Lipid metabolism in astrocytic structure and function

Seminars in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 112, P. 123 - 136

Published: Aug. 6, 2020

Language: Английский

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Primary cilia and ciliary signaling pathways in aging and age-related brain disorders

Neurobiology of Disease, Journal Year: 2021, Volume and Issue: 163, P. 105607 - 105607

Published: Dec. 31, 2021

Brain disorders are characterized by the progressive loss of structure and function brain as a consequence degeneration and/or death nerve cells. Aging is major risk factor for such Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS), stroke. Various cellular molecular events have been shown to play role in progress neurodegenerative diseases. Emerging studies suggest that primary cilia could be key regulator The cilium singular organelle expressed on surface many cell types, astrocytes neurons mature brain. Primary detect extracellular cues, Sonic Hedgehog (SHH) protein, transduce these signals into cells regulate various signaling pathways. Abnormalities ciliary length frequency (ratio ciliated cells) implicated human diseases, including disorders. This review summarizes current findings thoughts pathways aging age-related

Language: Английский

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Nigral overexpression of α‐synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome

Neurogastroenterology & Motility, Journal Year: 2019, Volume and Issue: 32(1)

Published: Oct. 2, 2019

Abstract Background A hallmark feature of Parkinson's disease (PD) is the build‐up α‐synuclein protein aggregates throughout brain; however also expressed in enteric neurons. Gastrointestinal (GI) symptoms and pathology are frequently reported PD, including constipation, increased intestinal permeability, glial pathology, alterations to gut microbiota composition. can propagate through neuronal systems but site origin whether it be or brain, still unknown. Physical exercise associated with alleviating PD altering composition microbiota. Methods This study investigated effects bilateral nigral injection adeno‐associated virus (AAV)‐α‐synuclein on neurons, glia neurochemistry, microbiome, bile acid metabolism rats, some whom were exposed voluntary exercise. Key Results Nigral overexpression resulted significant loss ileal submucosal plexus no change glia. In contrast, myenteric showed a increase expression, while numbers maintained. Concomitant observed microbiome related metabolism. Voluntary running protected against loss, modified brain‐injected AAV‐α‐synuclein model. Conclusions Inferences These results show that developing this model exerts nervous system (ENS) receptive modification by highlights brain communication as an important mechanism pathology.

Language: Английский

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Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson's disease: The therapeutic role of Nrf2 activators

Neurochemistry International, Journal Year: 2021, Volume and Issue: 145, P. 105014 - 105014

Published: March 8, 2021

Language: Английский

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Neuroprotective Effects of Resveratrol in In vivo and In vitro Experimental Models of Parkinson’s Disease: a Systematic Review

Neurotoxicity Research, Journal Year: 2022, Volume and Issue: 40(1), P. 319 - 345

Published: Jan. 11, 2022

Language: Английский

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The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Neurochemistry International, Journal Year: 2022, Volume and Issue: 158, P. 105376 - 105376

Published: June 3, 2022

Language: Английский

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Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia

Life Sciences, Journal Year: 2023, Volume and Issue: 337, P. 122356 - 122356

Published: Dec. 18, 2023

Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood glucose, obesity, and dyslipidemia, known to increase the risk of dementia accompanied memory loss depression. The direct pathways specific mechanisms in central nervous system (CNS) for addressing fatty acid imbalances MetS have not yet been fully elucidated. Among polyunsaturated acids, linoleic (LA, n6-PUFA) α-linolenic (ALA, n3-PUFA), are two essential acids that should be provided food sources (e.g., vegetable oils seeds), reported regulate various cellular including apoptosis, inflammatory responses, mitochondrial biogenesis, signaling. Furthermore, inadequate intake LA ALA involved neuropathology neuropsychiatric diseases as well imbalanced metabolic conditions. Herein, we review roles on metabolic-related focusing synaptic plasticity, cognitive function, issues. This suggests important concurrent treatment both neurological problems.

Language: Английский

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Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 85, P. 101838 - 101838

Published: Jan. 5, 2023

Language: Английский

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Lactoferrin: neuroprotection against Parkinson's disease and secondary molecule for potential treatment

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Sept. 5, 2023

Parkinson's disease (PD) is the second-most common neurodegenerative and largely caused by death of dopaminergic (DA) cells. Dopamine loss occurs in substantia nigra pars compacta leads to dysfunctions motor functions. Death DA cells can occur with oxidative stress dysfunction glial Parkinson-related gene mutations. Lactoferrin (Lf) a multifunctional glycoprotein that usually known for its presence milk, but recent research shows Lf also found brain regions. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mitochondrial toxin disturbs electron transport chain (ETC) system increases rate reactive oxygen species. Lf's high affinity metals decreases required iron Fenton reaction, reduces damage MPTP, their surveillance rate. Several studies investigated effect on neurons are treated MPTP. The results pointed out protective be observed without stress; thus, several potential mechanisms currently being researched, starting HSPG–Lf interaction cellular membrane activity region showed lactoferrin initiates receptor-mediated transcytosis blood–brain barrier (BBB) existence receptors endothelial both created idea using as secondary molecule therapeutic agents across BBB, especially nanoparticle development.

Language: Английский

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The Involvement of Neuroinflammation in the Onset and Progression of Parkinson’s Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14582 - 14582

Published: Sept. 26, 2023

Parkinson’s disease is a neurodegenerative exhibiting the fastest growth in incidence recent years. As with most diseases, pathophysiology incompletely elucidated, but compelling evidence implicates inflammation, both central nervous system and periphery, initiation progression of disease, although it not yet clear what triggers this inflammatory response where begins. Gut dysbiosis seems to be likely candidate for systemic inflammation. The therapies current use provide only symptomatic relief, do interfere progression. Nonetheless, animal models have shown promising results that target various vicious neuroinflammatory cascades. Translating these therapeutic strategies into clinical trials still its infancy, series issues, such as exact timing, identifying biomarkers able identify early pre-symptomatic stages, or proper indications genetic testing population at large, will need settled future guidelines.

Language: Английский

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