Genetic Parameter Estimates for Carcass and Meat Quality Traits and Their Genetic Associations With Sexual Precocity Indicator Traits in Nellore Cattle

Journal of Animal Breeding and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

ABSTRACT For developing beef cattle breeding programmes, it is essential to understand the genetic basis of economically relevant traits, such as carcass, meat quality and female sexual precocity. However, direct selection most these traits a challenge for producers because high cost measurement difficulty. Genetic correlation estimates between carcass obtained after slaughter precocity indicator in Nellore are limited literature. Thus, this study aimed estimate parameters longissimus muscle area (LMA), backfat thickness (BF), hot weight (HCW), shear force tenderness (SF), marbling score (MARB), intramuscular fat content (IMF), age at first calving (AFC), heifer pregnancy (HP) scrotal circumference (SC) cattle, using pedigree genomic information. this, data from 6910 young bulls with phenotypic information 230,682 17,850 animals genotyped or imputed Illumina Bovine HD BeadChip were used. The (co)variance components estimated considering BLUP single‐step GBLUP (ssGBLUP) models via Bayesian inference GIBBSF90+ software. multi‐trait animal model included additive residual effects random; fixed contemporary group (for all traits) date analysis classes BF, SF MARB); linear (all yearling (YW SC) covariates. Heritability ranged 0.13 0.34 SC, AFC HP, 0.33, 0.07 0.29, respectively. Favourable correlations YW‐HCW (0.79 ± 0.03), YW‐LMA (0.28 0.05), YW‐SC (0.35 HCW‐LMA (0.44 HCW‐SF (−0.22 0.09), HCW‐SC (0.19 MARB‐IMF (0.90 0.07), SF‐IMF (−0.20 0.11), BF‐MARB (0.29 0.08), BF‐IMF (0.22 BF‐AFC (−0.21 0.07) BF‐HP (0.24 0.10). In general, those low moderate. Additionally, did not exhibit strong indicators. So, achieve significant advances composition quality, must compose indices cattle.

Language: Английский

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Main regulatory factors of marbling level in beef cattle

Veterinary and Animal Science, Journal Year: 2021, Volume and Issue: 14, P. 100219 - 100219

Published: Nov. 21, 2021

The content of intramuscular fat (IMF), that determines marbling levels is considered as one the vital factors influencing beef sensory quality including tenderness, juiciness, flavour and colour. IMF formation in cattle commences around six months after conception, continuously grows throughout life animal. accumulation remarkably affected by genetic, sexual, nutritional management factors. In this review, adipogenesis lipogenesis process regulated various genes during fetal growing stages briefly presented. We also discuss findings recent studies on effects breed, gene, heritability gender accumulation. Various research reported feeding pregnancy, concentrate to roughage ratios supplementation or restriction vitamin A, C, D are crucial affecting development IMF. Castration early weaning combined with high energy effective strategies for improving Furthermore, age weight at slaughter reviewed because they have significant levels. combination several could positively affect improvement deposition. Therefore, advanced simultaneously apply achieve desired without detrimental impacts feed efficiency high-marbling production essential.

Language: Английский

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Genome-wide association study for carcass weight in pasture-finished beef cattle in Hawai’i

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: May 9, 2023

Introduction: Genome-wide association studies (GWAS) have identified genetic markers for cattle production and reproduction traits. Several publications reported Single Nucleotide Polymorphisms (SNPs) carcass-related traits in cattle, but these were rarely conducted pasture-finished beef cattle. Hawai'i, however, has a diverse climate, 100% of its are pasture-fed. Methods: Blood samples collected from 400 raised Hawai'i islands at the commercial harvest facility. Genomic DNA was isolated, 352 high-quality genotyped using Neogen GGP Bovine 100 K BeadChip. SNPs that did not meet quality control standards removed PLINK 1.9, 85 k 351 used mapping with carcass weight GAPIT (Version 3.0) R 4.2. Four models GWAS analysis: General Linear Model (GLM), Mixed (MLM), Fixed Random Circulating Probability Unification (FarmCPU), Bayesian-Information Linkage-Disequilibrium Iteratively Nested Keyway (BLINK). Results Discussion: Our results indicated two multi-locus models, FarmCPU BLINK, outperformed single-locus GLM MLM, herds this study. Specifically, five significant FarmCPU, while BLINK each other three. Also, three eleven ("BTA-40510-no-rs", "BovineHD1400006853", "BovineHD2100020346") shared by multiple models. The mapped to genes such as EIF5, RGS20, TCEA1, LYPLA1, MRPL15, which previously be associated traits, growth, feed intake several tropical breeds. This confirms study could candidate pasture-fed can selected further breeding programs improve yield productivity beyond.

Language: Английский

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Genomic signatures of selection, local adaptation and production type characterisation of East Adriatic sheep breeds

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 6, 2023

The importance of sheep breeding in the Mediterranean part eastern Adriatic has a long tradition since its arrival during Neolithic migrations. Sheep production system is extensive and generally carried out traditional systems without intensive systematic programmes for high uniform trait (carcass, wool milk yield). Therefore, eight indigenous Croatian breeds from treated here as metapopulation (EAS), are considered multipurpose (milk, meat wool), not specialised particular type production, but known their robustness resistance to certain environmental conditions. Our objective was identify genomic regions genes that exhibit patterns positive selection signatures, decipher biological productive functionality, provide "genomic" characterization EAS adaptation determine type.We identified signatures using several methods based on reduced local variation, linkage disequilibrium site frequency spectrum (eROHi, iHS, nSL CLR). analyses numerous (e.g., desmosomal cadherin desmoglein gene families) associated with economically important traits. Most candidate were related meat/production health/immune response traits, while some discovered domestication evolutionary processes HOXa family FSIP2). These results also confirmed by GO QTL enrichment analysis.Our contribute better understanding unique adaptive genetic architecture define type, ultimately providing new opportunity future programmes. At same time, will improve our ruminant (sheep) harsh specific environment.

Language: Английский

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Applying the algorithm for Proven and young in GWAS Reveals high polygenicity for key traits in Nellore cattle

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Background Identifying genomic regions associated with traits of interest and their biological processes provides valuable insights into the phenotypic variability these traits. This study aimed to identify candidate genes 16 currently evaluated by Brazilian Association Zebu Breeders (ABCZ). These include reproductive such as age at first calving (AFC), stayability (STAY), scrotal circumference 365 (SC365) 450 days (SC450). Growth birthweight (BW), expected progeny difference for weight 120days (EPD120), well 120 (W120), 210 (W210), (W365), (W450). Carcass body conformation (BC), finishing score (FS), marbling (MARB), muscularity (MUSC), precocity (FP), ribeye area (REA). Methods A dataset containing 304,782 Nellore cattle genotyped 437,650 SNPs (after quality control) was used this study. The Algorithm Proven Young (APY), implemented in PREGSF90 software, compute GAPY−1 matrix using 36,000 core animals (which explained 98% variance matrix). Subsequently, SNP solutions were estimated back-solving Genomic Estimated Breeding Values (GEBVs) predicted ABCZ single-step GBLUP method. identified sliding windows 175 consecutive SNPs, top 1% windows, ranked based on proportion additive genetic variance, annotate positional each Results all between 2.779% (STAY) 3.158% (FP) highlighting polygenic nature Functional analysis provided architecture underlying cattle. For instance, our results revealed important functions trait, SERPINA14 (plays a key role endometrial epithelium) AFC, HSPG2 (associated morphological development tissue differentiation) BW, among others. Conclusion We genes, some which have been previously reported literature, while others are novel discoveries that warrant further investigation. findings contribute gene prioritization efforts, facilitating identification functional can enhance selection strategies economically

Language: Английский

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Establishment of a repertoire of fertility associated sperm proteins and their differential abundance in buffalo bulls (Bubalus bubalis) with contrasting fertility

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 8, 2023

Abstract Sperm harbours a wide range of proteins regulating their functions and fertility. In the present study, we made an effort to characterize quantify proteome buffalo bull spermatozoa, identify fertility associated sperm through comparative proteomics. Using high-throughput mass spectrometry platform, identified 1305 from spermatozoa found that these were mostly enriched in glycolytic process, mitochondrial respiratory chain, tricarboxylic acid cycle, protein folding, spermatogenesis, motility binding zona pellucida (p < 7.74E−08) besides metabolic = 4.42E−31) reactive oxygen species 1.81E−30) pathways. Differential proteomic analysis revealed 844 commonly expressed both groups while 77 52 exclusively high- low-fertile bulls, respectively. 75 significantly 0.05) upregulated 176 downregulated; highly chain complex I assembly 2.63E−07) flagellated 7.02E−05) processes oxidative phosphorylation pathway 6.61E−15). The down regulated bulls involved motility, metabolism, sperm-egg recognition fertilization. These variations could be used as potential markers for selection

Language: Английский

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Genetic architecture of a composite beef cattle population

Journal of Animal Science, Journal Year: 2022, Volume and Issue: 100(9)

Published: June 30, 2022

Composite breeds are widely used in the beef industry. Composites allow producers to combine desirable traits from progenitor and simplify herd management, without repeated crossbreeding maintenance of purebreds. In this study, genomic information was evaluate genetic composition characteristics a three-breed cattle composite. This composite population referred as Gene Combination (CGC) consisted 50% Red Angus, 25% Charolais, Tarentaise. A total 248 animals were study: CGC (n = 79), Angus 61), Charolais Tarentaise 29). All genotyped with 777k HD panel. Principal component ADMIXTURE analyses carried out structure animals. The revealed proportion increased approximately 57%, whereas decreased 5% 38% across generations. To these changes different generations, runs homozygosity (ROH) conducted. analysis showed have highest length ROH segments per animal mean 349.92 Mb lowest 141.10 Mb. Furthermore, it formation new haplotypes around sixth generation. Selection signatures evaluated through Fst HapFlk analyses. Several selection sweeps identified especially chromosomes 5 14 which previously been reported be associated coat color growth traits. study supports our previous findings that combinations not stable over generations either direct or natural plays role modifying proportions. results contributed useful attributes cool semi-arid environment suggests re-exploration breed's may warranted.Composite commonly U.S. industry since they provide benefits such breed complementarity retained heterosis. However, genomes well characterized. Therefore, (50% Tarentaise). an increase 38%. genome formed These show proportions environment.

Language: Английский

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Assessment of Genomic Diversity and Selective Pressures in Crossbred Dairy Cattle of Pakistan

Biochemical Genetics, Journal Year: 2024, Volume and Issue: 62(5), P. 4137 - 4156

Published: April 25, 2024

Language: Английский

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Genome-Wide Detection of Copy Number Variations and Their Potential Association with Carcass and Meat Quality Traits in Pingliang Red Cattle

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5626 - 5626

Published: May 22, 2024

Copy number variation (CNV) serves as a significant source of genetic diversity in mammals and exerts substantial effects on various complex traits. Pingliang red cattle, an outstanding indigenous resource China, possess remarkable breeding value attributed to their tender meat superior marbling quality. However, the mechanisms influencing carcass quality traits cattle are not well understood. We generated comprehensive genome-wide CNV map for using GGP Bovine 100K SNP chip. A total 755 copy variable regions (CNVRs) spanning 81.03 Mb were identified, accounting approximately 3.24% bovine autosomal genome. Among these, we discovered 270 potentially breed-specific CNVRs including 143 gains, 73 losses, 54 mixed events. Functional annotation analysis revealed associations between these specific important such quality, reproduction, exterior traits, growth health Additionally, our network transcriptome highlighted CACNA2D1, CYLD, UBXN2B, TG, NADK, ITGA9 promising candidate genes associated with weight intramuscular fat deposition. The current study presents highlighting CNVRs, findings provide valuable insights into underlying characteristics cattle. These results offer potential avenues enhancing through targeted program.

Language: Английский

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Muscle allele-specific expression QTLs may affect meat quality traits in Bos indicus

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: April 1, 2021

Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specific expression (ASE SNPs) were previously identified the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting 190 steers. Given that pattern may result from cis-regulatory SNPs, called quantitative trait loci (aseQTLs), this study, we searched for aseQTLs window 1 Mb upstream and downstream each ASE SNP. After initial analysis, aiming to investigate variants with potential regulatory role, further screened our aseQTL data sequence similarity transcription factor binding sites microRNA (miRNA) sites. These overlapped methylation reduced representation bisulfite sequencing (RRBS) obtained 12 animals same population. We 1134 associated 126 different SNPs. For 215 aseQTLs, one allele potentially affected affinity muscle-expressed its site. 162 predicted affect 149 miRNA sites, which 114 miRNAs expressed muscle. Also, 16 methylated Integration GWAS revealed enrichment traits such as meat tenderness, ribeye area, intramuscular fat . To knowledge, is first report identification bovine Our findings indicate various epigenetic mechanisms can multiple modulate allelic expression. Some described here genes related interesting phenotypes livestock. Thus, these might be useful comprehension genetic control phenotypes.

Language: Английский

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