The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 6, 2024

Post COVID-19 syndrome, also known as "Long COVID," is a complex and multifaceted condition that affects individuals who have recovered from SARS-CoV-2 infection. This systematic review meta-analysis aim to comprehensively assess the global prevalence of depression, anxiety, sleep disorder in coping with syndrome.

Language: Английский

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Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review

Frontiers in Rehabilitation Sciences, Journal Year: 2023, Volume and Issue: 4

Published: April 28, 2023

Long COVID disproportionately affects premenopausal women, but relatively few studies have examined COVID's impact on female reproductive health. We conduct a review of the literature documenting health impacts which may include disruptions to menstrual cycle, gonadal function, ovarian sufficiency, menopause, and fertility, as well symptom exacerbation around menstruation. Given limited research, we also overlapping associated illnesses including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia (POTS), connective tissue disorders like Ehlers-Danlos (EDS), endometriosis, these help elucidate conditions in COVID. These illnesses, whose patients are 70%–80% increased rates dysmenorrhea, amenorrhea, oligomenorrhea, dyspareunia, infertility, vulvodynia, intermenstrual bleeding, cysts, uterine fibroids pelvic congestion syndrome, gynecological surgeries, adverse pregnancy complications such preeclampsia, maternal mortality, premature birth. Additionally, symptoms can be impacted by pregnancy, menopause. propose priorities for future research healthcare based literature. screening comorbid conditions; studying menopause illness progression; uncovering role sex differences hormones illnesses; addressing historical inequities that contributed detrimental knowledge gaps this patient population.

Language: Английский

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Role of Endothelium in Cardiovascular Sequelae of Long COVID

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2239 - 2239

Published: Aug. 9, 2023

The global action against coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, shed light on endothelial dysfunction. Although primarily affects the pulmonary system, multiple studies have documented pan-vascular involvement in COVID-19. virus is able to penetrate barrier, damaging it directly or indirectly and causing endotheliitis multi-organ injury. Several mechanisms cooperate development of dysfunction, including cell injury pyroptosis, hyperinflammation cytokine storm syndrome, oxidative stress reduced nitric oxide bioavailability, glycocalyx disruption, hypercoagulability, thrombosis. After acute-phase some patients reported signs symptoms a systemic disorder known as long COVID, which broad range cardiovascular (CV) disorders emerged. To date, exact pathophysiology COVID remains unclear: addition persistence infection mechanisms, specific pathways CV damage been postulated, such persistent viral reservoirs heart an autoimmune response cardiac antigens through molecular mimicry. aim this review provide overview main patterns enduring activation following offer latest summary complications COVID.

Language: Английский

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COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss

Human Reproduction Update, Journal Year: 2023, Volume and Issue: 30(2), P. 133 - 152

Published: Nov. 28, 2023

Abstract BACKGROUND Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates be stillborn or admitted a neonatal unit. The World Health Organization declared in May 2023 an end the disease 2019 (COVID-19) pandemic as global health emergency. However, pregnant still becoming SARS-CoV-2 there is limited information available regarding effect of infection early pregnancy on outcomes. OBJECTIVE AND RATIONALE We conducted this systematic review determine prevalence loss SARS-Cov-2 compare risk without infection. SEARCH METHODS Our based prospectively registered protocol. search PregCov19 consortium was supplemented extra electronic specifically up 10 March PubMed, Google Scholar, LitCovid. included retrospective prospective studies infection, provided that they contained losses first and/or second trimester. Primary outcome miscarriage defined before 20 weeks gestation, however, reported 22 24 were also included. Additionally, we report occur at trimester specifying gestational age, for only when study presented stillbirths foetal separately from miscarriages. Data stratified into Secondary outcomes ectopic (any extra-uterine pregnancy), termination pregnancy. At least three researchers independently extracted data assessed quality. calculated odds ratios (OR) differences (RDs) corresponding 95% CI pooled using random effects meta-analysis. To estimate prevalence, performed meta-analysis proportions. Heterogeneity by I2. OUTCOMES 120 comprising total 168 444 infection; which 18 233 Evidence level considered low moderate certainty, mostly owing selection bias. did not find evidence association between (OR 1.10, 0.81–1.48; I2 = 0.0%; RD 0.0012, −0.0103 0.0127; 0%; 9 studies, 4439 women). Miscarriage occurred 9.9% (95% 6.2–14.0%; 68%; 46 1797 women) SARS CoV-2 1.2% 0.3–2.4%; 34%; 33 studies; 3159 proportion pregnancies 1.4% 0.02–4.2%; 66%; 14 950 Termination 0.6% 0.01–1.6%; 79%; 39 1166 WIDER IMPLICATIONS found no indication increases provide better estimates, well-designed needed include conception consider clinical manifestation severity loss, well potential confounding factors such previous loss. For practice, should advised take precautions avoid exposure receive vaccination.

Language: Английский

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Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Diseases, Journal Year: 2024, Volume and Issue: 12(5), P. 95 - 95

Published: May 6, 2024

Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, outcomes persistent COVID-19 symptoms in encompassing vulnerable populations, such as pregnant women oncological patients. Our objective is to emphasize critical significance adopting an integrated approach for early detection appropriate management long COVID. The incidence severity can significant impact on quality life patients course disease case pre-existing pathologies. Particularly, fragile patients, presence PASC related significantly worse survival, independent from vulnerabilities treatment. It important try achieve recognition management. Various mechanisms are implicated, resulting wide range presentations. Understanding specific factors involved crucial tailoring effective interventions support strategies. Management approaches involve biopsychosocial assessments treatment comorbidities, autonomic dysfunction, well multidisciplinary rehabilitation. overall one gradual improvement, with recovery observed majority, though not all, As research long-COVID continues evolve, ongoing studies likely shed more light intricate relationship between chronic diseases, status, cardiovascular psychiatric disorders, effects This information could guide healthcare providers, researchers, policymakers developing targeted interventions.

Language: Английский

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Risk of neonatal SARS-CoV-2 infection: a retrospective cohort study based on infected mothers with gestational diabetes mellitus

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Background The COVID-19 pandemic has posed unprecedented challenges to global public health, especially for pregnant women and their offspring. However, little is known about the impact of maternal SARS-CoV-2 infection on neonatal outcomes, particularly in context coexisting gestational diabetes mellitus (GDM). Methods Hospitalized with were retrospectively enrolled between November 2022 January 2023, matched subjects free based propensity scores. All tested upon admission as part routine procedures, then divided into groups GDM (SARS2+GDM), but without (SARS2+noGDM), or (Normal group). A logistic regression model was used study risk GDM, perinatal infection, interaction infection. Results Of 378 rate higher group compared only group, both rates lower than that normal control group. Logistic analysis identified an where (odds ratio [OR] = 0.31, 95%CI: 0.22-0.44) vaccination anti-SARS-CoV-2 (OR 0.70, 0.50-0.98) associated odds while pre-pregnancy body mass index (BMI) 1.06, 95% CI: 1.02-1.10) 1.97, 1.21-3.21) Conclusions We demonstrate coexistence increased probability

Language: Английский

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A retrospective observational study on maternal and neonatal outcomes of COVID-19: Does the mild SARS-CoV-2 infection affect the outcome?

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e16651 - e16651

Published: Dec. 14, 2023

Currently, several SARS-CoV-2 variants, including Omicron, are still circulating globally. This underscores the necessity for a comprehensive understanding of their impact on obstetric and neonatal outcomes in pregnant women, even cases mild infection.We conducted retrospective, single-center observational study to investigate association between gestational infection maternal-fetal Chinese population. The enrolled 311 patients with (exposure group) 205 uninfected (control group). We scrutinized hospital records collect data demographics, clinical characteristics, maternal subsequently comparison.Similar characteristics were observed both groups, age, height, BMI, gravidity, parity, comorbidities (p > 0.05). A majority (97.4%) women exposure group COVID-19 experienced symptoms, fever (86.5%) cough (74.3%) as primary symptoms. exhibited significantly higher incidences cesarean section fetal distress compared control < Furthermore, showed reduced levels hemoglobin high-sensitivity C-reactive protein, while experiencing increased lymphocytes, prothrombin time, alanine aminotransferase, aspartate aminotransferase Notably, recent prior delivery appeared have an adverse liver function, blood coagulation women. When comparing two there no significant differences postpartum hemorrhage rate, premature birth weight, asphyxia department transfer pneumonia incidence.Our suggests that during pregnancy does not detrimental effects outcomes. However, risks events such section, coupled potential alterations physical reveal consequences pregnancy, cases. These findings emphasize importance proactive management monitoring individuals COVID-19.

Language: Английский

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Comparison of Perinatal Outcome of Delta and Omicron Variant of COVID-19 Infection—A Retrospective Observational Study

Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 935 - 935

Published: June 3, 2024

Background and Objectives: The aim of the present work was to compare characteristics delta omicron variants COVID-19 infection in pregnant women, association with comorbidity, clinical manifestation disease, type delivery, pregnancy outcome. Material Methods: study designed as an observational, retrospective a single center. analysis included cohort women who had SARS-CoV-2 during and/or childbirth period from 1 March 2020 30 June 2023. Results: Out total 675 infection, 130 gave birth 253 variant. In our analysis, both mild history most cases. period, significantly lower incidence loss (p < 0.01) premature = 0.62) admission mothers newborns intensive care unit 0.05) recorded. Conclusions: generally exhibited milder (delta omicron) viral infection. During delta-dominant ten percent affected experienced severe history. However, omicron-dominant complications, loss, preterm neonates This can be partly explained by greater presence natural or induced vaccine immunity.

Language: Английский

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SARS-CoV-2 infection elucidates features of pregnancy-specific immunity

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114933 - 114933

Published: Nov. 1, 2024

Language: Английский

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Long COVID – eine neue Herausforderung in der Medizin: Fokus auf Schwangerschaft und Stillzeit

Journal für Gynäkologische Endokrinologie/Österreich, Journal Year: 2023, Volume and Issue: 33(1), P. 7 - 12

Published: Feb. 2, 2023

Long COVID (coronavirus disease) has been described as a new multi-organ disease, which appears to be more prevalent in women than men. Pregnant and breastfeeding are special subgroup of patients consider with long COVID, only scarce data have collected date. Menstrual changes commonly observed during or after COVID-19; some studies also attribute slight cycle length previous inoculation against the virus. who symptomatic infection severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) at higher risk for adverse outcomes pregnancy-associated complications. Moreover, robust required evaluate vertical transmission. vaccines most effective tool pandemic, they prevent infection, but appear able ease symptoms. Vaccines proven safe both pregnant women. This article aims present current on elucidate factors possible treatment options.

Language: Английский

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