anti-inflammatory
non-steroidal
(indomethacin),
nutraceuticals
(curcumin)
were
successfully
encapsulated
prepared
single
emulsion
technique,
while
water-soluble
compounds,
such
aptamer,
peptides
proteins,
involved
use
double
systems
provide
compartment
prevent
molecular
degradation.
purpose
review
overview
about
preparation
characterization
drug-loaded
PLGA
obtained
single,
microfluidic
techniques,
their
current
applications
pharmaceutical
industry.
Graphic
abstract
