Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(3), P. 101008 - 101008
Published: June 30, 2023
Language: Английский
Cells, Journal Year: 2022, Volume and Issue: 11(2), P. 186 - 186
Published: Jan. 6, 2022
The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated many previous studies. In this study, we discuss the sources vesicles, including plant, salivary and urinary which are easily available but less sought after compared with blood tissue. Extensive research past decade established that breadth EV applications is wide. However, efforts on standardizing isolation purification methods have not brought us to a point can match potential for clinical use. standardization open doors researchers clinicians alike experiment proposed uses lesser concerns regarding untraceable side effects. It make it easier identify mechanism therapeutic benefits track any unforeseen effects observed.
Language: Английский
Citations
94
The Journal of Physiology, Journal Year: 2022, Volume and Issue: 601(22), P. 4853 - 4872
Published: May 16, 2022
Abstract Exosomes are membrane‐bound vesicles that released by most cells. They carry nucleic acids, cytokines, growth factors, proteins, lipids, and metabolites. responsible for inter‐ intracellular communications their role in drug delivery is well defined. have great potential therapeutic applications, but the clinical use restricted because of limitations standardized procedures isolation, purification, delivery. Bioengineering exosomes could be one approach to achieve standardization reproducible isolation use. important transporters targeted small size, stable structure, non‐immunogenicity, non‐toxic nature, as ability a wide variety compounds. These features can enhanced further bioengineering. In this review, possible exosome bioengineering approaches, biomedical discussed. image
Language: Английский
Citations
47
Cells, Journal Year: 2022, Volume and Issue: 11(13), P. 1989 - 1989
Published: June 21, 2022
Extracellular vesicles (EVs) include a heterogeneous group of natural cell-derived nanostructures that are increasingly regarded as promising biotherapeutic agents and drug delivery vehicles in human medicine. Desirable intrinsic properties EVs including the ability to bypass membranous barriers deliver their unique biomolecular cargo specific cell populations position them fiercely competitive alternatives for currently available therapies artificial platforms. with distinct characteristics can be released from various types into extracellular environment means transmitting bioactive components altering status target cell. Despite existence large number preclinical studies confirming therapeutic efficacy different originated treating several pathological conditions, this review, we first provide brief overview EV biophysical an emphasis on benefits over cell-based synthetic systems. Next, describe detail derived sources, compare advantages disadvantages, recapitulate effects disorders highlight progress made harnessing clinical applications. Finally, knowledge gaps concrete hurdles hinder translation debated futuristic perspective.
Language: Английский
Citations
46
Molecular Breeding, Journal Year: 2025, Volume and Issue: 45(2)
Published: Jan. 21, 2025
Language: Английский
Citations
1
Technology in Cancer Research & Treatment, Journal Year: 2021, Volume and Issue: 20
Published: Jan. 1, 2021
Extracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They stable circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. interact with target organs bind to receptors. Their specificity is important use EVs noninvasive diagnostic prognostic tools. play a vital role normal physiology cellular communication. known protect their cargo from degradation, which makes them drug targeted delivery. Using markers tracking path systemic circulation can be revolutionary using We will discuss scope of this paper. Although there limitations isolation storage, high biocompatibility fuel more innovations overcome these challenges.
Language: Английский
Citations
51
Agronomy, Journal Year: 2022, Volume and Issue: 12(10), P. 2248 - 2248
Published: Sept. 20, 2022
The global increase in temperature and associated meteorological disruptions, such as the earlier onset of high temperatures disruptions precipitation, are becoming severely limiting factors crop cultivation. Chickpea, a cool season crop, is under direct influence heat drought stress that not only affecting this its podding stage but, with current climate trends, now also stages, flowering. deteriorating effects droughts include reduced flowering, abortion flowers absence podding; thus, yield. Further research has been conducted to identify genes correlated higher tolerance utilize them developing more tolerant varieties. Different alleviation approaches have tested it determined some positive can be seen supplementation Zn through melioration water relations, seed priming transgenic genome editing approaches. Breeding strategies for future chickpea varieties focused on identification traits an improved yield stressed conditions. In review, we reviewed recent biotechnological used crops address two major abiotic stresses (heat drought) linked change.
Language: Английский
Citations
16
International Journal of Stem cell Research & Therapy, Journal Year: 2023, Volume and Issue: 10(1)
Published: July 7, 2023
Exosomes are small membrane-bound vesicles that released by various types of cells, including cancer and play a role in intercellular communication. CD9 is protein involved cell signaling adhesion. It found on the surface has been implicated communication between cells their microenvironment. contain bioactive molecules, such as proteins, lipids, nucleic acids. have shown to communication, they progression cancer. There evidence suggest packaging release exosomes cells. be important for formation tetraspanin-enriched microdomains (TEMs) exosomes. These TEMs thought sorting specific molecules into In summary, appears an microenvironment via The precise mechanisms which mediates this still being investigated, but involvement exosome uptake suggests it may promising target development novel therapies. Furthermore, recipient For example, studies CD9-positive can taken up other leading transfer oncogenic promotion progression.
Language: Английский
Citations
9
The Journal of Liquid Biopsy, Journal Year: 2024, Volume and Issue: 6, P. 100278 - 100278
Published: Nov. 20, 2024
Language: Английский
Citations
3
Cellular Signalling, Journal Year: 2023, Volume and Issue: 112, P. 110928 - 110928
Published: Oct. 14, 2023
Language: Английский
Citations
6
Saudi Pharmaceutical Journal, Journal Year: 2021, Volume and Issue: 29(10), P. 1181 - 1184
Published: Sept. 21, 2021
As the world faces a fourth COVID-19 spike, scientists are learning lot more about new SARS-CoV-2 strains that were previously unknown. Currently, Delta versions of have become prevalent in much since it first appeared India late 2020. Researchers believe they discovered why has been so successful: those infected with create significantly virus than original strain SARS-CoV-2, making extremely contagious. This redirected focus to how our immune system defends us from these various pathogens and initiates such varied responses. Hundreds research papers published on origins long-lasting responses disparities numbers different cell types COVID 19 survivors, but primary architect discrepancies yet be discovered. In this essay, we will concentrate protein, activation induced cytidine deaminase (AID), which triggers molecular processes allow produce powerful antibodies specific B cells, allowing outwit virus. We if ever achieve permanent immunity infection, AID key releasing it.
Language: Английский
Citations
7