Journal of Molecular and Cellular Cardiology Plus, Journal Year: 2023, Volume and Issue: 7, P. 100057 - 100057
Published: Dec. 9, 2023
Language: Английский
Metabolism, Journal Year: 2024, Volume and Issue: 157, P. 155953 - 155953
Published: June 15, 2024
Language: Английский
Citations
13
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 23, 2024
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 10, 2024
Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the world. The development and progression of HCC are closely correlated with abnormal regulation non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long (lncRNAs), circular (circRNAs). Important biological pathways cancer biology, cell proliferation, death, metastasis, impacted by these ncRNAs, which modulate gene expression. expression raises possibility that they could be applied new biomarkers for diagnosis, prognosis, treatment targets. Furthermore, controlling genes, miRNAs can function either tumor suppressors or oncogenes. On other hand, lncRNAs play role advancement interacting molecules within cell, which, turn, affects processes chromatin remodeling, transcription, post-transcriptional processes. importance ncRNA-driven regulatory systems being highlighted current research, sheds light on behavior therapy response. This research highlights great potential ncRNAs improve patient outcomes this difficult disease landscape augmenting present methods care through use precision medicine approaches.
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 9, 2024
Ferroptosis is a type of cell death that plays remarkable role in the growth and advancement malignancies including hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) have considerable impact on HCC by functioning as either oncogenes or suppressors. Recent research has demonstrated non-coding ability to control ferroptosis cells, hence impacting tumors resistance these cells drugs. Autophagy mechanism conserved throughout evolution maintaining balance body under normal settings. Nevertheless, occurrence dysregulation autophagy evident progression various human disorders, specifically cancer. dual roles cancer, potentially influencing both survival death. prevalent kind liver genetic mutations changes molecular pathways might worsen its advancement. The subject debate, it capacity repress promote tumor growth. activation can apoptosis, proliferation glucose metabolism, facilitate spread through EMT. Inhibiting hinder enhance respond treatment. regulated several signaling pathways, such STAT3, Wnt, miRNAs, lncRNAs, circRNAs. Utilizing anticancer drugs target may advantageous implications for efficacy cancer
Language: Английский
Citations
5
International Journal of Oncology, Journal Year: 2025, Volume and Issue: 66(3)
Published: Feb. 11, 2025
Long non‑coding (lnc)RNAs participate in colorectal cancer (CRC) occurrence and progression. The present study aimed to investigate whether lncRNA ABHD11‑AS1 regulates malignant biological behavior of CRC cells. Bioinformatic analysis, reverse transcription‑quantitative PCR situ hybridization revealed that expression was decreased samples associated with an unfavorable prognosis. overexpression significantly proliferation, migration invasion cells, whereas inhibition had the opposite effects. interacted EGFR inhibit phosphorylation attenuate EGFR/ERK signaling, which turn suppressed tumor suppressor function attenuated by agonist NSC228155. Finally, resveratrol (RSV) inhibited cell invasion, may be RSV‑induced decrease SPT6 homolog, histone chaperone transcription elongation factor protein increase transcript levels. signaling interacting EGFR, thereby delaying progression CRC. ABHD11‑AS1/EGFR/ERK axis a novel therapeutic target for preventing
Language: Английский
Citations
0
Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149462 - 149462
Published: April 1, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 766 - 766
Published: Feb. 13, 2024
The incidence of hepatocellular carcinoma (HCC) is increasing, and 40% patients are diagnosed at advanced stages. Over the past 5 years, number clinically available treatments has dramatically increased for HCC, making patient management particularly complex. Immune checkpoint inhibitors (ICIs) have improved overall survival patients, showing a durable treatment benefit over time different response pattern with respect to tyrosine kinase (TKIs). Although there in responder cases, sizeable group primary progressors or ineligible immunotherapy. Indeed, nonviral etiologies, such as nonalcoholic steatohepatitis (NASH), alterations specific driver genes might be less responsive Therefore, improving comprehension mechanisms drug resistance identifying biomarkers that informative best approach required actions improve survival. Abundant evidence indicates noncoding RNAs (ncRNAs) pivotal players cancer. Molecular through which ncRNAs exert their effects cancer progression been widely investigated. Nevertheless, no studies summarizing synergistic effect between ncRNA-based strategies TKIs ICIs preclinical setting. This review aims provide up-to-date information regarding possible use therapeutic targets association molecular-targeted agents immunotherapies predictive tools selection optimized options HCCs.
Language: Английский
Citations
2
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117769 - 117769
Published: Dec. 16, 2024
Language: Английский
Citations
2
Published: Jan. 22, 2024
The incidence of hepatocellular carcinoma (HCC) is increasing and 40% patients are diagnosed at advanced stages. Over the past 5 years, number clinical available treatments have dramatically increased for HCC, making patient management particularly complex. Immune checkpoint inhibitors (ICIs) improved overall survival showing a durable treatment benefit over time, different response pattern with respect to tyrosine kinase (TKIs). Although in responder cases, sizeable group primary progressors or ineligible immunotherapy. Indeed, non-viral etiologies, such non-alcoholic steatohepatitis (NASH), alterations specific driver genes might be less responsive Therefore, improving comprehension mechanisms drug resistance identifying biomarkers informative best approach required actions improve survival. Numerous evidence indicated non-coding RNAs (ncRNAs) as pivotal players cancer. Molecular through which ncRNAs exert their effects cancer progression been widely investigated. Nevertheless, there no studies summarizing synergistic effect between ncRNA-based strategies TKIs ICIs preclinical setting. This review aims provide up-to-date information regarding possible use therapeutic targets association molecular targeted agents immunotherapies predictive tools selection optimized options HCCs.
Language: Английский
Citations
1
Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 3, 2024
Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.
Language: Английский
Citations
1