Heliyon,
Journal Year:
2020,
Volume and Issue:
6(2), P. e03451 - e03451
Published: Feb. 1, 2020
Poly
(lactic-co-glycolic
acid)
has
received
much
academic
attention
for
developing
nanotherapeutics
and
FDA
approved
it
several
applications.
An
important
parameter
that
dictates
the
bioavailability
hence
biological
effect
of
drug
is
release
from
its
delivering
system.
This
study
offers
a
comparative
mathematical
analysis
acid)-based
nanoparticles
to
suggest
general
model
explaining
multi-mechanistic
they
provide.Eight
models,
zero
order,
first
Higuchi,
Hixson-Crowell,
square
root
mass,
three-second
Weibull
Korsmeyer-Peppas,
as
well
second
degree
polynomial
equation
were
applied
60
data
sets.
The
models
analysed
regarding
types
errors,
regression
parameters
average
Akaike
information
criterion.Most
sets
present
highest
R2,
lowest
overall
error
AIC
model.
with
mean
=
-36.37
OE
7.24
NE
less
than
5,
10,
15
20
%
in
most
cases
best
fits
various
PLGA-based
delivery
systems
are
studied.
seems
show
enough
flexibility
describe
patterns
PLGA
provides.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2020,
Volume and Issue:
8
Published: Feb. 11, 2020
Polymeric
biomaterials
have
found
widespread
applications
in
nanomedicine,
and
PLGA
particular
has
been
successfully
implemented
numerous
drug
delivery
formulations
due
to
its
synthetic
malleability
biocompatibility.
However,
the
need
for
preconception
these
is
increasing,
this
can
be
achieved
by
selection
elimination
of
design
variables
order
systems
tailored
their
specific
applications.
The
starting
materials
preparation
methods
shown
influence
various
parameters
PLGA-based
nanocarriers
implementation
systems,
while
computational
simulations
as
a
component
formulation
studies
provide
valuable
information
on
characteristics.
This
review
provides
critical
summary
synthesis
bio-medicine
outlines
experimental
considerations
systems.
Small,
Journal Year:
2018,
Volume and Issue:
14(28)
Published: May 27, 2018
Abstract
Biodegradable
transient
devices
represent
an
emerging
type
of
electronics
that
could
play
essential
role
in
medical
therapeutic/diagnostic
processes,
such
as
wound
healing
and
tissue
regeneration.
The
associated
biodegradable
power
sources,
however,
remain
a
major
challenge
toward
future
clinical
applications,
the
demonstrated
electrical
stimulation
sensing
functions
are
limited
by
wired
external
or
wireless
energy
harvesters
via
near‐field
coupling.
Here,
materials'
strategies
fabrication
schemes
enable
high‐performance
fully
magnesium–molybdenum
trioxide
battery
alternative
approach
for
vivo
on‐board
supply
reported.
can
deliver
stable
high
output
voltage
well
prolonged
lifetime
satisfy
requirements
representative
implantable
electronics.
is
demonstrates
desirable
biocompatibility.
system
provides
promising
solution
to
advanced
self‐powered
bioresorbable
implants
eco‐friendly
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(16), P. 8884 - 8884
Published: Aug. 18, 2021
Over
the
past
few
decades,
long
acting
injectable
(LAI)
depots
of
polylactide-co-glycolide
(PLGA)
or
polylactic
acid
(PLA)
based
microspheres
have
been
developed
for
controlled
drug
delivery
to
reduce
dosing
frequency
and
improve
therapeutic
effects.
Biopharmaceuticals
such
as
proteins
peptides
are
encapsulated
in
increase
their
bioavailability
provide
a
release
period
(days
months)
with
constant
plasma
concentration.
The
biodegradable
biocompatible
properties
PLGA/PLA
polymers,
including
but
not
limited
molecular
weight,
end
group,
lactide
glycolide
ratio,
minor
manufacturing
changes,
could
greatly
affect
quality
attributes
microsphere
formulations
profile,
size,
encapsulation
efficiency,
bioactivity
biopharmaceuticals.
Besides,
proteins/peptides
susceptible
harsh
processing
conditions
associated
fabrication
methods,
exposure
organic
solvent,
shear
stress,
temperature
fluctuations.
protein/peptide
containing
LAI
clinical
use
is
typically
prepared
by
double
emulsion,
coacervation,
spray
drying
techniques.
purpose
this
review
an
overview
formulation
conventional
techniques
that
currently
protein/peptides.
Furthermore,
physicochemical
characteristics
deliberated.
Drug Delivery,
Journal Year:
2021,
Volume and Issue:
28(1), P. 1342 - 1355
Published: Jan. 1, 2021
Poly(lactic-co-glycolic
acid)
(PLGA)
has
garnered
increasing
attention
as
a
candidate
drug
delivery
polymer
owing
to
its
favorable
properties,
including
excellent
biocompatibility,
biodegradability,
non-toxicity,
non-immunogenicity,
and
mechanical
strength.
PLAG
are
specifically
used
microspheres
for
the
sustained/controlled
targeted
of
hydrophilic
or
hydrophobic
drugs,
well
biological
therapeutic
macromolecules,
peptide
protein
drugs.
PLGAs
with
different
molecular
weights,
lactic
acid
(LA)/glycolic
(GA)
ratios,
end
groups
exhibit
unique
release
characteristics,
which
is
beneficial
obtaining
diverse
effects.
This
review
aims
analyze
composition
PLGA
microspheres,
understand
manufacturing
process
involved
in
their
production,
from
quality
by
design
perspective.
Additionally,
key
factors
affecting
microsphere
development
explored
principles
synthesis
degradation
interaction
active
Further,
effects
elicited
microcosmic
conditions
on
macroscopic
analyzed.
These
include
variations
organic
phase
(organic
solvent,
PLGA,
concentration),
continuous
(emulsifying
ability),
emulsifying
stage
interaction,
homogenization
parameters),
solidification
(relationship
between
solvent
volatilization
rate
curing
conditions).
The
challenges
achieving
consistency
batches
during
addressed,
production
discussed
potential
solution.
Finally,
critical
attributes
introduced,
may
facilitate
optimization
parameters.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(3), P. 454 - 454
Published: March 17, 2023
In
recent
years,
biodegradable
polymers
have
gained
the
attention
of
many
researchers
for
their
promising
applications,
especially
in
drug
delivery,
due
to
good
biocompatibility
and
designable
degradation
time.
Poly
(lactic-co-glycolic
acid)
(PLGA)
is
a
functional
polymer
made
from
polymerization
lactic
acid
(LA)
glycolic
(GA)
widely
used
pharmaceuticals
medical
engineering
materials
because
its
biocompatibility,
non-toxicity,
plasticity.
The
aim
this
review
illustrate
progress
research
on
PLGA
biomedical
as
well
shortcomings,
provide
some
assistance
future
development.
Technology in Cancer Research & Treatment,
Journal Year:
2023,
Volume and Issue:
22
Published: Jan. 1, 2023
Cancer
is
recognized
as
one
of
the
world's
deadliest
diseases,
with
more
than
10
million
new
cases
each
year.
Over
past
2
decades,
several
studies
have
been
performed
on
cancer
to
pursue
solutions
for
effective
treatment.
One
vital
benefits
utilizing
nanoparticles
(NPs)
in
treatment
their
high
adaptability
modification
and
amalgamation
different
physicochemical
properties
boost
anti-cancer
activity.
Various
nanomaterials
designed
nanocarriers
attributing
nontoxic
biocompatible
drug
delivery
systems
improved
bioactivity.
The
present
review
article
briefly
explained
various
types
nanocarriers,
such
organic-inorganic-hybrid
NPs,
targeting
mechanisms.
Here
a
special
focus
given
synthesis,
benefits,
applications
polymeric
NPs
(PNPs)
involved
therapeutics.
It
has
also
discussed
about
approach
by
functionalized/encapsulated
PNPs
(without/with
ability)
that
are
being
applied
therapy
diagnostic
(theranostics).
Overall,
this
can
give
glimpse
into
every
aspect
PNPs,
from
synthesis
application
cells.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 16, 2023
Nanoparticle
drug
delivery
systems
have
proved
anti-tumor
effects;
however,
they
are
not
widely
used
in
tumor
therapy
due
to
insufficient
ability
target
specific
sites,
multidrug
resistance
drugs,
and
the
high
toxicity
of
drugs.
With
development
RNAi
technology,
nucleic
acids
been
delivered
sites
replace
or
correct
defective
genes
knock
down
genes.
Also,
synergistic
therapeutic
effects
can
be
achieved
for
combined
delivery,
which
is
more
effective
overcoming
cancer
cells.
These
combination
therapies
achieve
better
than
delivering
chemotherapeutic
drugs
alone,
so
scope
has
also
expanded
three
aspects:
drug-drug,
drug-gene,
gene-gene.
This
review
summarizes
recent
advances
nanocarriers
co-delivery
agents,
including
i)
characterization
preparation
nanocarriers,
such
as
lipid-based
polymer
inorganic
carriers;
ii)
advantages
disadvantages
approaches;
iii)
effectual
cases
that
applied
systems;
iv)
future
perspectives
design
nanoparticle
co-deliver
agents.
