Nutritional Status, Diet, and Intestinal Permeability of Mexican Children with Autism Spectrum Disorders DOI Creative Commons
Karina Alejandra Pedroza-García, Miriam Aracely Anaya‐Loyola, Dolores Ronquillo

et al.

Gastroenterology Insights, Journal Year: 2024, Volume and Issue: 15(4), P. 912 - 925

Published: Oct. 16, 2024

Introduction: Autism spectrum disorder (ASD) comprises a group of developmental disorders characterized by deficits in social interaction and behavioral patterns. Children with ASD may face nutritional challenges, primarily due to their restrictive behaviors frequent gastrointestinal issues. Objective: The objective the present study was assess status, dietary habits, intestinal permeability sample individuals ASD. Methods: A cross-sectional conducted 24 children adolescents (both sexes), aged 4 18 years, living two cities Mexico (Aguascalientes Querétaro). Weight height were measured, body mass index for age calculated compared using WHO Z-scores. Diet assessed through three h recalls food frequency questionnaire. Intestinal evaluated lactulose/mannitol test HPLC. Results: high prevalence malnutrition observed; 12.5% participants underweight, 45.8% overweight or obese. had low intake fiber, vitamin E, folate, potassium, zinc, phosphorus sodium. On average, ratio 0.09 ± 0.05, 54.2% exhibiting permeability. Conclusions: It is advisable develop counseling strategies prevent micronutrient deficiencies, promote healthy weight, improve integrity.

Language: Английский

Impact of probiotic supplements on behavioural and gastrointestinal symptoms in children with autism spectrum disorder: A randomised controlled trial DOI Creative Commons
Himani Narula Khanna,

Sushovan Roy,

Aqsa Shaikh

et al.

BMJ Paediatrics Open, Journal Year: 2025, Volume and Issue: 9(1), P. e003045 - e003045

Published: March 1, 2025

To investigate whether probiotic supplementation can improve behavioural and gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD) aged 2-9 years further explore the correlation between these symptoms. Single-blinded, randomised, placebo-controlled study. Five developmental paediatric outpatient clinics of 'Continua Kids'. Children diagnosed ASD along their caregivers. Probiotic or placebo sachet reconstituted 50 mL lukewarm milk/water, taken two times per day for 3 months. Change (measured by Social Responsiveness Scale-2 (SRS-2) Aberrant Behaviour Checklist-2 (ABC-2) tools) GI Severity Index (GSI) score) after receiving intervention A total 180 were enrolled study (probiotic group: 90 90). All completed The group showed a significant reduction symptom severity as measured SRS-2 tool (47.77% vs 23.33%; p=0.000) compared placebo. Probiotic-treated demonstrated reductions severe symptoms, including social withdrawal/lethargy (40%), stereotypic behaviour (37.77%), hyperactivity (34.44%) inappropriate speech (32.22%) post-intervention (p=0.000). They also had marked improvements constipation (p=0.003) diarrhoea (p=0.043) group. Both groups exhibited statistically improved no adverse effects. significantly correlated. However, results need to be validated larger sample size. CTRI/2021/11/038213.

Language: Английский

Citations

0
Integrating Artificial Intelligence and Advanced Genomic Technologies in Unraveling Autism Spectrum Disorder and Gastrointestinal Comorbidities: A Multidisciplinary Approach to Precision Medicine DOI

Lama Ghunaim,

Ahmed S.A. Ali Agha, Talal Aburjaı

et al.

Jordan Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 17(3), P. 567 - 581

Published: Sept. 24, 2024

This article explores the potential impact of Artificial Intelligence (AI), Machine Learning (ML), CRISPR-Cas9 gene editing, and single-cell RNA sequencing on improving our understanding management Autism Spectrum Disorder (ASD) its gastrointestinal (GI) comorbidities. It examines how these technologies illuminate complex interplay between gut brain, identifying specific enzyme deficiencies microbial imbalances linked to GI symptoms in ASD. By leveraging AI ML, personalized intervention strategies are developed through analysis genomic, proteomic, environmental data, enhancing ability predict address issues Additionally, editing holds promise for correcting genetic abnormalities related production, potentially offering precise treatments. Single-cell provides critical insights into cellular diversity ASD gut, uncovering new therapeutic targets. The highlights transformative while addressing associated challenges ethical considerations. underscores necessity a multidisciplinary approach fully harness their benefits discusses significant progress emerging trends field, emphasizing role technological advancements advancing precision medicine

Language: Английский

Citations

2
Nutritional management and autism spectrum disorder: A systematic review DOI Open Access
Mohammed Al‐Beltagi

World Journal of Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 13(4)

Published: Oct. 30, 2024

BACKGROUND Autism spectrum disorder (ASD) presents unique challenges related to feeding and nutritional management. Children with ASD often experience difficulties, including food selectivity, refusal, gastrointestinal issues. Various interventions have been explored address these challenges, dietary modifications, vitamin supplementation, therapy, behavioral interventions. AIM To provide a comprehensive overview of the current evidence on management in ASD. We examine effectiveness interventions, supplements, mealtime practices addressing needs children METHODS systematically searched relevant literature up June 2024, using databases such as PubMed, PsycINFO, Scopus. Studies were included if they investigated or strategies improve behaviors assessed quality studies synthesized findings impact various difficulties outcomes. Data extraction focused intervention types, study designs, participant characteristics, outcomes measured, effectiveness. RESULTS The review identified 316 that met inclusion criteria. indicates while supplements may offer benefits managing specific symptoms deficiencies, approaches varies. Feeding therapy gradual exposure positive reinforcement, promise acceptance behaviors. also highlight importance creating supportive environments tailored sensory CONCLUSION Nutritional for requires multifaceted approach includes strategies. underscores need personalized further research refine treatment protocols Collaborative efforts among healthcare providers, educators, families are essential optimize this population's health practices. Enhancing our understanding sustainability long-term is optimizing care improving life their families.

Language: Английский

Citations

2
Alterations in Antioxidant Status and Erythrocyte Properties in Children with Autism Spectrum Disorder DOI Creative Commons

Tomáš Jasenovec,

Dominika Radošinská,

Katarína Janšáková

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2054 - 2054

Published: Nov. 28, 2023

Erythrocytes are responsible for the transport of oxygen within organism, which is particularly important nerve tissues. Erythrocyte quality has been shown to be deteriorated in oxidative stress conditions. In this study, we measured same series markers plasma and erythrocytes compare differences between neurotypical children (controls) with autism spectrum disorder (ASD). We also focused on erythrocyte properties including their deformability, osmotic resistance, Na,K-ATPase activity, nitric oxide levels free radical ASD controls. Greater damage proteins lipids was observed than subjects. Additionally, antioxidant enzymes were more active samples from erythrocytes. Significantly higher level enzyme activity detected individuals comparison Changes status could at least partially contribute deterioration morphology, as frequent echinocyte formation individuals. These alterations most probably worsening deformability ASD. can conclude that abnormalities involved pathomechanisms eventually its clinical manifestations.

Language: Английский

Citations

4
Metabolomic changes in children with autism DOI Open Access
Mohammed Al‐Beltagi,

Nermin Kamal Saeed,

Adel Salah Bediwy

et al.

World Journal of Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 13(2)

Published: June 7, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. Metabolomic profiling has emerged as valuable tool for understanding the underlying metabolic dysregulations associated with ASD.

Language: Английский

Citations

1
Case Series: Constipation and Fecal Incontinence in Children with ADHD and Autism Spectrum Disorder DOI Open Access

Sarah Alnahe

Journal of Sociology Psychology & Religious Studies, Journal Year: 2024, Volume and Issue: 6(1), P. 75 - 85

Published: July 29, 2024

The comorbidity of gastrointestinal (GI) diseases is high among attention deficit and hyperactivity disease (ADHD) children with autism spectrum disorder (ASD). Previous investigations report fecal incontinence constipation as the most prevalent GI disorders ADHD-ASD children, posing clinical questions regarding effective management approaches. This case series investigates incidences, symptomatology behavioral reported by without histories ADHD ASD to inform evidence-based interventions policy. Methods. investigated abnormalities 12 preschoolers in a psychiatric clinic. investigation considers history illness. Parents’ teachers’ accounts informed decisions. higher incidence retention male than female 7 5, respectively. international classification confirmed signs symptoms constipated including avoidance school public restrooms preference for home restrooms. Behavioral like hyperfocus, which are defense mechanism against sensory-rich environment, marked disorders. However, stool softeners, polyethylene glycol, other laxatives were administered stimulate defecation enhancing bowel motility. cognitive therapy was indicated impart coping skills necessary handle environments. Preschoolers presented fundamental symptoms, at due Medications softeners enhance movement, whereas psychotherapy enhances children’s prevent withholding feces environments schools places. These alleviated improved quality life. Keywords: Pediatric Constipation, Fecal Incontinence, ADHD, Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders

Language: Английский

Citations

1
Nörogelişimsel Hastalığı Olan Çocuklarda Duyusal İşlem Bozukluklarının Beslenme Davranışına Etkisi: Mini Bir Derleme DOI
Nevra Koç, Fatma Kılıç, Fatma Elif Eroğlu

et al.

Bingöl Üniversitesi Sağlık Dergisi, Journal Year: 2024, Volume and Issue: 5(3), P. 707 - 716

Published: June 28, 2024

Çocuklarda yaygın olarak görülen nörogelişimsel hastalıkların önemli semptomlarından birisi de duyusal işlem bozukluğudur. Duyusal bozukluğu, çevresel uyaranlara yanıt verilmesinde yaşanan aşırı duyarlılık veya kayıtsızlık tanımlanmaktadır. bozukluğu özellikle otizm spektrum dikkat eksikliği ve hiperaktivite gibi bozukluklara sahip olan çocukların genel beslenme davranışı ile ilişkilendirilmektedir. Oral, dokunsal koku duyularında hipersensitivite/hiposensitivite seçici yeme kısıtlı davranışlarının ortaya çıkmasına bu davranışların şiddetinin artmasına yol açmaktadır. Seçici durumlarını etkileyerek çocuklarda genellikle daha düşük sebze meyve, fazla doymuş yağ basit karbonhidrat tüketimiyle sonuçlanmaktadır. Bu durum enerji makro mikro besin ögesi gereksinimlerinin günlük önerilen düzeylerde alınmamasına sebep olmaktadır. Yetersiz dengesiz sonucunda obezite malnütrisyon görülebilmektedir. Yapılan son çalışmalarda davranışını da düzeyde etkileyen bozuklukları hakkında ebeveynlerin sağlık çalışanlarının farkındalığının yeterli olmadığı görülmüştür. Nörogelişimsel hastalıkları çocuklar sorunları açısından risk altındadır. bağlamda durumu değerlendirilirken bozukluklarının varlığı, var hassasiyet kayıtsızlığın tüketim üzerindeki etkisi sorgulanmalı çözüm arayışında dikkate alınmalıdır. derlemenin amacı, hastalığı ilişkili davranış sorunlarına çekerek konuyu güncel literatür ışığında değerlendirmektir.

Citations

0
Intervenção nutricional em pré-escolares com Transtorno do Espectro Autista: uma revisão integrativa DOI Creative Commons

Kaline Coelho Dantas Morais,

Karilany Dantas Coutinho, José Adaílton da Silva

et al.

Contribuciones a las Ciencias Sociales, Journal Year: 2024, Volume and Issue: 17(8), P. e9121 - e9121

Published: Aug. 6, 2024

O Transtorno do Espectro Autista (TEA) é um distúrbio complexo desenvolvimento, desencadeado por uma interação entre fatores genéticos e ambientais que se manifesta principalmente através de alterações neurológicas, comportamentais digestivas. As abordagens nutricionais emergem como perspectiva promissora para mitigar tais sintomas. Este estudo procurou encontrar evidências científicas sobre intervenções em pré-escolares com TEA, especialmente relação aos sintomas gastrointestinais e/ou comuns no transtorno. Foi realizada revisão integrativa a fim responder à pergunta: há estabeleçam o TEA terapia nutricional, favorecendo melhorias nos sinais pré-escolares? Foram analisados artigos janeiro 2018 2024, seguindo as recomendações The Joanna Briggs Institute, utilizando bases dados Medline/Pubmed, Embase, Cochrane Library Scopus. Seis estudos foram incluídos, abrangendo diferentes tipos nutricionais. Destacam-se dietas sem glúten, suplementos alimentares vitamina A, D, Ômega 3, soro leite rico cisteína probióticos. Concluiu-se intervenção nutricional pode trazer benefícios sintomatologia enfatizando necessidade mais pesquisas entender melhor esta

Citations

0
Cross-cultural adaptation and psychometric testing of the Turkish version of the Sensory Eating Problems Scale in children with neurodevelopmental disorders DOI
Tarık Demirok, Ezginur Gündoğmuş, Damla Ece Irmak

et al.

International Journal of Developmental Disabilities, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Sept. 4, 2024

Language: Английский

Citations

0
GastroSmart: Precision GI Health Monitoring with Non-Invasive GMR DOI Open Access

Dhakshunaamoorthiy,

K. Sudharson,

P. Girija

et al.

International Research Journal of Multidisciplinary Technovation, Journal Year: 2024, Volume and Issue: unknown, P. 17 - 37

Published: Oct. 30, 2024

Pathological conditions affecting the gastroenterological tract such as GERD, gastroparesis, gastric cancer, type 2 diabetes, and obesity among others present alarming levels of health risks. Conventional imaging methods ultrasonic have a very high cost do not provide real-time monitoring. To overcome these challenges, we new system based on GMR sensor capable non-invasively measuring volume over prolonged periods time. This uses Rational Dilation Wavelet Transformation in order to enhance accuracy evaluated dynamics. With help polynomial regression, changes can be predicted accurately by our model, which makes it possible prevent exacerbation gastrointestinal diseases early stages. The continuous evaluation condition patients their physical activity performed this non-invasive method will allow individualized treatment each patient best way improve healing without sacrificing safety. investigation is response for implementing low-cost effective solutions constant monitoring with distresses direction preventive nursing clinical care patients.

Language: Английский

Citations

0