The Journal of Infectious Diseases,
Journal Year:
2023,
Volume and Issue:
230(2), P. e496 - e502
Published: Nov. 22, 2023
Coronavirus
disease
2019
(COVID-19)
continues
to
be
a
global
health
concern,
and
booster
doses
are
necessary
for
maintaining
vaccine-mediated
protection,
limiting
the
spread
of
severe
acute
respiratory
syndrome
coronavirus
2.
Despite
multiple
COVID-19
vaccine
options,
uptake
remains
low.
Reactogenicity,
occurrence
adverse
local/systemic
side
effects,
plays
crucial
role
in
acceptance,
particularly
doses.
We
conducted
targeted
review
reactogenicity
authorized/approved
messenger
RNA
(mRNA)
protein-based
vaccines
demonstrated
by
clinical
trials
real-world
evidence.
It
was
found
that
mRNA-based
boosters
show
higher
incidence
an
increased
severity
compared
with
Novavax
(NVX-CoV2373).
In
recent
study
from
National
Institute
Allergy
Infectious
Diseases,
pain/tenderness,
swelling,
erythema,
fatigue/malaise,
headache,
muscle
pain,
or
fever
individuals
boosted
BNT162b2
(0.4%
41.6%
absolute
increase)
mRNA-1273
(5.5%
55.0%
NVX-CoV2373.
Evidence
suggests
NVX-CoV2373,
when
utilized
as
heterologous
booster,
demonstrates
less
mRNA
vaccines,
which,
if
communicated
hesitant
individuals,
may
strengthen
rates
worldwide.
Clinical
Trials
Registration
NCT04889209.
Journal of Multidisciplinary Healthcare,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 21 - 45
Published: Jan. 1, 2022
Abstract:
The
delay
or
refusal
of
vaccination,
which
defines
vaccine
hesitancy,
is
a
major
challenge
to
successful
control
COVID-19
epidemic.
huge
number
publications
addressing
hesitancy
necessitates
periodic
review
provide
concise
summary
acceptance
rates
worldwide.
In
the
current
narrative
review,
data
on
were
retrieved
from
surveys
in
114
countries/territories.
East
and
Southern
Africa
(n
=
9),
highest
rate
was
reported
Ethiopia
(92%),
while
lowest
Zimbabwe
(50%).
West/Central
13),
Niger
(93%),
Cameroon
(15%).
Asia
Pacific
16),
Nepal
Vietnam
(97%),
Hong
Kong
(42%).
Eastern
Europe/Central
7),
Montenegro
(69%)
Kazakhstan
(64%),
Russia
(30%).
Latin
America
Caribbean
20),
Mexico
(88%),
Haiti
(43%).
Middle
East/North
(MENA,
n
22),
Tunisia
Iraq
(13%).
Western/Central
Europe
North
27),
Canada
(91%)
Norway
(89%),
Cyprus
Portugal
(35%).
≥
60%
seen
72/114
countries/territories,
compared
42
countries/territories
with
between
13%
59%.
phenomenon
appeared
more
pronounced
MENA,
Central
Asia,
Africa.
More
studies
are
recommended
Africa,
address
intentions
general
public
get
vaccination.
Keywords:
SARS-CoV-2,
hesitance,
resistance,
rejection,
willingness
vaccinate,
intention
vaccinate
Journal of Infection and Public Health,
Journal Year:
2022,
Volume and Issue:
16(1), P. 4 - 14
Published: Nov. 19, 2022
Newly
emerging
variants
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
are
continuously
posing
high
global
public
health
concerns
and
panic
resulting
in
waves
disease
2019
(COVID-19)
pandemic.
Depending
on
the
extent
genomic
variations,
mutations
adaptation,
few
gain
ability
to
spread
quickly
across
many
countries,
acquire
higher
virulency
cause
disease,
morbidity
mortality.
These
have
been
implicated
lessening
efficacy
current
COVID-19
vaccines
immunotherapies
break-through
viral
infections
vaccinated
individuals
recovered
patients.
Altogether,
these
could
hinder
protective
herd
immunity
be
achieved
through
ongoing
progressive
vaccination.
Currently,
only
variant
interest
SARS-CoV-2
is
Omicron
that
was
first
identified
South
Africa.
In
this
review,
we
present
overview
with
a
special
focus
variant,
its
lineages
hybrid
variants.
We
discuss
hypotheses
origin,
genetic
change
underlying
molecular
mechanism
behind
transmissibility
immune
escape
variant.
Major
related
including
available
immunotherapeutics
vaccines,
transmissibility,
severity,
mortality
discussed.
last
part,
challenges
strategies
counter
amid
pandemic
presented.
Vaccines,
Journal Year:
2022,
Volume and Issue:
10(8), P. 1356 - 1356
Published: Aug. 19, 2022
Countries
worldwide
have
deployed
mass
COVID-19
vaccination
drives,
but
there
are
people
who
hesitant
to
receive
the
vaccine.
Studies
assessing
factors
associated
with
hesitancy
inconclusive.
This
study
aimed
assess
global
prevalence
of
and
determine
potential
such
hesitancy.
We
performed
an
organized
search
for
relevant
articles
in
PubMed,
Scopus,
Web
Science.
Extraction
required
information
was
each
study.
A
single-arm
meta-analysis
hesitancy;
related
vaccine
were
analyzed
using
a
Z-test.
total
56
included
our
analysis.
found
that
25%.
Being
woman,
being
50-year-old
or
younger,
single,
unemployed,
living
household
five
more
individuals,
having
educational
attainment
lower
than
undergraduate
degree,
non-healthcare-related
job
considering
vaccines
be
unsafe
higher
risk
In
contrast,
children
at
home,
maintaining
physical
distancing
norms,
ever
tested
COVID-19,
history
influenza
past
few
years
vaccination.
Our
provides
valuable
on
hesitancy,
we
recommend
special
interventions
sub-populations
increased
reduce
Vaccine,
Journal Year:
2022,
Volume and Issue:
40(13), P. 2114 - 2121
Published: Feb. 7, 2022
COVID-19
vaccine
hesitancy
is
a
worldwide
phenomenon
and
serious
threat
to
pandemic
control
efforts.
Until
recently,
was
not
the
cause
of
low
coverage
in
Nigeria;
scarcity
problem.
As
global
supply
vaccines
improves
second
half
2021
more
doses
are
deployed
Nigeria,
supply/demand
dynamic
will
switch.
Vaccine
acceptance
become
key
driver
coverage;
thus,
amplifying
impact
hesitancy.
Conspiracy
theories
misinformation
about
rampant
have
been
shown
drive
refusal.
This
study
systematically
elicits
conspiracy
circulating
among
Nigerian
public
understand
relevant
themes
potential
message
framing
for
communication
efforts
improve
uptake.
Narra J,
Journal Year:
2021,
Volume and Issue:
1(3)
Published: Dec. 1, 2021
The
coronavirus
disease
2019
(COVID-19),
caused
by
the
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
is
a
major
global
health
threat
to
human
civilization
and
has
disrupted
many
aspects
of
community
around
globe.
Vaccination
one
prominent
measures
control
COVID-19
pandemic.
More
than
120
vaccines
have
entered
clinical
trials
at
least
8
been
fully
approved.
However,
success
vaccination
programs
depends
on
how
accepts
vaccines.
Despite
having
initiated
for
while
now,
more
50%
population
not
vaccinated.
In
some
low-
middle-income
countries
(LMICs),
vaccine
coverage
less
20%.
Since
decision
accept
new
complex,
understanding
factors
underpinning
acceptance
critical.
This
review
aimed
summarize
rate
globe
as
well
its
associated
determinants.
Information
from
this
study
might
be
important
formulate
effective
strategies
increase
coverage,
able
achieve
herd
immunity.
Vaccines,
Journal Year:
2022,
Volume and Issue:
10(8), P. 1355 - 1355
Published: Aug. 19, 2022
Vaccination
to
prevent
influenza
virus
infection
and
lessen
its
severity
is
recommended
among
healthcare
workers
(HCWs).
Health
professionals
have
a
higher
risk
of
exposure
viruses
could
transmit
the
vulnerable
patients
who
are
prone
severe
disease
mortality.
The
aim
current
study
was
evaluate
levels
vaccine
acceptance
uptake
as
well
determinants,
Jordanian
HCWs
over
last
season
2021/2022.
This
based
on
self-administered
electronic
survey
that
distributed
in
March
2022.
Psychological
determinants
conspiracy
beliefs
were
assessed
using
previously
validated
5C
scale
questionnaire
(confidence,
complacency,
constraints,
calculation
collective
responsibility)
scale.
sample
comprised
total
1218
HCWs:
nurses
(n
=
412,
33.8%),
physicians
367,
30.1%),
medical
technicians
182,
14.9%),
pharmacists
161,
13.2%)
dentists
87,
7.1%),
others.
About
two-thirds
expressed
willingness
receive
vaccination
if
provided
free
charge
807,
66.3%),
whereas
less
than
one-third
willing
pay
for
388,
31.9%).
self-reported
62.8%.
following
factors
significantly
associated
with
freely,
opposed
hesitancy/rejection:
male
sex;
HCW
categories;
confidence
responsibility;
lower
constraints
calculation.
Higher
correlated
categories,
older
age,
monthly
income,
responsibility,
complacency
embrace
general
beliefs.
results
can
provide
helpful
clues
improve
coverage
Jordan.
Consequently,
this
help
protect
patient
groups
reserve
valuable
resources
settings.
appeared
be
most
significant
uptake,
rates
which
should
considered
educational
interventional
measures
aiming
promote
vaccination.
Journal of Medical Virology,
Journal Year:
2022,
Volume and Issue:
94(7), P. 3006 - 3016
Published: March 22, 2022
Broad-spectrum
antiviral
agents
targeting
viral
RNA-dependent
RNA
polymerase
(RdRp)
are
expected
to
be
a
key
therapeutic
strategy
in
the
ongoing
coronavirus
disease
2019
(COVID-19)
pandemic
and
its
future
variants
of
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
virus
that
causes
COVID-19.
Molnupiravir
is
nucleoside
analog
vivo
experiments
have
been
reported
inhibit
replication
SARS-CoV-2,
Clinical
trials
molnupiravir
as
therapy
for
patients
with
mild-to-moderate
COVID-19
also
suggest
significant
efficacy
comparison
placebo.
lethally
mutagenic
against
RNA,
but
effect
on
host
cell
DNA
being
questioned.
Herein,
safety
concerns
discussed
recent
findings
from
published
reports
clinical
trials.
The
unchanged
mutated
SARS-CoV-2
highlighted.
With
administration
via
oral
route,
turn
tide
pandemic.
Pathogens and Global Health,
Journal Year:
2021,
Volume and Issue:
116(4), P. 236 - 243
Published: Dec. 20, 2021
Vaccine
hesitancy
is
considered
one
of
the
greatest
threats
to
ongoing
coronavirus
disease
2019
(COVID-19)
vaccination
programs.
Lack
trust
in
vaccine
benefits,
along
with
concerns
about
side
effects
newly
developed
COVID-19
vaccine,
might
significantly
contribute
hesitancy.
The
objective
this
study
was
determine
level
among
communities
particular
their
belief
benefits
and
perceived
risks
new
vaccines.
An
online
cross-sectional
conducted
10
countries
Asia,
Africa,
South
America
from
February
May
2021.
Seven
items
WHO
SAGE
Hesitancy
Scale
were
used
measure
a
construct
benefit,
item
measured
riskiness
A
logistic
regression
which
sociodemographic
factors
associated
both
constructs.
total
1,832
respondents
included
final
analysis
36.2%
(range
5.6-52.2%)
77.6%
38.3-91.2%)
them
classified
as
hesitant
terms
beliefs
vaccines,
respectively.
Respondents
Pakistan
had
highest
while
those
Chile
lowest.
Being
females,
Muslim,
having
non-healthcare-related
job
not
receiving
flu
during
past
12
months
poor
benefits.
Those
who
living
rural
areas,
did
received
relatively
higher
that
vaccines
are
riskier.
High
prevalence
some
pandemic
hamper
programs
worldwide.
Programs
should
be
promote
groups
high
PLoS ONE,
Journal Year:
2022,
Volume and Issue:
17(12), P. e0278622 - e0278622
Published: Dec. 1, 2022
Amidst
an
unprecedented
Monkeypox
outbreak,
we
aimed
to
measure
knowledge,
attitudes,
practices
and
vaccination
intentions
among
the
U.S.
adult
population.
We
conducted
online
cross-sectional
survey,
representative
of
general
public
in
June
2022.
asked
participants
whether
they
would
receive
a
vaccine,
if
were
recommended
do
so.
Participants
also
answered
questions
on
their
self-assessed
level
risk
perception,
perceived
exaggeration
threat,
self-efficacy
around
Monkeypox.
Furthermore,
about
trusted
sources
information,
COVID-19
status
administered
6-item
Vaccine
Trust
Indicator
(VTI).
Survey
weights
created
based
age,
gender
race.
analyzed
predictors
using
logistic
regression,
adjusted
for
education,
race
ethnicity.
A
total
856
respondents
completed
which
51%
(n
=
436)
female
41%
348)
had
college
degree
or
higher.
If
recommended,
46%
intended
get
vaccinated
against
Monkeypox,
29%
not
25%
did
know.
Almost
half
(47%)
found
own
knowledge
poor
very
poor.
The
most
information
outbreak
healthcare
professionals
officials,
but
known
doctors
researchers
with
large
following.
Only
24%
indicated
that
Centers
Disease
Control
Prevention
should
be
charge
response.
Being
was
strong
predictor
intention
(adjusted
Odds
Ratio
(aOR)
29.2,
95%
Confidence
Interval
(CI)
13.1-65.3).
Increased
perception
positively
associated
(aOR
2.6,
CI
1.8-3.6),
scoring
high
VTI
as
well
(5.4,
(3.2-9.1).
low
levels
influence
point
lack
clear
communication.
Social Media + Society,
Journal Year:
2022,
Volume and Issue:
8(4)
Published: Oct. 1, 2022
The
coronavirus
disease
2019
(COVID-19)
pandemic
was
an
unexpected
event
and
resulted
in
catastrophic
consequences
with
long-lasting
behavioral
effects.
People
began
to
seek
explanations
for
different
aspects
of
COVID-19
resorted
conspiracy
narratives.
objective
this
article
is
analyze
the
changes
on
discussion
theories
throughout
Twitter.
We
have
collected
a
data
set
1.269
million
tweets
associated
between
January
2020
November
2021.
includes
related
eight
theories:
5G,
Big
Pharma,
Bill
Gates,
biological
weapon,
exaggeration,
FilmYourHospital,
genetically
modified
organism
(GMO),
vaccines
conspiracy.
analysis
highlights
several
behaviors
allows
categorizing
them
into
four
groups.
first
group
are
that
peaked
at
beginning
sharply
declined
afterwards,
including
5G
FilmYourHospital
conspiracies.
second
Pharma
vaccination-related
whose
role
increased
as
progressed.
third
conspiracies
remained
persistent
such
exaggeration
Gates
fourth
those
had
multiple
peaks
times
GMO
weapon
In
addition,
number
new
cases
found
be
significant
predictor
next
week
tweet
frequency
most