The Novavax Heterologous Coronavirus Disease 2019 Booster Demonstrates Lower Reactogenicity Than Messenger RNA: A Targeted Review DOI Creative Commons
Anthony M. Marchese, Matthew D. Rousculp,

John C. Macbeth

et al.

The Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 230(2), P. e496 - e502

Published: Nov. 22, 2023

Coronavirus disease 2019 (COVID-19) continues to be a global health concern, and booster doses are necessary for maintaining vaccine-mediated protection, limiting the spread of severe acute respiratory syndrome coronavirus 2. Despite multiple COVID-19 vaccine options, uptake remains low. Reactogenicity, occurrence adverse local/systemic side effects, plays crucial role in acceptance, particularly doses. We conducted targeted review reactogenicity authorized/approved messenger RNA (mRNA) protein-based vaccines demonstrated by clinical trials real-world evidence. It was found that mRNA-based boosters show higher incidence an increased severity compared with Novavax (NVX-CoV2373). In recent study from National Institute Allergy Infectious Diseases, pain/tenderness, swelling, erythema, fatigue/malaise, headache, muscle pain, or fever individuals boosted BNT162b2 (0.4% 41.6% absolute increase) mRNA-1273 (5.5% 55.0% NVX-CoV2373. Evidence suggests NVX-CoV2373, when utilized as heterologous booster, demonstrates less mRNA vaccines, which, if communicated hesitant individuals, may strengthen rates worldwide. Clinical Trials Registration NCT04889209.

Language: Английский

A Global Map of COVID-19 Vaccine Acceptance Rates per Country: An Updated Concise Narrative Review DOI Creative Commons
Malik Sallam, Mariam Alsanafi, Mohammed Sallam

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2022, Volume and Issue: Volume 15, P. 21 - 45

Published: Jan. 1, 2022

Abstract: The delay or refusal of vaccination, which defines vaccine hesitancy, is a major challenge to successful control COVID-19 epidemic. huge number publications addressing hesitancy necessitates periodic review provide concise summary acceptance rates worldwide. In the current narrative review, data on were retrieved from surveys in 114 countries/territories. East and Southern Africa (n = 9), highest rate was reported Ethiopia (92%), while lowest Zimbabwe (50%). West/Central 13), Niger (93%), Cameroon (15%). Asia Pacific 16), Nepal Vietnam (97%), Hong Kong (42%). Eastern Europe/Central 7), Montenegro (69%) Kazakhstan (64%), Russia (30%). Latin America Caribbean 20), Mexico (88%), Haiti (43%). Middle East/North (MENA, n 22), Tunisia Iraq (13%). Western/Central Europe North 27), Canada (91%) Norway (89%), Cyprus Portugal (35%). ≥ 60% seen 72/114 countries/territories, compared 42 countries/territories with between 13% 59%. phenomenon appeared more pronounced MENA, Central Asia, Africa. More studies are recommended Africa, address intentions general public get vaccination. Keywords: SARS-CoV-2, hesitance, resistance, rejection, willingness vaccinate, intention vaccinate

Language: Английский

Citations

209

Global emerging Omicron variant of SARS-CoV-2: Impacts, challenges and strategies DOI Creative Commons
Kuldeep Dhama, Firzan Nainu, Andri Frediansyah

et al.

Journal of Infection and Public Health, Journal Year: 2022, Volume and Issue: 16(1), P. 4 - 14

Published: Nov. 19, 2022

Newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuously posing high global public health concerns and panic resulting in waves disease 2019 (COVID-19) pandemic. Depending on the extent genomic variations, mutations adaptation, few gain ability to spread quickly across many countries, acquire higher virulency cause disease, morbidity mortality. These have been implicated lessening efficacy current COVID-19 vaccines immunotherapies break-through viral infections vaccinated individuals recovered patients. Altogether, these could hinder protective herd immunity be achieved through ongoing progressive vaccination. Currently, only variant interest SARS-CoV-2 is Omicron that was first identified South Africa. In this review, we present overview with a special focus variant, its lineages hybrid variants. We discuss hypotheses origin, genetic change underlying molecular mechanism behind transmissibility immune escape variant. Major related including available immunotherapeutics vaccines, transmissibility, severity, mortality discussed. last part, challenges strategies counter amid pandemic presented.

Language: Английский

Citations

206

Global Prevalence and Potential Influencing Factors of COVID-19 Vaccination Hesitancy: A Meta-Analysis DOI Creative Commons
Jonny Karunia Fajar, Malik Sallam, Gatot Soegiarto

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(8), P. 1356 - 1356

Published: Aug. 19, 2022

Countries worldwide have deployed mass COVID-19 vaccination drives, but there are people who hesitant to receive the vaccine. Studies assessing factors associated with hesitancy inconclusive. This study aimed assess global prevalence of and determine potential such hesitancy. We performed an organized search for relevant articles in PubMed, Scopus, Web Science. Extraction required information was each study. A single-arm meta-analysis hesitancy; related vaccine were analyzed using a Z-test. total 56 included our analysis. found that 25%. Being woman, being 50-year-old or younger, single, unemployed, living household five more individuals, having educational attainment lower than undergraduate degree, non-healthcare-related job considering vaccines be unsafe higher risk In contrast, children at home, maintaining physical distancing norms, ever tested COVID-19, history influenza past few years vaccination. Our provides valuable on hesitancy, we recommend special interventions sub-populations increased reduce

Language: Английский

Citations

100

Conspiracy theories and misinformation about COVID-19 in Nigeria: Implications for vaccine demand generation communications DOI Creative Commons
Chizoba Wonodi, Chisom Obi‐Jeff,

Funmilayo Adewumi

et al.

Vaccine, Journal Year: 2022, Volume and Issue: 40(13), P. 2114 - 2121

Published: Feb. 7, 2022

COVID-19 vaccine hesitancy is a worldwide phenomenon and serious threat to pandemic control efforts. Until recently, was not the cause of low coverage in Nigeria; scarcity problem. As global supply vaccines improves second half 2021 more doses are deployed Nigeria, supply/demand dynamic will switch. Vaccine acceptance become key driver coverage; thus, amplifying impact hesitancy. Conspiracy theories misinformation about rampant have been shown drive refusal. This study systematically elicits conspiracy circulating among Nigerian public understand relevant themes potential message framing for communication efforts improve uptake.

Language: Английский

Citations

82

Global acceptance and hesitancy of COVID-19 vaccination: A narrative review DOI Creative Commons
Wardah Hassan, Syeda Kanza Kazmi, Muhammad Junaid Tahir

et al.

Narra J, Journal Year: 2021, Volume and Issue: 1(3)

Published: Dec. 1, 2021

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), is a major global health threat to human civilization and has disrupted many aspects of community around globe. Vaccination one prominent measures control COVID-19 pandemic. More than 120 vaccines have entered clinical trials at least 8 been fully approved. However, success vaccination programs depends on how accepts vaccines. Despite having initiated for while now, more 50% population not vaccinated. In some low- middle-income countries (LMICs), vaccine coverage less 20%. Since decision accept new complex, understanding factors underpinning acceptance critical. This review aimed summarize rate globe as well its associated determinants. Information from this study might be important formulate effective strategies increase coverage, able achieve herd immunity.

Language: Английский

Citations

80

The Role of Psychological Factors and Vaccine Conspiracy Beliefs in Influenza Vaccine Hesitancy and Uptake among Jordanian Healthcare Workers during the COVID-19 Pandemic DOI Creative Commons
Malik Sallam, Ramy Mohamed Ghazy,

Khaled Al‐Salahat

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(8), P. 1355 - 1355

Published: Aug. 19, 2022

Vaccination to prevent influenza virus infection and lessen its severity is recommended among healthcare workers (HCWs). Health professionals have a higher risk of exposure viruses could transmit the vulnerable patients who are prone severe disease mortality. The aim current study was evaluate levels vaccine acceptance uptake as well determinants, Jordanian HCWs over last season 2021/2022. This based on self-administered electronic survey that distributed in March 2022. Psychological determinants conspiracy beliefs were assessed using previously validated 5C scale questionnaire (confidence, complacency, constraints, calculation collective responsibility) scale. sample comprised total 1218 HCWs: nurses (n = 412, 33.8%), physicians 367, 30.1%), medical technicians 182, 14.9%), pharmacists 161, 13.2%) dentists 87, 7.1%), others. About two-thirds expressed willingness receive vaccination if provided free charge 807, 66.3%), whereas less than one-third willing pay for 388, 31.9%). self-reported 62.8%. following factors significantly associated with freely, opposed hesitancy/rejection: male sex; HCW categories; confidence responsibility; lower constraints calculation. Higher correlated categories, older age, monthly income, responsibility, complacency embrace general beliefs. results can provide helpful clues improve coverage Jordan. Consequently, this help protect patient groups reserve valuable resources settings. appeared be most significant uptake, rates which should considered educational interventional measures aiming promote vaccination.

Language: Английский

Citations

63

Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review DOI
Sri Masyeni, Muhammad Iqhrammullah, Andri Frediansyah

et al.

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 94(7), P. 3006 - 3016

Published: March 22, 2022

Broad-spectrum antiviral agents targeting viral RNA-dependent RNA polymerase (RdRp) are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 (COVID-19) pandemic and its future variants of severe acute respiratory syndrome 2 (SARS-CoV-2), virus that causes COVID-19. Molnupiravir is nucleoside analog vivo experiments have been reported inhibit replication SARS-CoV-2, Clinical trials molnupiravir as therapy for patients with mild-to-moderate COVID-19 also suggest significant efficacy comparison placebo. lethally mutagenic against RNA, but effect on host cell DNA being questioned. Herein, safety concerns discussed recent findings from published reports clinical trials. The unchanged mutated SARS-CoV-2 highlighted. With administration via oral route, turn tide pandemic.

Language: Английский

Citations

62

Vaccine hesitancy among communities in ten countries in Asia, Africa, and South America during the COVID-19 pandemic DOI
Harapan Harapan, Samsul Anwar, Amanda Yufika

et al.

Pathogens and Global Health, Journal Year: 2021, Volume and Issue: 116(4), P. 236 - 243

Published: Dec. 20, 2021

Vaccine hesitancy is considered one of the greatest threats to ongoing coronavirus disease 2019 (COVID-19) vaccination programs. Lack trust in vaccine benefits, along with concerns about side effects newly developed COVID-19 vaccine, might significantly contribute hesitancy. The objective this study was determine level among communities particular their belief benefits and perceived risks new vaccines. An online cross-sectional conducted 10 countries Asia, Africa, South America from February May 2021. Seven items WHO SAGE Hesitancy Scale were used measure a construct benefit, item measured riskiness A logistic regression which sociodemographic factors associated both constructs. total 1,832 respondents included final analysis 36.2% (range 5.6-52.2%) 77.6% 38.3-91.2%) them classified as hesitant terms beliefs vaccines, respectively. Respondents Pakistan had highest while those Chile lowest. Being females, Muslim, having non-healthcare-related job not receiving flu during past 12 months poor benefits. Those who living rural areas, did received relatively higher that vaccines are riskier. High prevalence some pandemic hamper programs worldwide. Programs should be promote groups high

Language: Английский

Citations

56

Attitudes towards Monkeypox vaccination and predictors of vaccination intentions among the US general public DOI Creative Commons
Maike Winters, Amyn A. Malik, Saad B. Omer

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(12), P. e0278622 - e0278622

Published: Dec. 1, 2022

Amidst an unprecedented Monkeypox outbreak, we aimed to measure knowledge, attitudes, practices and vaccination intentions among the U.S. adult population. We conducted online cross-sectional survey, representative of general public in June 2022. asked participants whether they would receive a vaccine, if were recommended do so. Participants also answered questions on their self-assessed level risk perception, perceived exaggeration threat, self-efficacy around Monkeypox. Furthermore, about trusted sources information, COVID-19 status administered 6-item Vaccine Trust Indicator (VTI). Survey weights created based age, gender race. analyzed predictors using logistic regression, adjusted for education, race ethnicity. A total 856 respondents completed which 51% (n = 436) female 41% 348) had college degree or higher. If recommended, 46% intended get vaccinated against Monkeypox, 29% not 25% did know. Almost half (47%) found own knowledge poor very poor. The most information outbreak healthcare professionals officials, but known doctors researchers with large following. Only 24% indicated that Centers Disease Control Prevention should be charge response. Being was strong predictor intention (adjusted Odds Ratio (aOR) 29.2, 95% Confidence Interval (CI) 13.1-65.3). Increased perception positively associated (aOR 2.6, CI 1.8-3.6), scoring high VTI as well (5.4, (3.2-9.1). low levels influence point lack clear communication.

Language: Английский

Citations

52

COVID-19 Conspiracy Theories Discussion on Twitter DOI Creative Commons
Dmitry Erokhin, Abraham Yosipof, Nadejda Komendantova

et al.

Social Media + Society, Journal Year: 2022, Volume and Issue: 8(4)

Published: Oct. 1, 2022

The coronavirus disease 2019 (COVID-19) pandemic was an unexpected event and resulted in catastrophic consequences with long-lasting behavioral effects. People began to seek explanations for different aspects of COVID-19 resorted conspiracy narratives. objective this article is analyze the changes on discussion theories throughout Twitter. We have collected a data set 1.269 million tweets associated between January 2020 November 2021. includes related eight theories: 5G, Big Pharma, Bill Gates, biological weapon, exaggeration, FilmYourHospital, genetically modified organism (GMO), vaccines conspiracy. analysis highlights several behaviors allows categorizing them into four groups. first group are that peaked at beginning sharply declined afterwards, including 5G FilmYourHospital conspiracies. second Pharma vaccination-related whose role increased as progressed. third conspiracies remained persistent such exaggeration Gates fourth those had multiple peaks times GMO weapon In addition, number new cases found be significant predictor next week tweet frequency most

Language: Английский

Citations

42