An observational multi-center study on type 2 diabetes treatment prescribing pattern and patient adherence to treatment DOI Creative Commons
Muhammad Daoud Butt, Siew Chin Ong,

Azra Rafiq

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 27, 2023

Abstract In 2021, the International Diabetes Federation (IDF) reported that prevalence of diabetes in Pakistan was 9.6%, higher than global average. However, adherence to treatment guidelines, e.g., American Association and Endocrine Society prescription patterns for Oral anti-diabetes (OAD), is poorly understood Pakistan. Therefore, this study aimed examine prescribing practices anti-diabetic medications, an association lifestyle modification with drugs prescribed, their effectiveness preserving ideal glycemic levels diabetic patients undergoing tertiary care teaching hospitals rural urban cross-sectional study, data were collected from prescriptions outpatient different between October 2021 February 2022. 388 participants enrolled a detailed interview on evaluation control. The coinvestigators conducted patient used pre-validated questionnaire collect data. relationship following guidelines clinical demographic factors found using chi-square tests bivariate analyses. out 388, mean ages 48 ± 12.4, majority female. It observed 60.1% 66.5% have uncontrolled fasting random blood glucose, respectively. education level also below par complete understanding medical condition self-management therapy. Even though they taking right medications—an average regimen included 5.08 medications—52.1% studied people had glycated haemoglobin (HbA1c) therapeutic threshold set by Federation. modern era, it trend still focused traditional options Biguanides, sulfonylureas, dipeptidyl peptidase-4 inhibitors prescribed 64.6% patients. A significant control body mass index, modifications, number medications (p-value < 0.05). reveals Pakistan's do not align international national leading high widespread use polypharmacy among To address issue, policymakers should prioritize establishing comprehensive action plan. Additionally, there pressing need develop awareness programs emphasizing importance modifications effective management.

Language: Английский

Amylin, Another Important Neuroendocrine Hormone for the Treatment of Diabesity DOI Open Access

Stjepan Eržen,

Gašper Tonin, Dubravka Jurišić‐Eržen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1517 - 1517

Published: Jan. 26, 2024

Diabetes mellitus is a devastating chronic metabolic disease. Since the majority of type 2 diabetes patients are overweight or obese, novel term-diabesity-has emerged. The gut-brain axis plays critical function in maintaining glucose and energy homeostasis involves variety peptides. Amylin neuroendocrine anorexigenic polypeptide hormone, which co-secreted with insulin from β-cells pancreas response to food consumption. Aside its effect on homeostasis, amylin inhibits homeostatic hedonic feeding, induces satiety, decreases body weight. In this narrative review, we summarized current evidence ongoing studies mechanism action, clinical pharmacology, applications analogs, pramlintide cagrilintide, field diabetology, endocrinology, metabolism disorders, such as obesity.

Language: Английский

Citations

13
Inequalities in the provision of GLP-1 receptor agonists for the treatment of obesity DOI
Stephanie W. Waldrop, Veronica R. Johnson, Fatima Cody Stanford

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(1), P. 22 - 25

Published: Jan. 1, 2024

Language: Английский

Citations

11
Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now DOI Open Access
Joseph M Pappachan, Cornelius James Fernandez, Ambika P. Ashraf

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(5), P. 797 - 809

Published: May 10, 2024

Childhood-onset obesity has emerged as a major public healthcare challenge across the globe, fueled by an obesogenic environment and influenced both genetic epigenetic predispositions. This led to exponential rise in incidence of type 2 diabetes mellitus children adolescents. The looming wave diabetes-related complications early adulthood is anticipated strain budgets most countries. Unless there collective global effort curb devastation caused situation, impact poised be pro-found. A multifaceted research effort, governmental legislation, effective social action are crucial attaining this goal. article delves into current epidemiological landscape, explores evidence concerning potential risks consequences, pathobiology childhood obesity, discusses latest evidence-based management strategies for diabesity.

Language: Английский

Citations

10
Preoperative duration of type 2 diabetes mellitus and remission after Roux-en-Y gastric bypass: A single center long-term cohort study DOI Creative Commons
Karl Hage, Kamal Abi Mosleh, Jack W. Sample

et al.

International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(10), P. 6214 - 6221

Published: Feb. 9, 2024

Roux-en-Y gastric bypass (RYGB) has demonstrated excellent glycemic control and type 2 diabetes mellitus (T2DM) remission for patients with obesity T2DM. Duration of T2DM is a consistent negative predictor after RYGB. However, the exact timing to offer surgical intervention during course disease not well elucidated.

Language: Английский

Citations

9
EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation—targeting GPR120/PPARγ pathway DOI
Xian Yang, Xudong Li, Manjiang Hu

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 130, P. 109648 - 109648

Published: April 15, 2024

Language: Английский

Citations

9
Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions DOI Creative Commons

G. Martemucci,

Mohamad Khalil, Alessio Di Luca

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 327 - 327

Published: June 11, 2024

Several hallmarks of metabolic syndrome, such as dysregulation in the glucose and lipid metabolism, endothelial dysfunction, insulin resistance, low-to-medium systemic inflammation, intestinal microbiota dysbiosis, represent a pathological bridge between syndrome diabesity, cardiovascular, neurodegenerative disorders. This review aims to highlight some therapeutic strategies against involving integrative approaches improve lifestyle daily diet. The beneficial effects foods containing antioxidant polyphenols, control, physical activity were also considered. We comprehensively examined large body published articles basic, animal, human studie, well recent guidelines. As result, dietary polyphenols from natural plant-based antioxidants adherence Mediterranean diet, along with exercise, are promising complementary therapies delay or prevent onset counteract diabesity cardiovascular diseases, protect disorders cognitive decline. Modulation reduces risks associated MS, improves diabetes diseases (CVD), exerts neuroprotective action. Despite several studies, estimation polyphenol intake is inconclusive requires further evidence. Lifestyle interventions reduced calorie can outcomes.

Language: Английский

Citations

9
Comparative efficacy of sodium glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus: A real-world experience DOI Open Access

Lubna Islam,

Dhanya Jose, Mohammed Alkhalifah

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 463 - 474

Published: March 15, 2024

BACKGROUND Sodium glucose cotransporter-2 inhibitors (SGLT-2i) are a class of drugs with modest antidiabetic efficacy, weight loss effect, and cardiovascular benefits as proven by multiple randomised controlled trials (RCTs). However, real-world data on the comparative efficacy safety individual SGLT-2i medications is sparse. AIM To study using clinical data. METHODS We evaluated 3 (dapagliflozin, canagliflozin, empagliflozin) used for treating patients type 2 diabetes mellitus. Data reduction glycated hemoglobin (HbA1c), body weight, blood pressure (BP), urine albumin creatinine ratio (ACR), adverse effects were recorded retrospectively. RESULTS from 467 median age 64 (14.8) years, 294 (62.96%) males 375 (80.5%) Caucasians analysed. Median duration was 16.0 (9.0) use 3.6 (2.1) years. molecules dapagliflozin 10 mg (n = 227; 48.6%), canagliflozin 300 160; 34.3%), empagliflozin 25 80; 17.1). Baseline (interquartile range) HbA1c in mmol/mol were: - 78.0 (25.3), 80.0 (25.5), 75.0 (23.5) respectively. The respective at 12 months latest review (just prior to study) 66.5 (22.8) & 69.0 (24.0), 67.0 (16.3) 66.0 (28.0), (22.5) (25.8) respectively (P < 0.001 all comparisons baseline). Significant improvements (in kilograms) baseline end noticed 101 (29.5) 92.2 (25.6), 100 (28.3) 95.3 (27.5) only. reductions systolic diastolic BP, 144 (21) mmHg 139 (23) mmHg; 0.015), 82 (16) 78 (19) 0.001) also observed. A significant microalbuminuria observed only [ACR 14.6 (42.6) 8.9 (23.7) end; P 0.043]. Adverse follows: genital thrush urinary infection 20 (8.8%) 17 (7.5%) dapagliflozin; 9 (5.6%) 5 (3.13%) canagliflozin; 4 (5%) empagliflozin. Diabetic ketoacidosis (1.8%) 1 (0.63%) canagliflozin. CONCLUSION Treatment associated statistically HbA1c, better than those reported RCTs, low side effect profiles. large-scale needed inform practice decision making.

Language: Английский

Citations

4
Twenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a randomized clinical trial DOI Creative Commons
Larissa dos Santos Leonel, Ingrid A.V. Wolin, Angélica Danielevicz

et al.

Trials, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Physical exercise is crucial in type 2 diabetes management (T2D), and training the aquatic environment seems to be a promising alternative due its physical properties metabolic, functional, cardiovascular, neuromuscular benefits. Research on combined dry-land environments scarce, especially long-term interventions. Thus, this study aims investigate effects of both health outcomes related T2D patients. This randomized, unicentric, single-blinded, comparator clinical trial with two parallel arms. Participants T2D, sexes, aged at 45 80 years old, will randomized into groups (aquatic (AQUA) (LAND)), performing aerobic resistance three times week alternate days for 24 weeks. Aerobic performed using continuous pyramidal methods, linear intensity duration progression. Intensity prescribed by rated effort perception (Borg scale 6 20). Resistance trunk, upper lower limbs maximum speed, target repetition zone environments, respectively, multiple sets dosage Before, 12 weeks, after weeks training, biochemical analyses, functional capacity, muscle strength, body composition assessments, cardiovascular measures, administration questionnaires assess mental, cognitive, sleep quality, quality life conducted. Throughout load date acute capillary glucose blood pressure measurements also The data analyzed SPSS (29.0) statistical package, significance level 0.05. For intra- inter-group comparisons, generalized estimating equations applied intention-to-treat per-protocol adopting Bonferroni post hoc test. obtained results may provide insights enhance understanding benefits various outcomes, as well aspects safety considerations training. Moreover, could support development intervention strategies optimize management. Brazilian Clinical Trial Registry (ReBEC) RBR-10fwqmfy. Registered April 16, 2024.

Language: Английский

Citations

0
Metabolic bariatric surgery generates substantial, sustained weight loss and health improvement in a real‐world setting DOI Creative Commons
Wendy A. Brown, Dianne Brown, Jennifer Holland

et al.

ANZ Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Background To determine if the positive outcomes from clinical trials regarding safety and efficacy of metabolic bariatric surgery are reproducible at a national level. Methods A longitudinal registry‐based observation study with data collected all persons undergoing in Australia 28 February 2012–31 December 2021 including 122,567 index patients who underwent 134,625 completed procedures. Main Outcomes Measures Defined adverse 90‐days (unplanned readmission, intensive care admission re‐operation; death), annual change weight (percent total body loss (TBWL)), diabetes treatment need for re‐operation. Results 79.0% participants were female. Mean age on day was 44.0 years (SD 11.8; range 12.9‐87.9 years) mean BMI 41.7 kg/m2 7.6). At 5‐years one anastomosis gastric bypass had TBWL 34.88% 8.67%), roux‐en‐Y 30.73 % 9.47%); sleeve gastrectomy 26.5% 10.5%) adjustable bands 17.6% 12.1%). 3.6% procedures recorded defined event. 13,904 (13.6%) primary reported being treated baseline. No medication required by 71.6% (follow‐up 58%) 1‐year 61% 22%) 5‐years. 13 904 Conclusions Metabolic is safe induces substantial reduced medications real‐world. ClinicalTrials.gov ID NCT03441451.

Language: Английский

Citations

0
Diabetes mellitus und Adipositas: Risikooptimierung vor operativen Eingriffen DOI
Stéphan Martin

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

The prevalence of obesity has increased significantly in recent years and is a causal risk factor for the development type 2 diabetes. Moreover, chronic degenerative joint diseases are also triggered by obesity. Both obesity-related secondary diseases-type diabetes disease-can be prevented or at least delayed lifestyle intervention aimed weight reduction. progression these can favourably influenced radical loss. Diets with reduction carbohydrates-a so-called "low-carb" ketogenic diet-appear to superior low-fat diet. If replacement surgery necessary, preoperative perioperative interdisciplinary care team experienced therapists from fields orthopaedics obesity/type required. Düsseldorf TeDia model network Catholic hospitals takes requirements into account providing such patients orthopaedic centre St. Vinzenz Hospital West German Diabetes Health Centre (WDGZ). Patients pronounced mellitus presented preoperatively WDGZ on an outpatient basis, therapy optimization diabetic metabolic situation initiated. problems persist despite changes that require surgery, provides inpatient diabetology clinic option further follow-up care.

Language: Английский

Citations

0