Bulletin of the Chemical Society of Ethiopia,
Journal Year:
2024,
Volume and Issue:
38(2), P. 481 - 491
Published: Jan. 23, 2024
Treatment
of
sulfamethoxazole
(SMZ
)
(1)
with
different
aromatic
aldehydes
2a-f
within
few
minutes
(5-8
min)
afforded
the
corresponding
Schiff
bases
3a-f
which
were
subjected
to
react
thioglycolic
acid
(4)
under
refluxing
toluene/dimethlformamide
(DMF)
in
(1:1)
ratio
for
12-17
h,
yielded
N-(5-methylisoxazol-3-yl)-4-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)benzenesulfon-
amide
derivatives
5a-f.
On
other
hand,
same
products
5a-f
obtained
when
SMZ
was
treated
a
mixture
and
4
via
one-pot,
three-component
reaction
microwave
irradiation.
The
key
advantages
this
process
high
yields
79-88%,
shorter
times
6-11
min.,
easy
work-up,
problems
associated
toxic
solvent
use
(cost,
safety,
pollution)
avoided.
structures
newly
compounds
elucidated
by
elemental
spectral
analyses.
Three
5a,
5b
5f
tested
cytotoxicity
against
four
human
cancer
cell
lines
MCF-7,
HePG2,
HCT
116
PC-3.
Compound
exhibited
most
potent
cytotoxic
properties
on
HePG2
Furthermore,
it
showed
inhabitory
effect
MCF-7
cells.
KEY
WORDS:
Sulfamethoxazole,
4-Thiazolidinones,
bases,
Multicomponent
reaction,
Microwave,
Traditional
methods
cytotoxicity
Bull.
Chem.
Soc.
Ethiop.
2024,
38(2),
481-491.
DOI:
https://dx.doi.org/10.4314/bcse.v38i2.15
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(11)
Published: Aug. 26, 2024
ABSTRACT
The
current
investigation
involved
the
synthesis
and
detailed
characterization
of
novel
mixed‐ligand
complexes
Mn(II)
(MnDPPNPH)
Cu(II)
(CuDPPNPH).
These
incorporate
2,6‐di(1H‐pyrazol‐1‐yl)pyridine
(DPP)
a
Schiff
base
derived
from
2‐hydroxy
naphthaldehyde
(NPH).
synthesized
revealed
stoichiometric
ratio
1:1:1
(metal:DPP:NPH),
indicative
an
octahedral
coordination
geometry
around
centers,
as
represented
by
chemical
formula
[M
(DPP)(NPH)(Cl)].
To
elucidate
their
structural
electronic
properties,
theoretical
calculations
were
performed.
facilitated
optimization
geometrical
structures
provided
insights
into
molecular
orbital
characteristics
complexes.
MnDPPNPH
CuDPPNPH
demonstrated
potential
phenoxazinone
synthase
mimicking
activity
catalyzing
aerial
coupling
o‐aminophenol
(OAPh)
to
form
phenoxazine‐2‐one
(phenox).
these
was
quantitatively
assessed
using
Michaelis–Menten
enzymatic
kinetics.
Various
enzyme
kinetics
plots
employed
determine
several
kinetic
parameters,
including
specificity
constant
turnover
number
(k
cat
),
which
are
crucial
for
understanding
efficiency
catalytic
cycles.
Remarkably,
exhibited
significantly
higher
numbers
)
compared
previously
reported
This
finding
suggests
that
new
possess
superior
activity,
highlighting
effective
catalysts
reactions
function
synthase.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(36)
Published: Sept. 19, 2024
Abstract
Three
N‐substituted
benzimidazole
cobalt(II)
complexes
have
been
synthesized
and
fully
characterized
by
elemental
analysis,
FT‐IR
spectroscopy,
X‐ray
crystallography.
The
crystal
packing
formation
features
were
studied
AIM
the
energy
nature
of
both
weak
noncovalent
interactions
in
metal–ligand
coordination
bonds
assessed.
These
N‐coordinated
screened
for
antimicrobial
activities
against
Gram‐negative
(
Escherichia
coli
,
Bacillus
subtilis
)
Gram‐positive
Enterococcus
durans
bacteria.
Minimal
inhibitory
concentrations
(MIC
=
6.2
mg/mL)
found
complex
cobalt
chloride
with
allylbenzimidazole
ligands
E.
.
Its
activity
is
several
times
higher
compared
to
reference
gentamicin.
Molecular
docking
made
it
possible
consider
binding
metal
vinyl‐,
allyl‐
styrylbenzimidazole
biological
targets
estimate
their
energy.
meanings
depend
on
protein
ligand
type,
reaches
8
kcal/mol.
