Heliyon,
Journal Year:
2024,
Volume and Issue:
11(1), P. e41588 - e41588
Published: Dec. 31, 2024
Detection
of
biomolecules,
Glutathione
(GSH)
in
particular,
is
important
because
it
helps
assess
antioxidant
capacity,
cellular
protection,
detoxification
processes,
and
potential
disease
associations.
Monitoring
glutathione
levels
can
provide
valuable
information
about
overall
health
well-being.
Many
medical
disorders
have
been
connected
to
levels.
Higher
seen
several
cancer
cell
types,
which
may
increase
their
resistance
radiation
chemotherapy.
be
measured
through
various
methods,
such
as
colorimetric
assays
fluorescent
probes.
However,
surface-enhanced
Raman
scattering
(SERS)
has
known
an
efficient
selective
technique
for
biomolecule
detection.
Here
this
perspective
review,
we
reported
two
distinctive
methods
based
on
SERS
detection
GSH;
heat-induced
method
reversed
reporting
agent
method.
Several
variables
that
impact
the
scheme
were
elaborated
"heat-induced
method,"
including
pretreatment,
nanoparticle
reduction
time,
process
temperature,
pH
colloidal
solution,
concentration
citrate
buffer,
participating
nanoparticles.
To
choose
best
a
reverse
using
approaches,
agents
examined
second
In
order
grasp
situation
at
hand,
detection-specifically,
GSH
schemes-was
briefly
discussed.
spectroscopy
its
associated
terminology
then
covered
followed
by
outlook
end.
meet
demands
real-time
applications
everyday
life
enhance
detection-in
detection-such
thorough
investigation
unavoidable.
Chemical Biology & Drug Design,
Journal Year:
2025,
Volume and Issue:
105(1)
Published: Jan. 1, 2025
ABSTRACT
Invasive
fungal
infections
(IFIs)
pose
significant
challenges
in
clinical
settings,
particularly
due
to
their
high
morbidity
and
mortality
rates.
The
rising
incidence
of
these
infections,
coupled
with
increasing
antifungal
resistance,
underscores
the
urgent
need
for
novel
therapeutic
strategies.
Current
drugs
target
cell
membrane,
wall,
or
intracellular
components,
but
resistance
mechanisms
such
as
altered
drug‐target
interactions,
enhanced
efflux,
adaptive
cellular
responses
have
diminished
efficacy.
Recent
research
has
highlighted
potential
dual
inhibitors
that
simultaneously
multiple
pathways
enzymes
involved
growth
survival.
Combining
pharmacophores,
lanosterol
14α‐demethylase
(CYP51),
heat
shock
protein
90
(HSP90),
histone
deacetylase
(HDAC),
squalene
epoxidase
(SE)
inhibitors,
led
development
compounds
activity
reduced
resistance.
This
dual‐target
approach,
along
chemical
scaffolds,
not
only
represents
a
promising
strategy
combating
is
also
being
utilized
anticancer
agents.
review
explores
new
agents
employ
mono‐,
dual‐,
multi‐target
strategies
combat
IFIs.
We
discuss
emerging
targets,
mechanisms,
innovative
approaches
offer
hope
managing
challenging
infections.
BMC Plant Biology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: May 21, 2024
Abstract
Intercropping,
a
widely
adopted
agricultural
practice
worldwide,
aims
to
increase
crop
yield,
enhance
plant
nutrient
uptake,
and
optimize
the
utilization
of
natural
resources,
contributing
sustainable
farming
practices
on
global
scale.
However,
underlying
changes
in
soil
physio-chemical
characteristics
enzymatic
activities,
which
contribute
yield
uptake
intercropping
systems
are
largely
unknown.
Consequently,
two-year
(2021–2022)
field
experiment
was
conducted
maize/soybean
with/without
nitrogen
(N)
fertilization
(i.e.,
N
0
;
kg
ha
−1
1
225
for
maize
100
soybean
)
know
whether
such
cropping
system
can
improve
nutrients
yields,
characteristics,
enzymes,
ultimately
results
enhanced
yield.
The
revealed
that
treatments
MI
MI)
had
higher
biomass
dry
matter,
1000-grain
weight
than
mono-cropping
MM,
MM).
Nonetheless,
these
parameters
were
optimized
both
years.
For
instance,
produced
maximum
grain
(10,105
11,705
),
matter
(13,893
14,093
(420
449
g)
year
2021
2022,
respectively.
Conversely,
SI
SI)
reduced
soybean.
Also,
land
equivalent
ratio
(LER)
(LER
values
always
greater
1,
showing
system’s
benefits
terms
improved
resource
usage.
Moreover,
significantly
(
p
<
0.05)
N,
P,
K,
Ca,
Fe,
Zn)
soybean,
however,
uptakes
more
prominent
respectively
years
(2021
2022)
compared
with
their
treatments.
Similarly,
maize-soybean
MSI
MSI)
soil-based
NH
4
,
NO
3
organic
but,
pH.
Such
also
activities
as
protease
(PT),
sucrose
(SC),
acid
phosphatase
(AP),
urease
(UE),
catalase
(CT)
activities.
This
indicates
could
potentially
better
pool,
related
Thus,
preferring
be
preferable
choice
ecologically
viable
development.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(3), P. 471 - 471
Published: Feb. 27, 2022
Reactive
oxygen
species
(ROS)
are
necessary
for
normal
cell
signaling
and
the
antimicrobial
defense
of
skin.
However
excess
production
ROS
can
disrupt
cellular
redox
balance
overwhelm
antioxidant
(AO)
capacity,
leading
to
oxidative
stress.
In
skin,
stress
plays
a
key
role
in
driving
both
extrinsic
intrinsic
aging.
Sunlight
exposure
has
also
been
major
contributor
photoaging
skin
as
its
oxidising
components
redox-
iron-homeostasis,
promoting
damage
cells
tissue
constituents.
Upon
insults,
interplay
between
accumulation
redox-active
labile
iron
(LI)
detrimental
consequences
often
overlooked.
this
review
we
have
revisited
mechanisms
underlying
aging
by
focussing
on
concerted
action
LI
initiation
progression
processes.
Based
these,
propose
redefine
selection
criteria
antiaging
photoprotective
ingredients
include
natural
antioxidants
(AOs)
exhibiting
robust
redox-balancing
and/or
iron-chelating
properties.
This
would
promote
concept
natural-based
or
bio-inspired
bifunctional
anti-aging
skincare
sunscreen
formulations
with
AO
Artificial Cells Nanomedicine and Biotechnology,
Journal Year:
2024,
Volume and Issue:
52(1), P. 84 - 103
Published: Jan. 18, 2024
Neurological
disorders
such
as
neurodegenerative
diseases
and
nervous
system
tumours
affect
more
than
one
billion
people
throughout
the
globe.
The
physiological
sensitivity
of
tissue
limits
application
invasive
therapies
leads
to
poor
treatment
prognosis.
One
promising
solution
that
has
generated
attention
is
Photodynamic
therapy
(PDT),
which
can
potentially
revolutionise
landscape
for
neurological
disorders.
PDT
attracted
substantial
recognition
anticancer
efficacy
drug
conjugation
targeted
delivery.
This
review
thoroughly
explained
basic
principles
PDT,
scientific
interventions
advances
in
their
complicated
mechanism
treating
brain-related
pathologies.
Furthermore,
merits
demerits
context
offer
a
well-rounded
perspective
on
its
feasibility
challenges.
In
conclusion,
this
encapsulates
significant
potential
transforming
disorders,
emphasising
role
non-invasive,
therapeutic
approach
with
multifaceted
applications.
Catalysts,
Journal Year:
2021,
Volume and Issue:
11(2), P. 218 - 218
Published: Feb. 6, 2021
Heme
proteins
take
part
in
a
number
of
fundamental
biological
processes,
including
oxygen
transport
and
storage,
electron
transfer,
catalysis
signal
transduction.
The
redox
chemistry
the
heme
iron
biochemical
diversity
have
led
to
development
plethora
biotechnological
applications.
This
work
focuses
on
biosensing
devices
based
proteins,
which
they
are
electronically
coupled
an
electrode
their
activity
is
determined
through
measurement
catalytic
currents
presence
substrate,
i.e.,
target
analyte
biosensor.
After
overview
main
concepts
amperometric
biosensors,
we
address
transduction
schemes,
protein
immobilization
strategies,
performance
that
explore
reactions
biocatalysts,
peroxidase,
cytochrome
P450,
catalase,
nitrite
reductase,
c
oxidase,
derived
microperoxidases,
hemoglobin,
myoglobin.
We
further
discuss
how
structural
information
about
immobilized
can
lead
rational
design
devices,
ensuring
insights
into
efficiency
long-term
stability.
