Pancreatic Beta-cell Dysfunction in Type 2 Diabetes DOI Creative Commons
Phyu Phyu Khin, Jong Han Lee, Hee‐Sook Jun

et al.

European Journal of Inflammation, Journal Year: 2023, Volume and Issue: 21

Published: Jan. 30, 2023

Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a narrow range. Defects in the function mass of play significant role development progression diabetes. Increased β-cell deficiency apoptosis are observed pancreatic islets patients with type 2 At an early stage, adapt resistance, their secretion increases, but they eventually become exhausted, decreases. Various causal factors, such as high glucose, free fatty acids, inflammatory cytokines, islet amyloid polypeptides, contribute impairment function. Therefore, maintenance is logical approach for treatment prevention In this review, we provide overview these risk factors loss associated mechanisms. A better understanding molecular mechanisms underlying will opportunity identify novel therapeutic targets

Language: Английский

Trends in GPCR drug discovery: new agents, targets and indications DOI
Alexander S. Hauser, Misty M. Attwood, Mathias Rask‐Andersen

et al.

Nature Reviews Drug Discovery, Journal Year: 2017, Volume and Issue: 16(12), P. 829 - 842

Published: Oct. 27, 2017

Language: Английский

Citations

2301

Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention DOI Creative Commons
Yanling Wu,

Yanping Ding,

Yoshimasa Tanaka

et al.

International Journal of Medical Sciences, Journal Year: 2014, Volume and Issue: 11(11), P. 1185 - 1200

Published: Jan. 1, 2014

Type 2 diabetes is a serious and common chronic disease resulting from complex inheritance-environment interaction along with other risk factors such as obesity sedentary lifestyle.Type its complications constitute major worldwide public health problem, affecting almost all populations in both developed developing countries high rates of diabetes-related morbidity mortality.The prevalence type has been increasing exponentially, rate observed undergoing "westernization" or modernization.Multiple diabetes, delayed diagnosis until micro-and macro-vascular arise, life-threatening complications, failure the current therapies, financial costs for treatment this disease, make it necessary to develop new efficient therapy strategies appropriate prevention measures control diabetes.Herein, we summarize our understanding about epidemiology roles genes, lifestyle contributing rapid increase incidence diabetes.The core aims are bring forward cost-effective intervention trials diabetes.

Language: Английский

Citations

1125

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence DOI
Yi Tan, Zhiguo Zhang, Chao Zheng

et al.

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 17(9), P. 585 - 607

Published: Feb. 20, 2020

Language: Английский

Citations

582

Type II diabetes mellitus: a review on recent drug based therapeutics DOI Open Access

Santwana Padhi,

Amit Kumar Nayak, Anindita Behera

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110708 - 110708

Published: Sept. 10, 2020

Diabetes mellitus (DM) is a metabolic disorder that occurs in the body because of decreased insulin activity and/or secretion. Pathological changes such as nephropathy, retinopathy, and cardiovascular complications inevitably occur with progression disease. DM mainly categorized into 2 sub-types, type I II DM. While generally treated through replacement therapy, oral hypoglycaemics. The major drug therapy for comprises secretagogues, biguanides, sensitizers, alpha glucosidase inhibitors, incretin mimetics, amylin antagonists sodium-glucose co-transporter-2 (SGLT2) inhibitors. Dual therapies are often recommended patients who unable to achieve therapeutic goals first line hypoglycaemic agents monotherapy. Inspite appreciable benefits, conventional dosage forms depicts differential bioavailability short half-life, mandating frequent causing greater side effects leading ineffectiveness patient non-compliance. Given pathological complexity said disease, nanotechnology-based approaches more enticing it comes added advantage site-specific delivery higher reduced regimen. In present review article, we have made an attempt explore pathophysiology DM, treatment (mono combination therapy) well nano based

Language: Английский

Citations

529

Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies DOI
Seema Patel, Abdur Rauf, Haroon Khan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2017, Volume and Issue: 94, P. 317 - 325

Published: July 31, 2017

Language: Английский

Citations

503

Diabetes Mellitus in Saudi Arabia: A Review of the Recent Literature DOI
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, R. Braham

et al.

Current Diabetes Reviews, Journal Year: 2016, Volume and Issue: 12(4), P. 359 - 368

Published: Oct. 26, 2016

The World Health Organization (WHO) has reported that Saudi Arabia ranks the second highest in Middle East, and is seventh world for rate of diabetes. It estimated around 7 million population are diabetic almost 3 have pre-diabetes. Even more worrying perhaps, increasing pattern diabetes noted recent past. In fact, approximately registered a ten-fold increase past three eras Arabia. Diabetes mellitus (DM) been found to be related high mortality, morbidity vascular complications, accompanied by poor general health lower quality life. Arabia, DM quickly reaching disturbing proportions becoming significant cause medical complications even death. However, when compared with developed countries, research work conducted, focusing particularly on incidence, prevalence socio-demographic properties woefully inadequate. burden due predicted rise catastrophic levels, unless wide-ranging epidemic control program incorporated, great emphasis laid advocating healthy diet, including exercise active lifestyles, weight control. To properly manage multidisciplinary approach required. this review we discuss all aspects drawing from published literature currently available.

Language: Английский

Citations

446

Nitric Oxide Therapy for Diabetic Wound Healing DOI

Maggie J. Malone‐Povolny,

Sara E. Maloney, Mark H. Schoenfisch

et al.

Advanced Healthcare Materials, Journal Year: 2019, Volume and Issue: 8(12)

Published: Jan. 15, 2019

Abstract Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability regulate inflammation and eradicate bacterial infections. Two broad strategies exist utilize NO for healing; liberating from endogenous reservoirs, supplementing exogenous sources. This progress report examines the efficacy of variety NO‐based methods improve outcomes, with particular attention given diabetes‐associated chronic wounds.

Language: Английский

Citations

382

α-Glucosidase inhibition by flavonoids: anin vitroandin silicostructure–activity relationship study DOI Creative Commons
Carina Proença, Marisa Freitas, Daniela Ribeiro

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2017, Volume and Issue: 32(1), P. 1216 - 1228

Published: Jan. 1, 2017

α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used management of type 2 diabetes mellitus. As flavonoids promising modulators this enzyme's activity, a panel 44 flavonoids, organised five groups, was screened for their inhibitory activity α-glucosidase, based on vitro structure-activity relationship studies. Inhibitory kinetic analysis and molecular docking calculations were also applied selected compounds. A flavonoid with two catechol groups A- B-rings, together 3-OH group at C-ring, active, presenting an IC50 much lower than one found widely prescribed α-glucosidase inhibitor, acarbose. The present work suggests that several studied have potential to be alternatives regulation PPHG.

Language: Английский

Citations

349

The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes) DOI
Michael Halim, Alice Halim

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2019, Volume and Issue: 13(2), P. 1165 - 1172

Published: Jan. 27, 2019

Language: Английский

Citations

326

A healthy gastrointestinal microbiome is dependent on dietary diversity DOI Creative Commons
Mark L. Heiman, Frank L. Greenway

Molecular Metabolism, Journal Year: 2016, Volume and Issue: 5(5), P. 317 - 320

Published: March 6, 2016

Like all healthy ecosystems, richness of microbiota species characterizes the GI microbiome in individuals. Conversely, a loss diversity is common finding several disease states. This biome flooded with energy form undigested and partially digested foods, some cases drugs dietary supplements. Each microbiotic transforms that into new molecules, which may signal messages to physiological systems host. Dietary choices select substrates for species, providing competitive advantage over other microbiota. The more diverse diet, adaptable it will be perturbations. Unfortunately, has been lost during past 50 years exclude food products from animals or plants narrow further. Additional research expanding gut microbial by likely expand concepts nutrition, stimulate discovery diagnostics, open up novel therapeutic possibilities.

Language: Английский

Citations

321