PLGA nanoparticles for nasal drug delivery DOI Creative Commons

Salah Alghareeb,

Kofi Asare‐Addo, Barbara R. Conway

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105564 - 105564

Published: March 12, 2024

The nasal route has routinely been used in the local delivery of drugs, however with innovations nanotechnology, there increased interest exploring this more for systemic, and brain/CNS delivery. This is because safe, non-invasive, medications can be self-administered to achieve rapid therapeutic drug levels minimal doses. Polymeric nanoparticles (NPs) such as PLGA NPs have a wide range applications delivery, due their large surface area modification targeting ligands polymers which enhances cellular uptake, bioavailability at target sites. review covers recent research on use small molecule drugs macromolecules via route. It some background information about challenges delivering most common polymer coatings are highlighted. Finally, patents clinical trials also covered.

Language: Английский

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects DOI Creative Commons
Belén Begines, Tamara Ortíz, María Pérez‐Aranda

et al.

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(7), P. 1403 - 1403

Published: July 19, 2020

The complexity of some diseases-as well as the inherent toxicity certain drugs-has led to an increasing interest in development and optimization drug-delivery systems. Polymeric nanoparticles stand out a key tool improve drug bioavailability or specific delivery at site action. versatility polymers makes them potentially ideal for fulfilling requirements each particular system. In this review, summary state-of-the-art panorama polymeric systems has been conducted, focusing mainly on those applications which corresponding disease involves important morbidity, considerable reduction life quality patients-or even high mortality. A revision use ocular delivery, cancer diagnosis treatment, nutraceutical was carried out, short discussion about future prospects these is included.

Language: Английский

Citations

707
PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application DOI Creative Commons
Yue Su, Bolun Zhang, Ruowei Sun

et al.

Drug Delivery, Journal Year: 2021, Volume and Issue: 28(1), P. 1397 - 1418

Published: Jan. 1, 2021

Biodegradable microspheres have been widely used in the field of medicine due to their ability deliver drug molecules various properties through multiple pathways and advantages low dose side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one most biodegradable material currently has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid glycolic can be selected according requirements release rate. PLGA-based studied delivery, including delivery anticancer drugs, protein or peptide bacterial viral DNA, etc. This review describes basic knowledge current situation discusses selection polymer materials. Then, preparation methods are introduced, emulsification, microfluidic technology, electrospray, spray drying. Finally, this summarizes application treatment pulmonary ocular-related diseases.

Language: Английский

Citations

371
Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles DOI
Ranjit De, Manoj Kumar Mahata, Kyong‐Tai Kim

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Feb. 3, 2022

Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to but also subcellular organelles. Variety natural sources, availability different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, biodegradability presented polymers one the most desired materials for nanocarrier design. Recent innovative concepts advances PNC-associated nanotechnology providing unprecedented opportunities engineer their functions. The efficiency therapeutic loading has got considerably increased. Structural design-based varieties PNCs widely employed delivery small molecules genes, proteins. gained ever-increasing attention certainly paves way develop advanced nanomedicines. This article presents a comprehensive investigation structural influences properties on drug profiles with perspectives highlighting inevitability incorporating both multi-stimuli-responsive multi-drug single carrier design intelligent new emerging research directions this rapidly developing area.

Language: Английский

Citations

163
Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology DOI
Cátia Domingues, Ana Cláudia Paiva‐Santos, Carmen Alvarez‐Lorenzo

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041

Published: June 22, 2022

Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.

Language: Английский

Citations

129
Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance DOI Creative Commons
M. Mustafa Mamun, Adeola Julian Sorinolu, Mariya Munir

et al.

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: May 13, 2021

One primary mechanism for bacteria developing resistance is frequent exposure to antibiotics. Nanoantibiotics (nAbts) one of the strategies being explored counteract surge antibiotic resistant bacteria. nAbts are molecules encapsulated with engineered nanoparticles (NPs) or artificially synthesized pure antibiotics a size range ≤100 nm in at least dimension. NPs may restore drug efficacy because their nanoscale functionalities. As carriers and delivery agents, can reach target sites inside bacterium by crossing cell membrane, interfering cellular components, damaging metabolic machinery. Nanoscale systems deliver enormous particle number concentrations. The unique size-, shape-, composition-related properties pose multiple simultaneous assaults on Resistance toward diverse conjugates considerably slower generate non-biological adverse effects. physically break down interfere critical used bacterial processes. Genetic mutations from abiotic assault exerted less probable. This paper discusses how exploit fundamental physical chemical conventional We first described concept explained importance. then summarized physicochemical that be utilized manufacturing designing various types. epitomize potential Trojan horse strategy circumvent mechanisms. availability types targets increasing due advances nanotechnology. Studying functions provide an understanding preventing future outbreaks caused successful nAbts.

Language: Английский

Citations

109
Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines DOI Creative Commons
Mazen M. El‐Hammadi, José L. Arias

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(3), P. 354 - 354

Published: Jan. 22, 2022

Therapeutics are habitually characterized by short plasma half-lives and little affinity for targeted cells. To overcome these challenges, nanoparticulate systems have entered into the disease arena. Poly(d,l-lactide-

Language: Английский

Citations

80
Design of experiments in the optimization of nanoparticle-based drug delivery systems DOI
Riccardo Rampado, Dan Peer

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 398 - 419

Published: May 12, 2023

Language: Английский

Citations

57
Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents DOI
Talib M. Albayati, Saja Mohsen Alardhi,

Ali H. Khalbas

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(23)

Published: June 18, 2024

Abstract Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence toxicity cells, loading therapeutic agents, release active ions during hemostasis process. Therefore, understanding fundamentals tuning these is important design types carriers. While several literature reviews explored role MSNs control, comprehensive studies focusing on general specific applications remain scarce. This review concentrates principles synthesizing silica, MSNs, techniques for drugs methods onto site injury, kinetics models, biocompatibility, toxicity, unique properties MSNs. Furthermore, article examines mechanism action nanomaterial hemostatic agents.

Language: Английский

Citations

28
Fabrication of polymeric microspheres for biomedical applications DOI
Xuebing Li,

Luohuizi Li,

Dehui Wang

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(12), P. 2820 - 2855

Published: Jan. 1, 2024

A systematic summary of fabrication technologies, a variety structures and biomedical applications polymeric microspheres.

Language: Английский

Citations

23
Extracellular Matrix‐Bioinspired Anisotropic Topographical Cues of Electrospun Nanofibers: A Strategy of Wound Healing through Macrophage Polarization DOI

Hyeonseo Park,

Tejal V. Patil, Sayan Deb Dutta

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 31, 2024

Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.

Language: Английский

Citations

22